epidermal-growth-factor and luzindole

Neural stem cells (NSCs) in the adult brain transit from the quiescent state to proliferation to produce new neurons. The mechanisms regulating this transition in freely behaving animals are, however, poorly understood. We customized in vivo imaging protocols to follow NSCs for several days up to months, observing their activation kinetics in freely behaving mice. Strikingly, NSC division is more frequent during daylight and is inhibited by darkness-induced melatonin signaling. The inhibition of melatonin receptors affected intracellular Ca

Topics: Adult Stem Cells; Animals; Astrocytes; Behavior, Animal; Calcium; Cell Division; Cell Proliferation; Circadian Rhythm; Cytosol; Epidermal Growth Factor; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Space; Melatonin; Mice; Neural Stem Cells; Optogenetics; Signal Transduction; Tryptamines