ethyl-cellulose and lauric-acid

ethyl-cellulose has been researched along with lauric-acid* in 2 studies

Other Studies

2 other study(ies) available for ethyl-cellulose and lauric-acid

ArticleYear
A novel approach for dry powder coating of pellets with Ethylcellulose. Part I: Evaluation of film formulation and process set up.
    International journal of pharmaceutics, 2017, Jan-10, Volume: 516, Issue:1-2

    An innovative dry powder coating technology was developed in a high-shear granulator using ethylcellulose (E10) as polymer. Several solid plasticizers were investigated with the aim of decreasing the polymer Tg at least to the highest possible working temperature (80°C). DSC analysis of physical mixtures of E10 and plasticizers evidenced that lauric acid (LA) was the most effective plasticizer. In order to reach the target temperature a liquid plasticizer, oleic acid (OA), was introduced in the coating formulation. Free films were then prepared and the target minimum film forming temperature (MFFT) was established in the range 70-80°C. Depending on the LA:OA weight ratio, Kollidon VA64 was included to decrease the LA recrystallization, while talc served as anti-sticking agent. Curing at the MFFT ensured the formation of homogeneous and stable films with good stability on storage. The dry powder coating process of placebo pellets was then developed, consisting of a combination of liquid assisted and thermal adhesion methods. The best coating formulations in terms of yields, coating efficiency (expressed as Relative Standard Deviation of the weight applied) and low pellets aggregation were based on E10:LA:OA in a weight ratio of 65:20:15 and 60:20:20. Moreover pellets remained stable after 1year of storage (25°C/60% R.H.).

    Topics: Calorimetry, Differential Scanning; Cellulose; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Drug Storage; Excipients; Lauric Acids; Oleic Acid; Plasticizers; Polymers; Powders; Temperature; Time Factors

2017
Transdermal delivery of theophylline using an ethanol/panasate 800-ethylcellulose gel preparation.
    Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:1

    A novel ethylcellulose gel preparation using an ethanol/panasate 800 (tricaprylin) (40/60) binary lipophilic vehicle was developed and applied to the transdermal delivery of theophylline. The in vitro skin permeability of theophylline across excised hairless mouse skin was improved by the use of this ethanol/panasate 800 (40/60) binary vehicle compared with either ethanol or panasate 800 as a single vehicle, and the addition of lauric acid as a permeation enhancer to the binary vehicle shortened the lag time and increased the permeated amount of theophylline up to 6 h (initial permeation amount). The in vitro permeability of theophylline from the ethanol/panasate 800 (40/60)-ethylcellulose gels decreased with an increase in the content of ethylcellulose in the gels. In the in vivo evaluation using abdominal rat skin, the ethanol/panasate 800 (40/60)-7% (w/w) ethylcellulose gel produced a good feature as a sustained-release preparation, with a relatively high bioavailability (BA) of theophylline, and dose dependency was observed.

    Topics: Administration, Cutaneous; Animals; Biological Availability; Caprylates; Cellulose; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Diffusion; Ethanol; Excipients; Gels; In Vitro Techniques; Lauric Acids; Mice; Mice, Nude; Rats; Rats, Wistar; Skin Absorption; Theophylline; Triglycerides

1995