erastin and oblimersen

The effect of modulators of VDAC channels - G3139 and erastin on the mitochondrial permeability transition pore (mPTP) functioning and changes in the content of proteins involved in regulation of mPTP (VDAC, CNPase, and TSPO) has been investigated in liver mitochondria of rats with chronic alcohol intoxication. It was shown that the mitochondria of rats treated with ethanol were more sensitive to mPTP induction. Moreover, ethanol induced changes in the expression of mPTP regulator proteins. G3139 and erastin were also able to influence the studied mitochondrial parameters, and they increased their effect in the liver mitochondria of rats treated with ethanol, as compared to the mitochondria of control rats. We hypothesize that the results of this study may help to elucidate the mechanisms of chronic action of ethanol on mitochondria and contribute to the development of new therapeutic strategies for treating the consequences of ethanol-related diseases.. Issledovano vliianie moduliatorov VDAC-kanalov — G3139 i érastina — na funktsionirovanie mitokhondrial'noĭ pory (mitochondrial permeability transition pore, mPTP), a takzhe na izmeneniia v soderzhanii belkov, reguliruiushchikh rabotu mPTP (VDAC, CNPaza i TSPO) v mitokhondriiakh pecheni krys s khronicheskoĭ alkogol'noĭ intoksikatsieĭ. Pokazano, chto mitokhondrii pecheni krys, poluchavshikh étanol, bolee chuvstvitel'ny k induktsii mPTP. Bolee togo, pod vozdeĭstviem étanola proiskhodiat izmeneniia v ékspressii belkov-reguliatorov mPTP. G3139 i érastin takzhe sposobny vliiat' na issleduemye mitokhondrial'nye parametry, prichem ikh deĭstvie v mitokhondriiakh pecheni krys, poluchavshikh étanol, bolee vyrazheno po sravneniiu s mitokhondriiami pecheni kontrol'nykh krys. My predpolagaem, chto rezul'taty étogo issledovaniia mogut pomoch' vyiasnit' mekhanizmy khronicheskogo deĭstviia étanola na mitokhondrii i vnesti vklad v razrabotku novykh terapevticheskikh strategiĭ dlia lecheniia patologiĭ, sviazannykh s potrebleniem étanola.

Topics: Alcoholism; Animals; Ethanol; Mitochondria; Mitochondria, Liver; Rats