Compounds > erlotinib hydrochloride
Page last updated: 2024-09-05

erlotinib hydrochloride and pd 153035

erlotinib hydrochloride has been researched along with pd 153035 in 6 studies

Compound Research Comparison

Studies
(erlotinib hydrochloride)		Trials
(erlotinib hydrochloride)		Recent Studies (post-2010)
(erlotinib hydrochloride)		Studies
(pd 153035)		Trials
(pd 153035)		Recent Studies (post-2010) (pd 153035)
4,3537863,033232261

Protein Interaction Comparison

ProteinTaxonomyerlotinib hydrochloride (IC50)pd 153035 (IC50)
Cyclin-G-associated kinaseHomo sapiens (human)0.26
Mitogen-activated protein kinase 13Homo sapiens (human)6.3
Dihydrofolate reductaseHomo sapiens (human)0.2
Dihydrofolate reductaseMus musculus (house mouse)0.2
Tyrosine-protein kinase ABL1Homo sapiens (human)0.03
Tyrosine-protein kinase transforming protein AblAbelson murine leukemia virus0.4787
Epidermal growth factor receptorHomo sapiens (human)0.1416
Protein kinase C alpha typeBos taurus (cattle)0.4787
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.735
Cyclin-dependent kinase 1Homo sapiens (human)0.4787
Fructose-1,6-bisphosphatase 1Homo sapiens (human)1
Platelet-derived growth factor receptor betaHomo sapiens (human)0.2
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.709
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.4787
Dihydrofolate reductasePneumocystis carinii0.2
Potassium-transporting ATPase subunit betaSus scrofa (pig)0.03
Potassium-transporting ATPase alpha chain 1Sus scrofa (pig)0.03
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.8445
Mitogen-activated protein kinase 12Homo sapiens (human)6.3
Mitogen-activated protein kinase 11Homo sapiens (human)6.3
Mitogen-activated protein kinase 14Homo sapiens (human)6.3
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.2
MAP kinase-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.63
Histamine H3 receptorRattus norvegicus (Norway rat)1
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)2.025

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Breza, N; Keri, G; Orfi, L; Petak, I; Pinter, F; Robert, K; Schwab, R; Varkondi, E1
Haramoto, M; Horibe, T; Kawakami, K; Kohno, M; Matsuzaki, K; Nakajima, O; Ohara, K; Yano, Y1
Loo, BW; Ma, L; Meng, X; Murphy, JD; Sun, X; Yu, J1
Pick, A; Wiese, M1
Akama-Garren, EH; Edalati, A; Lindstrom, TM; Petralia, JD; Robinson, WH; Ruiz, PJ; Stein, EA; Swanson, CD1
Matsuo, K; Takada, Y1

Other Studies

6 other study(ies) available for erlotinib hydrochloride and pd 153035

ArticleYear
Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.
    Journal of receptor and signal transduction research, 2008, Volume: 28, Issue:3

    Topics: Aminoquinolines; Aniline Compounds; Biological Assay; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Inhibitory Concentration 50; Morpholines; Mutant Proteins; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tyrphostins

2008
A novel hybrid peptide targeting EGFR-expressing cancers.
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:5

    Topics: Animals; Antineoplastic Agents; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Mice; Mutant Chimeric Proteins; Neoplasm Transplantation; Neoplasms; Quinazolines; Receptor Protein-Tyrosine Kinases; Transplantation, Heterologous

2011
Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: a pilot study.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:10

    Topics: Aged; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Protein Kinase Inhibitors; Quinazolines; Radiopharmaceuticals; Tomography, X-Ray Computed; Treatment Outcome

2011
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
    ChemMedChem, 2012, Volume: 7, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins

2012
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
    Journal of immunology (Baltimore, Md. : 1950), 2012, Apr-01, Volume: 188, Issue:7

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Becaplermin; Cell Division; Cyclooxygenase 2; Cytokines; Drug Evaluation, Preclinical; Endothelial Cells; ErbB Receptors; Erlotinib Hydrochloride; Fibroblasts; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred DBA; Neovascularization, Pathologic; Osteoclasts; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Synovial Membrane

2012
Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung disease.
    The Keio journal of medicine, 2012, Volume: 61, Issue:4

    Topics: Animals; Antineoplastic Agents; Chemokine CCL2; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation; Lipopolysaccharides; Lung Diseases, Interstitial; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Tumor Necrosis Factor-alpha

2012