Compounds > epinastine

epinastine and astemizole

epinastine has been researched along with astemizole in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's2 (20.00)18.2507
2000's5 (50.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Keserü, GM1
Caron, G; Ermondi, G1
Nagashima, R; Nishikawa, T; Tobita, M1
Jia, L; Sun, H1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA1
Bechtel, WD; Fügner, A; Kuhn, FJ; Mierau, J1
Chachin, M; Horio, Y; Katayama, Y; Kitagawa, H; Kurachi, Y; Ohmura, T; Uchida, S; Yamada, M1
Chachin, M; Igarashi, T; Ikeda, H; Ikegami, K; Kitagawa, H; Nagakura, A; Ohmura, T; Tarui, S; Uchida, S1
Chen, Z; Kamei, C; Kawamoto, E; Sugimoto, Y1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1

Other Studies

10 other study(ies) available for epinastine and astemizole

ArticleYear
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs

2013
In vitro and in vivo studies of the non-sedating antihistamine epinastine.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Animals; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cats; Dibenzazepines; Dogs; Female; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Ileum; Imidazoles; In Vitro Techniques; Ketotifen; Male; Promethazine; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Sleep; Terfenadine; Wakefulness

1988
Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel.
    European journal of pharmacology, 1999, Jun-25, Volume: 374, Issue:3

    Topics: Animals; Astemizole; Cation Transport Proteins; Dibenzazepines; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression; Histamine H1 Antagonists; Humans; Imidazoles; Membrane Potentials; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Xenopus

1999
Effects of terfenadine, astemizole and epinastine on electrocardiogram in conscious cynomolgus monkeys.
    European journal of pharmacology, 1999, Aug-06, Volume: 378, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Astemizole; Dibenzazepines; Electrocardiography; Heart Block; Histamine H1 Antagonists; Imidazoles; Macaca fascicularis; Male; Terfenadine; Time Factors

1999
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
    Immunopharmacology, 2000, Volume: 48, Issue:1

    Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Imidazoles; Immunization; Ketotifen; Nasal Cavity; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Rhinitis, Allergic, Perennial; Sneezing; Time Factors

2000
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016