er-086526 and tetrahydrofuran

er-086526 has been researched along with tetrahydrofuran* in 1 studies

Other Studies

1 other study(ies) available for er-086526 and tetrahydrofuran

Article	Year
Structural corroboration of two important building blocks of the anticancer drug eribulin mesylate through two-dimensional NMR and single-crystal X-ray diffraction studies. Acta crystallographica. Section C, Structural chemistry, 2016, Volume: 72, Issue:Pt 1 Eribulin mesylate, one of the most synthetically challenging drugs to date, possesses 19 stereocentres in its structure and ascertaining the absolute stereochemistry at every stage of the 64-stage synthesis is crucial. In our quest to synthesize eribulin, we identified two critical building blocks of this molecule, namely 3,4:6,7-di-O-cyclohexylidene-D-glycero-α-L-talo-heptopyranose methanol monosolvate, C19H30O7·CH3OH, and (2R,3R,4R,5S)-5-allyl-2-[(S)-2,3-dihydroxypropyl]-4-[(phenylsulfonyl)methyl]tetrahydrofuran-3-ol, C17H24O6S, for which two-dimensional NMR (2D-NMR) data were not sufficient to prove the absolute configuration. To ensure structural integrity, single-crystal X-ray diffraction data were obtained to confirm the structures. This information provides useful insights into the structural framework of the large eribulin mesylate molecule. Topics: Allyl Compounds; Antineoplastic Agents; Crystallography, X-Ray; Cyclohexenes; Furans; Hydrogen Bonding; Ketones; Magnetic Resonance Spectroscopy; Monosaccharides; X-Ray Diffraction	2016

Article

Year

Structural corroboration of two important building blocks of the anticancer drug eribulin mesylate through two-dimensional NMR and single-crystal X-ray diffraction studies.

Acta crystallographica. Section C, Structural chemistry, 2016, Volume: 72, Issue:Pt 1

Eribulin mesylate, one of the most synthetically challenging drugs to date, possesses 19 stereocentres in its structure and ascertaining the absolute stereochemistry at every stage of the 64-stage synthesis is crucial. In our quest to synthesize eribulin, we identified two critical building blocks of this molecule, namely 3,4:6,7-di-O-cyclohexylidene-D-glycero-α-L-talo-heptopyranose methanol monosolvate, C19H30O7·CH3OH, and (2R,3R,4R,5S)-5-allyl-2-[(S)-2,3-dihydroxypropyl]-4-[(phenylsulfonyl)methyl]tetrahydrofuran-3-ol, C17H24O6S, for which two-dimensional NMR (2D-NMR) data were not sufficient to prove the absolute configuration. To ensure structural integrity, single-crystal X-ray diffraction data were obtained to confirm the structures. This information provides useful insights into the structural framework of the large eribulin mesylate molecule.

Topics: Allyl Compounds; Antineoplastic Agents; Crystallography, X-Ray; Cyclohexenes; Furans; Hydrogen Bonding; Ketones; Magnetic Resonance Spectroscopy; Monosaccharides; X-Ray Diffraction

2016