epz-6438 has been researched along with plumbagin* in 1 studies
1 other study(ies) available for epz-6438 and plumbagin
| Article | Year |
|---|---|
Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS.
A sensitive and rapid UPLC-MS/MS method for determination of tazemetostat in rat plasma was developed, and the pharmacokinetics of herb-drug interactions (HDIs) of plumbagin (PLB) and tazemetostat was investigated.. In the calibrated range of 1-1000 ng/mL, tazemetostat had a good linearity. The extraction recovery was more than 84%, and the RSD of intra-batch and inter-batch precision were both less than 15%. The C. A simple, rapid and sensitive UPLC-MS/MS method for the determination of tazemetostat in rat plasma was established. PLB can inhibit the metabolism of tazemetostat and increase the plasma exposure of tazemetostat in rats. Topics: Acetonitriles; Animals; Benzamides; Biphenyl Compounds; Carboxymethylcellulose Sodium; Chromatography, High Pressure Liquid; Chromatography, Liquid; Herb-Drug Interactions; Morpholines; Naphthoquinones; Pyridones; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sodium; Tandem Mass Spectrometry | 2022 |