ethyl 4-chloro-3-oxobutanoate has been researched along with ethyl 4-chloro-3-hydroxybutanoate in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukura, T; Kataoka, M; Kita, K; Nakase, KI; Okamoto, K; Shimizu, S; Yanase, H | 1 |
| Hasegawa, J; Kataoka, M; Kizaki, N; Shimizu, S; Wada, M; Yasohara, Y | 1 |
| Nishimura, A; Saratani, Y; Uheda, E; Yamamoto, H; Yoshizako, F | 1 |
| Houng, JY; Liau, JS | 1 |
| Esaki, N; Kimoto, N; Kobayashi, Y; Matsuyama, A; Mitsuhashi, K; Yamamoto, H | 1 |
| Esaki, N; Kimoto, N; Kobayashi, Y; Mitsuhashi, K; Yamamoto, H | 1 |
| Cen, P; Jiang, X; Jing, K; Lin, J; Liu, Y; Wang, F; Xu, Z | 1 |
| Cen, P; Jiang, X; Jing, K; Liu, Y; Peng, L; Xu, Z | 1 |
| Cen, P; Fang, L; Jiang, X; Jing, K; Liu, Y; Xu, Z | 1 |
| Cao, H; Chen, Y; Li, S; Li, Z; Xu, L; Yan, M; Ye, Q; Ying, H | 1 |
| Chadha, A; Gummadi, SN; Kaliaperumal, T; Kumar, S | 1 |
| Choi, H; Jung, J; Kim, HK; Park, HJ; Uhm, KN | 1 |
| An, M; Cai, P; Hao, N; Li, Y; Liu, H; Wang, S; Xu, L; Yan, M | 1 |
| An, M; Cai, P; Guo, K; Hao, N; Li, Y; Xu, L; Xu, S; Yan, M | 1 |
| Kim, HK; Yoon, SA | 1 |
| Chen, R; Ma, Z; Wang, Q; Xie, T; Ye, T; Yin, X | 1 |
| Ding, Y; He, YC; Liu, F; Lu, Y; Rui, H; Tao, ZC; Zhang, DP; Zhang, X; Zheng, GW; Zhu, ZZ | 1 |
| Ding, Y; He, YC; Liu, F; Lu, Y; Tao, ZC; Wang, LQ; Zhang, DP | 1 |
| Ding, Y; He, YC; Liu, F; Lu, Y; Tao, ZC; Wang, C; Wu, YQ; Xu, JH; Xue, YF; Zhang, DP | 1 |
| Dai, Y; He, YC; Huan, B; Zhang, HS | 1 |
| Aphale, AN; Basak, S; Ghosh, SK; Patra, PK; Punetha, VD; Sahoo, NG | 1 |
| Basak, S; Pavanasam, AK; Sahoo, NG | 1 |
22 other study(ies) available for ethyl 4-chloro-3-oxobutanoate and ethyl 4-chloro-3-hydroxybutanoate
| Article | Year |
|---|---|
Cloning, overexpression, and mutagenesis of the Sporobolomyces salmonicolor AKU4429 gene encoding a new aldehyde reductase, which catalyzes the stereoselective reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate.
Topics: Acetoacetates; Aldehyde Reductase; Amino Acid Sequence; Animals; Butyrates; Cloning, Molecular; Introns; Kinetics; Mammals; Mitosporic Fungi; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Phylogeny; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity | 1999 |
Synthesis of optically pure ethyl (S)-4-chloro-3-hydroxybutanoate by Escherichia coli transformant cells coexpressing the carbonyl reductase and glucose dehydrogenase genes.
Topics: Acetoacetates; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Base Sequence; Biotechnology; Butyrates; Enzyme Stability; Escherichia coli; Genes, Bacterial; Glucose 1-Dehydrogenase; Glucose Dehydrogenases; Oxidation-Reduction; Plasmids; Stereoisomerism; Transformation, Genetic | 2001 |
Stereoselective reduction of ethyl 4-chloro-3-oxobutanoate by fungi.
Topics: Acetoacetates; Biotransformation; Butyrates; Fungi; Hypocreales; Kinetics; Oxidation-Reduction; Stereoisomerism | 2001 |
Applying slow-release biocatalysis to the asymmetric reduction of ethyl 4-chloroacetoacetate.
Topics: Absorption; Acetoacetates; Butyrates; Catalysis; Hydrolysis; Oxidation-Reduction; Polystyrenes; Quality Control; Saccharomyces cerevisiae; Sensitivity and Specificity; Stereoisomerism | 2003 |
A novel NADH-dependent carbonyl reductase from Kluyveromyces aestuarii and comparison of NADH-regeneration system for the synthesis of ethyl (S)-4-chloro-3-hydroxybutanoate.
Topics: Acetoacetates; Alcohol Oxidoreductases; Amino Acid Sequence; Base Sequence; Butyrates; Cloning, Molecular; Conserved Sequence; Escherichia coli; Fatty Acid Synthases; Formate Dehydrogenases; Glucose 1-Dehydrogenase; Kluyveromyces; Molecular Sequence Data; NAD; NADH, NADPH Oxidoreductases; Plasmids; Sequence Analysis, DNA; Substrate Specificity | 2004 |
Robust NADH-regenerator: improved alpha-haloketone-resistant formate dehydrogenase.
Topics: Acetates; Acetoacetates; Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acid Substitution; Butyrates; Cysteine; Enzyme Activators; Enzyme Stability; Escherichia coli; Formate Dehydrogenases; Ketones; Kluyveromyces; Mutagenesis, Site-Directed; Mutation, Missense; Mycobacterium; NAD; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2005 |
Asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate with two co-existing, recombinant Escherichia coli strains.
Topics: Acetoacetates; Aldehyde Reductase; Butyrates; Escherichia coli; Glucose Dehydrogenases; Industrial Microbiology; NADP; Oxidation-Reduction; Recombinant Proteins | 2005 |
Efficient production of recombinant aldehyde reductase and its application for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate.
Topics: Acetoacetates; Aldehyde Reductase; Basidiomycota; Butyrates; Cloning, Molecular; Escherichia coli; Fungal Proteins; Oxidation-Reduction; Plasmids; Recombinant Proteins; Transformation, Bacterial | 2005 |
Construction of a two-strain system for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to (S)-4-chloro-3-hydroxybutanoate ethyl ester.
Topics: Acetoacetates; Alcohol Oxidoreductases; Biomass; Bioreactors; Butyrates; Candida; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genetic Engineering; Glucosephosphate Dehydrogenase; NADP; Oxidation-Reduction; Substrate Specificity; Temperature; Time Factors | 2006 |
A novel carbonyl reductase from Pichia stipitis for the production of ethyl (S)-4-chloro-3-hydroxybutanoate.
Topics: Acetoacetates; Alcohol Oxidoreductases; Amino Acid Sequence; Butyrates; Cloning, Molecular; Escherichia coli; Fungal Proteins; Gene Expression; Kinetics; Molecular Sequence Data; Open Reading Frames; Oxidation-Reduction; Pichia; Sequence Alignment; Sequence Homology, Amino Acid | 2009 |
Asymmetric synthesis of (S)-ethyl-4-chloro-3-hydroxybutanoate using Candida parapsilosis ATCC 7330.
Topics: Acetoacetates; Butyrates; Candida; Culture Media; Glucose; Hydrogen-Ion Concentration; Industrial Microbiology; Temperature | 2010 |
Enantioselective bioconversion using Escherichia coli cells expressing Saccharomyces cerevisiae reductase and Bacillus subtilis glucose dehydrogenase.
Topics: Acetoacetates; Bacillus subtilis; Biotechnology; Butyrates; Escherichia coli; Gene Expression; Genetic Engineering; Glucose 1-Dehydrogenase; NADP; Oxidoreductases; Recombinant Proteins; Saccharomyces cerevisiae Proteins | 2010 |
A novel reductase from Candida albicans for the production of ethyl (S)-4-chloro-3-hydroxybutanoate.
Topics: Acetates; Acetoacetates; Amino Acid Sequence; Biocatalysis; Butyrates; Candida albicans; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Fungal Proteins; Gene Expression; Glucose Dehydrogenases; Molecular Sequence Data; NADP; Open Reading Frames; Oxidoreductases; Plasmids; Stereoisomerism; Water | 2012 |
Development of a substrate-coupled biocatalytic process driven by an NADPH-dependent sorbose reductase from Candida albicans for the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate.
Topics: Acetoacetates; Butyrates; Candida albicans; Coenzymes; Hydrogen-Ion Concentration; NADP; Oxidation-Reduction; Sugar Alcohol Dehydrogenases; Sugar Alcohols | 2012 |
Development of a bioconversion system using Saccharomyces cerevisiae Reductase YOR120W and Bacillus subtilis glucose dehydrogenase for chiral alcohol synthesis.
Topics: Acetoacetates; Bacillus subtilis; Binding Sites; Butyrates; Coenzymes; DNA Mutational Analysis; Glucose 1-Dehydrogenase; Models, Molecular; Mutagenesis, Site-Directed; NADP; Oxidoreductases; Protein Conformation; Saccharomyces cerevisiae | 2013 |
Characterization and site-directed mutation of a novel aldo-keto reductase from Lodderomyces elongisporus NRRL YB-4239 with high production rate of ethyl (R)-4-chloro-3-hydroxybutanoate.
Topics: Acetoacetates; Aldehyde Reductase; Aldo-Keto Reductases; Butyrates; Coenzymes; Mutagenesis, Site-Directed; Mutation; Saccharomycetales | 2014 |
Improved biosynthesis of ethyl (S)-4-chloro-3-hydroxybutanoate by adding L-glutamine plus glycine instead of NAD+ in β-cyclodextrin-water system.
Topics: Acetoacetates; beta-Cyclodextrins; Butyrates; Escherichia coli; Glutamine; Glycine; NAD; Water | 2015 |
Biosynthesis of ethyl (S)-4-chloro-3-hydroxybutanoate with an NADH-dependent reductase (ClCR) discovered by genome data mining using a modified colorimetric screening strategy.
Topics: Acetoacetates; Bacterial Proteins; Butyrates; Data Mining; Escherichia coli; High-Throughput Screening Assays; Industrial Microbiology; NAD; Trans-Activators | 2015 |
Effective biosynthesis of ethyl (R)-4-chloro-3-hydroxybutanoate by supplementation of l-glutamine, d-xylose and β-cyclodextrin in n-butyl acetate-water media.
Topics: Acetates; Acetoacetates; Bacterial Proteins; beta-Cyclodextrins; Butyrates; Culture Media; Escherichia coli; Glutamine; Oxidoreductases; Water; Xylose | 2015 |
Effective Biotransformation of Ethyl 4-Chloro-3-Oxobutanoate into Ethyl (S)-4-Chloro-3-Hydroxybutanoate by Recombinant E. coli CCZU-T15 Whole Cells in [ChCl][Gly]-Water Media.
Topics: Acetoacetates; Biotransformation; Butyrates; Choline; Culture Media; DNA, Recombinant; Dose-Response Relationship, Drug; Escherichia coli; Ethylene Glycol; Glutamine; Polysorbates; Water | 2017 |
An experimental modeling of trinomial bioengineering- crp, rDNA, and transporter engineering within single cell factory for maximizing two-phase bioreduction.
Topics: Acetates; Acetoacetates; Alcohol Oxidoreductases; Biotransformation; Butyrates; Candida glabrata; DNA, Ribosomal; Dose-Response Relationship, Drug; Escherichia coli; Protein Engineering; Sesquiterpenes | 2017 |
Genome mining, in silico validation and phase selection of a novel aldo-keto reductase from Candida glabrata for biotransformation.
Topics: Acetoacetates; Aldo-Keto Reductases; Amino Acid Sequence; Binding Sites; Biocatalysis; Biotransformation; Butyrates; Candida glabrata; Crystallography, X-Ray; Data Mining; Fungal Proteins; Gene Expression; Genome, Fungal; Kinetics; Metabolic Engineering; Models, Molecular; NADP; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Thermodynamics | 2018 |