erythro-dihydrosphingosine and safingol

erythro-dihydrosphingosine has been researched along with safingol* in 1 studies

Other Studies

1 other study(ies) available for erythro-dihydrosphingosine and safingol

Article	Year
Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. Biochimica et biophysica acta, 2003, Dec-07, Volume: 1643, Issue:1-3 Measuring the cell death induced by tumor necrosis factor (TNF-alpha) in L929 cells, we discovered for the first time that L-cycloserine, an established inhibitor of serine palmitoyltransferase, as well as DL-threo-dihydrosphingosine (threo-DHS, threo-sphinganine) significantly protected against TNF-alpha-induced cytotoxicity. Under the same conditions sphingosine and DL-erythro-dihydrosphingosine (erythro-DHS) did not change TNF-alpha-induced cytotoxicity, thus underlining the specificity of threo-DHS. In serine-labeled cells, newly (de novo) synthetized labeled ceramide was significantly diminished by threo-DHS alone or together with TNF-alpha, which makes the (dihydro) ceramide synthase the likely target of threo-DHS. These results suggest the decisive role of ceramide de novo synthesis in TNF signaling. Topics: Animals; Cell Death; Cell Line, Tumor; Ceramides; Cycloserine; Drug Antagonism; Mice; Oxidoreductases; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha	2003

Article

Year

Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling.

Biochimica et biophysica acta, 2003, Dec-07, Volume: 1643, Issue:1-3

Measuring the cell death induced by tumor necrosis factor (TNF-alpha) in L929 cells, we discovered for the first time that L-cycloserine, an established inhibitor of serine palmitoyltransferase, as well as DL-threo-dihydrosphingosine (threo-DHS, threo-sphinganine) significantly protected against TNF-alpha-induced cytotoxicity. Under the same conditions sphingosine and DL-erythro-dihydrosphingosine (erythro-DHS) did not change TNF-alpha-induced cytotoxicity, thus underlining the specificity of threo-DHS. In serine-labeled cells, newly (de novo) synthetized labeled ceramide was significantly diminished by threo-DHS alone or together with TNF-alpha, which makes the (dihydro) ceramide synthase the likely target of threo-DHS. These results suggest the decisive role of ceramide de novo synthesis in TNF signaling.

Topics: Animals; Cell Death; Cell Line, Tumor; Ceramides; Cycloserine; Drug Antagonism; Mice; Oxidoreductases; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha

2003