ethyl-cellulose and miglyol-840

ethyl-cellulose has been researched along with miglyol-840* in 1 studies

Other Studies

1 other study(ies) available for ethyl-cellulose and miglyol-840

ArticleYear
Nonaqueous gel for the transdermal delivery of a DTPA penta-ethyl ester prodrug.
    The AAPS journal, 2013, Volume: 15, Issue:2

    Diethylenetriamine pentaacetic acid penta-ethyl ester, designated as C2E5, was successfully incorporated into a nonaqueous gel for transdermal delivery. The thermal and rheological properties of a formulation containing 40% C2E5, 20% ethyl cellulose, and 40% Miglyol 840® prepared using the solvent evaporation method demonstrated that the gel had acceptable content uniformity and flow properties. In vitro studies showed that C2E5 was steadily released from the gel at a rate suitable for transdermal delivery. Topical application of the gel at a 200 mg C2E5/kg dose level in rats achieved significantly higher plasma exposures of several active metabolites compared with neat C2E5 oil at the same dose level. The results suggest that transdermal delivery of a chelator prodrug is an effective radionuclide decorporation strategy by delivering chelators to the circulation with a pharmacokinetic profile that is more consistent with the biokinetic profile of transuranic elements in contaminated individuals.

    Topics: Administration, Cutaneous; Animals; Biotransformation; Calorimetry, Differential Scanning; Cellulose; Chelating Agents; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diglycerides; Drug Carriers; Drug Compounding; Female; Gels; Pentetic Acid; Prodrugs; Rats; Rats, Sprague-Dawley; Rheology; Skin Absorption; Solubility; Technology, Pharmaceutical

2013