Compounds > ethacrynic acid

ethacrynic acid and methotrexate

ethacrynic acid has been researched along with methotrexate in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's1 (10.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Endou, H; Hosoyamada, M; Kanai, Y; Sekine, T; Watanabe, N1
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Henderson, GB; Hughes, TR; Saxena, M2
Borst, P; Cnubben, NH; Evers, R; van Bladeren, PJ; van Deemter, L; Wijnholds, J1

Reviews

1 review(s) available for ethacrynic acid and methotrexate

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

9 other study(ies) available for ethacrynic acid and methotrexate

ArticleYear
Expression cloning and characterization of a novel multispecific organic anion transporter.
    The Journal of biological chemistry, 1997, Jul-25, Volume: 272, Issue:30

    Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Carrier Proteins; Cloning, Molecular; Dicarboxylic Acid Transporters; Gene Expression; Glycosylation; In Situ Hybridization; Kidney; Kinetics; Membrane Proteins; Molecular Sequence Data; Organic Anion Transporters, Sodium-Dependent; p-Aminohippuric Acid; Rats; RNA, Messenger; Symporters; Xenopus laevis

1997
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Distinct systems mediate the unidirectional efflux of methotrexate and cholate in human CCRF-CEM cells.
    Archives of biochemistry and biophysics, 1995, Jan-10, Volume: 316, Issue:1

    Topics: Biological Transport; Cells, Cultured; Cholic Acid; Cholic Acids; Dinitrochlorobenzene; Ethacrynic Acid; Hematopoietic Stem Cells; Humans; Indomethacin; Lymphocytes; Methotrexate; Prostaglandins A

1995
Functional implications from the effects of 1-chloro-2,4-dinitrobenzene and ethacrynic acid on efflux routes for methotrexate and cholate in L1210 cells.
    The Journal of biological chemistry, 1994, May-06, Volume: 269, Issue:18

    Topics: Adenosine Triphosphate; Animals; Anions; Biological Transport; Cholic Acid; Cholic Acids; Dinitrochlorobenzene; Ethacrynic Acid; Glutathione; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured

1994
Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.
    FEBS letters, 1997, Dec-08, Volume: 419, Issue:1

    Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cell Polarity; Cyclic AMP; Dogs; Erythrocytes; Ethacrynic Acid; Glutathione; Humans; Kidney; Methotrexate; Mice; Mice, Mutant Strains; Microsomes; Prostaglandins A, Synthetic; Stereoisomerism

1997