Page last updated: 2024-08-17

ethinyl estradiol and ritonavir

ethinyl estradiol has been researched along with ritonavir in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.00)18.2507
2000's4 (20.00)29.6817
2010's13 (65.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Jolivette, LJ; Nagilla, R; Ward, KW1
Dansette, PM; Fontana, E; Poli, SM1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Remmel, RP; Tracy, TS; Zhou, J1
Hollenberg, PF; Johnson, WW; Lin, HL; Medower, C; Zhang, H1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Denissen, JF; Grabowski, B; Kumar, GN; Lee, R1
Cavanaugh, JH; Eason, CJ; Granneman, GR; Hsu, A; Leonard, JM; Locke, CS; Ouellet, D; Qian, J1
De Pauw, M; Felicione, E; Guzman, SS; Hoetelmans, RM; Lefebvre, E; Sekar, VJ; Vangeneugden, T1
Aweeka, F; Cohn, SE; Kamemoto, L; Klingman, KL; Park, JG; Patterson, K; Vogler, MA; Watts, H1
Bertz, R; Chung, E; Eley, T; Mahnke, L; Persson, A; Xu, X; Yones, C; Zhang, J1
Kasserra, C; Li, J; March, B; O'Mara, E1
de Serres, M; Gould, E; Johnson, M; Kim, J; Lou, Y; Mayers, D; Pietropaolo, K; Piscitelli, S; White, S; Zhou, XJ1
Ananworanich, J; Bunupuradah, T; Cremers, S; Kancheva Landolt, N; Kerr, S; Kosalaraksa, P; Thammajaruk, N; Ubolyam, S; Zott, R1
Aweeka, F; Baker, P; Berzins, B; Cohn, SE; Coombs, R; Coughlin, K; Cramer, YS; Gingrich, D; Godfrey, C; Haas, DW; Moran, LE; Rosenkranz, SL; Scarsi, KK; Zorrilla, CD1

Reviews

1 review(s) available for ethinyl estradiol and ritonavir

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005

Trials

7 trial(s) available for ethinyl estradiol and ritonavir

ArticleYear
Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers.
    British journal of clinical pharmacology, 1998, Volume: 46, Issue:2

    Topics: Adult; Anti-HIV Agents; Area Under Curve; Contraceptives, Oral; Drug Interactions; Estradiol Congeners; Ethinyl Estradiol; Female; Half-Life; HIV Protease Inhibitors; Humans; Middle Aged; Ritonavir

1998
Pharmacokinetic interaction between ethinyl estradiol, norethindrone and darunavir with low-dose ritonavir in healthy women.
    Antiviral therapy, 2008, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Contraceptives, Oral; Cross-Over Studies; Darunavir; Drug Interactions; Drug Therapy, Combination; Ethinyl Estradiol; Female; HIV Protease Inhibitors; HIV Seronegativity; Humans; Norethindrone; Ritonavir; Sulfonamides

2008
Contraceptive efficacy of oral and transdermal hormones when co-administered with protease inhibitors in HIV-1-infected women: pharmacokinetic results of ACTG trial A5188.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Estrogens; Ethinyl Estradiol; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Middle Aged; Norgestrel; Oximes; Pyrimidinones; Ritonavir; Transdermal Patch; United States

2010
Effect of vicriviroc with or without ritonavir on oral contraceptive pharmacokinetics: a randomized, open-label, parallel-group, fixed-sequence crossover trial in healthy women.
    Clinical therapeutics, 2011, Volume: 33, Issue:10

    Topics: Adult; Anti-HIV Agents; CCR5 Receptor Antagonists; Contraceptives, Oral, Combined; Cross-Over Studies; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Ethinyl Estradiol; Female; Humans; Norethindrone; Piperazines; Pyrimidines; Ritonavir; Young Adult

2011
Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.
    British journal of clinical pharmacology, 2012, Volume: 74, Issue:2

    Topics: Adenine; Androstenes; Anti-HIV Agents; Atazanavir Sulfate; Atorvastatin; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Darunavir; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Interactions; Emtricitabine; Ethinyl Estradiol; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Least-Squares Analysis; Linear Models; Lopinavir; Male; Oligopeptides; Organophosphonates; Patient Safety; Phosphinic Acids; Pyridines; Pyrimidines; Pyrroles; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Risk Assessment; Ritonavir; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Tenofovir

2012
High Variability of Hormonal Levels and No Clinically Relevant Interaction Between Ethinyl Estradiol, Desogestrel and Lopinavir/Ritonavir in a Small Sample of HIV-positive Adolescents.
    Journal of acquired immune deficiency syndromes (1999), 2016, Aug-15, Volume: 72, Issue:5

    Topics: Adolescent; Anti-HIV Agents; Contraceptive Agents, Female; Desogestrel; Drug Combinations; Drug Interactions; Ethinyl Estradiol; HIV Infections; Humans; Lopinavir; Pilot Projects; Prospective Studies; Ritonavir; Treatment Outcome

2016
Pharmacogenetic interactions between antiretroviral drugs and vaginally administered hormonal contraceptives.
    Pharmacogenetics and genomics, 2020, Volume: 30, Issue:3

    Topics: Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Contraceptive Agents, Female; Contraceptive Agents, Hormonal; Contraceptive Devices, Female; Cyclopropanes; Cytochrome P-450 CYP2B6; Desogestrel; Drug Interactions; Ethinyl Estradiol; Female; Genetic Association Studies; Genotype; HIV Infections; Humans; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Ritonavir; Vagina

2020

Other Studies

12 other study(ies) available for ethinyl estradiol and ritonavir

ArticleYear
Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human.
    Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:2

    Topics: Administration, Oral; Animals; Area Under Curve; Dogs; Haplorhini; Humans; Models, Statistical; Rats; Software; Species Specificity; Xenobiotics

2005
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Bilirubin; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Humans; Pharmaceutical Preparations; Recombinant Proteins; Substrate Specificity

2011
Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Antineoplastic Agents; Binding Sites; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochromes b5; Dose-Response Relationship, Drug; Escherichia coli; Humans; Molecular Structure; Oxidation-Reduction; Protein Binding; Quinolines; Thiophenes

2011
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Glutathione; Pharmacology; Sulfur Radioisotopes

2011
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Hepatic drug-metabolizing activities in rats after 14 days of oral administration of the human immunodeficiency virus-type 1 protease inhibitor ritonavir (ABT-538).
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:5

    Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethinyl Estradiol; Female; Glucuronosyltransferase; HIV Protease Inhibitors; Male; Microsomes, Liver; Organ Size; Rats; Rats, Sprague-Dawley; Ritonavir

1996
The effect of atazanavir/ritonavir on the pharmacokinetics of an oral contraceptive containing ethinyl estradiol and norgestimate in healthy women.
    Antiviral therapy, 2011, Volume: 16, Issue:2

    Topics: Adult; Anti-HIV Agents; Atazanavir Sulfate; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Ethinyl Estradiol; Female; Humans; Middle Aged; Norgestrel; Oligopeptides; Pyridines; Ritonavir; Women's Health; Young Adult

2011