epiberberine has been researched along with berberine in 38 studies
| Studies (epiberberine) | Trials (epiberberine) | Recent Studies (post-2010) (epiberberine) | Studies (berberine) | Trials (berberine) | Recent Studies (post-2010) (berberine) |
|---|---|---|---|---|---|
| 49 | 0 | 37 | 4,106 | 102 | 2,791 |
| Protein | Taxonomy | epiberberine (IC50) | berberine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.7827 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 6.97 | |
| Cholinesterase | Homo sapiens (human) | 1.09 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.4 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 4.99 | |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | 6.71 | |
| Cholinesterase | Equus caballus (horse) | 9.4 | |
| Cytochrome P450 1B1 | Homo sapiens (human) | 0.9747 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 2 (5.26) | 29.6817 |
| 2010's | 28 (73.68) | 24.3611 |
| 2020's | 6 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y | 1 |
| Bae, GU; Jeong, JH; Lee, H; Lee, SJ; Ryu, JH; Tuong, LT | 1 |
| Fu, DJ; Li, J; Yu, B | 1 |
| Fang, DC; Wang, JL | 1 |
| Fang, XP; Li, D; Shuai, H; Wang, TZ; Xie, CK; Zhang, H | 1 |
| Liang, X; Ren, L; Xu, Q; Xue, X; Zhang, F | 1 |
| Gold, AB; Keller, AB; Perry, DC | 1 |
| Geng, Z; Luo, W; Qu, X; Zhang, Y; Zheng, H | 1 |
| Chen, LQ; Ding, PL; Li, YG; Lu, Y | 1 |
| Feng, W; Kong, J; Wang, Z; Zhang, Q; Zhu, J | 1 |
| Liang, JQ; Lu, ZM; Tu, PF; Wang, HT; Zhang, H; Zhao, SH | 1 |
| Fan, G; Lai, XR; Luo, WZ; Tang, C; Yue, QH; Zhang, MY; Zhang, Y; Zhou, XD | 1 |
| He, K; Li, X; Liu, X; Wang, D; Yang, Y; Ye, X; Yi, J | 1 |
| Huang, QW; Li, XF; Su, J; Wang, J; Zhang, YL | 1 |
| Kang, J; Zhang, Y | 1 |
| Li, BC; Li, JX; Wang, JY; Wang, RL; Xiao, XH; Yan, D; Zhang, LL | 1 |
| Liu, JX; Ma, ZT; Yang, XW; Zhang, Y | 1 |
| Bian, B; Han, L; Li, Y; Ren, W; Si, N; Wang, H; Wei, X; Xin, S; Yang, J; Zhao, H; Zuo, R | 1 |
| Chen, G; Jia, H; Lin, C; Liu, H; Shao, Y; Wang, Y; Yang, D; Zhang, L | 1 |
| Cai, F; Hu, P; Li, Y; Wang, Y; Zhang, H; Zhang, M | 1 |
| Miao, PP; Su, J; Sun, GX; Xue, BJ; Yang, XY; Ye, J; Zhang, YJ; Zhao, YY | 1 |
| Dai, GL; Feng, CT; Ju, WZ; Ma, ST; Miao, CG; Song, Y; Yu, H; Zhang, XL; Zhou, GL | 1 |
| Bergman, J; Desai, RI | 1 |
| Ali, MY; Choi, JS; Choi, RJ; Jung, HA; Jung, HJ; Kim, GD; Kim, JH; Min, BS | 1 |
| Bai, M; Jiang, H; Li, L; Song, F; Sun, S; Weng, Y; Zeng, S; Zhou, H; Zhou, S | 1 |
| Feng, M; Hu, YR; Li, XG; Ma, H; Ye, XL; Zou, ZY | 1 |
| Chen, C; Lian, W; Liu, S; Shi, L; Su, R; Wan, D; Wang, Y; Xu, N; Yang, H; Yao, W | 1 |
| Chen, H; Li, C; Liu, Y; Ma, Z; Mo, Z; Su, Z; Tan, L; Xie, J; Xu, Y; Yang, X; Zhou, J | 1 |
| Cong, H; Deng, S; Huo, X; Sun, C; Wang, C; Wang, Y; Wu, B; Xiang, T; Zhang, B; Zhang, H; Zhang, L; Zhao, X; Zheng, L | 1 |
| Bi, XN; Chen, HY; Chen, JH; Chen, N; Guo, CE; Li, HP; Lin, HY; Yang, XY; Zhang, YJ | 1 |
| Jiang, Y; Li, HJ; Li, P; Lu, J; Ni, H; Wu, TJ | 1 |
| Lin, C; Onel, B; Sakai, S; Shao, Y; Wang, K; Wu, G; Yang, D | 1 |
| Chen, J; Jia, B; Li, P; Liu, J; Ma, D; Tang, W; Wang, J; Zhou, J | 1 |
| Chen, X; Hou, Y; Kong, Q; Liu, X; Lu, JJ; Zhang, Q; Zhang, Y; Zhou, GJ | 1 |
| He, Y; Li, J; Liu, L | 1 |
| Deng, J; Gong, X; Gui, Z; Huang, J; Li, C; Li, X; Liu, Y; Xiao, Y; Ye, X; Zhang, Y | 1 |
| Chai, X; Fan, JH; Li, XD; Li, XG; Wang, QJ; Xiong, MY; Xu, MM; Ye, XL; Zhou, LM | 1 |
| Huang, T; Jiao, B; Li, X; Ma, H; Tang, Q; Tang, X; Wang, R; Wu, H; Xie, X; Ye, X; Zhu, X | 1 |
2 review(s) available for epiberberine and berberine
| Article | Year |
|---|---|
Annual review of LSD1/KDM1A inhibitors in 2020.
Topics: Antineoplastic Agents, Phytogenic; Enzyme Inhibitors; Histone Demethylases; Humans; Molecular Structure; Neoplasms | 2021 |
Multifunctional epiberberine mediates multi-therapeutic effects.
Topics: Adipogenesis; Animals; Anti-Obesity Agents; Antineoplastic Agents, Phytogenic; Berberine; Coptis; Humans; Hypolipidemic Agents; Molecular Structure; Phytochemicals | 2020 |
36 other study(ies) available for epiberberine and berberine
| Article | Year |
|---|---|
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites | 2011 |
Isoquinoline alkaloids from Coptis japonica stimulate the myoblast differentiation via p38 MAP-kinase and Akt signaling pathway.
Topics: Alkaloids; Animals; Cell Differentiation; Cell Line; Coptis; Mice; Myoblasts | 2017 |
[Effect of epiberberine on alpha-adrenoceptors].
Topics: Animals; Berberine; Blood Pressure; Dogs; Female; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
[Quantitative determination of 5 alkaloids in plants of Coptis from China].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, Thin Layer; Densitometry; Drugs, Chinese Herbal; Triterpenes | 1989 |
High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs.
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis chinensis; Drugs, Chinese Herbal; Mass Spectrometry; Molecular Structure; Phellodendron | 2007 |
Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Berberine; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Female; Male; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes; Synaptosomes; Thalamus; Tritium; Up-Regulation | 2009 |
[Simultaneous determination of six alkaloids in Coptis chinensis of different regions by RP-HPLC].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal | 2010 |
Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method.
Topics: Berberine; Berberine Alkaloids; Coptis; Limit of Detection; Magnetic Resonance Spectroscopy | 2012 |
[Quantitative analysis of four alkaloids in Xianglian preparations by QAMS method].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Evaluation Studies as Topic; Quality Control; Reference Standards | 2011 |
Total synthesis of epiberberine.
Topics: Berberine; Berberine Alkaloids; Catalysis; Cyclization; Molecular Structure | 2012 |
Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.
Topics: Berberine; Berberine Alkaloids; Coptis; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Multivariate Analysis; Plant Extracts; Principal Component Analysis; Rhizome; Species Specificity | 2012 |
Safety evaluation of main alkaloids from Rhizoma Coptidis.
Topics: 3T3-L1 Cells; Alkaloids; Animals; Berberine; Berberine Alkaloids; Blood Proteins; Body Weight; Coptis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Lethal Dose 50; Male; Mice; Organ Size; Rats; Rats, Sprague-Dawley; Rhizome | 2013 |
[Classification study of Coptis chinensis based on quantitative physical property characteristics of appearance and internal quality evaluation].
Topics: Berberine; Berberine Alkaloids; Coptis; Drugs, Chinese Herbal; Quality Control | 2012 |
[Screening of the active ingredients in natural products by capillary electrophoresis and high performance liquid chromatography-mass spectrometry].
Topics: Acetylcholinesterase; Alkaloids; Berberine; Berberine Alkaloids; Biological Products; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Electrophoresis, Capillary; Tandem Mass Spectrometry | 2013 |
[Microcalorimetric investigation on the interaction of six alkaloids from rhizoma coptidis].
Topics: Alkaloids; Berberine; Berberine Alkaloids; Coptis; Drug Interactions; Drug Synergism; Plants, Medicinal; Quality Control; Rhizome; Shigella dysenteriae | 2013 |
Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction.
Topics: Administration, Oral; Alkaloids; Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavonoids; Glucosides; Iridoids; Molecular Structure; Rats; Rats, Sprague-Dawley | 2014 |
Metabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer.
Topics: Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Metabolomics; Models, Animal; Tandem Mass Spectrometry; Zebrafish | 2015 |
Selective lighting up of epiberberine alkaloid fluorescence by fluorophore-switching aptamer and stoichiometric targeting of human telomeric DNA G-quadruplex multimer.
Topics: Alkaloids; Aptamers, Nucleotide; Berberine; Circular Dichroism; DNA; Fluorescence; Fluorescent Dyes; G-Quadruplexes; Humans; Light; Telomere | 2015 |
Two-stage fractionation of polar alkaloids from Rhizoma coptidis by countercurrent chromatography considering the strategy of reactive extraction.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chemical Fractionation; Countercurrent Distribution; Drugs, Chinese Herbal; Plants, Medicinal; Ranunculaceae | 2015 |
[Identification of metabolites of epiberberine in rat liver microsomes and its inhibiting effects on CYP2D6].
Topics: Animals; Berberine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drugs, Chinese Herbal; Male; Microsomes, Liver; Molecular Structure; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2014 |
In silico target fishing for the potential bioactive components contained in Huanglian Jiedu Tang (HLJDD) and elucidating molecular mechanisms for the treatment of sepsis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Berberine; Dinoprostone; Drugs, Chinese Herbal; Humans; KB Cells; Platelet Membrane Glycoproteins; Protein Transport; Receptors, G-Protein-Coupled; Receptors, Thromboxane A2, Prostaglandin H2; Sepsis; Tetradecanoylphorbol Acetate | 2015 |
Effects of the Nanoparticle-Based Vaccine, SEL-068, on Nicotine Discrimination in Squirrel Monkeys.
Topics: Analysis of Variance; Animals; Berberine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Immunization; Immunologic Factors; Male; Nanoparticles; Nicotine; Nicotinic Agonists; Saimiri; Time Factors; Vaccines; Varenicline | 2015 |
Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways.
Topics: 3T3-L1 Cells; Adipogenesis; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Berberine; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Oncogene Protein v-akt; raf Kinases; Signal Transduction | 2015 |
Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Berberine; Berberine Alkaloids; Cells, Cultured; Chromatography, Liquid; Dogs; Humans; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Octamer Transcription Factor-3; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymorphism, Genetic; Tandem Mass Spectrometry | 2016 |
Epiberberine reduces serum cholesterol in diet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolism.
Topics: Adipose Tissue; Animals; Berberine; Bile Acids and Salts; Biological Transport; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholesterol, Dietary; Cricetinae; Diet, High-Fat; Dyslipidemias; Feces; Gene Expression Regulation, Enzymologic; Liver; Male; Mesocricetus; Organ Size; Receptors, LDL | 2016 |
High-throughput screening of triplex DNA binders from complicated samples by 96-well pate format in conjunction with peak area-fading UHPLC-Orbitrap MS.
Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; DNA; High-Throughput Screening Assays; Mass Spectrometry; Phellodendron; Reproducibility of Results | 2017 |
Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: Susceptibility and mechanism.
Topics: Berberine; Canavalia; Coptis chinensis; Cysteine; Dithiothreitol; Drugs, Chinese Herbal; Glutathione; Helicobacter pylori; Hydroxamic Acids; Kinetics; Molecular Docking Simulation; Molecular Structure; Plant Proteins; Urease | 2017 |
Comparative pharmacokinetics study of five alkaloids in rat plasma and related compound-herb interactions mechanism after oral administration of Shuanghua Baihe tablets.
Topics: Administration, Oral; Alkaloids; Animals; Berberine; Berberine Alkaloids; Chromatography, Liquid; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Rats; Tablets; Tandem Mass Spectrometry | 2018 |
The oral bioavailability, excretion and cytochrome P450 inhibition properties of epiberberine: an in vivo and in vitro evaluation.
Topics: Administration, Oral; Animals; Berberine; Biological Availability; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Hepatobiliary Elimination; Humans; Intestinal Absorption; Intestinal Elimination; Male; Microsomes, Liver; Rats, Sprague-Dawley; Renal Elimination; Tandem Mass Spectrometry | 2018 |
Construction of an optimized method for quality evaluation and species discrimination of Coptidis Rhizoma by ion-pair high performance liquid chromatography combined with response surface methodology.
Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Ions; Reference Standards; Rhizome | 2018 |
Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures.
Topics: Base Sequence; Berberine; Binding Sites; Circular Dichroism; Drugs, Chinese Herbal; G-Quadruplexes; Humans; Intercalating Agents; Nucleic Acid Conformation; Potassium; Proton Magnetic Resonance Spectroscopy; Telomere | 2018 |
A method using angiotensin converting enzyme immobilized on magnetic beads for inhibitor screening.
Topics: Angiotensin-Converting Enzyme Inhibitors; Benzylisoquinolines; Berberine; Chromatography, Affinity; Chromatography, High Pressure Liquid; Cost-Benefit Analysis; Drug Evaluation, Preclinical; Enzyme Assays; Enzymes, Immobilized; HEK293 Cells; Humans; Oligopeptides; Peptidyl-Dipeptidase A; Recombinant Proteins; Tandem Mass Spectrometry | 2019 |
Natural alkaloid 8-oxo-epiberberine inhibited TGF-β1-triggred epithelial-mesenchymal transition by interfering Smad3.
Topics: Animals; Antineoplastic Agents; Berberine; Cell Adhesion; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Smad3 Protein; Transforming Growth Factor beta1 | 2020 |
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Topics: Angiotensinogen; Animals; Berberine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Gene Expression Regulation; Kidney; Male; Mesangial Cells; Mice, Obese; Molecular Docking Simulation; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2021 |
Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis.
Topics: Animals; Berberine; Lipids; Mice; Non-alcoholic Fatty Liver Disease | 2023 |
Epiberberine inhibits Helicobacter pylori and reduces host apoptosis and inflammatory damage by down-regulating urease expression.
Topics: Animals; Berberine; Helicobacter Infections; Helicobacter pylori; Inflammation; Molecular Docking Simulation; Urease | 2024 |