ethoxzolamide has been researched along with acetazolamide in 193 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (10.36) | 18.7374 |
| 1990's | 9 (4.66) | 18.2507 |
| 2000's | 98 (50.78) | 29.6817 |
| 2010's | 65 (33.68) | 24.3611 |
| 2020's | 1 (0.52) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, PS; Baldwin, JJ; Best, DB; Christy, ME; Freedman, MB; Gautheron, P; Graham, SL; Habecker, CN; Hoffman, JM; Shepard, KL | 1 |
| Bicking, JB; Brown, SL; deSolms, SJ; Fishman, DR; Gautheron, PD; Graham, SL; Hoffman, JM; Larson, RD; Schwam, H; Woltersdorf, OW | 1 |
| Briganti, F; Menabuoni, L; Mincione, F; Mincione, G; Scozzafava, A; Supuran, CT | 2 |
| Hashimoto, Y; Inui, KI; Saito, H; Uwai, Y | 1 |
| Casini, A; Ilies, MA; Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT | 1 |
| Menabuoni, L; Mincione, F; Scozzafava, A; Supuran, CT | 1 |
| Scozzafava, A; Supuran, CT | 2 |
| Casini, A; Montero, JL; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Abbate, F; Antel, J; Casini, A; David, S; Schäfer, S; Scozzafava, A; Supuran, CT; Waldeck, H | 1 |
| Franchi, M; Gallori, E; Pastorek, J; Pastorekova, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Caproiu, MT; Ilies, M; Ilies, MA; Pastorek, J; Pastorekova, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Casini, A; Montero, JL; Scozzafava, A; Supuran, CT; Vullo, D; Winum, JY | 2 |
| Casini, A; Menabuoni, L; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT | 1 |
| Abbate, F; Casini, A; Montero, JL; Potter, BV; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Antel, J; Franchi, M; Gallori, E; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Pastorek, J; Pastorekova, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Casini, A; de Leval, X; Dogné, JM; Ilies, M; Masini, E; Mincione, F; Scozzafava, A; Starnotti, M; Supuran, CT | 1 |
| Jaiswal, M; Khadikar, PV; Scozzafava, A; Supuran, CT | 1 |
| Fasolis, G; Garaj, V; Innocenti, A; Montero, JL; Puccetti, L; Scozzafava, A; Supuran, CT; Vullo, D; Winum, JY | 2 |
| Alcaro, MC; Casini, A; Innocenti, A; Papini, AM; Scozzafava, A; Supuran, CT | 1 |
| Cecchi, A; Innocenti, A; Montero, JL; Scozzafava, A; Supuran, CT; Vullo, D; Winum, JY | 1 |
| Casini, A; Ferry, JG; Innocenti, A; Scozzafava, A; Supuran, CT; Zimmerman, S | 1 |
| Durgun, M; Emul, M; Innocenti, A; Scozzafava, A; Supuran, CT; Turkmen, H; Vullo, D; Yilmaztekin, S | 1 |
| Innocenti, A; Jakubickova, L; Montero, JL; Pastorek, J; Pastorekova, S; Scozzafava, A; Supuran, CT; Vullo, D; Winum, JY | 1 |
| Innocenti, A; Nishimori, I; Pastorek, J; Pastoreková, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Innocenti, A; Kaila, K; Ranki, H; Rivera, C; Scozzafava, A; Supuran, CT; Voipio, J; Vullo, D | 1 |
| Antel, J; Firnges, MA; Innocenti, A; Scozzafava, A; Supuran, CT; Wurl, M | 1 |
| Casini, A; de Leval, X; Dogné, JM; Innocenti, A; Montero, JL; Scozzafava, A; Supuran, CT; Vullo, D; Winum, JY | 1 |
| Antel, J; Casini, A; De Simone, G; Di Fiore, A; Menchise, V; Pedone, C; Scozzafava, A; Supuran, CT; Wurl, M | 1 |
| Cecchi, A; Fasolis, G; Gamberi, A; Montero, JL; Puccetti, L; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Cecchi, A; Innocenti, A; Montero, JL; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Chohan, ZH; Fasolis, G; Puccetti, L; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Cecchi, A; Hulikova, A; Montero, JL; Pastorek, J; Pastoreková, S; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Innocenti, A; Mastrolorenzo, A; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D | 2 |
| Bacciottini, L; Casini, A; Masini, E; Mincione, F; Scozzafava, A; Scrivanti, C; Starnotti, M; Supuran, CT; Vullo, D | 1 |
| Gil, MJ; Innocenti, A; Martinez-Merino, V; Scozzafava, A; Supuran, CT; Villar, R; Vullo, D | 1 |
| Arslan, O; Fasolis, G; Ozensoy, O; Puccetti, L; Scozzafava, A; Supuran, CT | 1 |
| Minakuchi, T; Morimoto, K; Nishimori, I; Onishi, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Minakuchi, T; Morimoto, K; Nishimori, I; Onishi, S; Sano, S; Scozzafava, A; Supuran, CT; Takeuchi, H; Vullo, D | 1 |
| Brzozowski, Z; Innocenti, A; Kornicka, A; Pomarnacka, E; Saczewski, F; Scozzafava, A; Supuran, CT; Sławiński, J | 1 |
| De Simone, G; Di Fiore, A; Montero, JL; Pedone, C; Scozzafava, A; Supuran, CT; Vitale, RM; Winum, JY | 1 |
| Bornaghi, LF; Houston, TA; Innocenti, A; Poulsen, SA; Supuran, CT; Wilkinson, BL | 1 |
| Ciattini, S; El Cheikh, K; Innocenti, A; Montero, JL; Scozzafava, A; Supuran, CT; Temperini, C; Vullo, D; Winum, JY | 1 |
| Bornaghi, LF; Houston, TA; Innocenti, A; Poulsen, SA; Supuran, CT; Vullo, D; Wilkinson, BL | 2 |
| Huber, VJ; Nakada, T; Sakimura, K; Tsujita, M; Yamazaki, M | 1 |
| Minakuchi, T; Nishimori, I; Onishi, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Innocenti, A; Marques, S; Santos, MA; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Innocenti, A; Nencetti, S; Nuti, E; Orlandini, E; Rossello, A; Scozzafava, A; Supuran, CT | 1 |
| Kohsaki, T; Minakuchi, T; Nishimori, I; Onishi, S; Scozzafava, A; Supuran, CT; Takeuchi, H; Vullo, D | 1 |
| Alterio, V; De Simone, G; Monti, SM; Scozzafava, A; Supuran, CT | 1 |
| Montero, JL; Regainia, Z; Scozzafava, A; Smaine, FZ; Supuran, CT; Vullo, D; Winum, JY | 1 |
| Innocenti, A; Poulsen, SA; Salmon, AJ; Supuran, CT; Vullo, D; Williams, ML | 1 |
| Cecchi, A; Minakuchi, T; Nishimori, I; Onishi, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Innocenti, A; Montero, JL; Rami, M; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Huber, VJ; Kwee, IL; Nakada, T; Tsujita, M | 1 |
| Innocenti, A; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Brzozowski, Z; Innocenti, A; Kornicka, A; Pomarnacka, E; Saczewski, F; Scozzafava, A; Supuran, CT; Sławiński, J; Temperini, C | 1 |
| Innocenti, A; Poulsen, SA; Supuran, CT; Vullo, D; Wilkinson, BL | 1 |
| Antel, J; De Simone, G; Di Fiore, A; Pedone, C; Scozzafava, A; Supuran, CT; Waldeck, H; Witte, A; Wurl, M | 1 |
| Cecchi, A; Scozzafava, A; Supuran, CT; Temperini, C | 3 |
| D'Ambrosio, K; De Simone, G; Dogné, JM; Innocenti, A; Masereel, B; Scozzafava, A; Supuran, CT; Vitale, RM | 1 |
| Cecchi, A; Ciani, L; Montero, JL; Ristori, S; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Verkman, AS; Yang, B; Zhang, H | 1 |
| Badawi, AM; Cecchi, A; Morsy, SM; Scozzafava, A; Supuran, CT | 1 |
| Arslan, O; Guler, OO; Innocenti, A; Isik, S; Kockar, F; Supuran, CT | 1 |
| Arslan, O; Aydin, M; Guler, OO; Innocenti, A; Isik, S; Kockar, F; Scozzafava, A; Supuran, CT | 1 |
| Agbandje-McKenna, M; Avvaru, BS; Cao, W; Case, N; Genis, C; Govindasamy, L; McKenna, R; Rosser, CJ; Silverman, DN; Sippel, KH; Tartaglia, LJ; Tu, C | 1 |
| Crocetti, L; Hall, RA; Maresca, A; Mühlschlegel, FA; Scozzafava, A; Supuran, CT; Temperini, C | 1 |
| Hilvo, M; Innocenti, A; Kulomaa, MS; Parkkila, S; Salzano, AM; Scaloni, A; Scozzafava, A; Supuran, CT | 1 |
| Güzel, O; Hall, RA; Innocenti, A; Mühlschlegel, FA; Scozzafava, A; Supuran, CT | 1 |
| Eroğlu, E; Oltulu, O; Yaşar, MM | 1 |
| Minakuchi, T; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D | 2 |
| Innocenti, A; Minakuchi, T; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Hall, RA; Innocenti, A; Mühlschlegel, FA; Scozzafava, A; Supuran, CT; Winum, JY | 1 |
| Balaban, AT; Güzel, O; Maresca, A; Salman, A; Scozzafava, A; Supuran, CT | 1 |
| Güzel, O; Innocenti, A; Salman, A; Scozzafava, A; Supuran, CT | 1 |
| Hall, RA; Innocenti, A; Mühlschlegel, FA; Schlicker, C; Scozzafava, A; Steegborn, C; Supuran, CT | 1 |
| Bertucci, A; Innocenti, A; Scozzafava, A; Supuran, CT; Tambutté, S; Zoccola, D | 2 |
| Carta, F; Covarrubias, AS; Jones, TA; Maresca, A; Mowbray, SL; Supuran, CT | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Joseph, P; Köhler, S; Minakuchi, T; Montero, JL; Nishimori, I; Ouahrani-Bettache, S; Scozzafava, A; Supuran, CT; Turtaut, F; Vullo, D; Winum, JY | 1 |
| Brzozowski, Z; Innocenti, A; Saczewski, F; Supuran, CT; Sławiński, J | 1 |
| Güzel, O; Hall, RA; Maresca, A; Mastrolorenzo, A; Mühlschlegel, FA; Scozzafava, A; Supuran, CT | 1 |
| De Simone, G; Di Fiore, A; Innocenti, A; Monti, SM; Supuran, CT; Winum, JY | 1 |
| Capelo, A; Esteves, MA; Marques, SM; Ortet, O; Santos, MA; Supuran, CT | 1 |
| Brzozowski, Z; Innocenti, A; Supuran, CT; Sławiński, J | 1 |
| Arslan, O; Aydin, M; Güler, OO; Işik, S; Kockar, F; Maresca, A; Sinan, S; Supuran, CT; Turan, Y; Turkoglu, S | 1 |
| Joseph, P; Köhler, S; Minakuchi, T; Montero, JL; Nishimori, I; Ouahrani-Bettache, S; Scozzafava, A; Supuran, CT; Vullo, D; Winum, JY | 1 |
| Maresca, A; Supuran, CT | 1 |
| Cincinelli, A; Innocenti, A; Martellini, T; Scozzafava, A; Supuran, CT | 1 |
| Avvaru, BS; Carta, F; Garaj, V; Maresca, A; McKenna, R; Robbins, AH; Scozzafava, A; Supuran, CT; Wagner, J | 1 |
| Brzozowski, Z; Gdaniec, M; Innocenti, A; Supuran, CT; Sławiński, J | 1 |
| Ekinci, D; Karagoz, L; Senturk, M; Supuran, CT | 1 |
| Balaydın, HT; Menzek, A; Sentürk, M | 1 |
| Cavdar, H; Durdagi, S; Ekinci, D; Sentürk, M; Supuran, CT; Talaz, O | 1 |
| Jackson, DJ; Ohradanova, A; Pastorek, J; Pastorekova, S; Supuran, CT; Vullo, D; Wörheide, G | 1 |
| Alper, M; Arslan, O; Işık, S; Kockar, F; Maresca, A; Ozensoy, O; Sinan, S; Supuran, CT; Turkoglu, S | 1 |
| Hewitson, KS; Mastrolorenzo, A; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Carta, F; D'Ambrosio, K; De Simone, G; Smaine, FZ; Supuran, CT; Winum, JY | 1 |
| Capasso, C; Carginale, V; Luca, VD; Rossi, M; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Brzozowski, Z; Supuran, CT; Sławiński, J; Vullo, D | 1 |
| Gylytė, J; Jogaitė, V; Matulis, D; Michailovienė, V; Morkūnaitė, V; Zubrienė, A | 1 |
| Capasso, C; Carginale, V; De Luca, V; Del Prete, S; Isik, S; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Čapkauskaitė, E; Gylytė, J; Kišonaitė, M; Matulis, D; Tumkevičius, S; Zubrienė, A | 1 |
| Capaci Rodrigues, G; Capasso, C; Pan, P; Parkkila, S; Scozzafava, A; Supuran, CT; Tolvanen, ME; Vermelho, AB | 1 |
| Dudutienė, V; Gražulis, S; Gylytė, J; Manakova, E; Matulis, D; Smirnov, A; Timm, D; Zubrienė, A | 1 |
| Capasso, C; Leewattanapasuk, W; Mastrolorenzo, A; Mühlschlegel, FA; Supuran, CT; Vullo, D | 1 |
| Gao, R; Huang, J; Li, H; Liao, S; Liu, L; Lu, W; Wang, L; Xu, Y; Yang, C; Zhao, Z; Zhu, L; Zhu, W | 1 |
| Carta, F; Sethi, KK; Supuran, CT; Tanç, M; Verma, SM | 1 |
| Carta, F; Sethi, KK; Supuran, CT; Tanç, M; Verma, SM; Vullo, D | 1 |
| Capasso, C; Corte-Real, S; Pan, P; Parkkila, S; Rodrigues, Ide A; Salonen, T; Supuran, CT; Syrjänen, L; Vermelho, AB; Vullo, D | 1 |
| Čapkauskaitė, E; Gražulis, S; Gylytė, J; Jogaitė, V; Kazokaitė, J; Kišonaitė, M; Manakova, E; Matulis, D; Michailovienė, V; Smirnov, A; Torresan, J; Tumkevičius, S; Zubrienė, A | 1 |
| Chimirri, A; Damiano, FM; De Luca, L; Ferro, S; Gitto, R; Supuran, CT; Vullo, D | 1 |
| Chojnacki, J; Pogorzelska, A; Supuran, CT; Sławiński, J; Vullo, D; Żołnowska, B | 1 |
| Alothman, Z; Capasso, C; De Luca, V; Del Prete, S; Osman, SM; Scozzafava, A; Supuran, CT; Vullo, D | 2 |
| Saluja, AK; Supuran, CT; Tiwari, M; Vullo, D | 1 |
| Calafato, G; Carta, F; Purper, G; Sethi, KK; Supuran, CT; Tanç, M; Verma, SM | 1 |
| Capasso, C; Minakuchi, T; Nishimori, I; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Brożewicz, K; Pogorzelska, A; Supuran, CT; Sławiński, J; Vullo, D; Żołnowska, B | 1 |
| Brzozowski, Z; Pogorzelska, A; Supuran, CT; Szafrański, K; Sławiński, J; Vullo, D; Żołnowska, B | 1 |
| AlOthman, Z; Capasso, C; Osman, SM; Prete, SD; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Andrews, KT; Capasso, C; Del Prete, S; Fisher, GM; Poulsen, SA; Supuran, CT; Vullo, D | 1 |
| Capasso, C; Carginale, V; De Luca, V; Del Prete, S; Scozzafava, A; Supuran, CT; Vullo, D | 2 |
| Kuuslahti, M; Parkkila, S; Supuran, CT; Syrjänen, L; Tolvanen, M; Vullo, D | 1 |
| Ceruso, M; Durgun, M; Supuran, CT; Turkmen, H | 1 |
| Capasso, C; Dedeoglu, N; DeLuca, V; Isik, S; Kockar, F; Supuran, CT; Yildirim, H | 1 |
| Abou El Ella, DA; Ceruso, M; Ibrahim, AW; Ibrahim, DA; Lasheen, DS; Supuran, CT; Vullo, D; Zaky, MY | 1 |
| Cincinelli, A; Martellini, T; Supuran, CT; Vullo, D | 1 |
| Bhatt, A; Mahon, BP; McKenna, R; Supuran, CT; Vullo, D | 1 |
| AlOthman, Z; Capasso, C; Carginale, V; De Luca, V; Del Prete, S; Osman, SM; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| AlOthman, Z; Capasso, C; Carginale, V; De Luca, V; Del Prete, S; Ferraroni, M; Osman, SM; Supuran, CT; Vullo, D | 1 |
| Aşık, A; Beldüz, AO; Çanakçı, S; Çolak, DN; Eminoğlu, A; Supuran, CT; Vullo, D | 1 |
| AlOthman, Z; Capasso, C; Carginale, V; De Luca, V; Del Prete, S; Osman, SM; Supuran, CT; Vullo, D | 2 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Huang, J; Li, H; Liu, L; Wang, W; Xu, Y; Zhao, Z | 1 |
| Andring, J; Combs, J; Frost, SC; Mboge, MY; McKenna, R; Singh, S; Tu, C; Wolff, A; Zhang, Z | 1 |
| Schwartz, JH | 1 |
| Gelatt, KN; Gum, G; Gwin, RM; Williams, LW | 1 |
| Beall, OV; Lichter, PR; Newman, LP; Wheeler, NC | 1 |
| Cousin, JL; Motais, R; Sola, F | 1 |
| Bödeker, D; Höller, H; Oppelland, G | 1 |
| Chambers, TJ; Hall, TJ; Higgins, W; Tardif, C | 1 |
| Barrett, RJ; Gathright, CE; Nolan, JC; Radvany, CH; Sancilio, LF | 1 |
| Fischbarg, J; Koniarek, JP; Kuang, KY; Xu, M | 1 |
| Marumo, F; Sasaki, S | 1 |
| Deitmer, JW; Schlue, WR | 1 |
| Dodgson, SJ | 1 |
| Anderson, PS; Raisz, LG; Rodan, GA; Shepard, KL; Simmons, HA; Thompson, WJ | 1 |
| Scheid, P; Siffert, W | 1 |
| Barbarino, F; Brilinschi, C; Togănel, E | 1 |
| Dodgson, SJ; Forster, RE; Storey, BT | 1 |
| Lönnerholm, G | 1 |
| Friedland, BR; Muther, TF | 1 |
| Becker, G; Burmester, M; Gros, G; Hansen, K; Rechkemmer, G; von Engelhardt, W | 1 |
| Christie, KN; Hopwood, D; Ogden, GR; Thomson, C | 1 |
| Frithriksdóttir, H; Guthmundsson, O; Loftsson, T; Sigthórsson, T; Stefánsson, E; Thórisdóttir, S | 1 |
| Bidani, A; Heming, TA; Moghadasi, H; Stabenau, EK; Vanoye, CG | 1 |
| Ignatova, LK; Ivanov, BN; Kollmeier, MA; Moskvin, OV | 1 |
| Aguilera, J; Escassi, L; Fernández, JA; Figueroa, FL | 1 |
| Wistrand, PJ | 1 |
| Gros, G; Papadopoulos, S; Wetzel, P | 1 |
| Gros, G; Kleinke, T; Papadopoulos, S; Wetzel, P | 1 |
| Archer, DP; Roth, SH; Samanani, N; Wang, B | 1 |
| POSNER, A | 1 |
| FORD, RV; MOYER, JH | 1 |
| HIRANO, A; SOLOMON, S | 1 |
| DRANCE, SM | 1 |
| de CARVALHO, C; ELIEZER, CP | 1 |
| Bonapace, G; Shah, GN; Sly, WS; Waheed, A | 1 |
| Jaiswal, P; Kashyap, AK; Prasanna, R | 1 |
| Argent, BE; Boros, I; Fearn, A; Gray, MA; Hegyi, P; Rakonczay, Z | 1 |
| Andría, JR; Axelsson, L; Mercado, JM; Pérez-Llorens, JL; Vergara, JJ | 1 |
| Ignatova, LK; Ivanov, BN; Khristin, MS; Rudenko, NN | 1 |
| Boemke, W; Francis, RC; Höhne, C; Pickerodt, PA; Swenson, ER | 1 |
| Jain, A; Luke, T; Shih, HW; Shimoda, LA; Swenson, ER; Sylvester, JT | 1 |
| Carrasco, M; Mercado, JM; Niell, FX | 1 |
| Fedorchuk, TP; Ignatova, LK; Ivanov, BN; Mudrik, VA; Rudenko, NN | 1 |
| Bhattacharya, A; Sharma, A; Shrivastava, A | 1 |
| Olischläger, M; Wiencke, C | 1 |
| Fujiwara, S; Matsumoto, H; Miyagi, H; Nakamura, N; Ohta, T; Shiga, Y; Tsuzuki, M | 1 |
1 review(s) available for ethoxzolamide and acetazolamide
| Article | Year |
|---|---|
Carbonic anhydrases as targets for medicinal chemistry.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Isoenzymes; Models, Molecular; Tissue Distribution | 2007 |
1 trial(s) available for ethoxzolamide and acetazolamide
| Article | Year |
|---|---|
Patient tolerance to carbonic anhydrase inhibitors.
Topics: Acetazolamide; Anorexia; Carbonic Anhydrase Inhibitors; Confusion; Dichlorphenamide; Drug Evaluation; Ethoxzolamide; Fatigue; Glaucoma; Humans; Intraocular Pressure; Methazolamide | 1978 |
191 other study(ies) available for ethoxzolamide and acetazolamide
| Article | Year |
|---|---|
Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.
Topics: Animals; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Glaucoma; Guinea Pigs; Intraocular Pressure; Ocular Hypertension; Rabbits; Skin; Sulfonamides; Thiophenes | 1989 |
Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.
Topics: Animals; Benzothiazoles; Carbonic Anhydrase Inhibitors; Chemical Phenomena; Chemistry; Cornea; Ethoxzolamide; Guinea Pigs; Humans; Intraocular Pressure; Ophthalmic Solutions; Prodrugs; Rabbits; Thiazoles | 1989 |
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Topics: Administration, Topical; Animals; Aqueous Humor; Benzene Derivatives; Carbonic Anhydrase Inhibitors; Cattle; Eye; Humans; Intraocular Pressure; Isoenzymes; Male; Ophthalmic Solutions; Pyridines; Rabbits; Solubility; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Tissue Distribution | 1999 |
Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1.
Topics: Acetazolamide; Animals; Anion Transport Proteins; Biological Transport; Bumetanide; Carrier Proteins; Diuretics; Furosemide; Hydrochlorothiazide; Kidney Tubules; Organotechnetium Compounds; Rats | 2000 |
Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cattle; Glaucoma; Humans; Intraocular Pressure; Isoenzymes; Lung; Rabbits; Solubility; Structure-Activity Relationship; Sulfonamides; Tissue Distribution; Uvea | 2000 |
Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.
Topics: Animals; Carbonic Anhydrase Inhibitors; Cornea; Eye; Glaucoma; Hydrogen-Ion Concentration; Intraocular Pressure; Ophthalmic Solutions; Rabbits; Solubility; Structure-Activity Relationship; Sulfonamides; Thiourea; Tissue Distribution; Water | 2000 |
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chelating Agents; Chloroform; Chromatography, High Pressure Liquid; Cornea; DNA, Complementary; Edetic Acid; Enzyme Inhibitors; Escherichia coli; Glaucoma; Humans; Hydrogen-Ion Concentration; Imino Acids; Kinetics; Male; Models, Chemical; Nitrilotriacetic Acid; Pentetic Acid; Pressure; Rabbits; Sulfonamides; Temperature; Time Factors; Ultraviolet Rays; Water | 2002 |
Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.
Topics: Bile Acids and Salts; Carbonic Anhydrase Inhibitors; Sulfonamides | 2002 |
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
Topics: Amines; Binding Sites; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Cytosol; Humans; Models, Molecular; Structure-Activity Relationship; Sulfonamides | 2003 |
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.
Topics: Animals; Binding Sites; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; Cattle; Crystallography, X-Ray; Fructose; Humans; Hydrogen Bonding; Models, Molecular; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids; Topiramate; Zinc | 2003 |
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Topics: Animals; Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cattle; Heterocyclic Compounds; Humans; Hydrocarbons, Aromatic; Isoenzymes; Kinetics; Neoplasm Proteins; Neoplasms; Structure-Activity Relationship; Sulfonamides | 2003 |
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Benzene Derivatives; Bromine; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase IV; Carbonic Anhydrase IX; Carbonic Anhydrases; Chlorine; Enzyme Inhibitors; Humans; Iodine; Neoplasm Proteins; Structure-Activity Relationship; Sulfanilamides; Sulfonamides | 2003 |
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Topics: Antigens, Neoplasm; Arylsulfatases; Biomarkers, Tumor; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase IX; Carbonic Anhydrases; Cytosol; Enzyme Inhibitors; Estrone; Humans; Membrane Proteins; Neoplasm Proteins; Steryl-Sulfatase; Structure-Activity Relationship; Sulfonic Acids | 2003 |
Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.
Topics: Administration, Topical; Animals; Benzolamide; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; Cattle; Esters; Glaucoma; Humans; Intraocular Pressure; Rabbits; Structure-Activity Relationship; Sulfonamides; Thiazines; Thiophenes | 2003 |
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase IX; Carbonic Anhydrases; Cytosol; Enzyme Inhibitors; Humans; Isoenzymes; Membrane Proteins; Neoplasm Proteins; Neoplasms; Structure-Activity Relationship; Sulfonic Acids | 2003 |
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.
Topics: Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Estrone; Humans; Isoenzymes; Steryl-Sulfatase | 2004 |
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.
Topics: Animals; Benzene Derivatives; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase V; Coumarins; Mice; Mitochondria; Structure-Activity Relationship; Sulfonamides; Thiadiazoles | 2004 |
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.
Topics: Carbonic Anhydrase Inhibitors; Fluorine; Isoenzymes; Sulfonamides | 2004 |
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Topics: Administration, Topical; Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; Fluorine; Glaucoma; Heterocyclic Compounds; Intraocular Pressure; Rabbits; Structure-Activity Relationship; Sulfonamides | 2004 |
Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Isoenzymes; Quantitative Structure-Activity Relationship; Sulfonamides | 2004 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cytosol; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Sulfonamides; Triazines | 2004 |
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Combinatorial Chemistry Techniques; Databases, Factual; Humans; Structure-Activity Relationship; Sulfonamides; Thiourea | 2004 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.
Topics: Benzolamide; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cytosol; Humans; Neoplasms; Nerve Tissue Proteins; Sulfonamides | 2004 |
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
Topics: Archaea; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Isoenzymes; Molecular Structure; Structure-Activity Relationship; Sulfonamides | 2004 |
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.
Topics: Acetazolamide; Amines; Biomarkers, Tumor; Carbonic Anhydrase Inhibitors; Catalysis; Cytosol; Heterocyclic Compounds; Humans; Isoenzymes; Morpholines; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Sulfanilamide; Sulfanilamides | 2005 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cytosol; Humans; Isoenzymes; Neoplasm Proteins; Structure-Activity Relationship; Sulfonic Acids | 2005 |
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Topics: Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Drug Design; Glaucoma; Humans; Isoenzymes; Structure-Activity Relationship; Sulfonamides | 2005 |
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
Topics: Anticonvulsants; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Heterocyclic Compounds; Humans; Hydrocarbons, Aromatic; Isoenzymes; Protein Subunits; Structure-Activity Relationship; Sulfonamides | 2005 |
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; Cattle; Dose-Response Relationship, Drug; Humans; Isoenzymes; Kinetics; Membrane Proteins; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2005 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Membrane; Cytosol; Hydrazines; Isocyanates; Isoenzymes; Structure-Activity Relationship; Sulfonamides | 2005 |
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.
Topics: Binding Sites; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase V; Crystallography, X-Ray; Cytosol; Humans; Isoxazoles; Kinetics; Mitochondria; Models, Molecular; Protein Conformation; Zonisamide | 2005 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalytic Domain; Cytosol; Humans; Kinetics; Neoplasms; Structure-Activity Relationship; Sulfonamides; Urea | 2005 |
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Membrane; Cytosol; Humans; Isoenzymes; Molecular Structure; Structure-Activity Relationship; Sulfonamides; Triazines | 2005 |
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumo
Topics: Antigens, Neoplasm; Boron Compounds; Boron Neutron Capture Therapy; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2005 |
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Membrane; Chromones; Cytosol; Humans; Isoenzymes; Molecular Structure; Nerve Tissue Proteins; Schiff Bases; Structure-Activity Relationship; Sulfonamides; Zinc Compounds | 2005 |
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
Topics: Animals; Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalytic Domain; Cell Hypoxia; Cell Line; Cell Membrane Permeability; Dogs; Erythrocyte Membrane; Extracellular Fluid; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Isoenzymes; Mutation; Sequence Deletion; Sulfonamides | 2005 |
Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Fructose; Humans; Kinetics; Membrane Proteins; Protein Binding; Structure-Activity Relationship; Sulfonamides; Topiramate | 2005 |
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Topics: Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, Animal; Drug Design; Glaucoma; Intraocular Pressure; Rabbits; Structure-Activity Relationship; Sulfonamides | 2005 |
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cytosol; Humans; Neoplasm Proteins; Structure-Activity Relationship | 2005 |
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans; Neoplasm Proteins; Structure-Activity Relationship; Sulfonamides | 2005 |
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase V; Catalysis; Cloning, Molecular; Humans; Isoenzymes; Kinetics; Mitochondria; Molecular Sequence Data; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2005 |
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
Topics: Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Structure-Activity Relationship; Sulfonamides | 2006 |
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; DNA, Bacterial; Gastric Mucosa; Gastritis; Helicobacter pylori; Humans; Molecular Sequence Data; Polymorphism, Genetic; Stomach Neoplasms; Stomach Ulcer; Sulfonamides; Sulfonic Acids | 2006 |
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.
Topics: Carbonic Anhydrase Inhibitors; Cell Hypoxia; Cell Membrane; Cytosol; Humans; Isoenzymes; Molecular Structure; Neoplasms; Sulfonamides; Water | 2006 |
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
Topics: Antigens, Neoplasm; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Crystallography, X-Ray; Disulfides; Enzyme Activation; Humans; Hydrogen Bonding; Hypoxia; Isoenzymes; Models, Molecular; Molecular Structure; Neoplasms; Prodrugs; Protein Binding; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfonamides | 2006 |
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".
Topics: Benzene Derivatives; Carbohydrate Sequence; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Glycosylation; Indicators and Reagents; Isoenzymes; Molecular Sequence Data; Sulfonamides | 2006 |
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
Topics: Alanine; Anticonvulsants; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Drug Design; Fructose; Hydrogen Bonding; Isoenzymes; Models, Molecular; Molecular Structure; Protein Binding; Structure-Activity Relationship; Sulfonamides; Topiramate | 2006 |
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides.
Topics: Carbonic Anhydrase Inhibitors; Cyclization; Glycoconjugates; Humans; Isoenzymes; Membranes; Phenolsulfonphthalein; Recombinant Proteins; Sulfonamides | 2007 |
Identification of arylsulfonamides as Aquaporin 4 inhibitors.
Topics: Acetazolamide; Animals; Aquaporin 4; Arylsulfonic Acids; Biological Transport; Humans; Inhibitory Concentration 50; Oocytes; Osmosis; Phloretin; Structure-Activity Relationship; Sulfonamides; Transfection; Water | 2007 |
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalysis; Cloning, Molecular; DNA; Humans; Isoenzymes; Molecular Sequence Data; Protein Subunits; Sequence Homology, Amino Acid; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2007 |
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.
Topics: Carbonic Anhydrase Inhibitors; Cell Membrane; Cytosol; Humans; Hydroxamic Acids; Indicators and Reagents; Isoenzymes; Neoplasms; Structure-Activity Relationship; Sulfonamides | 2007 |
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.
Topics: Animals; Carbonic Anhydrase I; Carbonic Anhydrase II; Cytosol; Enzyme Inhibitors; Humans; Hydroxamic Acids; Isoenzymes; Matrix Metalloproteinase Inhibitors; Mice; Molecular Structure; Multiple Myeloma; Structure-Activity Relationship; Sulfonic Acids; Tumor Cells, Cultured | 2007 |
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
Topics: Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase III; Carbonic Anhydrase Inhibitors; Galactosides; Glycosides; Isoenzymes; Structure-Activity Relationship; Sulfonamides; Triazoles | 2007 |
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chemistry, Pharmaceutical; Cloning, Molecular; Drug Design; Enzyme Inhibitors; Helicobacter pylori; Humans; Molecular Sequence Data; Recombinant Proteins; Sequence Homology, Amino Acid; Stomach Neoplasms; Stomach Ulcer; Sulfonamides | 2007 |
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Hydrogen Bonding; Isoenzymes; Models, Molecular; Sulfonamides | 2007 |
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.
Topics: Carbonic Anhydrase Inhibitors; Isoenzymes; Sulfonamides | 2007 |
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Isoenzymes; Magnetic Resonance Spectroscopy; Organometallic Compounds; Substrate Specificity; Sulfonamides | 2007 |
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
Topics: Amino Acid Sequence; Carbonic Anhydrase III; Carbonic Anhydrase Inhibitors; Cloning, Molecular; Cytosol; Enzyme Activation; Humans; Isoenzymes; Kinetics; Molecular Sequence Data; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2007 |
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Topics: Amines; Carbonic Anhydrase Inhibitors; Copper; Heterocyclic Compounds; Isoenzymes; Neoplasms; Sulfonamides | 2008 |
Inhibition of aquaporin 4 by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Aquaporin 4; Computer Simulation; Drug Evaluation, Preclinical; Humans; Oocytes; Protein Binding; Thermodynamics; Xenopus | 2009 |
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).
Topics: Animals; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Mammals; Molecular Structure; Protein Binding; Protein Isoforms | 2008 |
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
Topics: Benzenesulfonamides; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cytosol; Humans; Hydrocarbons, Chlorinated; Isoenzymes; Methylation; Models, Molecular; Molecular Sequence Data; Molecular Structure; Neoplasms; Protein Folding; Sequence Alignment; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfonamides | 2008 |
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.
Topics: Antigens, Neoplasm; Benzene Derivatives; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Glycosides; Humans; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Triazoles | 2008 |
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
Topics: Animals; Binding Sites; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Catalysis; Crystallography, X-Ray; Ethoxzolamide; Glutamine; Humans; Isoenzymes; Mice; Models, Molecular; Molecular Structure; Protein Binding; Threonine | 2008 |
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Computer Simulation; Crystallography, X-Ray; Humans; Indapamide; Isoenzymes; Mice; Models, Molecular; Molecular Structure | 2008 |
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.
Topics: Amino Acid Sequence; Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Conserved Sequence; Crystallography, X-Ray; Humans; Isoenzymes; Models, Molecular; Molecular Sequence Data; Neoplasms; Nitro Compounds; Structure-Activity Relationship; Sulfonamides | 2008 |
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.
Topics: Antigens, Neoplasm; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Membrane; Cyclic N-Oxides; Cytosol; Drug Design; Drug Evaluation, Preclinical; Free Radicals; Humans; Isoenzymes; Molecular Structure; Recombinant Proteins; Spin Labels; Stereoisomerism; Structure-Activity Relationship; Sulfonamides | 2008 |
Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides.
Topics: Animals; Anticonvulsants; Aquaporin 4; Biological Transport, Active; Cell Line; Mice; Molecular Structure; Neuroglia; Permeability; Rats; Structure-Activity Relationship; Sulfonamides; Thyroid Gland; Water | 2008 |
Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; HCT116 Cells; Humans; Isoenzymes; Lung Neoplasms; Sulfonamides | 2009 |
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.
Topics: Acetazolamide; Amino Acid Sequence; Anions; Bromides; Candida albicans; Carbonic Anhydrase Inhibitors; Enzyme Inhibitors; Iodides; Isoenzymes; Kinetics; Models, Chemical; Molecular Sequence Data; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Sulfides | 2008 |
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.
Topics: Carbonic Anhydrase Inhibitors; Catalytic Domain; Chlorthalidone; Crystallography, X-Ray; Indapamide; Isoenzymes; Models, Molecular; Stereoisomerism; Water | 2009 |
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Topics: Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Chlorthalidone; Crystallography, X-Ray; Furosemide; Indapamide; Isoenzymes; Structure-Activity Relationship; Sulfonamides; Trichlormethiazide; Water | 2009 |
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
Topics: Amino Acid Sequence; Antifungal Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Kinetics; Molecular Sequence Data; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sulfonamides; Sulfonic Acids | 2009 |
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.
Topics: Amino Acid Sequence; Antigens, Neoplasm; Antineoplastic Agents; Blotting, Western; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalytic Domain; Cell Death; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Kinetics; Molecular Mimicry; Molecular Sequence Data; Proto-Oncogene Proteins c-bcl-2; Sequence Alignment; Structural Homology, Protein | 2009 |
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Mammals; Sulfonamides; Thiabendazole | 2009 |
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Isoenzymes; Kidney; Mice; Protein Processing, Post-Translational | 2009 |
Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Topics: Animals; Caenorhabditis elegans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Hydrazines; Indoles; Isoenzymes; Molecular Structure; Structure-Activity Relationship; Sulfonamides | 2009 |
A QSAR study on relationship between structure of sulfonamides and their carbonic anhydrase inhibitory activity using the eigenvalue (EVA) method.
Topics: Artificial Intelligence; Carbonic Anhydrase II; Computer Simulation; Isoenzymes; Models, Chemical; Quantitative Structure-Activity Relationship; Sulfonamides | 2009 |
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalysis; Cloning, Molecular; Drug Resistance, Multiple, Bacterial; Humans; Molecular Sequence Data; Mycobacterium tuberculosis; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2009 |
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
Topics: Amino Acid Sequence; Biocatalysis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Molecular Sequence Data; Mycobacterium tuberculosis; Sulfonamides; Sulfonic Acids | 2009 |
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Topics: Boronic Acids; Candida albicans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cryptococcus neoformans; Humans; Structure-Activity Relationship | 2009 |
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans; Pyridinium Compounds; Sulfonamides | 2009 |
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.
Topics: Acetylation; Brain Chemistry; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Hydrocarbons, Aromatic; Protein Isoforms; Structure-Activity Relationship; Sulfonamides | 2009 |
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
Topics: Amino Acid Sequence; Antifungal Agents; Bacterial Proteins; Candida albicans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cryptococcus neoformans; Helicobacter pylori; Humans; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Sequence Alignment; Structure-Activity Relationship; Sulfonamides | 2009 |
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
Topics: Amino Acid Sequence; Animals; Anthozoa; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Molecular Sequence Data; Molecular Structure; Recombinant Proteins; Sequence Alignment; Sulfonamides | 2009 |
Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalytic Domain; Drug Design; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brucella suis; Brucellosis; Carbonic Anhydrases; Cloning, Molecular; DNA, Bacterial; Humans; Kinetics; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Sequence Alignment; Sequence Analysis, DNA; Structure-Activity Relationship; Sulfonamides | 2010 |
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cytosol; Humans; Isoenzymes; Sulfonamides | 2010 |
Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.
Topics: Antifungal Agents; Candida albicans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cryptococcus neoformans; Humans; Sulfonamides | 2010 |
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
Topics: Amides; Boron; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalytic Domain; Crystallography, X-Ray; Hydrocarbons, Aromatic; Protein Binding; Protein Isoforms; Solutions; Sulfonic Acids; Zinc | 2010 |
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Enzyme Inhibitors; Humans; Isoenzymes; Matrix Metalloproteinase Inhibitors; Pyrimidinones; Sulfonamides | 2010 |
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Membrane; Cytosol; Humans; Isoenzymes; Neoplasms; Stereoisomerism; Substrate Specificity; Sulfonamides | 2010 |
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Binding Sites; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Cell Line, Tumor; Computer Simulation; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Sulfonamides | 2010 |
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
Topics: Animals; Anions; Anthozoa; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Structure-Activity Relationship; Sulfonamides | 2011 |
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
Topics: Anti-Bacterial Agents; Brucella suis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Drug Design; Drug Discovery; Inhibitory Concentration 50; Kinetics; Sulfonamides; Sulfonic Acids | 2011 |
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.
Topics: Animals; Camphor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cytosol; Enzyme Assays; Heterocyclic Compounds; Humans; Mitochondria; Molecular Structure; Stereoisomerism; Sulfonamides | 2011 |
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.
Topics: Animals; Anions; Antarctic Regions; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Protein Isoforms; Seals, Earless; Sulfonamides | 2011 |
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.
Topics: Antifungal Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Cytosol; Fungi; Humans; Isoenzymes; Models, Molecular; Structure-Activity Relationship; Sulfonamides; Triazines | 2011 |
Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
Topics: Anti-Bacterial Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Salmonella Infections; Salmonella typhimurium; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2011 |
Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.
Topics: Carbonic Anhydrase Inhibitors; Cytosol; Humans; Isoenzymes; Magnetic Resonance Spectroscopy; Models, Molecular; Sulfonamides | 2011 |
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Flavonoids; Humans; Molecular Structure; Protein Isoforms; Structure-Activity Relationship | 2013 |
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.
Topics: Bromine; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Cyclohexanones; Enzyme Activation; Humans; Models, Molecular; Molecular Structure; Phenols | 2012 |
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cattle; Humans; Indoles; Models, Molecular; Protein Isoforms; Structure-Activity Relationship | 2012 |
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
Topics: Amino Acid Sequence; Animals; Carbonic Anhydrases; Cloning, Molecular; Fossils; Humans; Molecular Sequence Data; Porifera; Protein Binding; Sequence Alignment; Sulfonamides; Sulfonic Acids | 2012 |
Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.
Topics: Amino Acid Sequence; Amino Acid Substitution; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalytic Domain; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Sulfonamides | 2012 |
Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
Topics: Amino Acid Sequence; Animals; Antifungal Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Dermatomycoses; Fungal Proteins; Humans; Isoenzymes; Malassezia; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Recombinant Fusion Proteins; Scalp Dermatoses; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2012 |
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Enzyme Assays; Humans; Isoenzymes; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Sulfonamides | 2012 |
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
Topics: Amino Acid Sequence; Bacteria; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Kinetics; Molecular Sequence Data; Phylogeny; Protein Binding; Recombinant Proteins; Sequence Alignment; Sulfonamides | 2013 |
Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Isoenzymes; Molecular Structure; Pyridines; Stereoisomerism; Structure-Activity Relationship; Sulfonamides | 2012 |
Characterization of human carbonic anhydrase XII stability and inhibitor binding.
Topics: Calorimetry; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Catalytic Domain; Humans; Hydrogen-Ion Concentration; Protein Binding; Protein Stability; Salts; Sulfonamides; Temperature; Thermodynamics | 2013 |
DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Topics: Amino Acid Sequence; Biocatalysis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; DNA; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Phylogeny; Sequence Homology, Amino Acid; Vibrio cholerae | 2012 |
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.
Topics: Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrophotometry, Infrared; Sulfonamides | 2014 |
Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chagas Disease; Cloning, Molecular; Humans; Molecular Sequence Data; Phylogeny; Protozoan Proteins; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfonamides; Thiadiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.
Topics: Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Halogenation; Humans; Isoenzymes; Models, Molecular; Structure-Activity Relationship; Sulfonamides | 2013 |
Carbonic anhydrase inhibitors: inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.
Topics: Acetazolamide; Amino Acid Sequence; Antifungal Agents; Candida glabrata; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Kinetics; Molecular Sequence Data; Phylogeny; Protein Binding; Sequence Alignment; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2013 |
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.
Topics: Carbonic Anhydrase Inhibitors; Drug Evaluation, Preclinical; Humans; Molecular Docking Simulation; Structure-Activity Relationship; Sulfonamides | 2013 |
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.
Topics: Animals; Benzenesulfonamides; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Phthalimides; Protein Binding; Structure-Activity Relationship; Sulfonamides | 2013 |
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Enzyme Activation; Humans; Models, Biological; Molecular Structure; Phthalimides; Protein Isoforms; Structure-Activity Relationship | 2013 |
Cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis.
Topics: Amino Acid Sequence; Antiprotozoal Agents; Biocatalysis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Leishmania infantum; Leishmaniasis; Molecular Sequence Data | 2013 |
Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII.
Topics: Benzenesulfonamides; Binding Sites; Calorimetry; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Crystallography, X-Ray; Enzyme Activation; Humans; Isoenzymes; Kinetics; Protein Binding; Protein Structure, Tertiary; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides | 2013 |
Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Drug Design; Humans; Molecular Docking Simulation; Structure-Activity Relationship | 2014 |
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associat
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Line, Tumor; Cytosol; Guanidines; Humans; Isoenzymes; Models, Molecular; Neoplasms; Structure-Activity Relationship | 2014 |
Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Diatoms; Dose-Response Relationship, Drug; Molecular Structure; Structure-Activity Relationship; Sulfonamides | 2014 |
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Molecular Structure; Porphyromonas gingivalis; Structure-Activity Relationship; Sulfonamides | 2014 |
Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII.
Topics: Antigens, Neoplasm; Benzene; Binding Sites; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalytic Domain; Enzyme Activation; Humans; Molecular Docking Simulation; Protein Binding; Structure-Activity Relationship; Sulfonamides; Triazines | 2014 |
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.
Topics: Benzenesulfonamides; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Humans; Isoindoles; Isoquinolines; Molecular Docking Simulation; Protein Isoforms; Structure-Activity Relationship; Sulfonamides | 2014 |
Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Legionella pneumophila; Molecular Sequence Data; Molecular Structure; Sequence Alignment; Structure-Activity Relationship; Sulfonamides | 2014 |
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Membrane; Dose-Response Relationship, Drug; Humans; Isoenzymes; Molecular Structure; Neoplasms; Structure-Activity Relationship; Sulfonamides | 2014 |
Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.
Topics: Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Isoenzymes; Molecular Structure; Structure-Activity Relationship; Sulfonamides | 2014 |
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Molecular Sequence Data; Molecular Structure; Phylogeny; Porphyromonas gingivalis; Structure-Activity Relationship; Sulfonamides | 2014 |
Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.
Topics: Antimalarials; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Plasmodium falciparum; Structure-Activity Relationship; Sulfonamides | 2015 |
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Molecular Sequence Data; Nostoc commune; Sequence Alignment; Sulfanilamide; Sulfanilamides; Sulfonamides; Thiazines; Thiophenes | 2015 |
The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.
Topics: Amino Acid Sequence; Animals; Anopheles; Baculoviridae; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Gene Expression; High-Throughput Screening Assays; Insect Proteins; Insecticides; Kinetics; Molecular Sequence Data; Phylogeny; Protons; Recombinant Proteins; Sequence Alignment; Sf9 Cells; Spodoptera; Sulfanilamides | 2015 |
Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII.
Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Imines; Isoenzymes; Molecular Structure; Sulfonamides | 2015 |
Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Molecular Structure; Phylogeny; Streptococcus mutans; Sulfonamides | 2015 |
Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.
Topics: Antigens, Neoplasm; Benzothiazoles; Binding Sites; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalytic Domain; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Binding; Structure-Activity Relationship; Sulfonamides | 2015 |
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
Topics: Acclimatization; Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cold Temperature; Humans; Molecular Sequence Data; Phylogeny; Pseudoalteromonas; Sequence Alignment; Sulfonamides | 2015 |
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.
Topics: Animals; Anions; Antarctic Regions; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Enzyme Activation; Fishes; Molecular Structure; Sulfonamides | 2015 |
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
Topics: Anti-Bacterial Agents; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Gammaproteobacteria; Molecular Docking Simulation; Sulfonamides | 2016 |
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
Topics: Alteromonadaceae; Anti-Bacterial Agents; Bacterial Proteins; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Kinetics; Phylogeny; Protein Binding; Sulfanilamide; Sulfanilamides | 2016 |
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Topics: Amino Acid Sequence; Base Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cholera; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Sequence Data; Sulfonamides; Vibrio cholerae | 2016 |
Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.
Topics: Acetazolamide; Benzenesulfonamides; Carbonic Anhydrase I; Carbonic Anhydrase Inhibitors; Enterobacter; Enterobacteriaceae Infections; Humans; Methazolamide; Structure-Activity Relationship; Sulfonamides | 2016 |
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
Topics: Amino Acid Sequence; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship; Sulfonamides; Vibrio cholerae | 2016 |
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.
Topics: Amino Acid Sequence; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cloning, Molecular; Humans; Kinetics; Molecular Sequence Data; Plasmodium falciparum; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; Sequence Alignment; Structure-Activity Relationship; Sulfonamides | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.
Topics: | 2018 |
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; Hydrogen-Ion Concentration; Models, Molecular; Triple Negative Breast Neoplasms | 2021 |
H+ current response to CO2 and carbonic anhydrase inhibition in turtle bladder.
Topics: Acetazolamide; Animals; Bicarbonates; Carbon Dioxide; Carbonic Anhydrases; Chlorides; Ethoxzolamide; Hydrogen; Hydrogen-Ion Concentration; Ouabain; Turtles; Urinary Bladder | 1976 |
Ocular hypotensive effects of carbonic anhydrase inhibitors in normotensive and glaucomatous Beagles.
Topics: Acetazolamide; Administration, Oral; Animals; Carbonic Anhydrase Inhibitors; Dichlorphenamide; Dog Diseases; Dogs; Ethoxzolamide; Glaucoma; Intraocular Pressure; Methazolamide; Time Factors | 1979 |
Transmembrane exchange of chloride with bicarbonate ion in mammalian red blood cells: evidence for a sulphonamide-sensitive "carrier".
Topics: Acetazolamide; Ammonium Chloride; Animals; Benzolamide; Bicarbonates; Biological Transport; Carbonic Anhydrases; Cattle; Cell Membrane Permeability; Chlorides; Erythrocytes; Ethoxzolamide; Hemolysis; Humans; Ion Exchange; Sulfonamides | 1975 |
Involvement of carbonic anhydrase in ammonia flux across rumen mucosa in vitro.
Topics: Acetazolamide; Ammonia; Animals; Biological Transport; Carbonic Anhydrases; Ethoxzolamide; Fatty Acids, Volatile; Gastric Mucosa; Rumen; Sheep | 1992 |
A comparison of the effects of inhibitors of carbonic anhydrase on osteoclastic bone resorption and purified carbonic anhydrase isozyme II.
Topics: Acetazolamide; Bone Resorption; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dimethyl Sulfoxide; Erythrocytes; Ethoxzolamide; Humans; Osteoclasts; Sulfonamides | 1991 |
Carbonic anhydrase inhibitors are antiarthritic in the rat.
Topics: Acetazolamide; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carbonic Anhydrase Inhibitors; Carrageenan; Dichlorphenamide; Edema; Ethoxzolamide; Female; Indomethacin; Methazolamide; Rats | 1991 |
Effects of ambient bicarbonate, phosphate and carbonic anhydrase inhibitors on fluid transport across rabbit corneal endothelium.
Topics: Acetazolamide; Animals; Bicarbonates; Biological Transport, Active; Carbonic Anhydrase Inhibitors; Endothelium, Corneal; Ethoxzolamide; Glucose; Male; Phosphates; Rabbits | 1990 |
Effects of carbonic anhydrase inhibitors on basolateral base transport of rabbit proximal straight tubule.
Topics: Acetazolamide; Animals; Bicarbonates; Carbonic Anhydrase Inhibitors; Cell Membrane; Choline; Ethoxzolamide; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Rabbits; Sodium; Thiazoles | 1989 |
Ionic mechanisms of intracellular pH regulation in the nervous system.
Topics: Acetazolamide; Amiloride; Ammonium Chloride; Animals; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carrier Proteins; Cell Membrane; Chloride-Bicarbonate Antiporters; Ethoxzolamide; Homeostasis; Hydrogen-Ion Concentration; Leeches; Microelectrodes; Neuroglia; Neurons; Protons; Sodium; Sodium-Hydrogen Exchangers; Stilbenes | 1988 |
Inhibition of mitochondrial carbonic anhydrase and ureagenesis: a discrepancy examined.
Topics: Acetazolamide; Animals; Carbonic Anhydrases; Citrulline; Cytosol; Electrophoresis, Polyacrylamide Gel; Ethoxzolamide; Guinea Pigs; In Vitro Techniques; Isoenzymes; Liver; Male; Mitochondria, Liver; Molecular Weight; Sulfonamides; Urea | 1987 |
Effects of a potent carbonic anhydrase inhibitor on bone resorption in organ culture.
Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitriol; Calcium Radioisotopes; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Dinoprostone; Ethoxzolamide; Interleukin-1; Organ Culture Techniques; Parathyroid Hormone; Prostaglandins E; Rats; Thiophenes | 1988 |
Effects of inhibiting carbonic anhydrase on isometric contraction of frog skeletal muscle.
Topics: Acetazolamide; Action Potentials; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ethoxzolamide; Hindlimb; In Vitro Techniques; Isometric Contraction; Methazolamide; Muscle Contraction; Muscles; Rana esculenta; Time Factors | 1985 |
The effects of acetazolamide and of ethoxzolamide on gastric microcirculation in rats (histochemical study).
Topics: Acetazolamide; Adenosine Triphosphatases; Animals; Ethoxzolamide; Female; Gastric Mucosa; Histocytochemistry; Microcirculation; Rats; Reserpine; Stomach Ulcer; Thiazoles | 1984 |
The role of carbonic anhydrase in hepatocyte metabolism.
Topics: Acetazolamide; Animals; Carbonic Anhydrases; Ethoxzolamide; Fatty Acids; Gluconeogenesis; Guinea Pigs; Kinetics; Liver; Mitochondria, Liver; Urea | 1984 |
Carbonic anhydrase in rat liver and rabbit skeletal muscle: further evidence for the specificity of the histochemical cobalt-phosphate method of Hansson.
Topics: Acetazolamide; Animals; Carbonic Anhydrases; Cobalt; Erythrocytes; Ethoxzolamide; Histocytochemistry; Liver; Male; Muscles; Phosphates; Rabbits; Rats | 1980 |
Autoradiographic localization of carbonic anhydrase in the rabbit ciliary body.
Topics: Acetazolamide; Animals; Autoradiography; Carbonic Anhydrases; Ciliary Body; Epithelium; Ethoxzolamide; Rabbits | 1980 |
Functional role of bicarbonate in propionate transport across guinea-pig isolated caecum and proximal colon.
Topics: Acetazolamide; Animals; Bicarbonates; Carbonic Anhydrases; Cecum; Colon; Dextrans; Ethoxzolamide; Guinea Pigs; Intestinal Mucosa; Ion Transport; Male; p-Aminoazobenzene; Propionates | 1994 |
A histochemical study of carbonic anhydrase in the plasma membranes of human oral epithelial cells.
Topics: Acetazolamide; Adolescent; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Membrane; Cell Nucleus; Cytoplasmic Granules; Epithelium; Ethoxzolamide; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Mouth Mucosa; Palate; Tongue | 1995 |
Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetazolamide; Administration, Topical; Animals; beta-Cyclodextrins; Cyclodextrins; Drug Combinations; Ethoxzolamide; Female; Intraocular Pressure; Male; Ophthalmic Solutions; Rabbits; Timolol | 1994 |
Roles of intra- and extracellular carbonic anhydrase in alveolar-capillary CO2 equilibration.
Topics: Acetazolamide; Animals; Capillaries; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ethoxzolamide; Extracellular Space; Hydrogen-Ion Concentration; Male; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Sulfanilamides | 1994 |
Light-induced stimulation of carbonic anhydrase activity in pea thylakoids.
Topics: Acetazolamide; Bicarbonates; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Electron Transport; Enzyme Activation; Ethoxzolamide; Hydrogen-Ion Concentration; Intracellular Membranes; Kinetics; Light; Nigericin; Pisum sativum; Proton-Motive Force; Protons; Thylakoids; Uncoupling Agents | 2000 |
Potassium drives daily reversible thallus enlargement in the marine red alga Porphyra leucosticta (Rhodophyta).
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Cell Division; Chlorides; Diethylstilbestrol; Diuron; Dose-Response Relationship, Drug; Ethoxzolamide; Light; Lithium; Osmotic Pressure; Photosynthesis; Potassium; Potassium Channel Blockers; Proton Pumps; Rhodophyta; Rubidium; Sodium; Vanadates; Water | 2002 |
Inhibition of carbonic anhydrase in the lens does not induce myopia in cynomolgus monkeys.
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cornea; Dose-Response Relationship, Drug; Ethoxzolamide; Female; Infusions, Intravenous; Isoenzymes; Lens, Crystalline; Macaca fascicularis; Myopia; Refraction, Ocular; Retina | 2001 |
Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres.
Topics: Acetazolamide; Animals; Benzolamide; Benzothiazoles; Bicarbonates; Buffers; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ethoxzolamide; Female; HEPES; Hydrogen-Ion Concentration; Muscle Contraction; Muscle Fibers, Skeletal; Muscle Relaxation; Muscle, Skeletal; Rats; Rats, Inbred WF; Sarcoplasmic Reticulum; Thiadiazoles; Thiazoles | 2002 |
Inhibition of muscle carbonic anhydrase slows the Ca(2+) transient in rat skeletal muscle fibers.
Topics: Acetazolamide; Action Potentials; Adenosine Triphosphatases; Animals; Benzothiazoles; Calcium; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chelating Agents; Dose-Response Relationship, Drug; Enzyme Activation; Ethoxzolamide; Female; Fura-2; In Vitro Techniques; Ion Transport; Isometric Contraction; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Rats; Sarcoplasmic Reticulum; Thiadiazoles; Thiazoles; Time Factors | 2002 |
Spinal carbonic anhydrase contributes to nociceptive reflex enhancement by midazolam, pentobarbital, and propofol.
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ethoxzolamide; Hypnotics and Sedatives; Injections, Spinal; Male; Midazolam; Pain; Pain Measurement; Pentobarbital; Propofol; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Spinal Cord | 2003 |
Use of a new carbonic anhydrase inhibitor (cardrase) in glaucoma.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Glaucoma; Humans | 1958 |
Laboratory and clinical observations on ethoxzolamide (cardrase) as a diuretic agent.
Topics: Acetazolamide; Diuresis; Diuretics; Ethoxzolamide; Heart Failure; Humans | 1958 |
Ethoxzolamide; a new anticonvulsant.
Topics: Acetazolamide; Anticonvulsants; Ethoxzolamide | 1959 |
The effects of ethoxzolamide (cardrase) on intraocular pressure.
Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Intraocular Pressure; Tonometry, Ocular | 1959 |
[Reduction of intraocular pressure induced by ethoxzolamide].
Topics: Acetazolamide; Ethoxzolamide; Eye Diseases; Glaucoma; Humans; Intraocular Pressure; Tonometry, Ocular | 1959 |
Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17.
Topics: Acetazolamide; Animals; Apoptosis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IV; COS Cells; DNA, Complementary; Endoplasmic Reticulum; Ethoxzolamide; Humans; Mutation; Phenylbutyrates; Protein Folding; Retinitis Pigmentosa; Transfection | 2004 |
Modulation of carbonic anhydrase activity in two nitrogen fixing cyanobacteria, Nostoc calcicola and Anabaena sp.
Topics: Acetazolamide; Anabaena; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chlorophyll; Chlorophyll A; Ethoxzolamide; Nitrogen Fixation; Nostoc | 2005 |
Characterization of H+ and HCO3- transporters in CFPAC-1 human pancreatic duct cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Anion Transport Proteins; Bicarbonates; Cell Line; Cell Membrane Permeability; Ethoxzolamide; Humans; Hydrogen-Ion Concentration; Pancreatic Ducts; Potassium | 2006 |
Evidence for a plasmalemma-based CO2 concentrating mechanism in Laminaria saccharina.
Topics: Acetazolamide; Carbon Dioxide; Cell Membrane; Ethoxzolamide; Hydrogen-Ion Concentration; Laminaria; Photosynthesis; Tromethamine | 2006 |
Heterogeneous origin of carbonic anhydrase activity of thylakoid membranes.
Topics: Acetazolamide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Ethoxzolamide; Glucosides; Photosystem I Protein Complex; Photosystem II Protein Complex; Pisum sativum; Plant Proteins; Thylakoids | 2006 |
Pulmonary vasodilation by acetazolamide during hypoxia is unrelated to carbonic anhydrase inhibition.
Topics: Acetazolamide; Acid-Base Equilibrium; Altitude Sickness; Animals; Benzolamide; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Dogs; Ethoxzolamide; Female; Humans; Hypoxia; Kidney; Lung; Vasodilation; Vasodilator Agents | 2007 |
Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition.
Topics: Acetazolamide; Benzolamide; Calcium; Calcium Signaling; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ethoxzolamide; Hydrogen-Ion Concentration; Hypoxia; Methazolamide; Muscle, Smooth, Vascular; Pulmonary Artery | 2007 |
Diversity of inorganic carbon acquisition mechanisms by intact microbial mats of Microcoleus chthonoplastes (Cyanobacteriae, Oscillatoriaceae).
Topics: Acetazolamide; Bicarbonates; Carbon; Cyanobacteria; Ethoxzolamide; Hydrogen-Ion Concentration; Photosynthesis | 2008 |
Carbonic anhydrase activity in Arabidopsis thaliana thylakoid membrane and fragments enriched with PSI or PSII.
Topics: Acetazolamide; Arabidopsis; Arabidopsis Proteins; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chlorophyll; Culture Media; Detergents; Electron Transport; Enzyme Activation; Ethoxzolamide; Fluorescence; Light; Membrane Proteins; Octoxynol; Photosystem I Protein Complex; Photosystem II Protein Complex; Plant Leaves; Thylakoids | 2011 |
Evaluation of enhanced thermostability and operational stability of carbonic anhydrase from Micrococcus species.
Topics: Acetazolamide; Bacterial Proteins; Cadmium; Calcium Carbonate; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Enzyme Activation; Enzyme Stability; Ethoxzolamide; Hydrogen-Ion Concentration; Micrococcus luteus; Molecular Weight; Temperature; Zinc | 2013 |
Ocean acidification alleviates low-temperature effects on growth and photosynthesis of the red alga Neosiphonia harveyi (Rhodophyta).
Topics: Acetazolamide; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Chlorophyll; Cold Temperature; Ethoxzolamide; Fluorescence; Hydrogen-Ion Concentration; Oxygen; Photosynthesis; Rhodophyta; Seawater | 2013 |
Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear.
Topics: Acetazolamide; Animal Fins; Animals; Apoptosis; Calcium; Carbonic Anhydrase Inhibitors; Cardiomegaly; Ear, Inner; Embryo, Nonmammalian; Embryonic Development; Ethoxzolamide; Hair Cells, Auditory; Otolithic Membrane; Sulfonamides; Swimming; Thiophenes; Zebrafish | 2017 |