Compounds > erlotinib hydrochloride
Page last updated: 2024-09-05

erlotinib hydrochloride and epigallocatechin gallate

erlotinib hydrochloride has been researched along with epigallocatechin gallate in 6 studies

Compound Research Comparison

Studies
(erlotinib hydrochloride)		Trials
(erlotinib hydrochloride)		Recent Studies (post-2010)
(erlotinib hydrochloride)		Studies
(epigallocatechin gallate)		Trials
(epigallocatechin gallate)		Recent Studies (post-2010) (epigallocatechin gallate)
4,3537863,0335,4561733,403

Protein Interaction Comparison

ProteinTaxonomyerlotinib hydrochloride (IC50)epigallocatechin gallate (IC50)
Chain A, POLYMERASE PAInfluenza A virus1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Prostaglandin E synthaseHomo sapiens (human)1.8
Telomerase reverse transcriptaseHomo sapiens (human)1.0867
NAD kinaseHomo sapiens (human)0.96
Urokinase-type plasminogen activatorHomo sapiens (human)0.091
Tissue-type plasminogen activatorHomo sapiens (human)0.091
Polymerase acidic proteinInfluenza A virus (A/Puerto Rico/8/1934(H1N1))5.86
Amyloid-beta precursor proteinHomo sapiens (human)2.7
Plasminogen activator inhibitor 1Homo sapiens (human)0.091
Urokinase-type plasminogen activatorMus musculus (house mouse)0.091
ATP-dependent translocase ABCB1Homo sapiens (human)0.1233
72 kDa type IV collagenaseHomo sapiens (human)4.3833
Hepatocyte growth factor receptorHomo sapiens (human)10
MatrilysinHomo sapiens (human)3.34
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIEscherichia coli K-125
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 21.15
Apoptosis regulator Bcl-2Homo sapiens (human)0.45
Microtubule-associated protein tauHomo sapiens (human)1.8
60 kDa heat shock protein, mitochondrialHomo sapiens (human)2.3
Glucose-6-phosphate 1-dehydrogenaseSaccharomyces cerevisiae S288C0.25
Lethal factorBacillus anthracis0.097
Phosphoglycerate mutase 1Homo sapiens (human)0.49
DNA (cytosine-5)-methyltransferase 1Homo sapiens (human)0.5
Proteasome subunit beta type-5Homo sapiens (human)0.543
DNA repair protein RAD52 homologHomo sapiens (human)2.5108
Matrix metalloproteinase-14Homo sapiens (human)6.8
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6Homo sapiens (human)3.34
Squalene monooxygenase Rattus norvegicus (Norway rat)0.69
6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)0.72
BH3-interacting domain death agonistHomo sapiens (human)1.0733
Beta-secretase 1Homo sapiens (human)1.1785
10 kDa heat shock protein, mitochondrialHomo sapiens (human)2.3
Bcl-2-like protein 1Homo sapiens (human)0.59
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)0.92
Alpha-(1,3)-fucosyltransferase 7Homo sapiens (human)3.34
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Homo sapiens (human)3.34
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)0.3055
Mitogen-activated protein kinase 14Homo sapiens (human)2.21
Bcl-2-related protein A1Homo sapiens (human)1.79
Thiosulfate sulfurtransferaseHomo sapiens (human)7.3
60 kDa chaperonin Escherichia coli0.47
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)10
Dual specificity tyrosine-phosphorylation-regulated kinase 1ARattus norvegicus (Norway rat)0.33
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.73
10 kDa chaperonin Escherichia coli0.47
3-oxoacyl-[acyl-carrier-protein] reductase Plasmodium falciparum 3D70.32
MAP kinase-activated protein kinase 5Homo sapiens (human)1
Bcl-2-like protein 2Homo sapiens (human)2.33
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)0.225
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)0.3
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)0.215
Bcl-2-like protein 10Homo sapiens (human)0.36

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Chen, Z'; Khuri, FR; Lee, JE; Shin, DM; Shin, HJ; Tighiouart, M; Yang, CS; Zhang, H; Zhang, X1
Amin, AR; Chen, ZG; Khuri, FR; Shin, DM1
Bigelow, RL; Burke, P; Cardelli, JA; Carroll, JL; Coleman, DT; Milligan, SA; Steffan, JJ; Williams, BJ1
Chen, ZG; Haque, A; Khuri, FR; Rahman, MA; Ruhul Amin, AR; Saba, NF; Shin, DM1
Genç, H; Sinan Özalp, S; Tansu Koparal, A; Tasa, BA; Telli, E1
Galeazzi, R; Laudadio, E; Minnelli, C; Mobbili, G1

Other Studies

6 other study(ies) available for erlotinib hydrochloride and epigallocatechin gallate

ArticleYear
Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor.
    International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Catechin; Cell Line, Tumor; Cell Proliferation; Disease Progression; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; Flow Cytometry; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Nude; Protein-Tyrosine Kinases; Quinazolines; Transplantation, Heterologous

2008
Synergistic growth inhibition of squamous cell carcinoma of the head and neck by erlotinib and epigallocatechin-3-gallate: the role of p53-dependent inhibition of nuclear factor-kappaB.
    Cancer prevention research (Philadelphia, Pa.), 2009, Volume: 2, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Squamous Cell; Catechin; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; NF-kappa B; Protein Kinase Inhibitors; Quinazolines; RNA, Small Interfering; Transcription Factor RelA; Tumor Suppressor Protein p53

2009
The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Aug-01, Volume: 15, Issue:15

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Non-Small-Cell Lung; Catechin; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Erlotinib Hydrochloride; Humans; Indoles; Lung Neoplasms; Male; Mice; Mice, SCID; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Quinazolines; Sulfonamides; Xenograft Model Antitumor Assays

2009
Combination of erlotinib and EGCG induces apoptosis of head and neck cancers through posttranscriptional regulation of Bim and Bcl-2.
    Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:7

    Topics: Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Catechin; Cell Line, Tumor; Cycloheximide; Drug Synergism; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Membrane Proteins; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; RNA Interference

2015
In vitro evaluation of combination of EGCG and Erlotinib with classical chemotherapeutics on JAR cells.
    In vitro cellular & developmental biology. Animal, 2017, Volume: 53, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Catechin; Cell Line, Tumor; Choriocarcinoma; Dactinomycin; Enzyme Activation; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Receptor, ErbB-2; RNA, Messenger

2017
Conformational Insight on WT- and Mutated-EGFR Receptor Activation and Inhibition by Epigallocatechin-3-Gallate: Over a Rational Basis for the Design of Selective Non-Small-Cell Lung Anticancer Agents.
    International journal of molecular sciences, 2020, Mar-03, Volume: 21, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Catechin; Cell Line, Tumor; Cell Membrane; ErbB Receptors; Erlotinib Hydrochloride; Humans; Molecular Docking Simulation; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Protein Structure, Secondary

2020