ergotoxine and ergocornine

Topics: Animals; Bromocriptine; Dose-Response Relationship, Drug; Ergolines; Female; Goats; Lactation; Pregnancy; Prolactin; Time Factors

Plasma levels of prolactin (PRL), growth hormone (GH), luteinizing hormone (LH), and corticosterone (CORT) were measured in parturient Rockland-Swiss (R-S) albino mice following the daily administration for 10 days of 0.5 mg ergocornine (ERGO), 0.5 mg bromocriptine (BROMO), or sesame oil (OIL). The dams were provided with replete foster young on a daily basis so as to prevent the decline in suckling activity that normally occurs in undernourished pups of ergot-treated dams. Circulating PRL levels were significantly reduced by both ergot drugs but plasma levels of the other hormones measured were not altered. Thus, ergot drugs have relatively specific effects on PRL even in parturient animals receiving sustained high levels of suckling stimulation.

Topics: Animals; Bromocriptine; Corticosterone; Ergolines; Female; Growth Hormone; Labor, Obstetric; Lactation; Luteinizing Hormone; Mice; Pregnancy; Prolactin

Effects of ergocornine and reserpine on tail resorption during metamorphosis in Bufo bufo japonicus tadpoles were studied. At prometamorphosis, ergocornine induced precocious tail resorption, while reserpine scarcely affected the tail size. At the climax of metamorphosis, ergocornine was almost ineffective in accelerating tail resorption, while reserpine was effective in inhibiting tail resorption. Since prolactin-like hormone is known to block the tail resorption induced by thyroid hormones, it was postulated that the release of the hormone is blocked by ergocornine during prometamorphosis and stimulated by reserpine during climax.

Topics: Animals; Bufonidae; Ergolines; Larva; Metamorphosis, Biological; Reserpine

Topics: Decidua; Embryo Implantation; Ergolines; Female; Humans; Ovum; Uterus