Page last updated: 2024-09-05

erlotinib and mibefradil

erlotinib has been researched along with mibefradil in 2 studies

Compound Research Comparison

Studies
(erlotinib)
Trials
(erlotinib)
Recent Studies (post-2010)
(erlotinib)
Studies
(mibefradil)
Trials
(mibefradil)
Recent Studies (post-2010) (mibefradil)
221018066769143

Protein Interaction Comparison

ProteinTaxonomyerlotinib (IC50)mibefradil (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.156
Voltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)1.0476
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.333
Voltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)0.4122
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.5
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
ATP-dependent translocase ABCB1Homo sapiens (human)1.58
Cytochrome P450 3A4Homo sapiens (human)0.2575
Cytochrome P450 2D6Homo sapiens (human)0.063
Cytochrome P450 2C9 Homo sapiens (human)2.14
Sodium channel protein type 4 subunit alphaRattus norvegicus (Norway rat)0.5
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.34
ATP-dependent translocase ABCB1Mus musculus (house mouse)7.4
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.98
Cytochrome P450 2J2Homo sapiens (human)2.14
Voltage-dependent L-type calcium channel subunit beta-3Rattus norvegicus (Norway rat)1
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)0.878
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.98
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.333
Voltage-dependent N-type calcium channel subunit alpha-1BRattus norvegicus (Norway rat)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4543
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.333
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.2795
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.98
Voltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)0.4187
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 10 subunit alphaHomo sapiens (human)0.98

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Ballard, TE; Henderson, JL; Kalgutkar, AS; Obach, RS; Orr, ST; Ripp, SL; Scott, DO; Sun, H1

Reviews

1 review(s) available for erlotinib and mibefradil

ArticleYear
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
    Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11

    Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Drug Interactions; Heme; Humans; Models, Biological; Pharmacokinetics; Structure-Activity Relationship; Time Factors

2012

Other Studies

1 other study(ies) available for erlotinib and mibefradil

ArticleYear
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009