epiglucan and indoleacetic-acid

As a serious public health concern, alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut-liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol-related liver diseases, including bile acids, indole-3-acetic acid, butyrate, long-chain fatty acids, endotoxin, cytolysin, β-glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol-related liver disease.

Topics: Alcohol Drinking; Animals; beta-Glucans; Bile Acids and Salts; Butyrates; Endotoxins; Fatty Liver, Alcoholic; Fungal Proteins; Gastrointestinal Microbiome; Humans; Indoleacetic Acids