epinastine and ketotifen

epinastine has been researched along with ketotifen in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.33)18.7374
1990's9 (37.50)18.2507
2000's10 (41.67)29.6817
2010's3 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chiba, Y; Kanai, Y; Misawa, M1
Kanai, Y; Misawa, M1
Bechtel, WD; Fügner, A; Kuhn, FJ; Mierau, J1
Adamus, WS; Lohmann, H; Oldigs-Kerber, J1
Mita, H; Shida, T1
Kamei, C; Nakamura, S; Tasaka, K1
Akagi, M; Akagi, R; Fukuishi, N; Hirose, K; Kan, T1
Iinuma, K; Onodera, K; Sato, M; Watanabe, T; Yokoyama, H1
Akuta-Ohnuma, K; Manabe, H; Ohmori, K1
Aritake, K; Hayashi, K; Hayashi, M; Hirotsu, I; Hizue, M; Kimura, Y; Matsushita, N; Mitsui, K; Nakajima, H; Takada, A; Tani, T2
Chen, Z; Kamei, C; Kawamoto, E; Sugimoto, Y1
Alejandra Hossen, M; Fujii, Y; Kamei, C; Kishi, Y; Tsumuro, T1
Ago, J; Ishikawa, T; Kamei, C; Matsumoto, N; Murakami, A; Rahman, A; Takechi, K1
Ohira, T; Saito, N; Tsujii, T; Watanabe, S; Yamamoto, E1
Beauregard, C; Gamache, D; Roberts, L; Stephens, D; Yanni, J1
Erb, KJ; Göggel, R; Werner-Klein, M; Westhof, A1
Akman, A; Akova, YA; Borazan, M; Erbek, SS; Karalezli, A; Kiyici, H1
Gomes, P; Ousler, GW; Torkildsen, GL1
Bonini, S; Lambiase, A; Micera, A1
Akiyama, T; Masuda, S; Ohira, T; Takahashi, T; Tsujii, T; Watanabe, S; Yamamoto, E1
Ohira, T; Takahashi, T; Tsujii, T; Watanabe, S; Yamamoto, E1
Chen, LJ; Kam, KW; Wat, N; Young, AL1
Ben-Eli, H; Solomon, A1

Reviews

3 review(s) available for epinastine and ketotifen

ArticleYear
Multiple action agents and the eye: do they really stabilize mast cells?
    Current opinion in allergy and clinical immunology, 2009, Volume: 9, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Conjunctivitis, Allergic; Cytokines; Dibenzazepines; Dibenzoxepins; Histamine; Histamine Antagonists; Humans; Imidazoles; Immunity, Innate; Ketotifen; Mast Cells; Olopatadine Hydrochloride; Phthalazines

2009
Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis.
    Ocular immunology and inflammation, 2017, Volume: 25, Issue:5

    Topics: Administration, Ophthalmic; Anti-Allergic Agents; Benzazepines; Conjunctivitis, Allergic; Dibenzazepines; Histamine H1 Antagonists; Humans; Imidazoles; Ketotifen; Olopatadine Hydrochloride; Ophthalmic Solutions; Treatment Outcome

2017
Topical antihistamines, mast cell stabilizers, and dual-action agents in ocular allergy: current trends.
    Current opinion in allergy and clinical immunology, 2018, Volume: 18, Issue:5

    Topics: Administration, Ophthalmic; Anti-Allergic Agents; Benzazepines; Conjunctivitis, Allergic; Cromolyn Sodium; Dibenzazepines; Histamine Antagonists; Humans; Hyperemia; Imidazoles; Ketotifen; Nedocromil; Olopatadine Hydrochloride; Phthalazines; Piperidines; Pruritus; Pyridines; Pyrimidinones

2018

Trials

5 trial(s) available for epinastine and ketotifen

ArticleYear
Pharmacodynamics of the new H1-antagonist 3-amino-9,13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine hydrochloride in volunteers.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:5

    Topics: Adult; Azepines; Dibenzazepines; Double-Blind Method; Emotions; Flicker Fusion; Histamine; Histamine H1 Antagonists; Humans; Imidazoles; Ketotifen; Male; Psychomotor Performance; Reaction Time; Skin Tests

1987
Effects of sedative and non-sedative H1 antagonists on cognitive tasks: behavioral and near-infrared spectroscopy (NIRS) examinations.
    Psychopharmacology, 2007, Volume: 194, Issue:1

    Topics: Administration, Oral; Adult; Asian People; Attention; Auditory Perception; Behavior; Cognition; Cross-Over Studies; Dibenzazepines; Dichotic Listening Tests; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Hypnotics and Sedatives; Imidazoles; Ketotifen; Male; Memory; Oxyhemoglobins; Prefrontal Cortex; Spectroscopy, Near-Infrared; Time Factors; Visual Perception

2007
Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.
    Acta ophthalmologica, 2009, Volume: 87, Issue:5

    Topics: Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Child; Conjunctival Diseases; Conjunctivitis, Allergic; Dibenzazepines; Dibenzoxepins; Double-Blind Method; Edema; Eyelid Diseases; Female; Fluorometholone; Histamine H1 Antagonists; Humans; Imidazoles; Ketotifen; Male; Middle Aged; Olopatadine Hydrochloride; Ophthalmic Solutions; Prospective Studies; Pruritus; Seasons; Tears; Treatment Outcome; Young Adult

2009
Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: a randomized, double-masked crossover study.
    Clinical therapeutics, 2008, Volume: 30, Issue:7

    Topics: Adult; Conjunctivitis, Allergic; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Imidazoles; Ketotifen; Male; Mast Cells; Ophthalmic Solutions; Phthalazines; Xerophthalmia

2008
Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: a near-infrared spectroscopy (NIRS) study.
    Psychopharmacology, 2009, Volume: 207, Issue:1

    Topics: Analysis of Variance; Child; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Female; Hemoglobins; Histamine H1 Antagonists; Humans; Imidazoles; Ketotifen; Language Tests; Male; Oxyhemoglobins; Prefrontal Cortex; Spectroscopy, Near-Infrared; Verbal Behavior

2009

Other Studies

16 other study(ies) available for epinastine and ketotifen

ArticleYear
Effects of the new antiallergic drug epinastine and ketotifen on repeated antigen challenge-induced airway hyperresponsiveness in rats.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:12

    Topics: Acetylcholine; Animals; Antigens, Helminth; Ascaris; Asthma; Bronchial Hyperreactivity; Dibenzazepines; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Rats; Rats, Inbred Strains

1991
Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:11

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bradykinin; Bronchoconstriction; Dibenzazepines; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Neurokinin A; Phthalazines; Piperazines; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; SRS-A; Substance P

1991
In vitro and in vivo studies of the non-sedating antihistamine epinastine.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Animals; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cats; Dibenzazepines; Dogs; Female; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Ileum; Imidazoles; In Vitro Techniques; Ketotifen; Male; Promethazine; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Sleep; Terfenadine; Wakefulness

1988
Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:1

    Topics: Asthma; Calcimycin; Dibenzazepines; Histamine H1 Antagonists; Humans; Hypersensitivity; Imidazoles; Immunoglobulin E; In Vitro Techniques; Ketotifen; Leukocytes; Leukotriene C4; Neutrophils; Piperazines; Platelet Activating Factor

1995
Inhibitory effect of epinastine on bronchoconstriction induced by histamine, platelet activating factor and serotonin in guinea pigs and rats.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:3

    Topics: Airway Resistance; Animals; Antigen-Antibody Reactions; Bronchoconstriction; Dibenzazepines; Guinea Pigs; Histamine H1 Antagonists; Imidazoles; In Vitro Techniques; Ketotifen; Male; Phthalazines; Platelet Activating Factor; Rats; Rats, Wistar; Serotonin Antagonists

1994
Inhibitory effect of epinastine on superoxide generation by rat neutrophils.
    Japanese journal of pharmacology, 1995, Volume: 68, Issue:4

    Topics: Animals; Anti-Allergic Agents; Dibenzazepines; Dose-Response Relationship, Drug; Imidazoles; Ketotifen; Male; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Piperazines; Rats; Rats, Wistar; Superoxides

1995
Centrally acting histamine H1 antagonists promote the development of amygdala kindling in rats.
    Neuroscience letters, 1996, Oct-18, Volume: 217, Issue:2-3

    Topics: Amygdala; Animals; Dibenzazepines; Electroencephalography; Histamine H1 Antagonists; Imidazoles; Ketotifen; Kindling, Neurologic; Male; Pyrilamine; Rats; Rats, Inbred F344; Seizures

1996
Inhibitory effect of oxatomide on oxygen-radical generation and peptide-leukotriene release from guinea pig eosinophils.
    Arzneimittel-Forschung, 1998, Volume: 48, Issue:1

    Topics: Animals; Anti-Allergic Agents; Calcimycin; Dibenzazepines; Eosinophils; Free Radicals; Guinea Pigs; Histamine H1 Antagonists; Imidazoles; In Vitro Techniques; Ketotifen; Leukotrienes; Luminescent Measurements; Male; Oxygen Consumption; Piperazines

1998
Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:1

    Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Bronchoconstriction; Capillary Permeability; Dibenzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Delayed; Imidazoles; Ketotifen; Leukocytes; Male; Mice; Mice, Inbred ICR; Nasal Mucosa; Passive Cutaneous Anaphylaxis; Piperidines; Rats; Rats, Wistar; Respiratory Hypersensitivity

1998
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:1

    Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antigens; Capillary Permeability; Dibenzazepines; Dinoprostone; Dose-Response Relationship, Drug; Free Radical Scavengers; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Ileum; Imidazoles; In Vitro Techniques; Intramolecular Oxidoreductases; Ketotifen; Leukotriene B4; Leukotriene C4; Lipocalins; Lung; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Piperidines; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Respiratory Hypersensitivity; Serotonin; Sheep; Skin Physiological Phenomena; Trachea

1998
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
    Immunopharmacology, 2000, Volume: 48, Issue:1

    Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Imidazoles; Immunization; Ketotifen; Nasal Cavity; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Rhinitis, Allergic, Perennial; Sneezing; Time Factors

2000
Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists.
    International immunopharmacology, 2006, Volume: 6, Issue:5

    Topics: Animals; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Nasal Mucosa; Plethysmography, Whole Body; Rats; Rats, Inbred BN; Rhinitis; Toluene 2,4-Diisocyanate

2006
Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3

    Topics: Administration, Oral; Animals; Animals, Suckling; Chlorpheniramine; Cyproheptadine; Dibenzazepines; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Rats; Rats, Wistar; Seizures; Terfenadine; Time Factors

2007
Duration of action of topical antiallergy drugs in a Guinea pig model of histamine-induced conjunctival vascular permeability.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2007, Volume: 23, Issue:4

    Topics: Administration, Topical; Animals; Anti-Allergic Agents; Capillary Permeability; Conjunctiva; Delayed-Action Preparations; Dibenzazepines; Dibenzoxepins; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imidazoles; Ketotifen; Male; Olopatadine Hydrochloride; Ophthalmic Solutions; Phthalazines

2007
Development and characterisation of a novel and rapid lung eosinophil influx model in the rat.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:4

    Topics: Alum Compounds; Aminopyridines; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Budesonide; Cyclopropanes; Dibenzazepines; Disease Models, Animal; Eosinophils; Histamine H1 Antagonists; Imidazoles; Ketotifen; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphodiesterase Inhibitors; Prednisolone; Rats; Rats, Inbred BN

2008
Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: a near-infrared spectroscopy (NIRS) study.
    Neuroscience research, 2010, Volume: 67, Issue:1

    Topics: Child; Child, Preschool; Dibenzazepines; Hemoglobins; Histamine H1 Antagonists; Humans; Imidazoles; Ketotifen; Memory, Short-Term; Oxyhemoglobins; Prefrontal Cortex; Spectroscopy, Near-Infrared

2010