ethyl-biscoumacetate and 4-hydroxycoumarin

ethyl-biscoumacetate has been researched along with 4-hydroxycoumarin* in 7 studies

Other Studies

7 other study(ies) available for ethyl-biscoumacetate and 4-hydroxycoumarin

Article	Year
Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 The synthesis is reported here of two novel series of inhibitors of human NAD(P)H quinone oxidoreductase-1 (NQO1), an enzyme overexpressed in several types of tumor cell. The first series comprises substituted symmetric dicoumarol analogues; the second series contains hybrid compounds where one 4-hydroxycoumarin system is replaced by a different aromatic moiety. Several compounds show equivalent or improved NQO1 inhibition over dicoumarol, both in the presence and in the absence of added protein. Further, correlation is demonstrated between the ability of these agents to inhibit NQO1 and computed binding affinity. We have solved the crystal structure of NQO1 complexed to a hybrid compound and find good agreement with the in silico model. For both MIA PaCa-2 pancreatic tumor cells and HCT116 colon cancer cells, dicoumarol shows the greatest toxicity of all compounds. Thus, we provide a computational, synthetic, and biological platform to generate competitive NQO1 inhibitors with superior pharmacological properties to dicoumarol. This will allow a more definitive study of NQO1 activity in cells, in particular, its drug activating/detoxifying properties and ability to modulate oncoprotein stability. Topics: 4-Hydroxycoumarins; Animals; Cattle; Cell Line, Tumor; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; NAD(P)H Dehydrogenase (Quinone); Quantitative Structure-Activity Relationship	2009
[PAPER CHROMATOGRAPHIC DEMONSTRATION OF THE ANTICOAGULANTS 3-(1-PHENYLPROPYL)-4-HYDROXYCOUMARIN (FALITHROM) AND THE ETHYL ESTER OF DIHYDROXYCOUMARINYLACETIC ACID (PELENTAN)]. Pharmazeutische Praxis, 1964, Volume: 204 Topics: 4-Hydroxycoumarins; Anticoagulants; Chemistry, Pharmaceutical; Chromatography; Chromatography, Paper; Coumarins; Esters; Ethyl Biscoumacetate; Pharmacy; Phenprocoumon; Research	1964
Clinical experience with 3-(1-phenylpropyl)-4-hydroxycoumarin. Proceedings of the staff meetings. Mayo Clinic, 1957, Jun-26, Volume: 32, Issue:13 Topics: 4-Hydroxycoumarins; Coumarins; Dicumarol; Ethyl Biscoumacetate; Humans; Thromboembolism	1957
[The secretion of drugs, especially 3,3' carboxymethylene bis (4-hydroxycoumarin) ethyl ester, tromexan, in human milk]. Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie, 1954, Volume: 137, Issue:1 Topics: 4-Hydroxycoumarins; Coumarins; Esters; Ethyl Biscoumacetate; Hemostatics; Humans; Infant; Infant Nutritional Physiological Phenomena; Milk, Human; Prothrombin	1954
[Clinical observations on the use of 3,3'carboxymethylene bis-(4-hydroxycoumarin) ethyl ester (tromexan) in the treatment of venous thrombosis in obstetrics and gynecology]. Minerva ginecologica, 1953, Feb-15, Volume: 5, Issue:3 Topics: 4-Hydroxycoumarins; Coumarins; Ethyl Biscoumacetate; Female; Gynecology; Humans; Obstetrics; Thrombophlebitis; Venous Thrombosis	1953
Bishydroxycoumarin, ethyl biscoumacetate, and 4-hydroxycoumarin anticoagulant No. 63; comparative effects. Journal of the American Medical Association, 1952, Jan-26, Volume: 148, Issue:4 Topics: 4-Hydroxycoumarins; Anticoagulants; Coumarins; Dicumarol; Ethyl Biscoumacetate	1952
Tromexan-3,3'-carboxymethylenebis (4-hydroxycoumarin) ethyl ester; experimental and clinical properties. Circulation, 1951, Volume: 3, Issue:2 Topics: 4-Hydroxycoumarins; Ethyl Biscoumacetate; Humans	1951