Compounds > erlotinib hydrochloride
Page last updated: 2024-09-05

erlotinib hydrochloride and pi103

erlotinib hydrochloride has been researched along with pi103 in 4 studies

Compound Research Comparison

Studies
(erlotinib hydrochloride)		Trials
(erlotinib hydrochloride)		Recent Studies (post-2010)
(erlotinib hydrochloride)		Studies
(pi103)		Trials
(pi103)		Recent Studies (post-2010) (pi103)
4,3537863,0331810139

Protein Interaction Comparison

ProteinTaxonomyerlotinib hydrochloride (IC50)pi103 (IC50)
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59FDrosophila melanogaster (fruit fly)2.3
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59FDrosophila melanogaster (fruit fly)2.3
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59FDrosophila melanogaster (fruit fly)2.3
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59FDrosophila melanogaster (fruit fly)2.3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0155
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaHomo sapiens (human)1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)0.0585
Cytochrome P450 1A2Homo sapiens (human)0.012
Cytochrome P450 3A4Homo sapiens (human)0.0111
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.011
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.011
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.011
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.0114
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.2038
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.0346
Serine/threonine-protein kinase mTORHomo sapiens (human)0.4746
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.069
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)0.0215
Rapamycin-insensitive companion of mTORHomo sapiens (human)0.083
Regulatory-associated protein of mTORHomo sapiens (human)0.02
Target of rapamycin complex 2 subunit MAPKAP1Homo sapiens (human)0.083
Target of rapamycin complex subunit LST8Homo sapiens (human)0.041

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cheng, CK; Fan, QW; Hackett, CS; Knight, ZA; Nicolaides, TP; Shokat, KM; Weiss, WA1
Donev, IS; Li, Q; Matsumoto, K; Nishioka, Y; Sone, S; Takeuchi, S; Wang, W; Yamada, T; Yamori, T; Yano, S1
Deng, ZL; Dong, YC; Han, QL; Jiang, T; Lv, XH; Ren, H; Xing, WJ; Zou, Y1
Eicheler, W; Holler, M; Meier, F; Minjgee, M; Rodemann, HP; Saki, M; Toulany, M1

Other Studies

4 other study(ies) available for erlotinib hydrochloride and pi103

ArticleYear
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
    Cancer research, 2007, Sep-01, Volume: 67, Issue:17

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Drug Evaluation, Preclinical; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Furans; Glioma; Humans; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; PTEN Phosphohydrolase; Pyridines; Pyrimidines; Quinazolines; TOR Serine-Threonine Kinases; Treatment Outcome; Tumor Cells, Cultured

2007
Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-15, Volume: 17, Issue:8

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Furans; Gefitinib; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Mice; Mice, SCID; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinazolines; Signal Transduction; Xenograft Model Antitumor Assays

2011
Effects of epidermal growth factor receptor and phosphatase and tensin homologue gene expression on the inhibition of U87MG glioblastoma cell proliferation induced by protein kinase inhibitors.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:1

    Topics: Butadienes; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Furans; Gene Expression; Glioblastoma; Humans; Nitriles; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Pyrimidines; Quinazolines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2013
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
    Cancer biology & therapy, 2014, Mar-01, Volume: 15, Issue:3

    Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clone Cells; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Flavonoids; Furans; Head and Neck Neoplasms; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyridines; Pyrimidines; Quinazolines; ras Proteins; Signal Transduction

2014