Page last updated: 2024-08-17

estrone and irosustat

estrone has been researched along with irosustat in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (66.67)	29.6817
2010's	5 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kim, BM; Liu, Y; Mostafa, Y; Phan, CM; Taylor, SD	1
Potter, BV; Purohit, A; Reed, MJ; Woo, LW	1
Malini, B; Potter, BV; Purohit, A; Reed, MJ; Woo, LL	1
Barrow, D; Hejaz, HA; Nicholson, RI; Potter, BV; Purohit, A; Reed, MJ; Woo, LW	1
Ahmed, S; James, K; Owen, CP; Patel, CK; Patel, MB	1
Ahmed, S; James, K; Owen, CP	1
Ho, Y; Potter, BV; Purohit, A; Reed, MJ; Robinson, J; Vicker, N; Woo, LL	1
Chander, SK; Potter, BV; Purohit, A; Reed, MJ; Woo, LW	1
Newman, SP; Potter, BV; Purohit, A; Reed, MJ; Woo, LW	1
Coombes, RC; Dobbs, N; Elliott, M; Kulinskaya, E; Potter, BV; Purohit, A; Reed, MJ; Stanczyk, FZ; Stanway, SJ; Sufi, S; Vigushin, D; Ward, R; Wilson, RH; Woo, LW	1
Akinaga, S; Anazawa, H; Ishida, H; Kuwabara, T; Li, PK; Murakata, C; Nakata, T; Sato, N; Shiotsu, Y; Suzuki, M; Takebayashi, M; Tanaka, H; Terasaki, Y	1
Coombes, RC; Januszewski, A; Palmieri, C; Stanway, S	1
Edwards, DR; Wolfenden, R	1
Ali, T; Allory, Y; de la Taille, A; Fiet, J; Franck, G; Gervais, M; Giton, F; Loric, S; Schmidlin, F; Sirab, N; Vacherot, F	1
Potter, BV; Thomas, MP	1

Reviews

2 review(s) available for estrone and irosustat

Article	Year
Steroid sulfatase: molecular biology, regulation, and inhibition. Endocrine reviews, 2005, Volume: 26, Issue:2 Topics: Animals; Breast Neoplasms; Clinical Trials, Phase I as Topic; Coumarins; Enzyme Inhibitors; Estrone; Female; Humans; Models, Molecular; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids	2005
Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer. Expert review of anticancer therapy, 2011, Volume: 11, Issue:2 Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase II as Topic; Dehydroepiandrosterone Sulfate; Estradiol; Estrone; Female; Fulvestrant; Humans; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonic Acids; Tamoxifen	2011

Article

Year

Steroid sulfatase: molecular biology, regulation, and inhibition.

Endocrine reviews, 2005, Volume: 26, Issue:2

Topics: Animals; Breast Neoplasms; Clinical Trials, Phase I as Topic; Coumarins; Enzyme Inhibitors; Estrone; Female; Humans; Models, Molecular; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids

2005

Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer.

Expert review of anticancer therapy, 2011, Volume: 11, Issue:2

Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase II as Topic; Dehydroepiandrosterone Sulfate; Estradiol; Estrone; Female; Fulvestrant; Humans; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonic Acids; Tamoxifen

2011

Trials

1 trial(s) available for estrone and irosustat

Article	Year
Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Mar-01, Volume: 12, Issue:5 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Androstenediol; Breast Neoplasms; Coumarins; Dose-Response Relationship, Drug; Estradiol; Estrone; Female; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids; Testosterone	2006

Article

Year

Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Mar-01, Volume: 12, Issue:5

Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Androstenediol; Breast Neoplasms; Coumarins; Dose-Response Relationship, Drug; Estradiol; Estrone; Female; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids; Testosterone

2006

Other Studies

12 other study(ies) available for estrone and irosustat

Article	Year
Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives. Bioorganic & medicinal chemistry, 2011, Oct-15, Volume: 19, Issue:20 Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrone; Female; Humans; Kinetics; Placenta; Pregnancy; Steryl-Sulfatase	2011
In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer research, 2000, Jul-01, Volume: 60, Issue:13 Topics: Animals; Antineoplastic Agents; Cell Division; Coumarins; Estrone; Female; Humans; Liver; Mammary Neoplasms, Experimental; Methylnitrosourea; Ovariectomy; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids; Time Factors; Uterus	2000
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates. Chemistry & biology, 2000, Volume: 7, Issue:10 Topics: Alanine; Antineoplastic Agents; Arylsulfatases; Binding Sites; Breast Neoplasms; Coumarins; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Estrone; Female; Glycine; Heterocyclic Compounds, 3-Ring; Humans; Hydrogen Bonding; Kinetics; Microsomes; Models, Molecular; Placenta; Postmenopause; Steryl-Sulfatase; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids	2000
Non-steroidal and steroidal sulfamates: new drugs for cancer therapy. Molecular and cellular endocrinology, 2001, Jan-22, Volume: 171, Issue:1-2 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Coumarins; Enzyme Inhibitors; Estrogens; Estrone; Female; Humans; Kinetics; Oxepins; Rats; Rats, Wistar; Sulfatases; Sulfonamides; Sulfonic Acids; Tumor Cells, Cultured	2001
Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. Bioorganic & medicinal chemistry letters, 2001, Dec-03, Volume: 11, Issue:23 Topics: Catalytic Domain; Coumarins; Enzyme Inhibitors; Estrone; Inhibitory Concentration 50; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids	2001
Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). The Journal of steroid biochemistry and molecular biology, 2002, Volume: 82, Issue:4-5 Topics: Coumarins; Drug Design; Enzyme Inhibitors; Estrone; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Mimicry; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids	2002
Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. Bioorganic & medicinal chemistry letters, 2003, Mar-10, Volume: 13, Issue:5 Topics: Binding Sites; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Coumarins; Estrone; Humans; Inhibitory Concentration 50; Models, Molecular; Steroids; Structure-Activity Relationship; Substrate Specificity; Sulfatases; Sulfonamides; Sulfonic Acids	2003
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates. Biochemical and biophysical research communications, 2004, Sep-10, Volume: 322, Issue:1 Topics: Animals; Coumarins; Drug Combinations; Estrogens; Estrone; Female; Homeostasis; Organ Size; Ovariectomy; Rats; Rats, Wistar; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids; Uterus	2004
A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. Breast cancer research and treatment, 2007, Volume: 106, Issue:2 Topics: Administration, Oral; Animals; Breast Neoplasms; Cell Proliferation; Coumarins; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrone; Female; Gene Expression Regulation, Enzymologic; Humans; Leukocytes; Methylnitrosourea; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Signal Transduction; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids; Tamoxifen; Tumor Cells, Cultured	2007
Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors. The Journal of organic chemistry, 2012, May-04, Volume: 77, Issue:9 Topics: Arylsulfatases; Catalysis; Coumarins; Esters; Estrone; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Structure; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids	2012
Evidence of estrone-sulfate uptake modification in young and middle-aged rat prostate. The Journal of steroid biochemistry and molecular biology, 2015, Volume: 152 Topics: Age Factors; Animals; Antiporters; Biological Transport; Cytokines; Estrogens; Estrogens, Conjugated (USP); Estrone; Eye Proteins; Male; Models, Animal; Organic Anion Transporters; Prostate; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steryl-Sulfatase; Sulfonic Acids	2015
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. Journal of medicinal chemistry, 2015, Oct-08, Volume: 58, Issue:19 Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Discovery; Endometriosis; Estrone; Female; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms; Steryl-Sulfatase; Sulfonic Acids; Tubulin Modulators	2015