erlotinib has been researched along with fosbretabulin in 6 studies
| Studies (erlotinib) | Trials (erlotinib) | Recent Studies (post-2010) (erlotinib) | Studies (fosbretabulin) | Trials (fosbretabulin) | Recent Studies (post-2010) (fosbretabulin) |
|---|---|---|---|---|---|
| 221 | 0 | 180 | 497 | 0 | 320 |
| Protein | Taxonomy | erlotinib (IC50) | fosbretabulin (IC50) |
|---|---|---|---|
| Tubulin polymerization-promoting protein | Homo sapiens (human) | 1.016 | |
| Tubulin alpha-1A chain | Sus scrofa (pig) | 1.82 | |
| Tubulin beta chain | Sus scrofa (pig) | 1.9428 | |
| Tubulin beta-4A chain | Homo sapiens (human) | 1.663 | |
| Tubulin beta chain | Homo sapiens (human) | 1.663 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 0.009 | |
| Tubulin alpha-3C chain | Homo sapiens (human) | 1.663 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 1.08 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 1.005 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.81 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 1.2 | |
| Tubulin alpha-1B chain | Homo sapiens (human) | 1.663 | |
| Tubulin alpha-4A chain | Homo sapiens (human) | 1.663 | |
| Tubulin beta-4B chain | Homo sapiens (human) | 1.663 | |
| Vesicular acetylcholine transporter | Tetronarce californica (Pacific electric ray) | 1.8 | |
| Tubulin beta-3 chain | Homo sapiens (human) | 1.5801 | |
| Tubulin beta-2A chain | Homo sapiens (human) | 1.663 | |
| Beta-tubulin | Leishmania donovani | 1.95 | |
| Tubulin beta-8 chain | Homo sapiens (human) | 1.663 | |
| Tubulin beta-2B chain | Bos taurus (cattle) | 1.4484 | |
| Tubulin alpha-3E chain | Homo sapiens (human) | 1.663 | |
| Tubulin alpha-1A chain | Homo sapiens (human) | 1.663 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 1.4928 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 1.4037 | |
| Tubulin alpha-1C chain | Homo sapiens (human) | 1.663 | |
| Tubulin beta-6 chain | Homo sapiens (human) | 1.663 | |
| Tubulin beta-2B chain | Homo sapiens (human) | 1.663 | |
| Tubulin beta-1 chain | Homo sapiens (human) | 1.6366 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Bailey-Downs, LC; Bastian, A; Disch, BC; Dybdal-Hargreaves, NF; Gangjee, A; Hamel, E; Ihnat, M; Mooberry, SL; Raghavan, S; Rohena, CC; Thorpe, JE; Zhang, X | 1 |
| Bastian, A; Gangjee, A; Hamel, E; Ihnat, M; Mooberry, SL; Raghavan, S; Zammiello, C; Zhang, X | 1 |
| Bai, R; Bastian, A; Choudhary, S; Gangjee, A; Hamel, E; Ihnat, MA; Pavana, RK | 1 |
| Choudhary, S; Devambatla, RKV; Gangjee, A; Hamel, E; Ihnat, M; Mooberry, SL | 1 |
| Baraldi, PG; Baraldi, S; Bortolozzi, R; Brancale, A; Chayah, M; Ferla, S; Hamel, E; Kimatrai Salvador, M; Lopez-Cara, LC; Mariotto, E; Mattiuzzo, E; Oliva, P; Prencipe, F; Romagnoli, R; Ronca, R; Schiaffino Ortega, S; Viola, G | 1 |
| Choudhary, S; Doshi, A; Gangjee, A; Hamel, E; Ihnat, M; Luckett-Chastain, L; Mooberry, SL | 1 |
6 other study(ies) available for erlotinib and fosbretabulin
| Article | Year |
|---|---|
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; Neoplasms, Experimental; Protein Kinase Inhibitors; Pyrimidines; Receptor Protein-Tyrosine Kinases; Solubility; Structure-Activity Relationship; Water | 2014 |
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Drug Design; ErbB Receptors; Furans; Humans; Inhibitory Concentration 50; Microtubules; Molecular Docking Simulation; Molecular Dynamics Simulation; Neovascularization, Physiologic; Protein Kinase Inhibitors; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Structure-Activity Relationship; Tubulin Modulators; Vascular Endothelial Growth Factor Receptor-2 | 2015 |
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microtubules; Molecular Docking Simulation; Molecular Structure; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship | 2017 |
Design, synthesis and preclinical evaluation of 5-methyl-N
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Neoplasms, Experimental; Protein Kinase Inhibitors; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Design; Drug Evaluation, Preclinical; Enzyme Activation; ErbB Receptors; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Microtubules; Poly(ADP-ribose) Polymerases; Polymerization; Pyrimidines; Reactive Oxygen Species; Tubulin; Vascular Endothelial Growth Factor Receptor-2 | 2019 |
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Structure; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2021 |