etanidazole has been researched along with azomycin in 145 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 82 (56.55) | 18.7374 |
1990's | 52 (35.86) | 18.2507 |
2000's | 8 (5.52) | 29.6817 |
2010's | 3 (2.07) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Stratford, MR | 1 |
Buswell, L; Coleman, CN; Noll, L; Riese, N; Rose, MA | 1 |
Abe, M; Oya, N; Sasai, K; Shibamoto, Y; Streffer, C | 1 |
Abe, M; Iwai, H; Kitakabu, Y; Nishimoto, S; Oya, N; Sasai, K; Shibamoto, Y; Takahashi, M; Yoshizawa, T | 1 |
Miyata, Y; Mori, T; Murayama, C; Sakaguchi, M; Sato, C; Shoji, T; Suzuki, A; Suzuki, T; Tanabe, Y | 1 |
Coleman, CN; Cosmatos, D; Davis, LW; Lee, DJ; Marcial, VA; Phillips, TL; Rubin, P; Wasserman, TH | 1 |
Alexander, E; Buswell, L; Coleman, CN; Hurwitz, SJ; Kramer, RA; Loeffler, JS; Neben, TY; Riese, N; Shargel, L | 1 |
Alexander, E; Buswell, L; Coleman, CN; Harris, JR; Howes, AE; Kramer, RA; Loeffler, JS; Noll, L; Riese, N; Wen, P | 1 |
Charreau, I; Chassagne, D; Eschwege, F; Malaise, EP; Sancho-Garnier, H | 2 |
Bertoni, F; Breccia, A; Busutti, L; Falcone, F; Ferri, E | 1 |
Degraff, WG; Garg, PK; Garg, S; Mitchell, JB; Zalutsky, MR | 1 |
Moore, SK; Wallen, CA; Wheeler, KT | 1 |
Bump, EA; Cerce, BA; Coleman, CN; McGinnis, DJ | 1 |
Hall, EJ; Hei, TK | 2 |
Chapman, JD; McPhee, MS; Santus, R; Stobbe, CC | 1 |
Basas, RA; Ling, CC; Wong, RS | 1 |
LaCreta, FP; O'Dwyer, PJ | 1 |
Brown, TD; Burris, HA; Havlin, KA; O'Rourke, TJ; Rodriguez, GI; Wall, JG; Weiss, GR | 1 |
Bubley, G; Coleman, CN; Eder, JP; Frei, E; Herman, TS; Holden, SA; Tanaka, J; Teicher, BA | 1 |
Alberti, D; Arzoomanian, RZ; Bailey, H; Mulcahy, RT; Rozental, JM; Tombes, MB; Trump, DL; Tutsch, KD; Wilding, G | 1 |
Brown, DQ; Curran, WJ; Evans, SM; Hanks, G; Helfand, S; LaCreta, F; VanWinkle, T | 1 |
Herman, TS; Holden, SA; Teicher, BA | 1 |
Coleman, N; Cosmatos, D; Davis, L; Lee, DJ; Marcial, V; Phillips, T; Stetz, J; Wasserman, TH | 1 |
Bleehen, NM; Maughan, TS; Newman, HF; Stenning, S; Ward, R; Workman, P | 1 |
Brown, JM; Cribbs, R; Hirst, VK; Luu, YH; Stone, HB | 1 |
Hisanaga, Y; Kagiya, T; Kitakabu, Y; Nishimoto, S; Sasai, K; Shibamoto, Y; Shimokawa, K; Takahashi, M; Wang, J; Zhou, L | 1 |
Bubley, G; Coleman, CN; Frei, E; Herman, TS; Shulman, L; Teicher, BA | 1 |
Wallen, CA; Wheeler, KT; Wong, KH | 2 |
Guichard, ME; Lespinasse, F; Taghian, A | 1 |
Basas, RD; Ling, CC; Wong, RS | 1 |
Herman, TS; Holden, SA; Jones, SM; Pfeffer, MR; Teicher, BA | 1 |
Abe, M; Hori, H; Inayama, S; Nagasawa, H; Sasai, K; Shibamoto, Y; Shibata, T; Takahashi, M; Zhou, L | 1 |
Bleehen, NM; Maughan, TS; Newman, HF; Ward, R; Workman, P | 2 |
Chapnick, RM; Herman, TS; Kalick, GS; Khandekar, V; Pfeffer, MR; Rabow, A; Teicher, BA | 1 |
Mori, T; Murayama, C | 2 |
Hirst, DG | 1 |
Coleman, CN; Halsey, J; Hancock, S; Noll, L; Phillips, TL; Urtasun, RC; Wasserman, TH | 1 |
Coldwell, DM; Coldwell, SG; Huff, J; Marcellus, H | 1 |
Workman, P | 1 |
DeGraff, WG; Gamson, J; Mitchell, JB; Russo, A | 1 |
abd el Baki, H; Akoush, H; Awwad, HK; el Badawy, S; el Moneim Osman, A; Fairchild, K; Zaghloul, M | 1 |
Coleman, CN; Harris, JR; Howes, AE; Kramer, RA; Noll, L; Zakar, J | 1 |
Bonnay, M; Guichard, M; Lespinasse, F; Malaise, EP; Thomas, C | 1 |
Calderwood, SK; Coleman, CN; Stevenson, MA | 1 |
Hickson, ID; Robson, CN; Stephens, M; Stratford, IJ | 1 |
Howes, AE; Kramer, RA; Montoya, VP; Soble, M | 1 |
Albright, N; DeGraff, WG; Mitchell, JB; Phillips, TL; Rajpal, R; Russo, A | 1 |
Mori, T | 1 |
Herman, TS; Holden, SA; Jones, SM; Teicher, BA | 1 |
Miyata, Y; Mori, T; Murayama, C; Sakaguchi, M; Suzuki, A; Suzuki, T; Tanabe, Y; Tanaka, N | 1 |
Abe, M; Kagiya, T; Nishimoto, S; Sasai, K; Shibamoto, Y; Takahashi, M; Wang, J; Zhou, L | 1 |
Allalunis-Turner, J; Applebaum, FR; Chapman, JD; Deeg, HJ; Graham, T; Shields, AF; Storb, R | 1 |
Bleehen, NM; Maughan, TS; Newman, HF; Workman, P | 1 |
Chapman, JD; Kanclerz, A | 1 |
Bleehen, NM; Newman, HF; Ward, R; Workman, P | 2 |
Edwards, MS; Gordon, DG | 1 |
Adams, GE; Stratford, IJ | 1 |
Astor, MB; Biaglow, JE; Clark, EP; Epp, ER; Hall, EJ; Roizen-Towle, L; Varnes, ME | 1 |
Bleehen, NM; Newman, HF; Workman, P | 2 |
Hill, RP | 1 |
Durand, RE; Harrison, I; Palcic, B; Skarsgard, LD | 1 |
Lam, KN; Luu, YH; Stone, HB | 1 |
Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Orchard, RA; Saunders, MI; Stratford, MR | 1 |
Minchinton, AI; Stratford, MR | 1 |
Dobson, PP; Fornace, AJ; Kinsella, TJ; Mitchell, JB; Russo, A | 1 |
Carmichael, J; DeGraff, W; Mitchell, JB; Phillips, TL; Rajpal, RK; Russo, A | 1 |
Biaglow, JE; Clark, EP; Donahue, LL; Epp, ER; Tuttle, SW; Varnes, ME | 1 |
Varghese, AJ; Whitmore, GF | 1 |
de Graff, W; Glatstein, E; Mitchell, JB; Phillips, TL; Russo, A | 1 |
Bussanich, N; Gallie, B; Kumi, C; Palcic, B; Rogers, B; Rootman, J | 1 |
Ling, CC; Schell, MC; Spiro, IJ; Stickler, R | 1 |
Biscay, P; Guichard, M; Lespinasse, F; Malaise, EP | 1 |
Ward, R; Workman, P | 1 |
Dennis, MF; Watts, ME; Woodcock, M | 1 |
Abe, M; Fushiki, M; Nishidai, T; Ono, K; Sasai, K; Shibamoto, Y; Takahashi, M; Tsutsui, K | 1 |
Freedman, LS; Workman, P | 1 |
Bleehen, NM; Honess, DJ; Ward, R; Wasserman, TH; Workman, P | 1 |
Wasserman, TH | 2 |
Bleehen, NM; Walton, MI; Workman, P | 1 |
Berenbaum, MC | 1 |
Brown, JM | 3 |
Coleman, CN; Halsey, J; Hancock, S; Hirst, VK; Phillips, TL; Urtasun, RC; Wasserman, TH | 1 |
Blaschke, T; Coleman, CN; Cox, RS; Halsey, J; Hancock, S; Hirst, VK; Howes, AE; Pajak, T; Urtasun, RC; Wasserman, TH | 1 |
Roizin-Towle, L | 1 |
Coleman, CN | 1 |
Dische, S | 1 |
DeGraff, W; Gamson, J; McPherson, S; Mitchell, JB; Russo, A; Zabell, A | 1 |
Harris, JW; Shrieve, DC | 1 |
Sinesi, MS; Stone, HB | 1 |
Geard, CR; Rutledge-Freeman, MH; Spunberg, JJ | 1 |
Abe, M; Hamanaka, D; Hiraoka, M; Nishidai, T; Ono, K; Takahashi, M | 1 |
Brown, JM; Hazlehurst, JL; Hirst, DG | 1 |
Brown, DM; Brown, JM; Dionet, C | 1 |
Abe, M; Nishidai, T; Ono, K; Shibamoto, Y; Takahashi, M | 1 |
Biaglow, JE; Meltzer, HL; Roizin-Towle, L; Varnes, ME | 1 |
Kehrberg, G; Moldenhauer, H; Rose, H; Saul, G; Wolf, G | 1 |
Adams, GE | 1 |
Brown, JM; Yu, NY | 2 |
Brown, JM; Eifel, PJ | 1 |
Battistella, R; McClelland, RA; Michaels, HB; Rauth, AM | 1 |
Blanke, G; Luscher, G; Streffer, C; Tamulevicius, P | 1 |
Hinchliffe, M; McNally, NJ | 1 |
Brown, JM; Hazlehurst, JL; Hirst, DG; Horsman, MR | 1 |
Coleman, CN; Phillips, TL; Urtasun, RC; Wasserman, TH | 1 |
Denekamp, J; Fowler, JF; Williams, MV | 1 |
Nelson, JS; VonGerichten, D; Wasserman, TH | 1 |
Coleman, CN; Halsey, J; Hancock, S; Harris, JW; Hirst, VK; Urtasun, RC; Wasserman, TH | 1 |
Brown, JM; White, RA; Workman, P | 1 |
Brown, DM; Brown, JM; Lee, WW; Yu, NY | 1 |
Siemann, DW | 1 |
Abe, M; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T; Sugiyama, T | 1 |
Streffer, C; Tamulevicius, P | 1 |
Abe, M; Ishigaki, T; Murata, R; Oya, N; Sasai, K; Shibamoto, Y; Shibata, T | 1 |
Abe, M; Iwai, H; Matsuno, E; Sasai, K; Shibamoto, Y | 1 |
el Gamoussi, R; Guichard, M; Stratford, IJ | 1 |
Giandomenico, AR; Iyengar, CW; Koch, CJ | 1 |
Harwell, L; Koch, CJ; Lord, EM | 1 |
Abe, M; Oya, N; Sasai, K; Shibamoto, Y; Sugiyama, T | 1 |
el Gamoussi, R; Guichard, M; Prade, M; Stratford, IJ; Threadgill, MD | 1 |
Miyata, Y; Mori, T; Murayama, C; Nishio, A; Sakaguchi, M; Sato, C; Shoji, T; Suzuki, A; Suzuki, T; Tanabe, Y | 1 |
Akuta, K; Kinashi, Y; Masunaga, S; Ono, K; Suzuki, M | 1 |
Battino, M; Breccia, A; Ferri, E; Gattavecchia, E; Genova, ML; Lenaz, G; Littarru, GP | 1 |
Skarsgard, LD; Wouters, BG | 1 |
De Bast, M; Gillart, J; Grégoire, V; Labar, D; Mahy, P | 1 |
Le, QT | 1 |
Koch, CJ | 1 |
Humm, JL; Li, GC; Li, XF; Ling, CC; Russell, J; Sun, X; Urano, M; Xing, L | 1 |
Chen, Q; Deng, X; He, F; Huang, Y; Li, GC; Ling, CC; Liu, Y; Minami, A; Sun, X; Wen, B; Xing, L; Zanzonico, PB | 1 |
Eskola, O; Grönroos, TJ; Komar, G; Lehtiö, K; Minn, H; Seppänen, M; Solin, O; Tuomela, J | 1 |
Burke, SA; Carlin, S; Ling, CC; Russell, J; Wen, B; Yang, KM | 1 |
Cho, H; Koutcher, JA; Li, XF; Ling, CC; Lupu, ME; Russell, J; Yang, KM | 1 |
Forsback, S; Heinonen, SE; Knuuti, J; Laine, VJ; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Ylä-Herttuala, S | 1 |
Carlin, S; Humm, JL | 1 |
Ackerley, DF; Anderson, RF; Ashoorzadeh, A; Copp, JN; Flanagan, JU; Guise, CP; Mowday, AM; Patterson, AV; Rich, MH; Smaill, JB; Williams, EM | 1 |
14 review(s) available for etanidazole and azomycin
Article | Year |
---|---|
Pharmacokinetics and subcellular localization of radiosensitizers.
Topics: Etanidazole; Humans; Hydrogen-Ion Concentration; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
Pharmacology and clinical investigation of SR-2508 (etanidazole).
Topics: Etanidazole; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
New anticancer agents.
Topics: Alkaloids; Animals; Antineoplastic Agents; Azacitidine; Biphenyl Compounds; Chrysenes; Deoxycytidine; Echinomycin; Epirubicin; Etanidazole; Flavonoids; Gemcitabine; Guanidines; Humans; Idarubicin; Menogaril; Mitoguazone; Neoplasms; Nitroimidazoles; Nogalamycin; Organoplatinum Compounds; Paclitaxel; Pentostatin; Polymers; Propylene Glycols; Ribavirin; Sulfonylurea Compounds; Trimetrexate; Vidarabine Phosphate | 1991 |
[Radiosensitizer: hypoxic cell radiosensitizer].
Topics: Animals; DNA; Dogs; Etanidazole; Hydroxamic Acids; Hydroxylation; Intercalating Agents; Lethal Dose 50; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Thymine | 1989 |
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neoplasms, Experimental; Nitrofurans; Nitrofurazone; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1986 |
Biochemistry of reduction of nitro heterocycles.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cell Division; Cell Survival; Etanidazole; Free Radicals; Glucose; Glutathione; Glycolysis; Hexosephosphates; Humans; Hypoxia; Methionine Sulfoximine; Microbodies; Microsomes; Misonidazole; Mitochondria; Nitroimidazoles; Oxidation-Reduction; Pentoses; Peroxidases; Sulfhydryl Compounds | 1986 |
Sensitizers and radiation dose fractionation: results and interpretations.
Topics: Animals; Combined Modality Therapy; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1986 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophosphamide; Doxorubicin; Etanidazole; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Imaging of tumor hypoxia to predict treatment sensitivity.
Topics: Animals; Cell Hypoxia; Drug Resistance, Neoplasm; Etanidazole; Humans; Hydrocarbons, Fluorinated; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals | 2008 |
PET of hypoxia: current and future perspectives.
Topics: Etanidazole; Humans; Hydrocarbons, Fluorinated; Hypoxia; Nitroimidazoles; Positron-Emission Tomography; Radioactive Tracers; Triazoles | 2012 |
22 trial(s) available for etanidazole and azomycin
Article | Year |
---|---|
The efficacy of pharmacokinetic monitoring and dose modification of etanidazole on the incidence of neurotoxicity: results from a phase II trial of etanidazole and radiation therapy in locally advanced prostate cancer.
Topics: Adenocarcinoma; Combined Modality Therapy; Drug Evaluation; Etanidazole; Humans; Male; Nitroimidazoles; Peripheral Nervous System Diseases; Prostatic Neoplasms; Radiation-Sensitizing Agents | 1992 |
Logistics in designing clinical trials for etanidazole (SR 2508): an RTOG experience.
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Etanidazole; Head and Neck Neoplasms; Humans; Nitroimidazoles; Radiation-Sensitizing Agents; Research Design | 1992 |
Final report of the phase I trial of continuous infusion etanidazole (SR 2508): a Radiation Therapy Oncology Group study.
Topics: Brachytherapy; Combined Modality Therapy; Drug Evaluation; Etanidazole; Female; Humans; Infusions, Intravenous; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1992 |
First analysis of tumor regression for the European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas.
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Etanidazole; Female; Head and Neck Neoplasms; Humans; Male; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
Kinetic uptake of etanidazole in lung carcinoma and normal tissue in vivo.
Topics: Aged; Carcinoma, Bronchogenic; Combined Modality Therapy; Etanidazole; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Reference Values | 1992 |
Pharmacology and clinical investigation of SR-2508 (etanidazole).
Topics: Etanidazole; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
A phase I study of SR-2508 and cyclophosphamide administered by intravenous injection.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Etanidazole; Female; Humans; Injections, Intravenous; Male; Middle Aged; Nitroimidazoles | 1991 |
Progress report of a phase II and a phase III trial with etanidazole (SR-2508): a multicentre European study.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Evaluation; Etanidazole; Europe; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Clinical trials with etanidazole (SR-2508) by the Radiation Therapy Oncology Group (RTOG).
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Evaluation; Etanidazole; Head and Neck Neoplasms; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
The combination of multiple doses of etanidazole and pimonidazole in 48 patients: a toxicity and pharmacokinetic study.
Topics: Adult; Aged; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Combinations; Etanidazole; Female; Humans; Male; Middle Aged; Neoplasms; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508).
Topics: Aged; Clinical Trials as Topic; Etanidazole; Humans; Male; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1990 |
Final report of the phase I trial of the hypoxic cell radiosensitizer SR 2508 (etanidazole) Radiation Therapy Oncology Group 83-03.
Topics: Adult; Canada; Combined Modality Therapy; Drug Evaluation; Etanidazole; Humans; Infusions, Intravenous; Multicenter Studies as Topic; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents; United States | 1990 |
Initial results of a phase I trial of continuous infusion SR 2508 (etanidazole): a radiation therapy oncology group study.
Topics: Brachytherapy; Combined Modality Therapy; Drug Evaluation; Etanidazole; Humans; Infusions, Intravenous; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
A multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Drug Combinations; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents | 1989 |
Hypoxic cell radiosensitizers: illusion or elusion?
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1988 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Dose-response relationships for human tumors: implications for clinical trials of dose modifying agents.
Topics: Animals; Clinical Trials as Topic; Dose-Response Relationship, Radiation; Etanidazole; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Neuropathy of nitroimidazole radiosensitizers: clinical and pathological description.
Topics: Etanidazole; Humans; Misonidazole; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents; Sural Nerve | 1984 |
Hypoxic cell radiosensitizers--present and future.
Topics: Animals; Central Nervous System; Clinical Trials as Topic; Etanidazole; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1981 |
114 other study(ies) available for etanidazole and azomycin
Article | Year |
---|---|
Radiosensitization efficacy of KU-2285, RP-170 and etanidazole at low radiation doses: assessment by in vitro cytokinesis-block micronucleus assay.
Topics: Animals; Cell Hypoxia; Dose-Response Relationship, Drug; Etanidazole; Mice; Micronucleus Tests; Nitroimidazoles; Nucleosides; Radiation Dosage; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1992 |
Pharmacokinetics of fluorinated 2-nitroimidazole hypoxic cell radiosensitizers in murine peripheral nervous tissue.
Topics: Animals; Cell Hypoxia; Etanidazole; Female; Half-Life; Mice; Mice, Inbred C3H; Nitroimidazoles; Peripheral Nerves; Radiation-Sensitizing Agents | 1992 |
Radiosensitization by 2-nitroimidazole nucleoside analog RP-170: radiosensitizing effects under both intravenous and oral administration.
Topics: Administration, Oral; Animals; Combined Modality Therapy; Etanidazole; Female; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains | 1992 |
Distribution of etanidazole into human brain tumors: implications for treating high grade gliomas.
Topics: Brain Neoplasms; Combined Modality Therapy; Drug Evaluation; Etanidazole; Humans; Infusions, Intravenous; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1992 |
4-Fluorobenzylamine and phenylalanine methyl ester conjugates of 2-nitroimidazole: evaluation as hypoxic cell radiosensitizers.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Drug Evaluation; Etanidazole; In Vitro Techniques; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
Modification of alkylating agent induced cell kill by 2-nitroimidazoles in unclamped and clamped SC 9L tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Survival; Cyclophosphamide; Etanidazole; Ifosfamide; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344 | 1992 |
Sensitization of Chinese hamster ovary cells to melphalan by etanidazole under intermittent hypoxia.
Topics: Animals; Cell Hypoxia; Cell Survival; CHO Cells; Cricetinae; Etanidazole; Melphalan; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1992 |
Oncogenic transforming potential of etanidazole.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Etanidazole; Mice; Neoplasms, Second Primary; Nitroimidazoles; Radiation-Sensitizing Agents; Risk | 1992 |
Protection against light-activated photofrin II killing of tumor cells by nitroimidazoles.
Topics: Animals; Dihematoporphyrin Ether; Drug Interactions; Etanidazole; Hematoporphyrins; Lasers; Mice; Misonidazole; Nitroimidazoles; Photochemotherapy; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1992 |
Enhancement of SR 2508 (etanidazole) radiosensitization by buthionine sulphoximine at low-dose-rate irradiation.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Hypoxia; Dose-Response Relationship, Radiation; Drug Combinations; Drug Synergism; Etanidazole; In Vitro Techniques; Methionine Sulfoximine; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Modulation of alkylating agents by etanidazole and Fluosol-DA/carbogen in the FSaIIC fibrosarcoma and EMT6 mammary carcinoma.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carbon Dioxide; Carboplatin; Carmustine; Cell Survival; Colony-Forming Units Assay; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Etanidazole; Fibrosarcoma; Flow Cytometry; Fluorocarbons; Hydroxyethyl Starch Derivatives; Mammary Neoplasms, Experimental; Melphalan; Mice; Nitroimidazoles; Organoplatinum Compounds; Oxygen; Radiation-Sensitizing Agents; Thiotepa | 1991 |
Technique, pharmacokinetics, toxicity, and efficacy of intratumoral etanidazole and radiotherapy for treatment of spontaneous feline oral squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; Combined Modality Therapy; Etanidazole; Mouth Neoplasms; Necrosis; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy; Radiotherapy Dosage | 1991 |
Effect of pH, oxygenation, and temperature on the cytotoxicity and radiosensitization by etanidazole.
Topics: Animals; Benzimidazoles; Cell Division; Cell Line; Cell Survival; Etanidazole; Fibrosarcoma; Flow Cytometry; Fluorescent Dyes; Hydrogen-Ion Concentration; Hyperthermia, Induced; Hypoxia; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Temperature | 1991 |
A comparison of radiosensitization by etanidazole and pimonidazole in mouse tumors.
Topics: Animals; Cell Survival; Combined Modality Therapy; Etanidazole; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer.
Topics: Animals; Combined Modality Therapy; Dose-Response Relationship, Radiation; Etanidazole; Female; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Combination of etanidazole with cyclophosphamide and platinum complexes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Cells; Carboplatin; Cell Survival; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Etanidazole; Fibrosarcoma; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Nitroimidazoles; Time Factors | 1991 |
2-Nitroimidazole potentiation of nitrosourea induced cytotoxicity in subcutaneous implants of rat 9L brain tumor cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred F344; Streptozocin; Tumor Stem Cell Assay | 1991 |
Radiosensitization by the combination of etanidazole (SR-2508) and pimonidazole (Ro 03-8799) in human tumor xenografts.
Topics: Adenocarcinoma; Animals; Cell Survival; Drug Synergism; Etanidazole; Female; Humans; Melanoma; Mice; Mice, Nude; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rectal Neoplasms | 1991 |
Glutathione depletion and cytotoxicity of buthionine sulphoximine and SR2508 in rodent and human cells.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Drug Synergism; Etanidazole; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Nitroimidazoles; Radiation-Sensitizing Agents | 1990 |
Addition of 2-nitroimidazole radiosensitizers to cis-diamminedichloroplatinum(II) with radiation and with or without hyperthermia in the murine FSaIIC fibrosarcoma.
Topics: Animals; Cell Survival; Cisplatin; Combined Modality Therapy; Drug Therapy, Combination; Etanidazole; Fibrosarcoma; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1990 |
KIH-802, an acetohydroxamic acid derivative of 2-nitroimidazole, as a new potent hypoxic cell radiosensitizer: radiosensitizing activity, acute toxicity, and pharmacokinetics.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Etanidazole; Female; Hydroxamic Acids; Hypoxia; Injections, Intravenous; Lethal Dose 50; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1990 |
Chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9L tumor model: pharmacokinetic and structure-activity considerations.
Topics: Animals; Carmustine; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1990 |
Effect of acidic pH on radiosensitization of FSaIIC cells in vitro by misonidazole, etanidazole, or cis-diamminedichloroplatinum (II).
Topics: Animals; Cell Line; Cell Survival; Cisplatin; Etanidazole; Fibrosarcoma; Hydrogen-Ion Concentration; In Vitro Techniques; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1990 |
[Radiosensitization by hypoxic cell radiosensitizer--present status of radiosensitizer].
Topics: Cell Hypoxia; Etanidazole; Humans; Misonidazole; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1990 |
Tumour radiosensitization by clofibrate and its analogs: possible mechanisms.
Topics: Animals; Bezafibrate; Clofibrate; Combined Modality Therapy; Etanidazole; Female; Hypoxia; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Regional Blood Flow | 1990 |
Experimental intra-arterial administration of SR-2508 in the rabbit V2 carcinoma model.
Topics: Animals; Etanidazole; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Neoplasms, Experimental; Nitroimidazoles; Rabbits; Radiation-Sensitizing Agents | 1989 |
Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: a possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination.
Topics: Animals; Brain; Drug Combinations; Enzyme Induction; Etanidazole; Mice; Mice, Inbred C3H; Microsomes, Liver; Neoplasm Transplantation; Nitroimidazoles; Phenobarbital; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Evaluation of nitroimidazole hypoxic cell radiosensitizers in a human tumor cell line high in intracellular glutathione.
Topics: Cell Line; Drug Evaluation, Preclinical; Etanidazole; Glutathione; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1989 |
Pharmacokinetics of etanidazole (SR-2508) in bladder and cervical cancer: evidence of diffusion from urine.
Topics: Carcinoma, Squamous Cell; Diffusion; Etanidazole; Female; Humans; Nitroimidazoles; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1989 |
Ro 03-8799: preferential relative uptake in human tumor xenografts compared to a murine tumor: comparison with SR-2508.
Topics: Animals; Cell Line; Etanidazole; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous | 1989 |
Effects of nitroimidazoles on neuronal cells in vitro.
Topics: Animals; Axons; Cell Line; Etanidazole; Intermediate Filaments; Mice; Misonidazole; Neurons; Nitroimidazoles; Radiation-Sensitizing Agents; Rats | 1989 |
Oncogenic transforming potential of nitroimidazole radiosensitizers.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Etanidazole; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione Transferase; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1989 |
The effect of glutathione (GSH) depletion in vivo by buthionine sulfoximine (BSO) on the radiosensitization of SR 2508.
Topics: Animals; Buthionine Sulfoximine; Etanidazole; Glutathione; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1989 |
Modification of SR 2508 sensitization in hypoxic V79 cells by manipulation of glutathione levels.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione; Methionine Sulfoximine; Nitroimidazoles; Oxygen; Pyrrolidonecarboxylic Acid; Radiation-Sensitizing Agents; Thiazoles; Thiazolidines | 1989 |
Addition of misonidazole, etanidazole, or hyperthermia to treatment with fluosol-DA/carbogen/radiation.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Drug Combinations; Etanidazole; Fibrosarcoma; Fluorocarbons; Hydroxyethyl Starch Derivatives; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Estimation of plasma area under the curve for etanidazole (SR 2508) in toxicity prediction and dose adjustment.
Topics: Etanidazole; Half-Life; Humans; Monitoring, Physiologic; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole (RP-170).
Topics: Animals; Cell Survival; Combined Modality Therapy; Etanidazole; In Vitro Techniques; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1989 |
A new, potent 2-nitroimidazole nucleoside hypoxic cell radiosensitizer, RP170.
Topics: Animals; Cell Survival; Etanidazole; Female; Lethal Dose 50; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1989 |
Bone marrow toxicity of total-body irradiation combined with radiosensitizers.
Topics: Animals; Bone Marrow; Dogs; Etanidazole; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Whole-Body Irradiation | 1989 |
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice.
Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Metastasis; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1988 |
Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Brain Neoplasms; Drug Therapy, Combination; Etanidazole; Glioblastoma; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Evaluation of SR-2508 induced neurotoxicity and myotoxicity in rats using brainstem auditory evoked potentials and the posterior auricular muscle response.
Topics: Animals; Brain Stem; Ear; Etanidazole; Evoked Potentials; Muscles; Neural Conduction; Neurotoxins; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Reflex | 1985 |
A phase I study of the combined hypoxic cell radiosensitizers, Ro 03-8799 and SR 2508: a preliminary report of single-dose toxicity, pharmacokinetics and tumour concentrations.
Topics: Adenocarcinoma; Drug Combinations; Drug Evaluation; Etanidazole; Humans; Melanoma; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Radiosensitization of hypoxic cells at low doses.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Etanidazole; In Vitro Techniques; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1986 |
Sensitization by SR-2508 plus Ro 03-8799.
Topics: Animals; Combined Modality Therapy; Drug Combinations; Etanidazole; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.
Topics: Aged; Etanidazole; Female; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
A phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: toxicity and pharmacokinetics.
Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Drug Combinations; Drug Evaluation; Etanidazole; Humans; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice.
Topics: Animals; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution | 1986 |
Modulation of X ray DNA damage by SR-2508 +/- buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; DNA; Drug Synergism; Etanidazole; Glutathione; In Vitro Techniques; Methionine Sulfoximine; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
The relationship of SR-2508 sensitizer enhancement ratio to cellular glutathione levels in human tumor cell lines.
Topics: Cell Line; Etanidazole; Glutathione; Humans; In Vitro Techniques; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Enhancement in the aerobic toxicity of misonidazole and SR-2508 by buthionine sulfoximine and 4-hydroxypyrazole: the role of hydrogen peroxide.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Etanidazole; Glutathione; Humans; Hydrogen Peroxide; In Vitro Techniques; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Pyrazoles; Radiation-Sensitizing Agents | 1986 |
Identification of a reactive glutathione conjugate as a metabolite of SR-2508 in CHO cells.
Topics: Animals; Cell Line; Cricetinae; Etanidazole; Glutathione; Imidazoles; In Vitro Techniques; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Variation in sensitizing efficiency for SR 2508 in human cells dependent on glutathione content.
Topics: Cell Line; Cell Survival; Etanidazole; Glutathione; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Ocular penetration, toxicity, and radiosensitization effects of two hypoxic cell radiosensitizers on retinoblastoma.
Topics: Absorption; Animals; Cell Line; Etanidazole; Eye; Eye Neoplasms; Female; Hypoxia; Nitroimidazoles; Rabbits; Radiation-Sensitizing Agents; Retinoblastoma | 1986 |
The effect of hypoxic cell sensitizers at different irradiation dose rates.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Etanidazole; Lung; Misonidazole; Nitroimidazoles; Regression Analysis | 1987 |
SR-2508 plus buthionine sulfoximine or SR-2508 alone: effects on the radiation response and the glutathione content of a human tumor xenograft.
Topics: Buthionine Sulfoximine; Cell Survival; Cysteine; Etanidazole; Glutathione; Humans; Methionine Sulfoximine; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1987 |
Gradient high-performance liquid chromatographic method for simultaneous assay of the radiosensitizers etanidazole (SR 2508) and pimonidazole (Ro 03-8799) in biological materials.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Etanidazole; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1987 |
Uptake and additivity of the radiosensitizing effects of Ro 03-8799 and SR-2508 in mammalian cells in vitro.
Topics: Animals; Cell Line; Cricetinae; Drug Synergism; Etanidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1987 |
[Present status of hypoxic cell sensitizers and PLDR inhibitors].
Topics: Animals; Cell Cycle; Cell Line; Etanidazole; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1987 |
When can the infusion period be safely ignored in the estimation of pharmacokinetic parameters of drugs in humans?
Topics: Algorithms; Antineoplastic Agents; Carmustine; Etanidazole; Humans; Infusions, Intravenous; Models, Biological; Nitroimidazoles; Time Factors | 1988 |
Additivity of radiosensitization by the combination of SR 2508 (etanidazole) and Ro 03-8799 (pimonidazole) in a murine tumor system.
Topics: Animals; Cell Survival; Drug Therapy, Combination; Etanidazole; Female; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Interactions of hyperthermia with hypoxic cell sensitisers.
Topics: Animals; Combined Modality Therapy; Etanidazole; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1988 |
The multi-dose clinical tolerance and pharmacokinetics of the combined radiosensitizers, Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Adult; Aged; Combined Modality Therapy; Drug Therapy, Combination; Etanidazole; Humans; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Antagonism between radiosensitizing agents.
Topics: Dose-Response Relationship, Drug; Etanidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
[Development of new hypoxic cell radiosensitizer in Japan].
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Etanidazole; Hydroxamic Acids; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Phase I trial of the hypoxic cell radiosensitizer SR-2508: the results of the five to six week drug schedule.
Topics: Drug Administration Schedule; Drug Evaluation; Etanidazole; Humans; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents | 1986 |
Relationship between the neurotoxicity of the hypoxic cell radiosensitizer SR 2508 and the pharmacokinetic profile.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Etanidazole; Humans; Kinetics; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents | 1987 |
Selective enhancement of hypoxic cell killing by melphalan via thiol depletion: in vitro studies with hypoxic cell sensitizers and buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Etanidazole; Melphalan; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Sulfhydryl Compounds | 1985 |
Oxygen dependence of hematoporphyrin derivative-induced photoinactivation of Chinese hamster cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Etanidazole; Hematoporphyrins; Neoplasms; Nitroimidazoles; Oxygen; Photochemotherapy | 1985 |
The in vitro sensitivity of chronically hypoxic EMT6/SF cells to X-radiation and hypoxic cell radiosensitizers.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Etanidazole; Female; Mammary Neoplasms, Experimental; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Sulfhydryl Compounds; X-Rays | 1985 |
Testing of new hypoxic cell sensitizers in vivo.
Topics: Animals; Drug Evaluation, Preclinical; Etanidazole; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1982 |
A comparison of the cytological effects of three hypoxic cell radiosensitizers.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Etanidazole; Lung; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sister Chromatid Exchange | 1982 |
Clinical perspectives for the use of new hypoxic cell sensitizers.
Topics: Animals; Cyclophosphamide; Dogs; Drug Therapy, Combination; Etanidazole; Humans; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Solubility | 1982 |
[Studies in radiosensitizing effects of misonidazole and SR-2508 on experimental animal tumors].
Topics: Animals; Etanidazole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1983 |
Sensitization of normal and malignant tissue to cyclophosphamide by nitroimidazoles with different partition coefficients.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Etanidazole; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole.
Topics: Aerobiosis; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Etanidazole; Female; Misonidazole; Nitroimidazoles; Ovary; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Time Factors | 1984 |
[Recent advances in hypoxic cell radiosensitizer].
Topics: Animals; Cells, Cultured; Etanidazole; Maleates; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Oxygen Consumption; Radiation-Sensitizing Agents | 1983 |
Clinical trials of radiosensitizers: what should we expect?
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Etanidazole; Humans; Kinetics; Lethal Dose 50; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Factors associated with the preincubation effect of hypoxic cell sensitizers in vitro and their possible implications in chemosensitization.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cysteamine; Dose-Response Relationship, Drug; Drug Resistance; Etanidazole; Hydrogen Peroxide; Hyperthermia, Induced; Hypoxia; Melphalan; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Time Factors | 1984 |
Radiosensitizers: a conference preview.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: a preliminary report.
Topics: Animals; Combined Modality Therapy; Dose-Response Relationship, Radiation; Etanidazole; Female; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Depletion of glutathione in vivo as a method of improving the therapeutic ratio of misonidazole and SR 2508.
Topics: Animals; Buthionine Sulfoximine; Combined Modality Therapy; Etanidazole; Glutathione; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Pharmacokinetics and toxicology of continuously infused nitroimidazoles.
Topics: Animals; Brain; Etanidazole; Female; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system.
Topics: Acetophenones; Cobalt Radioisotopes; Etanidazole; Gamma Rays; Metronidazole; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Oxygen; Radiation-Sensitizing Agents | 1984 |
The effects of radiosensitizers on intermediary metabolism in vivo.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenocarcinoma; Animals; Dihydroxyacetone Phosphate; Etanidazole; Glycerophosphates; Hydroxybutyrates; Lactates; Liver; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Pyruvates; Radiation-Sensitizing Agents | 1984 |
A comparison of the ability of some radiosensitizers undergoing clinical trials to act as chemosensitizers.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etanidazole; Fibrosarcoma; Melphalan; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
The effect of timing on chemosensitization by clinical levels of SR-2508.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Etanidazole; Melphalan; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1984 |
Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508.
Topics: Drug Evaluation; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1984 |
The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.
Topics: Administration, Oral; Animals; Biological Availability; Dog Diseases; Dogs; Drug Evaluation, Preclinical; Etanidazole; Female; Injections, Intravenous; Kinetics; Male; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1980 |
SR-2508: a 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use.
Topics: Animals; Carcinoma; Cell Line; Central Nervous System; Cricetinae; Dogs; Etanidazole; Female; In Vitro Techniques; Lipid Metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; X-Rays | 1981 |
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte Count; Lomustine; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1982 |
Combined cytokinesis-block micronucleus and chromosomal aberration assay for the evaluation of radiosensitizers at low radiation doses.
Topics: Aerobiosis; Animals; Cell Line; Chromosome Aberrations; Dose-Response Relationship, Radiation; Etanidazole; Female; Mice; Mice, Inbred BALB C; Micronucleus Tests; Mutagenicity Tests; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1994 |
Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers.
Topics: Adenosine Triphosphate; Animals; Brain; Etanidazole; Glucose; Male; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1994 |
Comparison of radiosensitizing effect of KU-2285 and SR-2508 at low drug concentrations and doses.
Topics: Animals; Carcinoma, Squamous Cell; Cell Survival; Dose-Response Relationship, Drug; Etanidazole; Female; Mice; Mice, Inbred C3H; Micronucleus Tests; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1994 |
Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice.
Topics: Animals; Carcinoma, Squamous Cell; Etanidazole; Female; Male; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Peripheral Nerves; Radiation-Sensitizing Agents | 1994 |
Relationship between intracellular concentration and radiosensitizing effect of pimonidazole and etanidazole on two human melanoma cell lines.
Topics: Etanidazole; Humans; In Vitro Techniques; Melanoma; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Bioreductive metabolism of AF-2[2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide] combined with 2-nitroimidazoles. Implications for use as hypoxic cell markers.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Drug Interactions; Etanidazole; Furylfuramide; Glucose; Guinea Pigs; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Rats; Tumor Cells, Cultured | 1993 |
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.
Topics: Animals; Antibodies, Monoclonal; Cell Hypoxia; Etanidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitroimidazoles | 1993 |
In vivo radiosensitization efficacy of KU-2285 and etanidazole at clinically relevant low radiation doses.
Topics: Animals; Cell Division; Cell Line; Chromosome Aberrations; Dose-Response Relationship, Radiation; Etanidazole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Micronucleus Tests; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Tumor Cells, Cultured | 1993 |
Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole.
Topics: Animals; Autoradiography; Cell Line; Etanidazole; Humans; Melanins; Melanoma; Mice; Mice, Nude; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Radiosensitization by a new potent nucleoside analog: 1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole(RP-343).
Topics: Animals; Cell Hypoxia; Cell Survival; Dogs; Dose-Response Relationship, Drug; Etanidazole; Female; In Vitro Techniques; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1993 |
The radiosensitizing effects of hypoxic cell sensitizer on SCCVII tumors in mice evaluated by highly accurate colony formation assay assisted by microcomputer.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Survival; Etanidazole; Male; Mice; Mice, Inbred C3H; Microcomputers; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Mitochondrial respiratory chain features after gamma-irradiation.
Topics: Animals; Cattle; Chromatography, Gas; Chromatography, High Pressure Liquid; Electron Transport; Etanidazole; Gamma Rays; Misonidazole; Mitochondria, Heart; Nitroimidazoles; Spectrophotometry; Succinate Dehydrogenase; Ubiquinone | 1997 |
Substructure in the cell survival response at low radiation dose: effect of different subpopulations.
Topics: Animals; Cell Separation; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Etanidazole; Humans; Nitroimidazoles; Oxygen; Relative Biological Effectiveness; Tumor Cells, Cultured; X-Rays | 1997 |
Detection of tumour hypoxia: comparison between EF5 adducts and [18F]EF3 uptake on an individual mouse tumour basis.
Topics: Animals; Cell Hypoxia; Drug Evaluation, Preclinical; Etanidazole; Fibrosarcoma; Fluorescent Antibody Technique; Hydrocarbons, Fluorinated; Male; Mammary Neoplasms, Experimental; Metabolic Clearance Rate; Mice; Mice, Inbred C3H; Nitroimidazoles; Organ Specificity; Oxygen; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 2006 |
Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches.
Topics: Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Electrodes; Etanidazole; Head and Neck Neoplasms; Humans; Hydrocarbons, Fluorinated; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Neoplasm Proteins; Nitroimidazoles; Osteopontin; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 2007 |
Importance of antibody concentration in the assessment of cellular hypoxia by flow cytometry: EF5 and pimonidazole.
Topics: Animals; Area Under Curve; Calibration; Cell Hypoxia; Cell Line, Tumor; Etanidazole; Flow Cytometry; Humans; Hydrocarbons, Fluorinated; Kinetics; Microscopy, Fluorescence; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Time Factors | 2008 |
Changes in tumor hypoxia induced by mild temperature hyperthermia as assessed by dual-tracer immunohistochemistry.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Cell Hypoxia; Colorectal Neoplasms; Etanidazole; Female; Hydrocarbons, Fluorinated; Hyperthermia, Induced; Immunohistochemistry; Mice; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Transplantation, Heterologous | 2008 |
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Topics: Animals; Antigens, Neoplasm; Arabinofuranosyluracil; Autoradiography; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; Gene Expression; Green Fluorescent Proteins; Herpesvirus 1, Human; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Immunohistochemistry; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Thymidine Kinase; Tissue Distribution; Transplantation, Heterologous | 2008 |
Immunohistochemical detection of changes in tumor hypoxia.
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Mice, Nude; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 2009 |
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model.
Topics: Adenocarcinoma; Animals; Atrasentan; Colonic Neoplasms; Combined Modality Therapy; Etanidazole; Gadolinium DTPA; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Nitroimidazoles; Perfusion; Pyrrolidines; Radiation-Sensitizing Agents; Radiotherapy; Treatment Outcome; Xenograft Model Antitumor Assays | 2009 |
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Topics: Analysis of Variance; Animals; Aorta; Apolipoprotein B-100; Atherosclerosis; Autoradiography; Disease Models, Animal; Etanidazole; Female; Fluorine Radioisotopes; Genotype; Hydrocarbons, Fluorinated; Hypoxia; Immunohistochemistry; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, LDL; Tissue Distribution | 2011 |
Engineering
Topics: Antineoplastic Agents; Biosensing Techniques; Cell Hypoxia; Drug Monitoring; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Etanidazole; Genetic Therapy; HCT116 Cells; Humans; Hydrocarbons, Fluorinated; Imidazoles; Molecular Imaging; Neoplasms; Nitroimidazoles; Nitroreductases; Positron-Emission Tomography; Prodrugs; Protein Engineering | 2019 |