Compounds > erlotinib hydrochloride
Page last updated: 2024-09-05

erlotinib hydrochloride and enzastaurin

erlotinib hydrochloride has been researched along with enzastaurin in 2 studies

Compound Research Comparison

Studies
(erlotinib hydrochloride)		Trials
(erlotinib hydrochloride)		Recent Studies (post-2010)
(erlotinib hydrochloride)		Studies
(enzastaurin)		Trials
(enzastaurin)		Recent Studies (post-2010) (enzastaurin)
4,3537863,0331885299

Protein Interaction Comparison

ProteinTaxonomyerlotinib hydrochloride (IC50)enzastaurin (IC50)
Protein kinase C gamma typeHomo sapiens (human)0.7915
Protein kinase C alpha typeRattus norvegicus (Norway rat)0.7
Protein kinase C beta typeHomo sapiens (human)0.1797
Protein kinase C delta typeRattus norvegicus (Norway rat)0.7
Protein kinase C epsilon typeRattus norvegicus (Norway rat)0.7
Protein kinase C zeta typeRattus norvegicus (Norway rat)0.7
Protein kinase C alpha typeHomo sapiens (human)0.4695
Protein kinase C eta typeHomo sapiens (human)0.4
Protein kinase C gamma typeRattus norvegicus (Norway rat)0.7
Protein kinase C beta typeRattus norvegicus (Norway rat)0.7
Protein kinase C epsilon typeHomo sapiens (human)0.38
Protein kinase C zeta typeHomo sapiens (human)8
Protein kinase C delta typeHomo sapiens (human)1
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)10
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)10
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)10
Protein kinase C eta typeRattus norvegicus (Norway rat)0.7
Calcium/calmodulin-dependent protein kinase type II subunit alphaHomo sapiens (human)10
Protein kinase C theta typeRattus norvegicus (Norway rat)0.7

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chhatwani, L; Colevas, AD; Decker, R; Fisher, GA; Krupitskaya, Y; Latz, JE; Padda, SK; San Pedro-Salcedo, M; Wakelee, HA1
Bernstein, ED; Clément-Duchêne, C; Dudek, AZ; Jahan, T; Krupitskaya, Y; Latz, JE; Natale, RB; Osarogiagbon, R; Sanborn, RE; Shi, P; Wakelee, HA1

Trials

2 trial(s) available for erlotinib hydrochloride and enzastaurin

ArticleYear
A phase I dose-escalation and pharmacokinetic study of enzastaurin and erlotinib in patients with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:4

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Interactions; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Indoles; Male; Middle Aged; Neoplasms; Quinazolines

2012
A phase II study of enzastaurin in combination with erlotinib in patients with previously treated advanced non-small cell lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2012, Volume: 78, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Erlotinib Hydrochloride; Female; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Quinazolines; Risk Factors; Treatment Outcome

2012