ethyl-cellulose and mebeverine

ethyl-cellulose has been researched along with mebeverine* in 2 studies

Other Studies

2 other study(ies) available for ethyl-cellulose and mebeverine

ArticleYear
Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.
    Pharmaceutical development and technology, 2011, Volume: 16, Issue:4

    Mebeverine HCl is a water soluble drug commonly used to treat irritable bowel syndrome by acting directly on the smooth muscles of the colon. This work was aimed at the formulation and in vitro evaluation of a colon-targeted drug delivery system containing mebeverine HCl. Matrix tablets were prepared using ethyl cellulose (EC), Eudragit RL 100 either solely or in combination by wet granulation technique. Dissolution was carried out in 0.1 N HCl for 2?h followed by pH 6.8 phosphate buffer for eight hours. Uncoated forms released more than 5% drug in 0.1 N HCl therefore, Eudragit L100 was used as a coat. The results indicated very slow release profile. As a result, single retardant was used to prepare the matrix and coated by Eudragit L 100. The matrix containing 7% Eudragit RL 100 and 6% of binder was subjected to further studies to assess the effect of different coats (Eudragit L 100-55 and cellulose acetate phthalate) and different binders (pectin and sodium alginate) on the release profile. Eudragit L 100 and pectin were the best coating agent and binder, respectively. The final formula was stable and it can be concluded that the prepared system has the potential to deliver mebeverine HCl in vivo to the colon.

    Topics: Alginates; Cellulose; Colon; Drug Delivery Systems; Excipients; Glucuronic Acid; Hexuronic Acids; Humans; Hydrogen-Ion Concentration; Parasympatholytics; Pectins; Phenethylamines; Polymethacrylic Acids; Solubility; Tablets, Enteric-Coated

2011
A novel formulation for mebeverine hydrochloride.
    Drug development and industrial pharmacy, 2007, Volume: 33, Issue:10

    The antispasmodic drug mebeverine hydrochloride was formulated into a film-forming gel to be used as a topical local anesthetic. A mixture of cellulose derivatives was used as a base. Additives were used to enhance the release as well as the residence time. Formulations were characterized in terms of drug release, mucoadhesion and rheology. Clinically, the selected formula has shown faster onset (p = 0.0156), longer duration (p = 0.0313), better film residence (p = 0.0313), and no foreign body sensation (p = 0.0313) in comparison to Solcoseryl dental paste. Histopathological examination showed no change in inflammatory cells count, concluding that this topical anesthetic is efficacious and safe orally.

    Topics: Cellulose; Chemistry, Pharmaceutical; Gels; Phenethylamines; Povidone; Solubility; Surface-Active Agents; Viscosity

2007