epidermal-growth-factor and phthalocyanine

epidermal-growth-factor has been researched along with phthalocyanine* in 2 studies

Other Studies

2 other study(ies) available for epidermal-growth-factor and phthalocyanine

Article	Year
Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery? Small (Weinheim an der Bergstrasse, Germany), 2011, Aug-22, Volume: 7, Issue:16 EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers. Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Epidermal Growth Factor; ErbB Receptors; Glioma; Gold; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Isoindoles; Metal Nanoparticles; Mice; Nanocapsules; Nanoconjugates; Photochemotherapy; Photosensitizing Agents; Treatment Outcome	2011
Cytotoxic action of conjugates of alpha-fetoprotein and epidermal growth factor with photoheme, chlorines, and phthalocyanines. Biochemistry. Biokhimiia, 2000, Volume: 65, Issue:6 Covalently bound conjugates of alpha-fetoprotein (AFP) and epidermal growth factor (EGF) with photoheme (PH), 3-desvinyl-3-formylchlorine p6 (Chl p6), chlorine e6 (Chl e6), aluminum disulfochloride phthalocyanine (PC(Al)), and cobalt octa-4,5-carboxyphthalocyanine (teraphthal, TP(Co)) were synthesized. Their molar ratios were 1:4 for AFP-cytotoxin conjugates (cf. 1:10 for AFP-TP(Co)) and 1:2 for EGF conjugates (cf. 1:1 for EGF-PC(Al)). Dark toxicity of both protein conjugates with PH, chlorines, and PC(Al) was much lower than their phototoxicity. Studies on phototoxicity demonstrated that PC(Al) conjugates with AFP and EGF and also EGF-Chl p6 were the most effective. The cytotoxic activity (CTA) of AFP-PC(Al) and EGF-Chl p6 was 80% and of EGF-PC(Al) 64% higher than the CTA of the free drugs. Conjugates with TP(Co) were much more toxic on their activation with ascorbic acid (AA): in the presence of AA the CTA of AFP-TP(Co) and of EGF-TP(Co) was 19 and 61.1% higher, respectively, than the CTA of the free TP(Co). Topics: alpha-Fetoproteins; Antineoplastic Agents; Cell Division; Chlorine; Epidermal Growth Factor; Heme; Humans; Indoles; Isoindoles; Tumor Cells, Cultured	2000

Article

Year

Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery?

Small (Weinheim an der Bergstrasse, Germany), 2011, Aug-22, Volume: 7, Issue:16

EGF-modified Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide-targeted Au NPs. Compared to the untargeted conjugates, EGF-Au NP-Pc 4 conjugates showed 10-fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard-to-reach cancers.

Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Delayed-Action Preparations; Epidermal Growth Factor; ErbB Receptors; Glioma; Gold; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Isoindoles; Metal Nanoparticles; Mice; Nanocapsules; Nanoconjugates; Photochemotherapy; Photosensitizing Agents; Treatment Outcome

2011

Cytotoxic action of conjugates of alpha-fetoprotein and epidermal growth factor with photoheme, chlorines, and phthalocyanines.

Biochemistry. Biokhimiia, 2000, Volume: 65, Issue:6

Covalently bound conjugates of alpha-fetoprotein (AFP) and epidermal growth factor (EGF) with photoheme (PH), 3-desvinyl-3-formylchlorine p6 (Chl p6), chlorine e6 (Chl e6), aluminum disulfochloride phthalocyanine (PC(Al)), and cobalt octa-4,5-carboxyphthalocyanine (teraphthal, TP(Co)) were synthesized. Their molar ratios were 1:4 for AFP-cytotoxin conjugates (cf. 1:10 for AFP-TP(Co)) and 1:2 for EGF conjugates (cf. 1:1 for EGF-PC(Al)). Dark toxicity of both protein conjugates with PH, chlorines, and PC(Al) was much lower than their phototoxicity. Studies on phototoxicity demonstrated that PC(Al) conjugates with AFP and EGF and also EGF-Chl p6 were the most effective. The cytotoxic activity (CTA) of AFP-PC(Al) and EGF-Chl p6 was 80% and of EGF-PC(Al) 64% higher than the CTA of the free drugs. Conjugates with TP(Co) were much more toxic on their activation with ascorbic acid (AA): in the presence of AA the CTA of AFP-TP(Co) and of EGF-TP(Co) was 19 and 61.1% higher, respectively, than the CTA of the free TP(Co).

Topics: alpha-Fetoproteins; Antineoplastic Agents; Cell Division; Chlorine; Epidermal Growth Factor; Heme; Humans; Indoles; Isoindoles; Tumor Cells, Cultured

2000