erythronolide-a has been researched along with propadiene* in 1 studies
1 other study(ies) available for erythronolide-a and propadiene
Article | Year |
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Direct Entry to 4,10-Didesmethyl (9S)-Dihydroerythronolide A via Catalytic Allene Osmylation.
Desmethyl erythronolides have emerged as macrolide targets that may prove effective against resistant bacteria. A five-step sequence to 4,10-didesmethyl (9S)-dihydroerythronolide A (1) from known cyclic bis[allene] 13 is reported. Key structural and mechanistic aspects of the synthesis are discussed along with catalytic allene osmylation. An improved route to 13 is also described. Topics: Alkadienes; Anti-Bacterial Agents; Catalysis; Erythromycin; Molecular Structure; Stereoisomerism | 2016 |