Compounds > erlotinib hydrochloride
Page last updated: 2024-09-05

erlotinib hydrochloride and plx4032

erlotinib hydrochloride has been researched along with plx4032 in 12 studies

Compound Research Comparison

Studies
(erlotinib hydrochloride)		Trials
(erlotinib hydrochloride)		Recent Studies (post-2010)
(erlotinib hydrochloride)		Studies
(plx4032)		Trials
(plx4032)		Recent Studies (post-2010) (plx4032)
4,3537863,0331,6571031,587

Protein Interaction Comparison

ProteinTaxonomyerlotinib hydrochloride (IC50)plx4032 (IC50)
Chain A, AKAP9-BRAF fusion proteinHomo sapiens (human)0.031
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.182
Serine/threonine-protein kinase A-RafHomo sapiens (human)0.521
Serine/threonine-protein kinase B-rafHomo sapiens (human)0.0897
Serine/threonine-protein kinase B-raf Mus musculus (house mouse)0.03
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.36
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)1.5
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)1.5
Mitogen-activated protein kinase kinase kinase 20Homo sapiens (human)0.0272

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (75.00)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Bollag, G; Bradley, WD; Heimbrook, D; Higgins, B; Kolinsky, K; Kopetz, S; Lee, RJ; Lestini, B; Packman, K; Schostack, K; Simcox, ME; Su, F; Yang, H1
Bardelli, A; Beijersbergen, RL; Bernards, R; Di Nicolantonio, F; Huang, S; Prahallad, A; Salazar, R; Sun, C; Zecchin, D1
Lo, RS1
Blanchet, B; Boudou-Rouquette, P; Dupin, N; Goldwasser, F; Mortier, L; Sakji, L; Thomas-Schoemann, A; Vidal, M; Zhen, Y1
Belani, CP; Joshi, M; Liu, X; Miller, B; Rice, SJ1
Cho-Phan, CD; Diehn, M; Myall, NJ; Neal, JW; Stehr, H; Wakelee, HA; Zhou, L; Zhou, LY1
Azan, A; Bakker Schut, TC; Besse, B; Boutros, C; Caspers, PJ; Eggermont, AM; Kamsu Kom, N; Koljenović, S; Lanoy, E; Mateus, C; Mir, LM; Noordhoek Hegt, V; Paci, A; Planchard, D; Puppels, GJ; Robert, C; Routier, E; Roy, S; Seck, A; Texier, M; Tomasic, G1
Boespflug, A; Kaya, A; Kaya, G; Saurat, JH; Saxer-Sekulic, N; Sorg, O; Thomas, L1
Baranyi, M; Berger, W; Donia, M; Garay, T; Grusch, M; Hegedűs, B; Molnár, E; Rittler, D; Tímár, J1
Aldape, K; Cheng, K; Ruppin, E; Schäffer, AA; Schiff, E; Sinha, S1
Niederer, R; Samalia, P; Sims, J1
Ananda, S; Chandrashekar, S; Dawson, SJ; Desai, J; Gibbs, P; Guinto, J; Hicks, RJ; Koldej, R; Link, E; Markman, B; McArthur, GA; Michael, M; Ritchie, D; Solomon, BJ; Tan, L; Tebbutt, NC; Tie, J; Tran, B; Wong, SQ1

Trials

2 trial(s) available for erlotinib hydrochloride and plx4032

ArticleYear
A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents.
    Cancer research, 2017, 01-15, Volume: 77, Issue:2

    Topics: Aged; Algorithms; Antineoplastic Agents; Area Under Curve; Biomarkers; Drug Eruptions; Erlotinib Hydrochloride; Female; Humans; Imidazoles; Indoles; Male; Middle Aged; Oximes; Pilot Projects; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; ROC Curve; Sensitivity and Specificity; Skin; Spectrum Analysis, Raman; Sulfonamides; Vemurafenib

2017
A Phase Ib/II Trial of Combined BRAF and EGFR Inhibition in BRAF V600E Positive Metastatic Colorectal Cancer and Other Cancers: The EVICT (Erlotinib and Vemurafenib In Combination Trial) Study.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2023, 03-14, Volume: 29, Issue:6

    Topics: Colonic Neoplasms; Colorectal Neoplasms; ErbB Receptors; Erlotinib Hydrochloride; Humans; Indoles; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Rectal Neoplasms; Sulfonamides; Vemurafenib

2023

Other Studies

10 other study(ies) available for erlotinib hydrochloride and plx4032

ArticleYear
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
    Cancer research, 2012, Feb-01, Volume: 72, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bevacizumab; Blotting, Western; Camptothecin; Capecitabine; Cell Line, Tumor; Cell Proliferation; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Indoles; Irinotecan; Kaplan-Meier Estimate; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Proto-Oncogene Proteins B-raf; Quinazolines; Sulfonamides; Vemurafenib; Xenograft Model Antitumor Assays

2012
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
    Nature, 2012, Jan-26, Volume: 483, Issue:7387

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cetuximab; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; ErbB Receptors; Erlotinib Hydrochloride; Feedback, Physiological; Female; Gefitinib; HEK293 Cells; Humans; Indoles; Melanoma; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Quinazolines; RNA Interference; Sulfonamides; Vemurafenib; Xenograft Model Antitumor Assays

2012
Receptor tyrosine kinases in cancer escape from BRAF inhibitors.
    Cell research, 2012, Volume: 22, Issue:6

    Topics: Animals; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Indoles; Melanoma; Mice; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Quinazolines; Receptor Protein-Tyrosine Kinases; Sulfonamides; Transplantation, Heterologous; Vemurafenib

2012
An HPLC-UV method for the simultaneous quantification of vemurafenib and erlotinib in plasma from cancer patients.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Jun-01, Volume: 928

    Topics: Carcinoma, Non-Small-Cell Lung; Chromatography, High Pressure Liquid; Drug Monitoring; Erlotinib Hydrochloride; Humans; Indoles; Liquid-Liquid Extraction; Melanoma; Protein Kinase Inhibitors; Quinazolines; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Sulfonamides; Vemurafenib

2013
Trametinib with or without vemurafenib in BRAF mutated non-small cell lung cancer.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Erlotinib Hydrochloride; G1 Phase; Humans; Indoles; Lung Neoplasms; MAP Kinase Signaling System; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Pyridones; Pyrimidinones; Quinazolines; Sulfonamides; Up-Regulation; Vemurafenib

2015
Long-Term Survival of a Patient With Non-Small-Cell Lung Cancer Harboring a V600E Mutation in the BRAF Oncogene.
    Clinical lung cancer, 2016, Volume: 17, Issue:2

    Topics: Adenocarcinoma; Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Erlotinib Hydrochloride; Humans; Indoles; Lung Neoplasms; Male; Molecular Targeted Therapy; Mutation; Precision Medicine; Proto-Oncogene Proteins B-raf; Sulfonamides; Vemurafenib

2016
RASopathic comedone-like or cystic lesions induced by vemurafenib: a model of skin lesions similar but not identical to those induced by dioxins MADISH.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2018, Volume: 32, Issue:8

    Topics: Antineoplastic Agents; Chloracne; Cytochrome P-450 CYP1A1; Dioxins; Drug Eruptions; Enzyme Activation; Epidermal Cyst; Erlotinib Hydrochloride; Female; Gefitinib; Hep G2 Cells; Humans; Male; Melanoma; Protein Kinase Inhibitors; Skin Neoplasms; Vemurafenib

2018
Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression.
    International journal of molecular sciences, 2019, Sep-11, Volume: 20, Issue:18

    Topics: Adult; Aged; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Male; Melanoma; Middle Aged; Mutation; Neoplasm Proteins; Phenotype; Proto-Oncogene Proteins B-raf; RNA, Messenger; Signal Transduction; Time Factors; Vemurafenib

2019
In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression.
    Molecular systems biology, 2020, Volume: 16, Issue:7

    Topics: A549 Cells; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Betacoronavirus; Bleomycin; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dexamethasone; Drug Design; Drug Evaluation, Preclinical; Erlotinib Hydrochloride; Fluphenazine; HEK293 Cells; Humans; Kidney; Lung; MCF-7 Cells; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; SARS-CoV-2; Systems Biology; Up-Regulation; Vemurafenib

2020
Drug-induced ocular inflammation.
    The New Zealand medical journal, 2020, 12-18, Volume: 133, Issue:1527

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alendronate; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Brimonidine Tartrate; Diphosphonates; ErbB Receptors; Erlotinib Hydrochloride; Etanercept; Female; Humans; Imidazoles; Immune Checkpoint Inhibitors; Male; Middle Aged; Nivolumab; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Retrospective Studies; Scleritis; Uveitis, Anterior; Vemurafenib; Zoledronic Acid

2020