epothilone-a and mycothiazole

epothilone-a has been researched along with mycothiazole* in 1 studies

Other Studies

1 other study(ies) available for epothilone-a and mycothiazole

Article	Year
A reassignment of (-)-mycothiazole and the isolation of a related diol. Journal of natural products, 2006, Volume: 69, Issue:1 A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta14,15 of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration. Topics: Alcohols; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Epothilones; Molecular Structure; Polyketide Synthases; Porifera; Stereoisomerism; Thiazoles; Thiazolidines; Vanuatu	2006

Article

Year

A reassignment of (-)-mycothiazole and the isolation of a related diol.

Journal of natural products, 2006, Volume: 69, Issue:1

A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta14,15 of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration.

Topics: Alcohols; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Drug Screening Assays, Antitumor; Epothilones; Molecular Structure; Polyketide Synthases; Porifera; Stereoisomerism; Thiazoles; Thiazolidines; Vanuatu

2006