Page last updated: 2024-09-03

estrone-3-o-sulfamate and irosustat

estrone-3-o-sulfamate has been researched along with irosustat in 16 studies

Compound Research Comparison

Studies
(estrone-3-o-sulfamate)
Trials
(estrone-3-o-sulfamate)
Recent Studies (post-2010)
(estrone-3-o-sulfamate)
Studies
(irosustat)
Trials
(irosustat)
Recent Studies (post-2010) (irosustat)
8901568532

Protein Interaction Comparison

ProteinTaxonomyestrone-3-o-sulfamate (IC50)irosustat (IC50)
Carbonic anhydrase 2Homo sapiens (human)0.018
Steryl-sulfataseHomo sapiens (human)0.0755
AromataseHomo sapiens (human)0.3
Amine oxidase [flavin-containing] A Rattus norvegicus (Norway rat)0.3

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (56.25)29.6817
2010's5 (31.25)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Ahmed, S; James, K; Owen, CP; Patel, CK; Patel, MB1
Ahmed, S; James, K; Owen, CP; Patel, CK1
Ho, Y; Potter, BV; Purohit, A; Reed, MJ; Robinson, J; Vicker, N; Woo, LL1
Ahmed, S; Owen, CP; Patel, CK1
Dahse, HM; Gräfe, U; Härtl, A; Jütten, P; Schumann, W1
Acharya, KR; Chander, SK; Cozier, G; Jackson, T; Leonard, P; Potter, BV; Purohit, A; Putey, A; Reed, MJ; Woo, LW1
Kim, BM; Liu, Y; Mostafa, Y; Phan, CM; Taylor, SD1
Jaggi, AS; Shah, R; Singh, D; Singh, J; Singh, N1
Han, KL; Jia, Y; Li, P; Qiao, Y; Zhang, MM1
Biernacki, K; Ciupak, O; Daśko, M; Demkowicz, S; Kozak, W; Kubiński, K; Martyna, A; Masłyk, M; Nocentini, A; Rachon, J; Rak, J; Śliwka-Kaszyńska, M; Supuran, CT; Świtalska, M; Wietrzyk, J1
Malini, B; Potter, BV; Purohit, A; Reed, MJ; Woo, LL1
Ahmed, S; James, K; Owen, CP1
Chander, SK; Potter, BV; Purohit, A; Reed, MJ; Woo, LW1
Newman, SP; Potter, BV; Purohit, A; Reed, MJ; Woo, LW1
Edwards, DR; Wolfenden, R1
Potter, BV; Thomas, MP1

Reviews

2 review(s) available for estrone-3-o-sulfamate and irosustat

ArticleYear
Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review.
    European journal of medicinal chemistry, 2016, May-23, Volume: 114

    Topics: Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Neoplasm Recurrence, Local; Sulfatases; Sulfonic Acids

2016
Steroid sulfatase: molecular biology, regulation, and inhibition.
    Endocrine reviews, 2005, Volume: 26, Issue:2

    Topics: Animals; Breast Neoplasms; Clinical Trials, Phase I as Topic; Coumarins; Enzyme Inhibitors; Estrone; Female; Humans; Models, Molecular; Neoplasms, Hormone-Dependent; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids

2005

Other Studies

14 other study(ies) available for estrone-3-o-sulfamate and irosustat

ArticleYear
Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.
    Bioorganic & medicinal chemistry letters, 2001, Dec-03, Volume: 11, Issue:23

    Topics: Catalytic Domain; Coumarins; Enzyme Inhibitors; Estrone; Inhibitory Concentration 50; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids

2001
Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).
    Bioorganic & medicinal chemistry letters, 2002, May-20, Volume: 12, Issue:10

    Topics: Coumarins; Drug Design; Enzyme Inhibitors; Kinetics; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids

2002
Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.
    Bioorganic & medicinal chemistry letters, 2003, Mar-10, Volume: 13, Issue:5

    Topics: Binding Sites; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Coumarins; Estrone; Humans; Inhibitory Concentration 50; Models, Molecular; Steroids; Structure-Activity Relationship; Substrate Specificity; Sulfatases; Sulfonamides; Sulfonic Acids

2003
Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.
    Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3

    Topics: Antineoplastic Agents; Benzoic Acid; Coumarins; Enzyme Inhibitors; Esters; Inhibitory Concentration 50; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids

2004
Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chickens; Female; Humans; In Vitro Techniques; Microsomes; Neoplasms, Hormone-Dependent; Placenta; Salicylates; Structure-Activity Relationship; Sulfatases; Thiosemicarbazones; Toxicity Tests, Acute

2007
Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.
    Journal of medicinal chemistry, 2010, Mar-11, Volume: 53, Issue:5

    Topics: Animals; Aromatase Inhibitors; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Female; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Steryl-Sulfatase; Structure-Activity Relationship; Triazoles

2010
Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives.
    Bioorganic & medicinal chemistry, 2011, Oct-15, Volume: 19, Issue:20

    Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrone; Female; Humans; Kinetics; Placenta; Pregnancy; Steryl-Sulfatase

2011
New Protocol-Guided Exploitation of a Lysosomal Sulfatase Inhibitor to Suppress Cell Growth in Glioblastoma Multiforme.
    Journal of medicinal chemistry, 2021, 06-24, Volume: 64, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Fluorescent Dyes; Glioblastoma; Glucosides; Humans; Lysosomes; Naphthalimides; Prognosis; Sulbactam; Sulfatases

2021
Development of Sulfamoylated 4-(1-Phenyl-1
    Journal of medicinal chemistry, 2022, 03-24, Volume: 65, Issue:6

    Topics: Animals; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; MCF-7 Cells; Mice; Phenol; Steryl-Sulfatase; Structure-Activity Relationship

2022
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates.
    Chemistry & biology, 2000, Volume: 7, Issue:10

    Topics: Alanine; Antineoplastic Agents; Arylsulfatases; Binding Sites; Breast Neoplasms; Coumarins; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Estrone; Female; Glycine; Heterocyclic Compounds, 3-Ring; Humans; Hydrogen Bonding; Kinetics; Microsomes; Models, Molecular; Placenta; Postmenopause; Steryl-Sulfatase; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids

2000
Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).
    The Journal of steroid biochemistry and molecular biology, 2002, Volume: 82, Issue:4-5

    Topics: Coumarins; Drug Design; Enzyme Inhibitors; Estrone; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Mimicry; Structure-Activity Relationship; Sulfatases; Sulfonamides; Sulfonic Acids

2002
The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates.
    Biochemical and biophysical research communications, 2004, Sep-10, Volume: 322, Issue:1

    Topics: Animals; Coumarins; Drug Combinations; Estrogens; Estrone; Female; Homeostasis; Organ Size; Ovariectomy; Rats; Rats, Wistar; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids; Uterus

2004
Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors.
    The Journal of organic chemistry, 2012, May-04, Volume: 77, Issue:9

    Topics: Arylsulfatases; Catalysis; Coumarins; Esters; Estrone; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Structure; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids

2012
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
    Journal of medicinal chemistry, 2015, Oct-08, Volume: 58, Issue:19

    Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Discovery; Endometriosis; Estrone; Female; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms; Steryl-Sulfatase; Sulfonic Acids; Tubulin Modulators

2015