Compounds > eseroline
Page last updated: 2024-09-03

eseroline and naloxone

eseroline has been researched along with naloxone in 8 studies

Compound Research Comparison

Studies
(eseroline)		Trials
(eseroline)		Recent Studies (post-2010)
(eseroline)		Studies
(naloxone)		Trials
(naloxone)		Recent Studies (post-2010) (naloxone)
290120,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomyeseroline (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19907 (87.50)18.7374
1990's1 (12.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brossi, A; Flippen-Anderson, JL; Gilardi, R; Jacobson, AE; Klee, WA; Schönenberger, B; Streaty, R1
Bartolini, A; Bartolini, R; Galli, A; Malmberg-Aiello, P; Renzi, G1
Liu, WF1
Bartolini, A; Conte, B; Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P1
Biella, G; Braga, PC; Fraschini, F; Tiengo, M1
Biella, G; Braga, PC; Dall'Oglio, G; Fraschini, F; Tiengo, M1
Aiello-Malmberg, P; Bartolini, A; Bartolini, R; Friedmann, T; Fürst, S; Galli, A; Knoll, J; Somogyi, GT1
Elliott, J; Jhamandas, K; Sutak, M1

Other Studies

8 other study(ies) available for eseroline and naloxone

ArticleYear
Comparison of (-)-eseroline with (+)-eseroline and dihydroseco analogues in antinociceptive assays: confirmation of rubreserine structure by X-ray analysis.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:11

    Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; In Vitro Techniques; Indoles; Physostigmine; Rats; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction

1986
Inhibition of [3H]naloxone binding in homogenates of rat brain by eseroline, a drug, with analgesic activity, related to physostigmine.
    The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:11

    Topics: Analgesics; Animals; Binding, Competitive; Brain; In Vitro Techniques; Indoles; Kinetics; Naloxone; Physostigmine; Rats; Receptors, Opioid

1979
Effect of eseroline on schedule-controlled behavior in the rat.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:4

    Topics: Analgesics; Animals; Atropine; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Male; Naloxone; Rats; Rats, Inbred Strains; Reinforcement Schedule; Time Factors

1991
Opioid-like action of eseroline on micturition reflex in rats.
    General pharmacology, 1989, Volume: 20, Issue:1

    Topics: Acetylcholine; Analgesics, Opioid; Animals; Atropine; Cholinesterase Inhibitors; Electric Stimulation; Indoles; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Urinary Bladder; Urination

1989
Eseroline depresses the responses of dorsal horn neurons to C-fiber afferents in the spinal rat.
    Neuroscience letters, 1986, Oct-30, Volume: 71, Issue:1

    Topics: Action Potentials; Analgesics, Opioid; Animals; Indoles; Male; Morphine; Naloxone; Nerve Fibers; Rats; Rats, Inbred Strains; Spinal Cord; Spinothalamic Tracts

1986
Inhibitory effect of eseroline, an opiate like drug, on the rat nociceptive thalamic neurons activated by peripheral noxious stimuli.
    Brain research, 1984, Mar-26, Volume: 296, Issue:1

    Topics: Analgesics, Opioid; Animals; Electric Conductivity; Hot Temperature; Indoles; Male; Naloxone; Neurons; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Inbred Strains; Thalamus

1984
Direct evidence that eseroline possesses morphine-like effects.
    European journal of pharmacology, 1982, Sep-24, Volume: 83, Issue:3-4

    Topics: Acetylcholine; Animals; Catalepsy; Cats; Female; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Male; Morphine; Muscle Contraction; Muscles; Naloxone; Nociceptors; Rats; Receptors, Opioid; Sleep

1982
Opiatelike actions of eseroline, an eserine derivative.
    Canadian journal of physiology and pharmacology, 1981, Volume: 59, Issue:3

    Topics: Acetylcholine; Analgesics; Animals; Catalepsy; Cerebral Cortex; Guinea Pigs; Humans; Indoles; Male; Muscle Contraction; Naloxone; Narcotics; Rats

1981