Page last updated: 2024-09-05

erlotinib hydrochloride and dasatinib

erlotinib hydrochloride has been researched along with dasatinib in 35 studies

Compound Research Comparison

Studies
(erlotinib hydrochloride)
Trials
(erlotinib hydrochloride)
Recent Studies (post-2010)
(erlotinib hydrochloride)
Studies
(dasatinib)
Trials
(dasatinib)
Recent Studies (post-2010) (dasatinib)
4,3537863,0332,7072162,081

Protein Interaction Comparison

ProteinTaxonomyerlotinib hydrochloride (IC50)dasatinib (IC50)
Aurora kinase AHomo sapiens (human)2.633
Mitogen-activated protein kinase 13Homo sapiens (human)0.1
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.109
Bile salt export pumpHomo sapiens (human)10
Tyrosine-protein kinase ABL1Homo sapiens (human)0.9374
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.1922
Epidermal growth factor receptorHomo sapiens (human)0.7144
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.164
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)0.71
Tyrosine-protein kinase LckHomo sapiens (human)0.0015
Proto-oncogene tyrosine-protein kinase LCK Mus musculus (house mouse)0.0004
Tyrosine-protein kinase FynHomo sapiens (human)0.0012
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)0.0078
Tyrosine-protein kinase YesHomo sapiens (human)0.0006
Tyrosine-protein kinase LynHomo sapiens (human)0.0012
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)1.2665
Tyrosine-protein kinase HCKHomo sapiens (human)0.001
Platelet-derived growth factor receptor betaHomo sapiens (human)0.028
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.0276
Breakpoint cluster region proteinHomo sapiens (human)0.4946
Fibroblast growth factor receptor 1Homo sapiens (human)0.88
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0015
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.0365
Tyrosine-protein kinase BlkMus musculus (house mouse)0.008
Ephrin type-A receptor 2Homo sapiens (human)0.0689
Ephrin type-B receptor 2Homo sapiens (human)0.0044
Vascular endothelial growth factor receptor 2Homo sapiens (human)2.36
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)1.7
Tyrosine-protein kinase CSKHomo sapiens (human)0.0013
Tyrosine-protein kinase TecHomo sapiens (human)0.297
Tyrosine-protein kinase TXKHomo sapiens (human)0.0003
Tyrosine-protein kinase SYKHomo sapiens (human)4.82
Casein kinase I isoform alphaHomo sapiens (human)0.001
LIM domain kinase 1Homo sapiens (human)0.6097
LIM domain kinase 2Homo sapiens (human)0.5186
Mitogen-activated protein kinase 12Homo sapiens (human)0.1
Ephrin type-B receptor 4Homo sapiens (human)0.001
Serine/threonine-protein kinase SIK1Homo sapiens (human)0.001
Myelin transcription factor 1Homo sapiens (human)0.063
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)1.7
Tyrosine-protein kinase BTKHomo sapiens (human)0.0036
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)0.0143
Tyrosine-protein kinase ITK/TSKHomo sapiens (human)0.228
Protein-tyrosine kinase 6Homo sapiens (human)0.0071
Mitogen-activated protein kinase 11Homo sapiens (human)0.1
Mitogen-activated protein kinase 14Homo sapiens (human)0.1
Discoidin domain-containing receptor 2Homo sapiens (human)0.1127
Aurora kinase BHomo sapiens (human)6.485
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseHomo sapiens (human)0.104
Serine/threonine-protein kinase SIK2Homo sapiens (human)0.003
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)2
Serine/threonine-protein kinase SIK3Homo sapiens (human)0.005

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (5.71)29.6817
2010's26 (74.29)24.3611
2020's7 (20.00)2.80

Authors

AuthorsStudies
Curtiss, FR1
Gelderblom, H; Guchelaar, HJ; van Erp, NP1
Fukuoka, M; Hatashita, E; Jänne, PA; Kuwata, K; Nakagawa, K; Nishio, K; Okamoto, I; Okamoto, W; Yamada, Y; Yoshida, T1
Antonia, S; Bepler, G; Chiappori, A; Gray, J; Haura, EB; Litschauer, S; Neuger, A; Rawal, B; Schell, MJ; Simon, G; Song, L; Tanvetyanon, T; Tetteh, L; Williams, C1
Merchant, NB; Nagaraj, NS; Washington, MK1
Egloff, AM; Grandis, JR1
Geoerger, B; Leblond, P1
Azzoli, CG; Ginsberg, MS; Johnson, ML; Kris, MG; Miller, VA; Pao, W; Riely, GJ; Rizvi, NA; Sima, CS1
Ansén, S; Bass, AJ; Beer, DG; Brace, LE; Brambilla, C; Brambilla, E; Brustugun, OT; Cho, J; Clement, JH; Deng, X; Dutt, A; Eck, MJ; Gabler, F; Gray, NS; Greulich, H; Groen, H; Hammerman, PS; Hanna, M; Hatton, C; Haura, EB; Helland, A; Heuckmann, JM; Heynck, S; Janne, PA; Johnson, BE; Koker, M; Lawrence, MS; Leenders, F; Lim, SM; Lin, W; Lorimier, P; Meyerson, M; Moch, H; Onofrio, RC; Peifer, M; Petersen, I; Querings, S; Ramos, AH; Rauh, D; Salvesen, HB; Seidel, D; Sietsma, H; Simard, JR; Soltermann, A; Sos, ML; Stoelben, E; Thomas, RK; Timens, W; Tsao, MS; Winckler, W; Wolf, J; Wong, KK; Woods, BA; Xu, C; Zander, T; Zhang, J; Zhou, W1
Coan, A; Desjardins, A; Friedman, HS; Herndon, JE; McLendon, RE; McSherry, F; Peters, KB; Reardon, DA; Rich, JN; Sampson, JH; Sathornsumetee, S; Threatt, S; Vredenburgh, JJ; Zhang, S1
Elmquist, WF; Mittapalli, RK; Sane, R1
Andriamanana, I; Duretz, B; Gana, I; Hulin, A1
Chen, SS; Falchook, G; Fok, JY; Fu, S; Heymach, J; Hong, D; Janku, F; Kurzrock, R; Naing, A; Piha-Paul, S; Stephen, B; Tsimberidou, AM; Wheler, J1
Ding, JF; Zhong, DF1
Crews, LA; Gonzales, T; Kouznetsova, VL; Masliah, E; Overk, CR; Patrick, C; Paulino, A; Price, D; Rockenstein, E; Stocking, E; Tsigelny, IF; Wrasidlo, W1
Blumenschein, GR; Erasmus, JJ; Gold, KA; Harun, N; Johnson, FM; Kawedia, JD; Lee, JJ; Price, J; Tang, X; Tran, HT; William, WN; Wistuba, II1
Bustos, D; Kirkpatrick, DS; Lin, E; Nicholes, K; Settleman, J; Song, Q; Stephan, JP; Wilson, C1
Dittmann, K; Fehrenbacher, B; Huber, S; Mayer, C; Paasch, A; Rodemann, HP; Schaller, M1
Bianco, R; Brillante, S; Cosconati, S; D'Amato, V; De Placido, S; Di Mauro, C; Formisano, L; Marciano, R; Montuori, N; Orsini, RC; Parsons, SJ; Raimondo, L; Randazzo, A; Rosa, R; Servetto, A; Veneziani, BM1
Berndsen, RH; Ding, X; Dyson, PJ; Griffioen, AW; Ho, CM; Nowak-Sliwinska, P; van den Bergh, H; Weiss, A1
Bahra, M; Büchler, MW; Eils, R; Eisen, C; Engelhardt, J; Espinet, E; Espinosa, O; Giese, NA; Hackert, T; Jiang, X; Klaus, B; Klein, C; Kopp-Schneider, A; Kulke, M; Lutz, C; Muckenhuber, A; Nadler, W; Neuhaus, P; Noll, EM; Rösli, C; Schlesner, M; Sinn, BV; Sprick, MR; Stenzinger, A; Strobel, O; Trumpp, A; Vogel, V; Weichert, W; Werner, J; Zickgraf, FM1
Mehra, R; Zibelman, M1
Broutin, S; Gil, S; Jovelet, C; Mir, O; Paci, A1
Heath, JR; Johnson, H; Kravchenko-Balasha, N; Levine, RD; White, FM1
Chiba, M; Kobayashi, Y; Mitsudomi, T; Mizuuchi, H; Sato, K; Sesumi, Y; Shimoji, M; Suda, K; Takemoto, T; Tomizawa, K1
Aderhold, C; Birk, R; Hock, C; Hörmann, K; Kramer, B; Kuhlin, B; Lammert, A; Schultz, JD1
Anderson, KI; Bailey, J; Baldock, PA; Boulghourjian, A; Chtanova, T; Conway, JRW; Croucher, PI; Del Monte-Nieto, G; Gallego-Ortega, D; Grey, ST; Gunning, PW; Hardeman, EC; Harvey, RP; Herrmann, D; Herzog, H; Johnsson, AE; Kadir, S; Killen, M; Law, AM; Leung, W; Lucas, MC; Magenau, A; Masedunskas, A; McGhee, EJ; Morton, JP; Mrowinska, A; Nobis, M; Ormandy, CJ; Pajic, M; Quinn, JMW; Reischmann, N; Samuel, MS; Sansom, OJ; Schwarz, JP; Stevenson, D; Strathdee, D; Timpson, P; Vennin, C; Walters, SN; Warren, SC; Welch, HCE; Zaratzian, A; Zhang, L1
Dekker, H; Labots, M; Meijer, GA; Pham, TV; Ruijter, R; Van der Hoeven, JJM; Van der Mijn, JC; Van der Vliet, HJ; Verheul, HMW1
Caprioli, R; Dai, X; Dosch, AR; Kashikar, N; Kwon, D; Mehra, S; Merchant, NB; Nagathihalli, NS; Reyzer, ML; Srinivasan, S; Willobee, BA1
Aderhold, C; Birk, R; Huber, L; Kramer, B; Mueller, CE; Rotter, N; Schell, A1
Aderhold, C; Birk, R; Huber, L; Jungbauer, F; Knuettel, M; Kramer, B; Lammert, A; Rotter, N; Scherl, C1
Cole, BL; Leary, SES; Lockwood, CM; Starr, K1
Feng, M; Li, Q; Liao, W; Qian, Z; Wen, F; Wu, Q; Yang, Y1
Tan, J; Xu, M; Zhong, Z1
Matin, AA; Mohammadnejad, M; Rezaei, H1

Reviews

5 review(s) available for erlotinib hydrochloride and dasatinib

ArticleYear
Clinical pharmacokinetics of tyrosine kinase inhibitors.
    Cancer treatment reviews, 2009, Volume: 35, Issue:8

    Topics: Administration, Oral; Antineoplastic Agents; Benzamides; Benzenesulfonates; Biological Availability; Cytochrome P-450 Enzyme System; Dasatinib; Drug Interactions; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Indoles; Intestinal Absorption; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Tissue Distribution

2009
[Indications and current development of new targeted therapies in pediatric oncology].
    Bulletin du cancer, 2011, Volume: 98, Issue:5

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Benzenesulfonates; Bevacizumab; Child; Dasatinib; Erlotinib Hydrochloride; Hedgehog Proteins; Humans; Imatinib Mesylate; Indoles; Integrins; Molecular Targeted Therapy; Neoplasms; Niacinamide; Nifurtimox; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; TOR Serine-Threonine Kinases

2011
[Clinical pharmacokinetics of small molecule tyrosine kinase inhibitors].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:7

    Topics: Antineoplastic Agents; Crown Ethers; Cytochrome P-450 Enzyme System; Dasatinib; Drug Interactions; Erlotinib Hydrochloride; Gefitinib; Glucuronosyltransferase; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib

2013
Overview of Current Treatment Options and Investigational Targeted Therapies for Locally Advanced Squamous Cell Carcinoma of the Head and Neck.
    American journal of clinical oncology, 2016, Volume: 39, Issue:4

    Topics: Afatinib; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azepines; Carcinoma, Squamous Cell; Cetuximab; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Head and Neck Neoplasms; Humans; Lapatinib; Molecular Targeted Therapy; Panitumumab; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Quinazolinones; Signal Transduction; Sirolimus

2016
[Tyrosine kinase inhibitors and pregnancy: A risk to the fetus?].
    Bulletin du cancer, 2016, Volume: 103, Issue:5

    Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Agents; Dasatinib; Erlotinib Hydrochloride; Female; Fetus; Gefitinib; Humans; Imatinib Mesylate; Lapatinib; Maternal Age; Placenta; Pregnancy; Pregnancy Complications, Neoplastic; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Risk

2016

Trials

5 trial(s) available for erlotinib hydrochloride and dasatinib

ArticleYear
Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-10, Volume: 28, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Carcinoma, Non-Small-Cell Lung; Dasatinib; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; ErbB Receptors; Erlotinib Hydrochloride; Female; Fibroblast Growth Factor 2; Humans; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Thiazoles; Vascular Endothelial Growth Factor A

2010
Phase II trial of dasatinib for patients with acquired resistance to treatment with the epidermal growth factor receptor tyrosine kinase inhibitors erlotinib or gefitinib.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2011, Volume: 6, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Thiazoles; Treatment Outcome

2011
Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma.
    Journal of neuro-oncology, 2012, Volume: 108, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dasatinib; Erlotinib Hydrochloride; Female; Glioma; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Pyrimidines; Quinazolines; Thiazoles; Tissue Distribution; Young Adult

2012
Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population.
    Oncotarget, 2013, Volume: 4, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Boronic Acids; Bortezomib; Carcinoma, Non-Small-Cell Lung; Cetuximab; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Quinazolines; Retrospective Studies; Sirolimus; Survival; Thiazoles; Treatment Outcome

2013
A phase I/II study combining erlotinib and dasatinib for non-small cell lung cancer.
    The oncologist, 2014, Volume: 19, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Maximum Tolerated Dose; src-Family Kinases; Treatment Outcome

2014

Other Studies

25 other study(ies) available for erlotinib hydrochloride and dasatinib

ArticleYear
Pharmacy benefit spending on oral chemotherapy drugs.
    Journal of managed care pharmacy : JMCP, 2006, Volume: 12, Issue:7

    Topics: Administration, Oral; Ambulatory Care; Antineoplastic Agents; Benzamides; Benzenesulfonates; Capecitabine; Dasatinib; Deoxycytidine; Drug Costs; Employer Health Costs; Erlotinib Hydrochloride; Fluorouracil; Gefitinib; Health Benefit Plans, Employee; Humans; Imatinib Mesylate; Indoles; Insurance, Pharmaceutical Services; Lenalidomide; Neoplasms; Niacinamide; Phenylurea Compounds; Piperazines; Prescription Fees; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thalidomide; Thiazoles; United States

2006
Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification.
    Cancer science, 2010, Volume: 101, Issue:1

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Gene Amplification; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Pyrimidines; Quinazolines; Receptor, ErbB-3; Receptors, Growth Factor; Signal Transduction; src-Family Kinases; Thiazoles

2010
Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Feb-01, Volume: 17, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Movement; Dasatinib; Deoxycytidine; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; src-Family Kinases; STAT3 Transcription Factor; Thiazoles; Xenograft Model Antitumor Assays

2011
Response to combined molecular targeting: defining the role of P-STAT3.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Feb-01, Volume: 17, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Clinical Trials as Topic; Dasatinib; Deoxycytidine; ErbB Receptors; Erlotinib Hydrochloride; Gemcitabine; Humans; Molecular Targeted Therapy; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; STAT3 Transcription Factor; Thiazoles; Xenograft Model Antitumor Assays

2011
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.
    Cancer discovery, 2011, Volume: 1, Issue:1

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Dasatinib; Discoidin Domain Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mice; Mice, Nude; Mutation; NIH 3T3 Cells; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; src-Family Kinases; Thiazoles

2011
Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:4

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport; Brain; Cell Line; Dasatinib; Dogs; Drug Delivery Systems; Emulsions; Erlotinib Hydrochloride; Humans; Mice; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Solubility; Tetrahydroisoquinolines; Thiazoles

2013
Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, May-01, Volume: 926

    Topics: Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Chromatography, Liquid; Dasatinib; Erlotinib Hydrochloride; Humans; Imatinib Mesylate; Indoles; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Pyrazines; Pyrimidines; Pyrroles; Quinazolines; Reproducibility of Results; Sorafenib; Sunitinib; Tandem Mass Spectrometry; Thiazoles

2013
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.
    British journal of pharmacology, 2014, Volume: 171, Issue:24

    Topics: AIDS Dementia Complex; Animals; Antineoplastic Agents; Cyclin-Dependent Kinase 5; Dasatinib; Erlotinib Hydrochloride; Flavonoids; HIV Envelope Protein gp120; In Vitro Techniques; Indoles; Lapatinib; Mice; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Purines; Pyrimidines; Pyrroles; Quinazolines; Rats; Roscovitine; Sunitinib; Thiazoles

2014
Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition.
    Oncotarget, 2014, Sep-15, Volume: 5, Issue:17

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dasatinib; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Flow Cytometry; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Genes, erbB-1; Humans; Immunoblotting; Lung Neoplasms; Mice; Mice, Nude; Mutation; Pyrimidines; Quinazolines; Signal Transduction; src-Family Kinases; Thiazoles; Xenograft Model Antitumor Assays

2014
Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015, Volume: 116, Issue:3

    Topics: Blotting, Western; Bronchial Neoplasms; Cell Line, Tumor; Cell Nucleus; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid; Nuclear Proteins; Oxadiazoles; Protein Kinase Inhibitors; Pyrazoles; Radiation Tolerance; RNA, Messenger

2015
Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status.
    Oncotarget, 2015, Sep-22, Volume: 6, Issue:28

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzodioxoles; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cetuximab; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Mutation; Protein Kinase Inhibitors; Quinazolines; ras Proteins; RNA Interference; src-Family Kinases; Tumor Burden; Xenograft Model Antitumor Assays

2015
A streamlined search technology for identification of synergistic drug combinations.
    Scientific reports, 2015, Sep-29, Volume: 5

    Topics: Antineoplastic Agents; Axitinib; Benzamides; Cell Line, Tumor; Cell Survival; Dasatinib; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Epithelial Cells; Erlotinib Hydrochloride; Humans; Imidazoles; Indazoles; Kidney; Piperazines; Pyrazoles

2015
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
    Nature medicine, 2016, Volume: 22, Issue:3

    Topics: Aged; Animals; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cytochrome P-450 CYP3A; Dasatinib; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 4; Humans; Immunohistochemistry; Keratins, Hair-Specific; Keratins, Type II; Male; Mice, Inbred NOD; Middle Aged; Neoplasm Transplantation; Paclitaxel; Pancreatic Neoplasms; Pregnane X Receptor; Prognosis; Protein Kinase Inhibitors; Receptors, Steroid; Up-Regulation

2016
A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes.
    The journal of physical chemistry. B, 2016, 07-07, Volume: 120, Issue:26

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Computational Biology; Dasatinib; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genetic Heterogeneity; Glioblastoma; Humans; Imatinib Mesylate; Molecular Targeted Therapy; Neoplasm Proteins; Phosphoproteins; Signal Transduction; Thermodynamics

2016
Effect of dasatinib on EMT-mediated-mechanism of resistance against EGFR inhibitors in lung cancer cells.
    Lung cancer (Amsterdam, Netherlands), 2017, Volume: 104

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dasatinib; Drug Resistance, Neoplasm; Drug Therapy, Combination; Epithelial-Mesenchymal Transition; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Treatment Outcome

2017
Impact of Small Molecules on β-Catenin and E-Cadherin Expression in HPV16-positive and -negative Squamous Cell Carcinomas.
    Anticancer research, 2017, Volume: 37, Issue:6

    Topics: Antigens, CD; Antineoplastic Agents; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Line, Tumor; Dasatinib; Erlotinib Hydrochloride; Gefitinib; Head and Neck Neoplasms; Human papillomavirus 16; Humans; Protein Kinase Inhibitors; Pyrimidines; Quinazolines

2017
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
    Cell reports, 2017, Oct-03, Volume: 21, Issue:1

    Topics: Animals; Antineoplastic Agents; Biosensing Techniques; Bone and Bones; Cell Movement; Dasatinib; Erlotinib Hydrochloride; Female; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Intestine, Small; Intravital Microscopy; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mechanotransduction, Cellular; Mice; Mice, Transgenic; Neutrophils; Osteocytes; Pancreatic Neoplasms; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Time-Lapse Imaging

2017
Selection of Protein Kinase Inhibitors Based on Tumor Tissue Kinase Activity Profiles in Patients with Refractory Solid Malignancies: An Interventional Molecular Profiling Study.
    The oncologist, 2018, Volume: 23, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents; Dasatinib; Erlotinib Hydrochloride; Everolimus; Female; Humans; Lapatinib; Male; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Sorafenib; Sunitinib

2018
Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
    Molecular cancer research : MCR, 2020, Volume: 18, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Dasatinib; Deoxycytidine; Disease Models, Animal; ErbB Receptors; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Protein Kinase Inhibitors; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Stromal Cells; Survival Analysis; Xenograft Model Antitumor Assays

2020
Tyrosine Kinase Inhibitors and Everolimus Reduce IGF1R Expression in HPV16-positive and -negative Squamous Cell Carcinoma.
    Anticancer research, 2020, Volume: 40, Issue:7

    Topics: Antineoplastic Agents; Cell Line, Tumor; Dasatinib; Erlotinib Hydrochloride; Everolimus; Gefitinib; Head and Neck Neoplasms; Human papillomavirus 16; Humans; Papillomavirus Infections; Protein Kinase Inhibitors; Pyrimidines; Receptor, IGF Type 1; Squamous Cell Carcinoma of Head and Neck

2020
FGF Expression in HPV16-positive and -negative SCC After Treatment With Small-molecule Tyrosine Kinase Inhibitors and Everolimus.
    Anticancer research, 2020, Volume: 40, Issue:10

    Topics: Cell Line, Tumor; Dasatinib; Erlotinib Hydrochloride; Everolimus; Fibroblast Growth Factors; Gefitinib; Human papillomavirus 16; Humans; Papillomaviridae; Protein Kinase Inhibitors; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases

2020
The "SEED" Study: The Feasibility of Selecting Patient-Specific Biologically Targeted Therapy with Sorafenib, Everolimus, Erlotinib or Dasatinib for Pediatric and Young Adult Patients with Recurrent or Refractory Brain Tumors.
    Frontiers in bioscience (Landmark edition), 2022, 07-12, Volume: 27, Issue:7

    Topics: Brain Neoplasms; Child; Dasatinib; Erlotinib Hydrochloride; Everolimus; Feasibility Studies; Humans; Neoplasm Recurrence, Local; Patient Selection; Prospective Studies; Sorafenib; Young Adult

2022
Study on the prognosis, immune and drug resistance of m6A-related genes in lung cancer.
    BMC bioinformatics, 2022, Oct-19, Volume: 23, Issue:1

    Topics: Adenosine; Afatinib; Crizotinib; Dasatinib; Drug Resistance; Erlotinib Hydrochloride; Etoposide; Humans; Lapatinib; Lung Neoplasms; Tumor Microenvironment; Ubiquitin-Protein Ligases

2022
Identification of an Oxidative Stress-Related LncRNA Signature for Predicting Prognosis and Chemotherapy in Patients With Hepatocellular Carcinoma.
    Pathology oncology research : POR, 2022, Volume: 28

    Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Dasatinib; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Liver Neoplasms; Oxidative Stress; Prognosis; RNA, Long Noncoding; Sorafenib

2022
Cold atmospheric plasma treated 3D printed polylactic acid film; application in thin film solid phase microextraction of anticancer drugs.
    Talanta, 2024, Jan-01, Volume: 266, Issue:Pt 2

    Topics: Antineoplastic Agents; Dasatinib; Erlotinib Hydrochloride; Humans; Plasma Gases; Polyesters; Printing, Three-Dimensional; Solid Phase Microextraction

2024