Compounds > erlotinib hydrochloride
Page last updated: 2024-09-05

erlotinib hydrochloride and nvp-aew541

erlotinib hydrochloride has been researched along with nvp-aew541 in 2 studies

Compound Research Comparison

Studies
(erlotinib hydrochloride)		Trials
(erlotinib hydrochloride)		Recent Studies (post-2010)
(erlotinib hydrochloride)		Studies
(nvp-aew541)		Trials
(nvp-aew541)		Recent Studies (post-2010) (nvp-aew541)
4,3537863,03395061

Protein Interaction Comparison

ProteinTaxonomyerlotinib hydrochloride (IC50)nvp-aew541 (IC50)
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)8.9
Epidermal growth factor receptorHomo sapiens (human)5.2
Insulin receptorHomo sapiens (human)0.7885
Tyrosine-protein kinase LckHomo sapiens (human)5.6
Tyrosine-protein kinase LynHomo sapiens (human)1.4
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)3.3
Insulin-like growth factor 1 receptorHomo sapiens (human)0.0534
Mast/stem cell growth factor receptor KitHomo sapiens (human)6.3
Fibroblast growth factor receptor 1Homo sapiens (human)4.3
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)4
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.8
Fibroblast growth factor receptor 2Homo sapiens (human)2.7
Fibroblast growth factor receptor 4Homo sapiens (human)5
Vascular endothelial growth factor receptor 2Homo sapiens (human)7.1
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)1.4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)3.2
Activin receptor type-1Homo sapiens (human)2.9
Tyrosine-protein kinase BTKHomo sapiens (human)7.6
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.13
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)1.7

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baxter, RC; Gill, AJ; Hugh, TJ; Julovi, SM; Pavlakis, N; Peters, L; Samra, JS; Smith, RC; Wong, MH; Xue, A1
Lian, J; Ning, G; Qi, Y; Wang, W; Wang, X; Xu, L; Xu, Y; Zhu, Y1

Other Studies

2 other study(ies) available for erlotinib hydrochloride and nvp-aew541

ArticleYear
Cotargeting of epidermal growth factor receptor and PI3K overcomes PI3K-Akt oncogenic dependence in pancreatic ductal adenocarcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Aug-01, Volume: 20, Issue:15

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Movement; Cell Proliferation; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2014
Co-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma.
    Oncotarget, 2016, Jun-14, Volume: 7, Issue:24

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Male; Mice, Nude; Middle Aged; Pyrimidines; Pyrroles; Receptor, IGF Type 1; Xenograft Model Antitumor Assays

2016