ergoline and zelandopam

ergoline has been researched along with zelandopam* in 1 studies

Other Studies

1 other study(ies) available for ergoline and zelandopam

ArticleYear
D-1 dopamine receptors mediate dopamine-induced pancreatic exocrine secretion in anesthetized dogs.
    Hypertension research : official journal of the Japanese Society of Hypertension, 1995, Volume: 18 Suppl 1

    Characterization of dopamine (DA) receptor subtypes was examined on the canine exocrine pancreas using selective DA receptor agonists and antagonists in anesthetized dogs. Each drug was injected i.a. in a single bolus fashion. Graded doses of DA (0.01-3 mumol) produced dose-dependent increases in the secretory rate of pancreatic juice, with a maximum effect at approximately 1 mumol. SCH23390 (3-30 nmol), a selective D-1 DA receptor antagonist, caused a progressive parallel shift to the right in the dose-response curve for DA-induced pancreatic secretion without changes in the maximal response. However, domperidone (3 mumol), a selective D-2 DA receptor antagonist, did not antagonize the DA-induced pancreatic exocrine secretion. A Schild analysis of the data indicates that the inhibitory constant value for SCH23390 to inhibit DA-stimulated secretion was 6.9 nmol. In addition, the stimulatory effects of SKF38393 (0.1-10 mumol) and YM435 (0.3-30 nmol), selective D-1 DA receptor agonists, and LY171555 (1-10 mumol), a selective D-2 DA receptor agonist, on pancreatic secretion were demonstrated. The rank order of agonist potency was YM435 > DA > SKF38393 >> LY171555. These results suggest that DA-induced pancreatic exocrine secretion is mediated by activation of D-1 DA receptors.

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Anesthesia; Animals; Benzazepines; Dogs; Domperidone; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Ergolines; Isoquinolines; Pancreas; Pancreatic Juice; Quinpirole; Receptors, Dopamine D1; Receptors, Dopamine D2; Tetrahydroisoquinolines; Vasodilator Agents

1995