estrone-3-o-sulfamate has been researched along with irosustat in 16 studies
| Studies (estrone-3-o-sulfamate) | Trials (estrone-3-o-sulfamate) | Recent Studies (post-2010) (estrone-3-o-sulfamate) | Studies (irosustat) | Trials (irosustat) | Recent Studies (post-2010) (irosustat) |
|---|---|---|---|---|---|
| 89 | 0 | 15 | 68 | 5 | 32 |
| Protein | Taxonomy | estrone-3-o-sulfamate (IC50) | irosustat (IC50) |
|---|---|---|---|
| Carbonic anhydrase 2 | Homo sapiens (human) | 0.018 | |
| Steryl-sulfatase | Homo sapiens (human) | 0.0755 | |
| Aromatase | Homo sapiens (human) | 0.3 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 0.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, S; James, K; Owen, CP; Patel, CK; Patel, MB | 1 |
| Ahmed, S; James, K; Owen, CP; Patel, CK | 1 |
| Ho, Y; Potter, BV; Purohit, A; Reed, MJ; Robinson, J; Vicker, N; Woo, LL | 1 |
| Ahmed, S; Owen, CP; Patel, CK | 1 |
| Dahse, HM; Gräfe, U; Härtl, A; Jütten, P; Schumann, W | 1 |
| Acharya, KR; Chander, SK; Cozier, G; Jackson, T; Leonard, P; Potter, BV; Purohit, A; Putey, A; Reed, MJ; Woo, LW | 1 |
| Kim, BM; Liu, Y; Mostafa, Y; Phan, CM; Taylor, SD | 1 |
| Jaggi, AS; Shah, R; Singh, D; Singh, J; Singh, N | 1 |
| Han, KL; Jia, Y; Li, P; Qiao, Y; Zhang, MM | 1 |
| Biernacki, K; Ciupak, O; Daśko, M; Demkowicz, S; Kozak, W; Kubiński, K; Martyna, A; Masłyk, M; Nocentini, A; Rachon, J; Rak, J; Śliwka-Kaszyńska, M; Supuran, CT; Świtalska, M; Wietrzyk, J | 1 |
| Malini, B; Potter, BV; Purohit, A; Reed, MJ; Woo, LL | 1 |
| Ahmed, S; James, K; Owen, CP | 1 |
| Chander, SK; Potter, BV; Purohit, A; Reed, MJ; Woo, LW | 1 |
| Newman, SP; Potter, BV; Purohit, A; Reed, MJ; Woo, LW | 1 |
| Edwards, DR; Wolfenden, R | 1 |
| Potter, BV; Thomas, MP | 1 |
2 review(s) available for estrone-3-o-sulfamate and irosustat
| Article | Year |
|---|---|
Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review.
Topics: Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Neoplasm Recurrence, Local; Sulfatases; Sulfonic Acids | 2016 |
Steroid sulfatase: molecular biology, regulation, and inhibition.
Topics: Animals; Breast Neoplasms; Clinical Trials, Phase I as Topic; Coumarins; Enzyme Inhibitors; Estrone; Female; Humans; Models, Molecular; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids | 2005 |
14 other study(ies) available for estrone-3-o-sulfamate and irosustat
| Article | Year |
|---|---|
Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.
Topics: Catalytic Domain; Coumarins; Enzyme Inhibitors; Estrone; Inhibitory Concentration 50; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids | 2001 |
Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).
Topics: Coumarins; Drug Design; Enzyme Inhibitors; Kinetics; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids | 2002 |
Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.
Topics: Binding Sites; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Coumarins; Estrone; Humans; Inhibitory Concentration 50; Models, Molecular; Steroids; Structure-Activity Relationship; Substrate Specificity; Sulfatases; Sulfonamides; Sulfonic Acids | 2003 |
Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.
Topics: Antineoplastic Agents; Benzoic Acid; Coumarins; Enzyme Inhibitors; Esters; Inhibitory Concentration 50; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids | 2004 |
Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chickens; Female; Humans; In Vitro Techniques; Microsomes; Neoplasms, Hormone-Dependent; Placenta; Salicylates; Structure-Activity Relationship; Sulfatases; Thiosemicarbazones; Toxicity Tests, Acute | 2007 |
Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.
Topics: Animals; Aromatase Inhibitors; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Female; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Steryl-Sulfatase; Structure-Activity Relationship; Triazoles | 2010 |
Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives.
Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrone; Female; Humans; Kinetics; Placenta; Pregnancy; Steryl-Sulfatase | 2011 |
New Protocol-Guided Exploitation of a Lysosomal Sulfatase Inhibitor to Suppress Cell Growth in Glioblastoma Multiforme.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Fluorescent Dyes; Glioblastoma; Glucosides; Humans; Lysosomes; Naphthalimides; Prognosis; Sulbactam; Sulfatases | 2021 |
Development of Sulfamoylated 4-(1-Phenyl-1
Topics: Animals; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; MCF-7 Cells; Mice; Phenol; Steryl-Sulfatase; Structure-Activity Relationship | 2022 |
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates.
Topics: Alanine; Antineoplastic Agents; Arylsulfatases; Binding Sites; Breast Neoplasms; Coumarins; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Estrone; Female; Glycine; Heterocyclic Compounds, 3-Ring; Humans; Hydrogen Bonding; Kinetics; Microsomes; Models, Molecular; Placenta; Postmenopause; Steryl-Sulfatase; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids | 2000 |
Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).
Topics: Coumarins; Drug Design; Enzyme Inhibitors; Estrone; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Mimicry; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids | 2002 |
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates.
Topics: Animals; Coumarins; Drug Combinations; Estrogens; Estrone; Female; Homeostasis; Organ Size; Ovariectomy; Rats; Rats, Wistar; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids; Uterus | 2004 |
Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors.
Topics: Arylsulfatases; Catalysis; Coumarins; Esters; Estrone; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Structure; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids | 2012 |
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Discovery; Endometriosis; Estrone; Female; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms; Steryl-Sulfatase; Sulfonic Acids; Tubulin Modulators | 2015 |