esermethole has been researched along with phosphine* in 1 studies
1 other study(ies) available for esermethole and phosphine
Article | Year |
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Phosphine-catalyzed enantioselective γ-addition of 3-substituted oxindoles to 2,3-butadienoates and 2-butynoates: use of prochiral nucleophiles.
The first phosphine-catalyzed enantioselective γ-addition with prochiral nucleophiles and 2,3-butadienoates as the reaction partners has been developed. Both 3-alkyl- and 3-aryl-substituted oxindoles could be employed in this process, which is catalyzed by a chiral phosphine that is derived from an amino acid, thus affording oxindoles that bear an all-carbon quaternary center at the 3-position in high yields and excellent enantioselectivity. The synthetic value of these γ-addition products was demonstrated by the formal total synthesis of two natural products and by the preparation of biologically relevant molecules and structural scaffolds. Topics: Allyl Compounds; Biological Products; Catalysis; Fatty Acids, Unsaturated; Indoles; Iridium; Oxindoles; Phosphines; Physostigmine; Stereoisomerism | 2014 |