epidermal-growth-factor and carvacrol

The aim of this study was to evaluate the effect of carvacrol on serum level of inflammatory mediators and respiratory symptoms in the veterans exposed to sulfur mustard (SM).. Twenty-one patients who were exposed to SM more than two decades' ago were divided to placebo and carvacrol (1.2 mg/kg/day) treated groups. Serum levels of Tumor Necrosis Factor-α (TNF-α), Monocyte chemotactic protein-1 (MCP-1), Vascular endothelial growth factor (VEGF), Epidermal growth factor (EGF), forced expiratory volume-one second (FEV. FEV. Two months' treatment with carvacrol reduced inflammatory cytokine and chemokine while increased anti-inflammatory cytokines and improved respiratory symptom and FEV. This trial was registered under IRCT2014031617020N1 at http://www.irct.ir/.

Topics: Chemokine CCL2; Chemokines; Cough; Cymenes; Cytokines; Epidermal Growth Factor; Forced Expiratory Volume; Humans; Inflammation Mediators; Inhalation Exposure; Middle Aged; Mustard Gas; Placebos; Respiratory Function Tests; Respiratory Sounds; Respiratory Tract Diseases; Terpenes; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Veterans

The transient receptor potential vanilloid 3 (TRPV3) channel is a Ca

Topics: Boron Compounds; Cell Line, Transformed; Cymenes; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; HEK293 Cells; Humans; Keratinocytes; MAP Kinase Signaling System; Membrane Transport Modulators; Mitogen-Activated Protein Kinase 3; Monoterpenes; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Phosphorylation; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Recombinant Proteins; Threonine; TRPV Cation Channels; Up-Regulation