epidermal-growth-factor and 2-(4-amylcinnamoyl)amino-4-chlorobenzoic-acid

epidermal-growth-factor has been researched along with 2-(4-amylcinnamoyl)amino-4-chlorobenzoic-acid* in 1 studies

Other Studies

1 other study(ies) available for epidermal-growth-factor and 2-(4-amylcinnamoyl)amino-4-chlorobenzoic-acid

Article	Year
Cytoplasmic phospholipase A2 antagonists inhibit multiple endocytic membrane trafficking pathways. Biochemical and biophysical research communications, 2009, Oct-30, Volume: 388, Issue:4 Previous studies have suggested a role for cytosolic Ca(2+)-independent phospholipase A(2) (PLA(2)) activity in the formation of endosome membrane tubules that participate in the export of transferrin (Tf) and transferrin receptors (TfR) from sorting endosomes (SEs) and the endocytic recycling compartment (ERC). Here we show that the PLA(2) requirement is a general feature of endocytic trafficking. The reversible cytoplasmic PLA(2) antagonist ONO-RS-082 (ONO) produced a concentration-dependent, differential block in the endocytic recycling of both low-density lipoprotein receptor (LDLR) and TfRs, and in the degradative pathways of LDL and epidermal growth factor (EGF). These results are consistent with the model that a cytoplasmic PLA(2) plays a general role in the export of cargo from multiple endocytic compartments by mediating the formation of membrane tubules. Topics: Aminobenzoates; Biological Transport; Chlorobenzoates; Cinnamates; Cytoplasm; Endocytosis; Epidermal Growth Factor; Humans; Intracellular Membranes; ortho-Aminobenzoates; Phosphodiesterase Inhibitors; Phospholipases A2, Cytosolic; Receptors, LDL; Receptors, Transferrin	2009

Article

Year

Cytoplasmic phospholipase A2 antagonists inhibit multiple endocytic membrane trafficking pathways.

Biochemical and biophysical research communications, 2009, Oct-30, Volume: 388, Issue:4

Previous studies have suggested a role for cytosolic Ca(2+)-independent phospholipase A(2) (PLA(2)) activity in the formation of endosome membrane tubules that participate in the export of transferrin (Tf) and transferrin receptors (TfR) from sorting endosomes (SEs) and the endocytic recycling compartment (ERC). Here we show that the PLA(2) requirement is a general feature of endocytic trafficking. The reversible cytoplasmic PLA(2) antagonist ONO-RS-082 (ONO) produced a concentration-dependent, differential block in the endocytic recycling of both low-density lipoprotein receptor (LDLR) and TfRs, and in the degradative pathways of LDL and epidermal growth factor (EGF). These results are consistent with the model that a cytoplasmic PLA(2) plays a general role in the export of cargo from multiple endocytic compartments by mediating the formation of membrane tubules.

Topics: Aminobenzoates; Biological Transport; Chlorobenzoates; Cinnamates; Cytoplasm; Endocytosis; Epidermal Growth Factor; Humans; Intracellular Membranes; ortho-Aminobenzoates; Phosphodiesterase Inhibitors; Phospholipases A2, Cytosolic; Receptors, LDL; Receptors, Transferrin

2009