ethionamide has been researched along with thionicotinamide* in 2 studies
2 other study(ies) available for ethionamide and thionicotinamide
| Article | Year |
|---|---|
The S-oxidation of thioamides by rat liver microsomes.
Topics: Amines; Animals; Ethionamide; Kinetics; Male; Methimazole; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains | 1991 |
The effect of methimazole on thioamide bioactivation and toxicity.
The hepatotoxicity induced by administration of ethionamide and thionicotinamide (TNA) was shown to be decreased by pre-administration of methimazole (MMI). Pre-administration of MMI was also shown to decrease the levels of excretion of TNA S-oxide. This indicates that thioamide S-oxidation, mediated by the flavin-containing mono-oxygenase, may be linked to the initiation of hepatotoxicity induced by these thioamides. SK&F-525-A, the cytochrome P-450 inhibitor, did not affect either thioamide-induced toxicity or levels of excretion of TNA S-oxide; however, the role of the P-450 isoenzymes cannot be totally ruled out. Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Ethionamide; Liver; Male; Methimazole; Microsomes, Liver; Niacinamide; Organ Size; Proadifen; Rats; Rats, Inbred Strains; Reference Values | 1991 |