epoxomicin and dihydroeponemycin

epoxomicin has been researched along with dihydroeponemycin* in 1 studies

Other Studies

1 other study(ies) available for epoxomicin and dihydroeponemycin

Article	Year
Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorganic & medicinal chemistry letters, 1999, Dec-06, Volume: 9, Issue:23 While two structurally related epoxyketone-containing antitumor natural products, epoxomicin and eponemycin, share the proteasome as a common intracellular target, they differ in their antiproliferative activity, proteasome subunit binding specificity, and rates of proteasome inhibition. As a first step towards understanding such differences and developing novel proteasome subunit-specific inhibitors, we report here the synthesis and characterization of epoxomicin/dihydroeponemycin chimerae. Topics: Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Serine; Substrate Specificity	1999

Article

Year

Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency.

Bioorganic & medicinal chemistry letters, 1999, Dec-06, Volume: 9, Issue:23

While two structurally related epoxyketone-containing antitumor natural products, epoxomicin and eponemycin, share the proteasome as a common intracellular target, they differ in their antiproliferative activity, proteasome subunit binding specificity, and rates of proteasome inhibition. As a first step towards understanding such differences and developing novel proteasome subunit-specific inhibitors, we report here the synthesis and characterization of epoxomicin/dihydroeponemycin chimerae.

Topics: Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Serine; Substrate Specificity

1999