epibatidine has been researched along with nicotine in 257 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 47 (18.29) | 18.2507 |
| 2000's | 155 (60.31) | 29.6817 |
| 2010's | 53 (20.62) | 24.3611 |
| 2020's | 2 (0.78) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, P; Anderson, DJ; Bannon, AW; Brioni, JD; Buckley, MJ; Decker, MW; Donnelly-Roberts, D; Kang, CH; Piattoni-Kaplan, M; Sullivan, JP | 1 |
| Biftu, T; Eckman, J; Ip, S; Li, T; Libertine-Garahan, L; Qian, C; Shen, TY | 1 |
| Damaj, MI; Martin, BR | 1 |
| Nordberg, A; Warpman, U | 1 |
| Khan, IM; Marsala, M; Printz, MP; Taylor, P; Yaksh, TL | 1 |
| Changeux, JP; Léna, C | 2 |
| Baranyi, M; Lajtha, A; Lendvai, B; Santha, E; Sershen, H; Vizi, ES | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS | 1 |
| Flores, CM; Hargreaves, KM; Ulrich, YM | 1 |
| Dávila-García, MI; Flores, CM; Kellar, KJ; Ulrich, YM | 1 |
| Bickler, PE; Eilers, H; Forsayeth, JR; Schaeffer, E | 1 |
| Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M | 1 |
| Gallardo, KA; Leslie, FM | 1 |
| Bishop, K; Gong, ZH; Liu, C; Miao, H; Nordberg, A; Zhang, X | 1 |
| Gorbounova, O; Hellström-Lindahl, E; Jönsson, P; Miao, H; Mousavi, M; Nordberg, A; Svensson, AL | 1 |
| Bencherif, M; Bhatti, BS; Caldwell, WS; Crooks, P; Fowler, K; Lippiello, PM; Lovette, ME; Reeves, L; Schmitt, JD | 1 |
| Baylis, HA; Buckingham, SD; Freeman, JC; Matsuda, K; Sattelle, DB; Squire, MD | 1 |
| Friberg, L; Gillespie, A; Hellström-Lindahl, E; Nordberg, A; Warpman, U; Zhang, X | 1 |
| Arneric, SP; Delbono, O; Gopalakrishnan, M; Messi, ML; Molinari, EJ; Renganathan, M; Sullivan, JP | 1 |
| Gurley, DA; Lanthorn, TH | 1 |
| Mellerup, E; Plenge, P | 1 |
| Gillberg, PG; Nordberg, A; Sihver, W | 1 |
| Kellar, KJ; Meyer, EL; Surin, A; Thompson, JM; Wroblewski, J; Xiao, Y | 1 |
| Gorbounova, O; Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Seiger, A | 1 |
| Dannals, RF; Finley, P; Mochizuki, T; Musachio, JL; Scheffel, U; Villemagne, VL; Wagner, HN; Zhan, Y | 1 |
| Bogdanovic, N; Marutle, A; Nordberg, A; Warpman, U | 1 |
| Albuquerque, EX; Conti-Fine, BM; Cortes, WS; Horton, RM; Karachunski, PI; Macklin, K; Maus, AD; Navaneetham, D; Pereira, EF | 1 |
| Beck, A; Luetje, CW; Parker, MJ | 1 |
| Gong, ZH; Liu, C; Miao, H; Nordberg, A; Zhang, X | 1 |
| Buerkle, H; Khan, IM; Taylor, P; Yaksh, TL | 1 |
| Bayer, BM; Mellon, RD | 1 |
| Bogdanovic, N; Lannfelt, L; Marutle, A; Nordberg, A; Warpman, U | 1 |
| Bottlaender, M; Coulon, C; Crouzel, C; Dollé, F; Fuseau, C; Guenther, I; Hinnen, F; Ottaviani, M; Valette, H | 1 |
| Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Ravid, R; Zhang, X | 1 |
| Kellar, KJ; Wainer, IW; Xiao, Y; Zhang, Y | 1 |
| Changeux, JP; Cordero-Erausquin, M; Damaj, MI; de Kerchove d'Exaerde, A; del Mar Arroyo-Jimenez, M; Huchet, M; Le Novère, N; Léna, C; Marubio, LM | 1 |
| Lembeck, F | 1 |
| Cohen, BN; Crooks, PA; Dwoskin, LP; Figl, A; Forsayeth, JR; Houng, M; Sandhu, S; Shafaee, N; Truong, A; Viseshakul, N | 1 |
| Gillberg, PG; Nordberg, A; Sihver, W; Svensson, AL | 1 |
| Nordberg, A; Svensson, AL | 1 |
| Bertrand, D; Blanchet, C; Raggenbass, M; Tribollet, E; Zaninetti, M | 1 |
| Collins, AC; Gallagher, T; Kaiser, S; Marks, MJ; Sharples, CG; Soliakov, L; Spencer, JA; Washburn, M; Whiteaker, P; Wonnacott, S; Wright, E | 1 |
| Boye, S; Clarke, PB; Reuben, M | 1 |
| Anderson, DJ; Dart, MJ; Decker, MW; Kim, KH; Meyer, MD; Rueter, LE; Sullivan, JP; Williams, M | 1 |
| Fujii, S; Jia, Y; Sumikawa, K; Yang, A | 1 |
| Clementi, F; Di Angelantonio, S; Gotti, C; Moretti, M; Nistri, A | 1 |
| Boyce, S; Hill, RG; Rupniak, NMJ; Russell, MGN; Shepheard, SL; Webb, JK | 1 |
| Davis, CB; Lee, J; Reitz, AB; Rivero, RA; Shank, RP | 1 |
| Booth, S; Breese, CR; Caggiula, AR; Donny, EC; Lee, MJ; Leonard, S; McCallum, SE; Sved, AF | 1 |
| Berkovic, SF; Clifford, JJ; Drago, J; Horne, MK; Kinsella, A; Kola, I; Massalas, JS; Ross, SA; Scheffer, IE; Waddington, JL; Wong, JY | 1 |
| Adams, CE; Breese, CR; Collins, AC; Gillen, KM; Lee, MJ; Leonard, S; Logel, J; Marks, MJ; Sullivan, B | 1 |
| Collins, AC; Jimenez, M; Marks, MJ; McIntosh, JM; Whiteaker, P | 1 |
| Bertrand, D; Buisson, B; Green, WN; Vallejo, YF | 1 |
| Faltynek, CR; Jacobs, I; Puttfarcken, PS | 1 |
| Ahtee, L; Seppä, T | 1 |
| Perry, DC; Tizabi, Y | 1 |
| Hauser, KF; Opanashuk, LA; Pauly, JR | 1 |
| Breese, CR; Lee, MJ; Leonard, S; Strook, ML | 1 |
| Morgan, D; Parsons, ME; Whelan, CJ | 1 |
| Gaynor, CM; Handley, SL | 1 |
| Cormier, A; Lagrue, G; Morin, C; Tillement, JP; Zini, R | 1 |
| Tuominen, RK; Vainio, PJ | 1 |
| Ridley, DL; Rogers, A; Wonnacott, S | 1 |
| Kellar, KJ; Meyer, EL; Xiao, Y | 1 |
| Hellström-Lindahl, E; Kjaeldgaard, A; Nordberg, A | 1 |
| Gündisch, D; Harms, K; Schwarz, S; Seitz, G; Stubbs, MT; Wegge, T | 1 |
| Genzen, JR; McGehee, DS; Van Cleve, W | 1 |
| Casida, JE; Cowan, A; Tomizawa, M | 1 |
| Bassetto, L; Broide, R; De Biasi, M; Franceschini, D; Gotti, C; Paylor, R; Salas, R | 1 |
| Bessis, A; Champtiaux, N; Changeux, JP; Han, ZY; Marubio, L; McIntosh, JM; Rossi, FM; Zoli, M | 1 |
| Changeux, JP; Grutter, T; Le Novère, N | 1 |
| Gong, ZH; Meyerson, B; Nordberg, A; Svensson, AL; Tian, JY; Zhang, X | 1 |
| Bottlaender, M; Coulon, C; Dannals, RF; Dolle, F; Kassiou, M; Loc'h, C; Maziere, B; Musachio, JL; Ottaviani, M | 1 |
| Anderson, DJ; Jacobs, I; Puttfarcken, PS; Surowy, CS | 1 |
| Rashid, MH; Ueda, H | 1 |
| Gálvez, E; Iriepa, I; Maseras, F; Morreale, A | 1 |
| Harkness, PC; Millar, NS | 1 |
| Gentry, CL; Lukas, RJ; Wilkins, LH | 1 |
| Margiotta, JF; McIntosh, JM; Nai, Q | 1 |
| Lee, DH; Wang, HY | 1 |
| Markus, RP; Reno, LA; Santos, JM; Zago, W | 1 |
| Pauly, JR; Scheff, SW; Verbois, SL | 1 |
| Kiss, JP; Mandl, P; Vizi, ES | 1 |
| Guan, ZZ; Nordberg, A; Yu, WF | 1 |
| Arroyo-Jimenez, MM; Champtiaux, N; Changeux, JP; David, D; Durier, S; Gardier, AM; Klink, R; Marubio, LM; McIntosh, JM; Rossi, F; Zoli, M | 1 |
| Bourgeois, JP; Cardona, A; Changeux, JP; Han, ZY; Le Novère, N; Zoli, M | 1 |
| Dávila-García, MI; Kellar, KJ; Musachio, JL | 1 |
| Dukat, M; Glennon, RA | 1 |
| Hopkins, DM; Pauly, JR; Scheff, SW; Verbois, SL | 1 |
| Akamatsu, M; Komai, K; Kuwamura, M; Matsuda, K; Miyagawa, H; Nakagawa, Y; Nishiwaki, H; Sato, K | 1 |
| Bräuner-Osborne, H; Falch, E; Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Mikkelsen, I | 1 |
| Ascarrunz, VS; Avila, AM; Dávila-García, MI; Kellar, KJ; Xiao, Y | 1 |
| Nguyen, HN; Perry, DC; Rasmussen, BA | 2 |
| Adams, P; Correa, LD; Rao, TS; Sacaan, AI; Santori, EM | 1 |
| Matsumoto, A; Matsuyama, S | 1 |
| Dussor, GO; Flores, CM; Gracia, NB; Hargreaves, KM; Kilo, S; Leong, AS; Price, TJ | 1 |
| Fernández, R; Larraín, C; Reyes, EP; Zapata, P | 1 |
| Court, JA; Davis, KL; Haroutunian, VH; Long, P; Martin-Ruiz, CM; Perry, EK; Young, AH | 1 |
| Fu, Y; Lindstrom, JM; Luo, J; McAllen, K; McIntosh, JM; Parker, SL; Sharp, BM | 1 |
| Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Ravid, R | 1 |
| Kellar, KJ; Xiao, Y | 1 |
| Kellar, KJ; Kozikowski, AP; Wei, ZL; Xiao, Y | 1 |
| Cao, JZ; Collins, AC; Grady, SR; Marks, MJ; McCallum, SE; Rowell, PP | 1 |
| Ahtee, L; Janhunen, S | 1 |
| Bednar, I; Friberg, L; Nordberg, A | 1 |
| Bordia, T; Clementi, F; Fan, H; Gotti, C; Kulak, JM; McIntosh, JM; Quik, M; Vailati, S | 1 |
| Collins, AC; Deshpande, P; Labarca, C; Lester, HA; Marks, MJ; McKinney, SL; Nashmi, R; Schwarz, J; Tapper, AR; Whiteaker, P | 1 |
| De Biasi, M; Pieri, F; Salas, R | 1 |
| Frenz, CM; Gueorguiev, VD; Ronald, KM; Sabban, EL | 1 |
| Fryer, JD; George, AA; Groppi, VE; Hurst, RS; Leonard, SS; Lukas, RJ; Morrissy, S; Peng, JH; Schroeder, KM | 1 |
| Chaijale, N; Commons, KG; Cucchiaro, G | 1 |
| Ingram, N; Loiacono, R; Martin, S; van den Buuse, M; van der Laan, S; Wang, JH | 1 |
| Cashin, AL; Dougherty, DA; Lester, HA; Petersson, EJ | 1 |
| Genzen, JR; McGehee, DS | 1 |
| Jozwiak, K; Moaddel, R; Wainer, IW; Whittington, K | 1 |
| Casida, JE; Durkin, KA; Kanne, DB; Tomizawa, M | 1 |
| Edwards, B; Richmond, JE; Sattelle, DB; Towers, PR | 1 |
| Ahtee, L; Janhunen, S; Piepponen, TP; Tuominen, RK | 1 |
| Collins, AC; Grady, SR; Marks, MJ; McIntosh, JM; Salminen, O; Whiteaker, P | 1 |
| Eaton, JB; Kuo, YP; Lukas, RJ; Wu, J; Xu, L; Zhao, L | 1 |
| Ahtee, L; Nuutinen, S; Tuominen, RK | 1 |
| Ahtee, L; Janhunen, S; Tuominen, RK | 1 |
| Grilli, M; Marchi, M; Parodi, M; Raiteri, M | 1 |
| Changeux, JP; Corringer, PJ; Devillers-Thiery, A; Pons, S; Prado de Carvalho, L; Sallette, J; Soudant, M | 1 |
| Jones, IW; Pullar, IA; Rousseau, SJ; Wonnacott, S | 1 |
| Collins, AC; Marks, MJ; McCallum, SE; Paylor, R | 1 |
| Chen, H; Matta, SG; Parker, SL; Sharp, BM | 1 |
| Gao, J; Hui, X; Ogiku, T; Suto, N; Wang, MW; Xie, X | 1 |
| Bills, KL; Botting, SK; Lindstrom, J; Liu, H; Person, AM; Wells, GB | 1 |
| Guan, ZZ; Mousavi, M; Nordberg, A; Nordman, T; Olsson, JM; Shan, KR; Xiu, J; Yu, WF | 1 |
| Canu-Boido, C; Clementi, F; Di Angelantonio, S; Gaimarri, A; Gotti, C; Matteoni, C; Nistri, A; Riganti, L; Sparatore, F | 1 |
| Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA | 1 |
| Garzotti, M; Heidbreder, CA; Mugnaini, M; Pilla, M; Repeto, P; Sartori, I; Tessari, M | 1 |
| Badyuk, M; Daly, JW; Kellar, KJ; Ohtani, M; Oka, T; Xiao, Y | 1 |
| Abin-Carriquiry, JA; Bermúdez, I; Cassels, BK; Dajas, F; Wonnacott, S | 1 |
| Ahtee, L; Janhunen, S; Linnervuo, A; Svensk, M | 1 |
| Grilli, M; Marchi, M; Parodi, M; Patti, L; Raiteri, L; Raiteri, M | 1 |
| Hu, J; Kuo, YP; Liu, Q; Lukas, RJ; Segerberg, M; St John, PA; Wu, J; Yu, K | 1 |
| Bordia, T; Fan, H; Langston, JW; McIntosh, JM; Parameswaran, N; Quik, M | 1 |
| Akamatsu, M; Ihara, M; Matsuda, K; Sattelle, DB; Shimomura, M; Yokota, M | 1 |
| Casares, FM; Kream, RM; Mantione, KJ; Sheehan, MH; Stefano, GB; Zhu, W | 1 |
| Huang, LZ; Winzer-Serhan, UH | 1 |
| Abraham, P; Damaj, MI; Ivy Carroll, F; Ma, W; Martin, BR; Navarro, HA; Wolckenhauer, SA | 1 |
| Di Monte, DA; Khwaja, M; McCormack, A; McIntosh, JM; Quik, M | 1 |
| Collins, AC; Damaj, MI; Deshpande, P; Fonck, C; Labarca, C; Lester, HA; Marks, MJ; Martin, BR | 1 |
| Abbott, LC; Huang, LZ; Winzer-Serhan, UH | 1 |
| Drisdel, RC; Green, WN; Hales, TG; Henderson, T; Sharp, D | 1 |
| Boyd, RT; Dávila-García, MI; Langley, R; Mishra, NC; Nandi, JS; Pena-Philippides, JC; Razani-Boroujerdi, S; Singh, SP; Sopori, ML | 1 |
| Kellar, KJ; Mao, D; Perry, DC; Wolfe, BB; Yasuda, RP | 1 |
| Gahring, LC; Osborne-Hereford, AV; Rogers, SW; Vasquez-Opazo, GA | 1 |
| Bernier, M; Hyppolite, P; Juhaszova, M; Kellar, KJ; Kimura, T; Moaddel, R; Oliveira, RV; Wainer, IW; Xiao, Y | 1 |
| Kaniaková, M; Krůsek, J; Lindovský, J; Svobodová, L; Vyskocil, F | 1 |
| Gross, D; James, JR; Pehrson, AL; Philibin, SD; Robinson, SE; Rosecrans, JA; Vann, RE | 1 |
| Besanger, TR; Brennan, JD; Sharma, J | 1 |
| Huang, LZ; Quik, M; Riveles, K | 1 |
| Kuryatov, A; Lindstrom, J; Onksen, J | 1 |
| Casida, JE; Harel, M; Hibbs, RE; Radic, Z; Talley, TT; Taylor, P; Tomizawa, M | 1 |
| De Biasi, M; Salas, R | 1 |
| Parker, R; Vincler, M; Wittenauer, S; Young, T | 1 |
| Benowitz, NL | 1 |
| Ben-Ari, S; De Biasi, M; Gangitano, DA; Main, A; Salas, R; Soreq, H; Zimmerman, G | 1 |
| Gandía, L; García, AG; García-Eguiagaray, J; Tapia, L | 1 |
| Bernal, JA; Castillo, M; Criado, M; Mulet, J; Sala, F; Sala, S | 1 |
| Bertrand, D; D'hoedt, D | 1 |
| Chen, Y; Cui, Y; Lin, JW; Liu, WF; Wang, TH; Xiang, QL | 1 |
| Andreasen, JT; Nielsen, EO; Redrobe, JP | 1 |
| Arnaud-Neu, F; Bibal, B; Buffeteau, T; Givelet, C; Hubscher-Bruder, V | 1 |
| Crouch, EL; Hesterberg, KG; Homanics, GE; Stitzel, JA; Wilking, JA | 1 |
| Bordia, T; Campos, C; McIntosh, JM; Quik, M | 1 |
| Belozertseva, I; Chistyakov, V; Galankin, T; Patkina, N; Salminen, O; Talka, R; Tammimäki, A; Tuominen, R; Zvartau, E | 1 |
| Blum, AP; Dougherty, DA; Lester, HA | 1 |
| Dederer, H; Ilg, T; Werr, M | 1 |
| Cook, D; Gardner, DR; Green, BT; Welch, KD | 1 |
| Antolin-Fontes, B; Auer, S; Ferrarese, L; Filkin, S; Fontaine, JF; Frahm, S; Ibañez-Tallon, I; Maskos, U; Pons, S; Santos-Torres, J; Slimak, MA; Tsetlin, V | 1 |
| Arias, HR; Feuerbach, D; Jozwiak, K; Targowska-Duda, KM | 1 |
| Grady, SR; Huang, LZ; Quik, M | 1 |
| Brooks, EA; Jutkiewicz, EM; Kynaston, AD; Rice, KC; Woods, JH | 1 |
| Booker, TK; Grady, SR; Heinemann, SF; McGranahan, TM; Patzlaff, NE | 1 |
| De Esch, IJ; de Kloe, G; Edink, E; Heus, F; Irth, H; Kool, J; Leurs, R; Lingeman, H; Niessen, WM; Smit, AB | 1 |
| Hussmann, GP; Kellar, KJ; Lomazzo, E; Perry, DC; Wolfe, BB; Yasuda, RP | 1 |
| Alvehus, M; Andersson, T; Jacobsson, SO; Rodriguez-Gaztelumendi, A | 1 |
| Costello, MR; Jiang, F; Khroyan, TV; Leslie, FM; Polgar, WE; Stauber, GB; Toll, L; Xie, XS; Zaveri, NT; Zhou, W | 1 |
| Sieber, M | 1 |
| Collins, AC; Grady, SR; Marks, MJ; Salamander, RM; Zambrano, CA | 1 |
| Crouch, EL; Horton, WJ; Maier, SI; Marsolek, M; Mexal, S; Stitzel, JA; Wilkinson, AL | 1 |
| Blendy, JA; Gould, TJ; Turner, JR; Wilkinson, DS | 1 |
| He, YX; Qi, JS; Wu, MN; Zhang, H | 1 |
| Camarasa, J; Escubedo, E; Garcia-Ratés, S; Pubill, D | 1 |
| Lukas, RJ; Salminen, O; Talka, R; Tuominen, RK; Whiteaker, P | 1 |
| Blum, AP; Dougherty, DA; German, LA; Lester, HA; Van Arnam, EB | 1 |
| Al-Hasani, R; Bailey, A; Berwick, A; Farshim, P; Hourani, S; Kitchen, I; Ledent, C; Metaxas, A; Tubby, K | 1 |
| Carroll, FI; Coaker, H | 1 |
| Feng, CS; Liu, Y; Piao, MH; Qiu, JP; Wang, YS | 1 |
| Grady, SR; Marks, MJ; Wageman, CR | 1 |
| Ahring, PK; Dyhring, T; Grunnet, M; Jensen, ML; Peters, D; Rasmussen, AH; Strøbæk, D; Timmermann, DB | 1 |
| Gelernter, J; Levy, AD; Lindstrom, J; McClure-Begley, TD; Papke, RL; Picciotto, MR; Stokes, C; Stone, KL; Xie, P | 1 |
| Grady, SR; Marks, MJ; McIntosh, JM; Paley, MA; Salminen, O; Wageman, CR; Whiteaker, P | 1 |
| Carroll, FI; Cunningham, CS; McMahon, LR; Moura, FB; Ondachi, P; Rodriguez, JS | 1 |
| Loetz, EC; Marks, MJ; Meyers, EE | 1 |
| Ahring, PK; Balle, T; Chebib, M; Gajhede, M; Indurthi, DC; Kastrup, JS; Nielsen, EØ; Olsen, JA; Pedersen, MH; Peters, D; Rohde, LA; Shahsavar, A | 1 |
| Aguilar, BL; Ahern, GP; Kellar, KJ; Olson, TT; Smart, AE; Ton, HT | 1 |
| Hoegberg, BG; Lee, NH; Lomazzo, E; Perry, DC | 1 |
| Ellis, JD; Fleckenstein, AE; Hanson, GR; McFadden, LM; McIntosh, JM; Nielsen, SM; Stout, KA; Vieira-Brock, PL; Walters, ET; Wilkins, DG | 1 |
| Brown, LL; Dávila-García, MI; Fortunak, JM; Ogunjirin, AE; Xiao, Y | 1 |
| Daugherty, SL; de Groat, WC; Yu, Y | 1 |
| Cook, D; Green, BT; Kem, WR; Lee, ST; Welch, KD | 1 |
| Carroll, FI; Cunningham, CS; Javors, MA; McMahon, LR; Moerke, MJ | 1 |
| de Moura, FB; McMahon, LR | 2 |
| Bredt, DS; Davini, WB; Gu, S; Harrington, AW; Lord, B; Matta, JA; Siuda, ER | 1 |
| Al-Muhtasib, N; Fitch, RW; Foxman, BM; Olson, TT; Pandya, AA; Panter, KE; Snider, BB; Welch, KD; Xiao, Y; Yakel, JL; Zhou, Q | 1 |
| Jin, X; Markou, A; Marks, MJ; McClure-Begley, TD; Semenova, S; Tadman, MP | 1 |
| Bollinger, I; Escobar, D; Ramos-Santiago, T; Stitzel, J; Zambrano, CA | 1 |
| Abreo, MA; Anderson, DJ; Arneric, SP; Donnelly-roberts, DL; Garvey, DS; Gunn, DE; Hettinger, AM; Holladay, MW; Lin, NH; Martin, YC; Pavlik, PA; Sullivan, JP; Wasicak, JT; Williams, M | 1 |
| Abraham, P; Carroll, FI; Ding, YS; Fowler, J; Kotian, P; Kuhar, MJ; Liang, F; Navarro, HA; Volkow, N | 1 |
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Bottlaender, M; Coulon, C; Crouzel, C; Dolci, L; Doll, F; Fuseau, C; Guenther, I; Hinnen, F; Valette, H; Vaufrey, F | 1 |
| Caldwell, WS; Schmitt, JD; Sharples, CG | 1 |
| Begtrup, M; Christensen, B; Ehrbar, U; Hansen, JB; Olesen, PH; Pettersson, I; Rimvall, K; Tønder, JE | 1 |
| Casida, JE; Lee, DL; Tomizawa, M | 1 |
| Abraham, P; Brieaddy, LE; Carroll, FI; Damaj, MI; Lee, JR; Martin, BR; Navarro, HA | 1 |
| Gohlke, H; Gündisch, D; Schwarz, S; Seitz, G; Tilotta, MC; Wegge, T | 1 |
| Casida, JE; Tomizawa, M; Zhang, N | 1 |
| Chen, S; Cheng, J; Izenwasser, S; Paul, D; Stevens, ED; Trudell, ML; Wade, D; Zhang, C | 1 |
| George, C; Kellar, KJ; Kozikowski, AP; Petukhov, PA; Tückmantel, W; Wei, ZL; Xiao, Y | 1 |
| Damaj, MI; Dukat, M; Ferretti, G; Giannella, M; Glennon, RA; Martin, BR; Piergentili, A; Pigini, M; Quaglia, W | 1 |
| Bremner, JB; Godfrey, CA; Jensen, AA; Smith, RJ | 1 |
| Baydyuk, M; Davis, HE; Kellar, KJ; Wang, HP; Xiao, Y | 1 |
| Carroll, FI | 1 |
| Basak, S; Chen, HT; Jozwiak, K; Lin, CC; Moaddel, R; Sarkar, TK; Wainer, I; Yamaguchi, R | 1 |
| Brieaddy, LE; Carroll, FI; Damaj, MI; Lee, JR; Ma, W; Martin, BR; Navarro, HA; Yokota, Y | 1 |
| Baydyuk, M; Kellar, KJ; Kozikowski, AP; Musachio, JL; Petukhov, PA; Wei, ZL; Xiao, Y; Yuan, H | 1 |
| Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T | 1 |
| Huang, Y; Laruelle, M; Xiao, Y; Zhu, Z | 1 |
| Chellappan, SK; Kellar, KJ; Kozikowski, AP; Tueckmantel, W; Xiao, Y | 1 |
| Burlingame, AL; Casida, JE; Durkin, KA; Maltby, D; Medzihradszky, KF; Talley, TT; Taylor, P; Tomizawa, M | 1 |
| Anderson, DJ; Barlocco, D; Buckley, M; Bunnelle, WH; Cao, YJ; Curzon, P; Daanen, JF; Dart, MJ; Frost, JM; Gelain, A; Ji, J; Meyer, MD; Putman, CB; Puttfarcken, P; Ryther, KB; Schrimpf, MR; Searle, X; Surowy, C; Toma, L | 1 |
| Ahring, PK; Anderson, DJ; Bunnelle, WH; Dyhring, T; Faltynek, C; Ji, J; Li, T; Meyer, MD; Schrimpf, MR; Sippy, KB; Surowy, CS | 1 |
| Brieaddy, LE; Burgess, JP; Damaj, MI; Ivy Carroll, F; Lee, JR; Ma, W; Martin, BR; Navarro, HA; Yokota, Y | 1 |
| Anderson, DJ; Bunnelle, WH; Hutchins, CW; Schrimpf, MR; Sippy, KB | 1 |
| Alexander, M; Dannals, RF; Endres, CJ; Gao, Y; Hilton, J; Holt, DP; Horti, AG; Kumar, A; Kuwabara, H; Ravert, HT; Wong, DF; Xiao, Y | 1 |
| Anderson, DJ; Bunnelle, WH; Dyhring, T; Frost, JM; Grønlien, JH; Ji, J; Li, T; Meyer, MD; Peters, D; Scanio, MJ; Shi, L; Thorin-Hagene, K; Tietje, KR; Ween, H | 1 |
| Jiang, F; Olsen, C; Polgar, W; Toll, L; Zaveri, N | 1 |
| Casida, JE; Tomizawa, M | 1 |
| Bertrand, D; Bertrand, S; Bréthous, L; Garcia-Delgado, N; Reymond, JL; Schwartz, J | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bartkowiak, JM; Carroll, FI; Castro, AH; Damaj, MI; Luetje, CW; Mascarella, SW; Navarro, HA; Ondachi, PW | 1 |
| Asproni, B; Deligia, F; Fasoli, F; Fucile, S; Gotti, C; Loriga, G; Murineddu, G; Pinna, GA; Plutino, S; Ragusa, G; Sciaccaluga, M | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Abraham, P; Brieaddy, LE; Carroll, FI; Damaj, MI; Liang, F; Martin, BR; Navarro, HA | 1 |
| Kagabu, S; Kiriyama, K; Kumamoto, Y; Nishimura, K; Nishiwaki, H; Tada, T | 1 |
| Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA; Ware, R | 1 |
| Abdrakhmanova, GR; Carroll, FI; Damaj, MI; Deschamps, J; Hu, X; Martin, BR; Navarro, HA | 1 |
| Danielson, UH; de Esch, IJ; de Kloe, GE; Geitmann, M; Homan, E; Retra, K; Smit, AB | 1 |
| de la Fuente Revenga, M; Estrada-Valencia, M; Herrera-Arozamena, C; Martí-Marí, O; Pérez, C; Rodríguez-Franco, MI; Villalba-Galea, CA | 1 |
7 review(s) available for epibatidine and nicotine
| Article | Year |
|---|---|
Epibatidine: impact on nicotinic receptor research.
Topics: Acetylcholine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System; Humans; Models, Molecular; Molecular Structure; Neurons; Nicotine; Pyridines; Receptors, Nicotinic | 2003 |
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Drug Design; Humans; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship | 2005 |
Nicotinic acetylcholine receptors: an overview on drug discovery.
Topics: Allosteric Regulation; Analgesics; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Diseases; Drug Discovery; Hearing; Humans; Myasthenia Gravis; Neurodegenerative Diseases; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Protein Subunits; Psoriasis; Pyridines; Receptors, Nicotinic; Schizophrenia; Smoking; Smoking Cessation; Tobacco Use Disorder | 2009 |
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Epibatidine structure-activity relationships.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Molecular Structure; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2004 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic | 2005 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
250 other study(ies) available for epibatidine and nicotine
| Article | Year |
|---|---|
(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors.
Topics: Alkaloids; Analgesics; Animals; Azocines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Motor Activity; Nicotine; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes | 1994 |
Epibatidine is a nicotinic analgesic.
Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Mecamylamine; Mice; Nicotine; Pyridines; Quinolizines; Rats; Receptors, Nicotinic | 1993 |
Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Stereoisomerism | 1996 |
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection | 1995 |
Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats.
Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Excitatory Amino Acids; Injections, Spinal; Male; Microdialysis; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord | 1996 |
Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Alkaloids; Animals; Arousal; Atropine; Azocines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cations, Divalent; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; GABA Antagonists; gamma-Aminobutyric Acid; Ion Transport; Lobeline; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium; Pyridazines; Pyridines; Quinolizines; Receptors, GABA-A; Receptors, Nicotinic; Tetrodotoxin; Thalamic Nuclei | 1997 |
Differential mechanisms involved in the effect of nicotinic agonists DMPP and lobeline to release [3H]5-HT from rat hippocampal slices.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tritium; Tubocurarine | 1996 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission | 1997 |
A comparison of multiple injections versus continuous infusion of nicotine for producing up-regulation of neuronal [3H]-epibatidine binding sites.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Infusions, Intravenous; Injections, Subcutaneous; Male; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Trigeminal Ganglion; Up-Regulation | 1997 |
Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration.
Topics: Adrenal Glands; Alkaloids; Animals; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Male; Multivariate Analysis; Neurons; Nicotine; Nicotinic Agonists; Organ Specificity; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Thalamus; Up-Regulation | 1997 |
Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Enzyme Inhibitors; Humans; Kinetics; Neurons; Nicotine; Nicotinic Agonists; Phosphoric Monoester Hydrolases; Protein Conformation; Protein Kinase C; Pyridines; Receptors, Nicotinic; Sensitivity and Specificity; Transfection; Up-Regulation | 1997 |
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission | 1998 |
Nicotine-stimulated release of [3H]norepinephrine from fetal rat locus coeruleus cells in culture.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Dimethylphenylpiperazinium Iodide; Fetus; Locus Coeruleus; N-Methylaspartate; Neurons; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Rhombencephalon; Structure-Activity Relationship; Tetrodotoxin; Tritium | 1998 |
Nicotine exposure during a critical period of development leads to persistent changes in nicotinic acetylcholine receptors of adult rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Mice; Nicotine; Nicotinic Agonists; Organ Specificity; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus | 1998 |
Chronic ethanol treatment decreases [3H]epibatidine and [3H]nicotine binding and differentially regulates mRNA levels of nicotinic acetylcholine receptor subunits expressed in M10 and SH-SY5Y neuroblastoma cells.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System Depressants; Culture Media; Ethanol; Gene Expression Regulation; Humans; Mice; Neuroblastoma; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; RNA, Messenger; Tritium; Tumor Cells, Cultured | 1998 |
The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cholinergic Agents; Female; Guinea Pigs; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Nicotine; Pyridines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship | 1998 |
Effects of the alpha subunit on imidacloprid sensitivity of recombinant nicotinic acetylcholine receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drosophila; Evoked Potentials; Female; Imidazoles; Insecticides; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pyridines; Receptors, Nicotinic; Recombinant Proteins; Xenopus laevis | 1998 |
Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Chickens; Humans; Mice; Neuroblastoma; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Cholinergic; Receptors, Nicotinic; RNA, Messenger; Time Factors; Tumor Cells, Cultured | 1998 |
Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Benzylidene Compounds; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dimethylphenylpiperazinium Iodide; Humans; Insecticides; Iodine Radioisotopes; Kidney; Kinetics; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Transfection; Up-Regulation | 1998 |
Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Animals; Bacterial Toxins; Benzylidene Compounds; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Choline; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; DNA, Complementary; Female; Marine Toxins; Mice; Microcystins; Multigene Family; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin Antagonists; Structure-Activity Relationship; Xenopus laevis | 1998 |
Non-acetylcholine displaceable 3[H]epibatidine binding in the rat brain.
Topics: Acetylcholine; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Tritium | 1998 |
Laminar distribution of nicotinic receptor subtypes in human cerebral cortex as determined by [3H](-)nicotine, [3H]cytisine and [3H]epibatidine in vitro autoradiography.
Topics: Aged; Aged, 80 and over; Alkaloids; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Humans; In Vitro Techniques; Kinetics; Male; Microtomy; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic | 1998 |
Rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Dose-Response Relationship, Drug; Humans; Ligands; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Rubidium; Sodium; Transfection | 1998 |
Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord.
Topics: Aged; Aged, 80 and over; Alkaloids; Azocines; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; DNA Probes; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Medulla Oblongata; Mesencephalon; Middle Aged; Nicotine; Nicotinic Agonists; Peptidylprolyl Isomerase; Polymerase Chain Reaction; Pons; Pregnancy; Pregnancy Trimester, First; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA-Directed DNA Polymerase; RNA, Messenger; Spinal Cord; Tritium | 1998 |
Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: gender differences.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Female; Iodine Radioisotopes; Male; Mice; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Sex Characteristics; Up-Regulation | 1998 |
Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (+/-)-[3H]epibatidine.
Topics: Aged; Aged, 80 and over; Aging; Binding Sites; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Female; Humans; Isomerism; Male; Middle Aged; Nicotine; Protein Binding; Pyridines; Receptors, Nicotinic; Tritium | 1998 |
Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Cell Adhesion; Cell Size; Cells, Cultured; Cholinergic Antagonists; Epithelial Cells; Fluorescent Antibody Technique; Humans; In Situ Hybridization; Membrane Potentials; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rabbits; Rats; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Species Specificity; Trachea; Tritium | 1998 |
Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.
Topics: Acetylcholine; Alkaloids; Anabasine; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Dimethylphenylpiperazinium Iodide; Lobeline; Nicotine; Nicotinic Agonists; Oocytes; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Xenopus laevis | 1998 |
Postnatal changes of nicotinic acetylcholine receptor alpha 2, alpha 3, alpha 4, alpha 7 and beta 2 subunits genes expression in rat brain.
Topics: Animals; Brain; Brain Chemistry; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cerebellum; Cerebral Cortex; Corpus Striatum; DNA Primers; Female; Gene Expression Regulation, Developmental; Hippocampus; Nicotine; Nicotinic Agonists; Pregnancy; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Thalamus; Tritium | 1998 |
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal | 1998 |
The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses.
Topics: Adjuvants, Immunologic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chlorisondamine; Dose-Response Relationship, Drug; Drug Interactions; Hypothalamo-Hypophyseal System; Lymphocyte Activation; Male; Morphine; Naltrexone; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pituitary-Adrenal System; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid; T-Lymphocytes | 1999 |
Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor protein 670/671 mutation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Apolipoproteins E; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Humans; Kinetics; Male; Middle Aged; Mutation; Neurofibrillary Tangles; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Sweden | 1999 |
Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo.
Topics: Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Fluorine Radioisotopes; Frontal Lobe; Kinetics; Ligands; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus; Tissue Distribution | 1999 |
Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain.
Topics: Aged; Aged, 80 and over; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cerebellum; Female; Hippocampus; Humans; Iodine Radioisotopes; Male; Middle Aged; Nicotine; Nicotinic Agonists; Peptidylprolyl Isomerase; Pyridines; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temporal Lobe; Tritium | 1999 |
Liquid chromatographic studies with immobilized neuronal nicotinic acetylcholine receptor stationary phases: effects of receptor subtypes, pH and ionic strength on drug-receptor interactions.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Ion Exchange; Hydrogen-Ion Concentration; Neurons; Nicotine; Osmolar Concentration; Prosencephalon; Pyridines; Rats; Receptors, Nicotinic; Recombinant Proteins | 1999 |
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits.
Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Raphe Nuclei; Receptors, Nicotinic; Spinal Cord; Thalamus | 1999 |
The role of beta 2-subunit-containing nicotinic acetylcholine receptors in the brain explored with a mutant mouse.
Topics: Alkaloids; Animals; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Dopamine Agonists; Mice; Mice, Knockout; Nicotine; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic | 1999 |
Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors.
Topics: Animals; Auditory Pathways; Brain; Bridged Bicyclo Compounds, Heterocyclic; Decerebrate State; Female; Ganglia, Sympathetic; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Nicotine; Nicotinic Agonists; Oculomotor Muscles; Pain Threshold; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Succinylcholine; Sympathetic Fibers, Postganglionic | 1999 |
Pharmacological similarities between native brain and heterologously expressed alpha4beta2 nicotinic receptors.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Dihydro-beta-Erythroidine; Female; Gene Expression; Humans; Kinetics; Nicotine; Oocytes; Precipitin Tests; Pyridines; Rats; Receptors, Nicotinic; Recombinant Fusion Proteins; Tritium; Xenopus | 1999 |
Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease.
Topics: Acetylcholine; Age Factors; Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Female; Humans; Male; Membrane Transport Proteins; Middle Aged; Nicotine; Piperidines; Pyridines; Quinolizines; Reference Values; Temporal Lobe; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1999 |
Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors.
Topics: Aconitine; Amyloid beta-Peptides; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cell Survival; Cholinesterase Inhibitors; Estradiol; Formazans; Humans; Mecamylamine; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Tetrazolium Salts; Tumor Cells, Cultured | 1999 |
Magnocellular neurons of the rat supraoptic nucleus are endowed with functional nicotinic acetylcholine receptors.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Iodine Radioisotopes; Male; Membrane Potentials; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Supraoptic Nucleus; Tritium; Vasodilator Agents | 2000 |
UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.
Topics: Animals; Bacterial Toxins; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cells, Cultured; Conotoxins; Corpus Striatum; Cyanobacteria Toxins; Dopamine; Humans; Marine Toxins; Microcystins; Neurotoxins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic; Synaptosomes; Tropanes; Xenopus | 2000 |
Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Hippocampus; Male; Mecamylamine; Motor Activity; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Synaptosomes; Tetrodotoxin; Tritium | 2000 |
The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain.
Topics: Analgesics; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Humans; Models, Molecular; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2000 |
Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region.
Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Insecticides; Interneurons; Long-Term Potentiation; Muscimol; Neural Pathways; Nicotine; Nicotinic Agonists; Pyramidal Cells; Pyridines; Rats; Receptors, GABA-A; Receptors, Nicotinic | 2000 |
Antagonism of nicotinic receptors of rat chromaffin cells by N,N, N-trimethyl-1-(4-trans-stilbenoxy)-2-propylammonium iodide: a patch clamp and ligand binding study.
Topics: Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Chickens; Chromaffin Cells; Drug Interactions; Electrophysiology; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Species Specificity; Stereoisomerism; Stilbenes | 2000 |
Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Hot Temperature; Hypertension; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Postural Balance; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Substance-Related Disorders | 2000 |
Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Esters; Inhibitory Concentration 50; Ligands; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Receptors, Nicotinic; Structure-Activity Relationship | 2000 |
Mecamylamine prevents tolerance but enhances whole brain [3H]epibatidine binding in response to repeated nicotine administration in rats.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Tolerance; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2000 |
Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.
Topics: Aggression; Alkaloids; Animals; Autoradiography; Azocines; Base Sequence; Body Constitution; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Exploratory Behavior; Female; Fertility; Habituation, Psychophysiologic; Homozygote; Male; Mice; Mice, Knockout; Molecular Sequence Data; Motor Activity; Neurons; Nicotine; Oligonucleotide Probes; Phenotype; Pyridines; Quinolizines; Receptors, Nicotinic; Restriction Mapping; Social Behavior; Tritium | 2000 |
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia.
Topics: Aconitine; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Bridged Bicyclo Compounds, Heterocyclic; Child; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Regression Analysis; Schizophrenia; Smoking | 2000 |
Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine.
Topics: Alkaloids; Animals; Autoradiography; Azetidines; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Iodine Radioisotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic | 2000 |
The unusual nature of epibatidine responses at the alpha4beta2 nicotinic acetylcholine receptor.
Topics: Algorithms; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; DNA; Ion Channel Gating; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Up-Regulation | 2000 |
Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Dopamine; Exocytosis; Male; Neostriatum; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Temperature | 2000 |
Comparison of the effects of epibatidine and nicotine on the output of dopamine in the dorsal and ventral striatum of freely-moving rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Male; Microdialysis; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic | 2000 |
Prenatal nicotine exposure is associated with an increase in [125I]epibatidine binding in discrete cortical regions in rats.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Female; Iodine Radioisotopes; Male; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Sprague-Dawley | 2000 |
Effect of nicotine on cerebellar granule neuron development.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cells, Cultured; Cellular Senescence; Cerebellum; DNA; Mice; Mice, Inbred ICR; Neurons; Nicotine; Nicotinic Agonists; Protein Isoforms; Pyridines; Quinolizines; Receptors, Cholinergic; Stem Cells | 2001 |
The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain.
Topics: Aconitine; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Antagonists; Haloperidol; Insecticides; Male; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Nicotinic; Schizophrenia; Smoking; Spiperone; Tritium | 2001 |
Investigation of nicotine binding to THP-1 cells: evidence for a non-cholinergic binding site.
Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Humans; Monocytes; Nicotine; Nicotinic Agonists; Pyridines; Tritium; Tumor Cells, Cultured | 2001 |
Effects of nicotine on head-shakes and tryptophan metabolites.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Head Movements; Hydroxyindoleacetic Acid; Indophenol; Kynurenine; Male; Mice; Nicotine; Nicotinic Agonists; Pyridines; Serotonin; Serotonin Receptor Agonists; Tics; Tryptophan | 2001 |
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anthraquinones; Antimycin A; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cotinine; Electron Transport Complex I; Electron Transport Complex II; Hexamethonium; Male; Membrane Proteins; Mitochondria; Mitochondrial Proton-Translocating ATPases; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Neuroprotective Agents; Nicotine; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Prosencephalon; Pyridines; Quinolizines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic; Rotenone; Succinate Dehydrogenase; Superoxides; Synaptosomes | 2001 |
Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Membrane; Chromaffin Cells; Cotinine; Frontal Lobe; Hippocampus; Male; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic | 2001 |
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bacterial Toxins; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cells, Cultured; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; Hippocampus; Humans; Inhibitory Concentration 50; Marine Toxins; Microcystins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Tubocurarine; Tumor Cells, Cultured; Up-Regulation; Verapamil | 2001 |
Agonist regulation of rat alpha 3 beta 4 nicotinic acetylcholine receptors stably expressed in human embryonic kidney 293 cells.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Humans; Kidney; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Time Factors; Transfection; Tritium | 2001 |
Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain.
Topics: Alkaloids; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA, Messenger; Smoking; Tritium; Up-Regulation | 2001 |
Synthesis and evaluation of diazine containing bioisosteres of (-)-ferruginine as ligands for nicotinic acetylcholine receptors.
Topics: Animals; Bacterial Toxins; Brain; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Chromatography, Thin Layer; Crystallography, X-Ray; Cyanobacteria Toxins; Ligands; Marine Toxins; Mesylates; Microcystins; Molecular Conformation; Molecular Structure; Nicotine; Organotin Compounds; Palladium; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Tropanes; Vinyl Compounds | 2001 |
Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Size; Cells, Cultured; DNA Primers; Electrophysiology; Ganglia, Spinal; Gene Expression; Insecticides; Neurons, Afferent; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Vasodilator Agents | 2001 |
Analgesic and toxic effects of neonicotinoid insecticides in mice.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Fibroblasts; Imidazoles; Insecticides; Mecamylamine; Mice; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Thiazines; Time Factors | 2001 |
Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dose-Response Relationship, Drug; Female; Hippocampus; Injections, Intraperitoneal; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Protein Subunits; Pyridines; Receptors, Nicotinic; RNA, Messenger; Seizures | 2002 |
Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Dopamine; Homozygote; Mice; Mice, Knockout; Mice, Mutant Strains; Nicotine; Nicotinic Antagonists; Organ Specificity; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Retinal Ganglion Cells; Tobacco Use Disorder; Visual Pathways | 2002 |
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Carrier Proteins; Chickens; Cholinergic Agonists; Models, Molecular; Molecular Sequence Data; Nicotine; Protein Structure, Tertiary; Pyridines; Rats; Receptors, Nicotinic; Sequence Homology, Amino Acid; Torpedo | 2002 |
Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.
Topics: Aging; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Male; Nicotine; Nicotinic Agonists; Parasympathomimetics; Pirenzepine; Pyridines; Radioligand Assay; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Tacrine; Tritium | 2002 |
Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Animals; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Agents; Ellipticines; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors; Tomography, Emission-Computed | 2002 |
Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dopamine; Hippocampus; Male; Membranes; Neostriatum; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2002 |
Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism.
Topics: Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Spinal; Mice; Nicotine; Nicotinic Agonists; Pyridines; Sciatic Nerve; Sciatica; Spinal Cord | 2002 |
Ligand-receptor interaction at the neural nicotinic acetylcholine binding site: a theoretical model.
Topics: Acetylcholine; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Computer Simulation; Ligands; Models, Molecular; Molecular Structure; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic | 2002 |
Changes in conformation and subcellular distribution of alpha4beta2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras.
Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Humans; Immunoblotting; Kidney; Ligands; Mice; Nicotine; Protein Conformation; Protein Folding; Protein Subunits; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Recombinant Fusion Proteins; Time; Up-Regulation | 2002 |
Effects of prolonged nicotinic ligand exposure on function of heterologously expressed, human alpha4beta2- and alpha4beta4-nicotinic acetylcholine receptors.
Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Cholinergic Agents; Humans; In Situ Hybridization; Ligands; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Rubidium Radioisotopes | 2003 |
Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function.
Topics: Animals; Benzylidene Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Chick Embryo; Cholinergic Antagonists; Conotoxins; Kinetics; Neurons; Nicotine; Nicotinic Agonists; Protein Subunits; Pyridines; Receptors, Nicotinic | 2003 |
Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.
Topics: Acetylcholine; Alkaloids; Amyloid beta-Peptides; Animals; Atropine; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Conotoxins; Dose-Response Relationship, Drug; Frontal Lobe; In Vitro Techniques; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Potassium; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Subcellular Fractions; Synaptosomes | 2003 |
Melatonin nocturnal surge modulates nicotinic receptors and nicotine-induced [3H]glutamate release in rat cerebellum slices.
Topics: Adrenergic beta-Antagonists; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Choline; Circadian Rhythm; Darkness; Glutamic Acid; In Vitro Techniques; Light; Male; Melatonin; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Propranolol; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic | 2003 |
Chronic nicotine treatment attenuates alpha 7 nicotinic receptor deficits following traumatic brain injury.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Isradipine; Male; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Protein Isoforms; Pyridines; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Tritium | 2003 |
Functional neurochemical evidence for the presence of presynaptic nicotinic acetylcholine receptors at the terminal region of myenteric motoneurons: a study with epibatidine.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Motor Neurons; Muscle, Skeletal; Myenteric Plexus; Nicotine; Nicotinic Agonists; Osmolar Concentration; Presynaptic Terminals; Pyridines; Receptors, Nicotinic | 2003 |
Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Lipid Peroxidation; Neuroprotective Agents; Nicotine; Oxidative Stress; PC12 Cells; Pyridines; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Tritium | 2003 |
Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors.
Topics: Animals; Autoradiography; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; In Vitro Techniques; Iodine Isotopes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Mutagenesis; Neural Networks, Computer; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Substantia Nigra; Time Factors; Ventral Tegmental Area | 2003 |
Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Azocines; Binding Sites; Brain; Brain Mapping; Bridged Bicyclo Compounds, Heterocyclic; Diencephalon; Macaca mulatta; Male; Mesencephalon; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Telencephalon; Tissue Distribution | 2003 |
Chronic nicotine administration does not increase nicotinic receptors labeled by [125I]epibatidine in adrenal gland, superior cervical ganglia, pineal or retina.
Topics: Adrenal Glands; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Infusion Pumps, Implantable; Iodine Radioisotopes; Ligands; Male; Nicotine; Nicotinic Agonists; Pineal Gland; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Retina; Superior Cervical Ganglion; Time | 2003 |
Chronic intermittent nicotine administration attenuates traumatic brain injury-induced cognitive dysfunction.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cognition Disorders; Drug Administration Schedule; Male; Maze Learning; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Up-Regulation | 2003 |
Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities.
Topics: Algorithms; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Drosophila; Electrophysiology; Imidazoles; Insecticides; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Oocytes; Pyridines; Receptors, Nicotinic; Tritium; Xenopus laevis | 2003 |
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.
Topics: Aconitine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cells, Cultured; Humans; N-Methylscopolamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympatholytics; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Tritium | 2003 |
Differential regulation of nicotinic acetylcholine receptors in PC12 cells by nicotine and nerve growth factor.
Topics: Animals; Azetidines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Differentiation; Iodine Radioisotopes; Nerve Growth Factor; Nicotine; Nicotinic Agonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Rubidium Radioisotopes; Tritium | 2003 |
Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Drug Tolerance; Male; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tobacco Use Disorder; Up-Regulation | 2003 |
Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Prefrontal Cortex; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tetrodotoxin | 2003 |
Epibatidine induces long-term potentiation (LTP) via activation of alpha4beta2 nicotinic acetylcholine receptors (nAChRs) in vivo in the intact mouse dentate gyrus: both alpha7 and alpha4beta2 nAChRs essential to nicotinic LTP.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Choline; Dentate Gyrus; Drug Synergism; In Vitro Techniques; Long-Term Potentiation; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic | 2003 |
Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; In Situ Hybridization; Male; Mecamylamine; Mouth Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Nicotinic; Trigeminal Ganglion | 2003 |
Cholinergic actions on carotid chemosensory system.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carotid Body; Cats; Chemoreceptor Cells; Cholinergic Agents; Electrophysiology; In Vitro Techniques; Nicotine; Nicotinic Agonists; Pyridines; Tidal Volume | 2003 |
Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia.
Topics: Aged; Aged, 80 and over; Bridged Bicyclo Compounds, Heterocyclic; Case-Control Studies; Cotinine; Dementia; Female; Humans; Male; Middle Aged; Nicotine; Prefrontal Cortex; Psychiatric Status Rating Scales; Pyridines; Radioligand Assay; Receptors, Nicotinic; RNA, Messenger; Schizophrenia; Severity of Illness Index; Smoking | 2003 |
Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the alpha6 subunit.
Topics: Animals; Antibodies; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Immunosorbent Techniques; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Prosencephalon; Protein Subunits; Pyridines; Rats; Rats, Inbred Lew; Receptors, Nicotinic; Self Administration; Sodium Chloride; Time; Up-Regulation | 2004 |
Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cystine; Down-Regulation; Humans; Iodine Radioisotopes; Middle Aged; Nicotine; Nicotinic Agonists; Peptide Fragments; Pyridines; Radioligand Assay; Receptors, Nicotinic; Smoking; Tritium | 2004 |
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Cholinergic Agonists; Gene Expression; Humans; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Transfection; Tritium; Up-Regulation | 2004 |
Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Ligands; Molecular Structure; Neurons; Nicotine; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2004 |
Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment.
Topics: Acetylcholine; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Iodine Radioisotopes; Mice; Mice, Inbred C57BL; Nicotine; Pyridines; Receptors, Cholinergic; Rubidium Radioisotopes | 2004 |
Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cotinine; Dose-Response Relationship, Drug; Infusion Pumps, Implantable; Ligands; Male; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes; Time Factors; Up-Regulation | 2004 |
Comparison of the effects of nicotine and epibatidine on the striatal extracellular dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Caudate Nucleus; Dopamine; Extracellular Space; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Microdialysis; Neostriatum; Nicotine; Nicotinic Agonists; Putamen; Pyridines; Rats; Rats, Wistar | 2004 |
Modulation of dopamine release by the nicotinic agonist epibatidine in the frontal cortex and the nucleus accumbens of naive and chronic nicotine treated rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Frontal Lobe; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Pyridines; Rats; Rats, Sprague-Dawley | 2004 |
Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Amino Acid Sequence; Animals; Antibodies; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Humans; Iodine Radioisotopes; Levodopa; Molecular Sequence Data; Nicotine; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Saimiri | 2005 |
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization.
Topics: Alkaloids; Animals; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Drug Tolerance; Leucine; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Nicotine; Point Mutation; Pyridines; Quinolizines; Receptors, Nicotinic; Reward; Serine; Tobacco Use Disorder; Up-Regulation | 2004 |
Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Grooming; Hyperalgesia; Infusion Pumps, Implantable; Male; Mastication; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nicotine; Pyridines; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tremor | 2004 |
Nicotine and epibatidine triggered prolonged rise in calcium and TH gene transcription in PC12 cells.
Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Dideoxyadenosine; Dose-Response Relationship, Drug; Egtazic Acid; Luciferases; Nicotine; PC12 Cells; Promoter Regions, Genetic; Pyridines; Rats; Recombinant Fusion Proteins; Time Factors; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2004 |
High-affinity epibatidine binding of functional, human alpha7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Autoradiography; Blotting, Northern; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line; Cell Line, Tumor; DNA, Complementary; Epithelial Cells; Humans; Immunohistochemistry; Immunoprecipitation; Membrane Potentials; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Plasmids; Pyridines; Receptors, Nicotinic; RNA; Transfection | 2005 |
The dorsal raphe nucleus as a site of action of the antinociceptive and behavioral effects of the alpha4 nicotinic receptor agonist epibatidine.
Topics: Analgesics; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Formaldehyde; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2005 |
Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice.
Topics: Adrenalectomy; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Body Weight; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Conditioning, Classical; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organ Size; Pyridines; Reflex, Startle; Spleen; Time Factors | 2005 |
Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chemical Phenomena; Chemistry, Physical; Cholinergic Agonists; Crystallography, X-Ray; Hydrogen Bonding; Kinetics; Models, Molecular; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Static Electricity; Surface Properties; Threonine; Tryptophan; Xenopus laevis | 2005 |
Nicotinic modulation of GABAergic synaptic transmission in the spinal cord dorsal horn.
Topics: Analgesics; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Long-Term Synaptic Depression; Lumbar Vertebrae; Neural Inhibition; Nicotine; Nicotinic Agonists; Organ Culture Techniques; Patch-Clamp Techniques; Posterior Horn Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glycine; Receptors, Nicotinic; Spinal Cord; Synaptic Transmission | 2005 |
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.
Topics: Alkaloids; Azocines; Binding, Competitive; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Dextromethorphan; Mecamylamine; Membranes, Artificial; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic | 2005 |
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Humans; Models, Molecular; Molecular Conformation; Nicotine; Protein Binding; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Tropanes | 2005 |
The Caenorhabditis elegans lev-8 gene encodes a novel type of nicotinic acetylcholine receptor alpha subunit.
Topics: Action Potentials; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antinematodal Agents; Behavior, Animal; Blotting, Northern; Body Size; Bridged Bicyclo Compounds, Heterocyclic; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cloning, Molecular; Electrophysiology; Epithelial Cells; Feeding Behavior; Gene Expression; Genomics; Green Fluorescent Proteins; Levamisole; Movement; Muscles; Mutation; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Pharynx; Phenotype; Pyridines; Receptors, Nicotinic; Reproduction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transgenes | 2005 |
Nicotine and epibatidine alter differently nomifensine-elevated dopamine output in the rat dorsal and ventral striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Caudate Nucleus; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Homovanillic Acid; Male; Microdialysis; Nicotine; Nicotinic Agonists; Nomifensine; Nucleus Accumbens; Putamen; Pyridines; Rats; Rats, Wistar | 2005 |
The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay.
Topics: Acetylcholine; Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Conotoxins; Dose-Response Relationship, Drug; Drug Interactions; Hydrogen-Ion Concentration; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Protein Subunits; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Time Factors | 2005 |
Roles for nicotinic acetylcholine receptor subunit large cytoplasmic loop sequences in receptor expression and function.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cloning, Molecular; Cytoplasm; DNA, Complementary; Humans; Immunoprecipitation; Mice; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Rubidium Radioisotopes; Transfection | 2005 |
Time and brain region specific up-regulation of low affinity neuronal nicotinic receptors during chronic nicotine administration in mice.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Mesencephalon; Mice; Mice, Inbred Strains; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Time Factors; Tritium; Up-Regulation | 2005 |
Comparison of the effects of nicotine and epibatidine given in combination with nomifensine on rotational behaviour in rats.
Topics: Adrenergic Agents; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nomifensine; Oxidopamine; Parkinsonian Disorders; Pyridines; Rats; Rats, Wistar | 2005 |
Chronic nicotine differentially affects the function of nicotinic receptor subtypes regulating neurotransmitter release.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; D-Aspartic Acid; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; Male; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium; Protein Isoforms; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptosomes | 2005 |
Nicotine upregulates its own receptors through enhanced intracellular maturation.
Topics: Antibodies; Autoradiography; Binding, Competitive; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; Glycosylation; Humans; Immunoprecipitation; Intracellular Space; Membrane Potentials; Models, Biological; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Binding; Protein Subunits; Pyridines; Receptors, Nicotinic; Time Factors; Transfection; Tritium; Up-Regulation | 2005 |
Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Aspartic Acid; Azetidines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Choline; Cyanobacteria Toxins; Dicarboxylic Acids; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Frontal Lobe; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Mecamylamine; Microcystins; Microscopy, Confocal; Neurotransmitter Uptake Inhibitors; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphopyruvate Hydratase; Potassium Chloride; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium; Tropanes | 2005 |
Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation.
Topics: Animals; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chromosome Deletion; Genotype; Heterozygote; Infusions, Intravenous; Injections, Intravenous; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Mutation; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Tobacco Use Disorder; Up-Regulation | 2006 |
Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Dopamine; Female; Gene Expression Regulation, Developmental; Male; Microscopy, Confocal; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Factors | 2005 |
A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor.
Topics: Alkaloids; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Drug Evaluation, Preclinical; Embryo, Mammalian; Humans; Kidney; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Scintillation Counting | 2005 |
Extracellular domain nicotinic acetylcholine receptors formed by alpha4 and beta2 subunits.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cross-Linking Reagents; Crystallography, X-Ray; Detergents; Dimerization; DNA; Dose-Response Relationship, Drug; Epitopes; Glycosylation; Humans; Immunoblotting; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Nicotine; Oocytes; Plasmids; Protein Binding; Protein Structure, Tertiary; Pyridines; Receptors, Nicotinic; Time Factors; Xenopus laevis | 2005 |
Lovastatin stimulates up-regulation of alpha7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the alpha-form of secreted amyloid precursor protein.
Topics: Amyloid beta-Protein Precursor; Animals; Blotting, Northern; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line, Tumor; Cholesterol; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isotopes; Lovastatin; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; PC12 Cells; Protein Binding; Pyridines; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ubiquinone; Up-Regulation | 2005 |
Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Membrane Potentials; Nerve Tissue Proteins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Structure, Quaternary; Protein Transport; Pyridines; Quinolizines; Receptors, Nicotinic; Subcellular Fractions; Time Factors; Up-Regulation | 2005 |
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Ligands; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Norbornanes; Pain; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism | 2005 |
Selective down-regulation of [(125)I]Y0-alpha-conotoxin MII binding in rat mesostriatal dopamine pathway following continuous infusion of nicotine.
Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Iodine Radioisotopes; Male; Mesencephalon; Neural Pathways; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Substance Withdrawal Syndrome; Substantia Nigra; Tobacco Use Disorder; Ventral Tegmental Area | 2006 |
Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release.
Topics: Alkaloids; Animals; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Signaling; Cell Membrane; Dimethylphenylpiperazinium Iodide; Insulin; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Mice; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic; Tumor Cells, Cultured | 2006 |
Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Psychological; Male; Motor Activity; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar | 2005 |
P2X(7) receptors exert a permissive role on the activation of release-enhancing presynaptic alpha7 nicotinic receptors co-existing on rat neocortex glutamatergic terminals.
Topics: Adenosine Triphosphate; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Choline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Enzyme Activation; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Neocortex; Nicotine; Nicotinic Agonists; Presynaptic Terminals; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Time Factors; Tritium | 2006 |
Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors.
Topics: Acetylcholine; Alkaloids; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Electrophysiology; Epithelial Cells; Hexamethonium; Humans; Lobeline; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Quinolizines; Receptors, Nicotinic; Transfection | 2006 |
Partial recovery of striatal nicotinic receptors in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with chronic oral nicotine.
Topics: Animals; Azetidines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Female; MPTP Poisoning; Nicotine; Parkinson Disease; Pyridines; Receptors, Nicotinic; Saimiri | 2006 |
Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site.
Topics: Acetylcholine; Anabasine; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Imidazoles; Insecticides; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Oocytes; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus laevis | 2006 |
Cholinergic regulation of endogenous morphine release from lobster nerve cord.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Ethanol; Ganglia, Invertebrate; Hexamethonium; In Vitro Techniques; Morphine; Nephropidae; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic | 2006 |
Chronic neonatal nicotine upregulates heteromeric nicotinic acetylcholine receptor binding without change in subunit mRNA expression.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Female; Gene Expression Regulation, Developmental; In Situ Hybridization; Iodine Isotopes; Male; Nicotine; Nicotinic Agonists; Pregnancy; Protein Binding; Protein Subunits; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger | 2006 |
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs.
Topics: Aconitine; Analgesics; Animals; Anticonvulsants; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Data Interpretation, Statistical; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain Measurement; Pyridines; Rats; Reaction Time; Receptors, Nicotinic; Seizures | 2007 |
Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs.
Topics: Analysis of Variance; Animals; Autoradiography; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Conotoxins; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Paraquat; Protein Binding; Pyridines; Receptors, Nicotinic; Substantia Nigra | 2007 |
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord | 2007 |
Effects of chronic neonatal nicotine exposure on nicotinic acetylcholine receptor binding, cell death and morphology in hippocampus and cerebellum.
Topics: Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Count; Cell Death; Cerebellum; Female; Gene Expression Regulation, Developmental; Hippocampus; In Situ Hybridization; In Situ Nick-End Labeling; Nicotine; Nicotinic Agonists; Pregnancy; Protein Binding; Protein Subunits; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2007 |
High affinity binding of epibatidine to serotonin type 3 receptors.
Topics: Animals; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Humans; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists | 2008 |
T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; CD3 Complex; Cell Membrane; Humans; Immunoprecipitation; Jurkat Cells; Leukocytes; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Neurons; Nicotine; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fyn; Pyridines; Rats; Receptors, Antigen, T-Cell; Receptors, Nicotinic; RNA, Small Interfering; T-Lymphocytes | 2007 |
The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Immunoprecipitation; Nicotine; Nicotinic Agonists; Protein Subunits; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Up-Regulation | 2008 |
Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Humans; Kidney; Nicotine; Nicotinic Agonists; p38 Mitogen-Activated Protein Kinases; Pyridines; Radioligand Assay; Receptors, Nicotinic; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line; Cell Membrane; Cells, Immobilized; Chromatography, Affinity; Fluorescein-5-isothiocyanate; Humans; Kinetics; Microscopy, Confocal; Nicotine; Organ Specificity; Pyridines; Receptors, Nicotinic | 2008 |
Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors.
Topics: Amino Acid Sequence; Amino Acids; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chlorocebus aethiops; COS Cells; Kinetics; Molecular Sequence Data; Mutation; Neurons; Nicotine; Nicotinic Agonists; Protein Structure, Secondary; Protein Subunits; Pyridines; Rats; Receptors, Nicotinic; Sequence Alignment; Structure-Activity Relationship; Tubocurarine | 2008 |
The effects of acute and repeated nicotine doses on spontaneous activity in male and female Sprague Dawley rats: analysis of brain area epibatidine binding and cotinine levels.
Topics: Animals; Behavior, Animal; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cotinine; Female; Male; Motor Activity; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2008 |
Assaying small-molecule-receptor interactions by continuous flow competitive displacement chromatography/mass spectrometry.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Affinity; Fluorescein; Kinetics; Nanotechnology; Nicotine; Pyridines; Receptors, Nicotinic; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Torpedo | 2008 |
Cigarette smoke, nicotine and cotinine protect against 6-hydroxydopamine-induced toxicity in SH-SY5Y cells.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Catecholamines; Cell Count; Cell Differentiation; Cell Line; Cell Survival; Cotinine; Humans; Immunohistochemistry; Neuroprotective Agents; Nicotiana; Nicotine; Nicotinic Agonists; Oxidopamine; Phenotype; Pyridines; Receptors, Nicotinic; Smoke; Smoking; Tyrosine 3-Monooxygenase | 2008 |
Roles of accessory subunits in alpha4beta2(*) nicotinic receptors.
Topics: Acetylcholine; Allosteric Regulation; Antibodies, Monoclonal; Binding Sites; Biotinylation; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Galantamine; Humans; Inhibitory Concentration 50; Kidney; Mecamylamine; Mutation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioimmunoassay; Receptors, Nicotinic; Transfection; Up-Regulation | 2008 |
Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
Topics: Animals; Aplysia; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Imidazoles; Imidazolines; Kinetics; Ligands; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Protein Conformation; Pyridines; Receptors, Nicotinic; Thiazines | 2008 |
Opposing actions of chronic stress and chronic nicotine on striatal function in mice.
Topics: Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Female; In Vitro Techniques; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Stress, Physiological | 2008 |
Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Male; Nicotine; Pain; Peripheral Nervous System Diseases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Spinal Nerves | 2008 |
Nicotine and postoperative management of pain.
Topics: Administration, Cutaneous; Analgesics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Humans; Mice; Nicotine; Pain; Postoperative Period; Pyridines; Receptors, Cholinergic; Receptors, Nicotinic; Smoking; Spinal Cord | 2008 |
Nicotine relieves anxiogenic-like behavior in mice that overexpress the read-through variant of acetylcholinesterase but not in wild-type mice.
Topics: Acetylcholinesterase; Animals; Anxiety; Behavior, Animal; Brain; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Isoenzymes; Maze Learning; Mice; Mice, Transgenic; Motor Activity; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Pyridines; Radioligand Assay; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Up-Regulation | 2008 |
Preconditioning stimuli that augment chromaffin cell secretion.
Topics: Acetylcholine; Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Catecholamines; Cattle; Cells, Cultured; Choline; Chromaffin Cells; Dose-Response Relationship, Drug; Mecamylamine; Methacholine Chloride; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Potassium; Pyridines; Receptors, Muscarinic; Receptors, Nicotinic; Sympathetic Nervous System; Time Factors | 2009 |
Single-channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor.
Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cattle; Cholinergic Agonists; Ion Channel Gating; Models, Biological; Nicotine; Patch-Clamp Techniques; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin 5-HT3 Receptor Agonists; Xenopus | 2009 |
Modulatory role of estradiol in nicotinic antinociception in adult female rats.
Topics: Analgesics; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Estradiol; Female; Immunohistochemistry; Injections, Spinal; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ovariectomy; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic; Spinal Cord | 2009 |
Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nicotinic Agonists; Norepinephrine; Pyridines; Radioligand Assay; Receptors, Nicotinic; Serotonin; Stress, Psychological | 2009 |
A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine.
Topics: Acetylcholine; Ammonia; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Magnetic Resonance Spectroscopy; Molecular Structure; Nicotine; Pyridines; Solubility; Thermodynamics; Water | 2009 |
Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity.
Topics: Acetylcholine; Administration, Oral; Animals; Bridged Bicyclo Compounds, Heterocyclic; Gene Knock-In Techniques; Mice; Mutation; Nicotine; Organ Specificity; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Reproducibility of Results | 2010 |
Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization.
Topics: Amphetamine; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Central Nervous System Stimulants; Cocaine; Conotoxins; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Male; Mecamylamine; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereotyped Behavior | 2010 |
Nicotine exposure throughout early development promotes nicotine self-administration in adolescent mice and induces long-lasting behavioural changes.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cotinine; Female; Fetal Development; Lactation; Maternal Exposure; Mice; Motor Activity; Nicotine; Pregnancy; Pyridines; Self Administration; Smoking; Swimming; Time Factors | 2010 |
Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.
Topics: Acetylcholine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Carbon; Female; Hydrogen Bonding; Membrane Potentials; Microinjections; Models, Molecular; Molecular Structure; Mutation; Nicotine; Nicotinic Agonists; Oocytes; Protein Structure, Tertiary; Pyridines; Rats; Receptors, Nicotinic; RNA, Messenger; Xenopus laevis | 2010 |
Differential sensitivity of Ctenocephalides felis and Drosophila melanogaster nicotinic acetylcholine receptor α1 and α2 subunits in recombinant hybrid receptors to nicotinoids and neonicotinoid insecticides.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cats; Chickens; Cloning, Molecular; Ctenocephalides; Dose-Response Relationship, Drug; Drosophila melanogaster; Imidazoles; Insecticides; Kinetics; Molecular Sequence Data; Neonicotinoids; Nicotine; Nitro Compounds; Oocytes; Phylogeny; Protein Subunits; Pyridines; Receptors, Nicotinic; Recombinant Proteins; Xenopus laevis | 2011 |
Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors.
Topics: Acetylcholine; Aconitine; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cholinesterase Inhibitors; Diterpenes; Drug Synergism; Fetus; Humans; Ligands; Membrane Potentials; Muscles; Neostigmine; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship | 2011 |
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.
Topics: Administration, Oral; Analysis of Variance; Animals; Animals, Newborn; Asparagine; Aspartic Acid; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Conditioning, Operant; Electric Stimulation; Green Fluorescent Proteins; Habenula; Humans; In Vitro Techniques; Iodine Isotopes; Mice; Mice, Transgenic; Models, Molecular; Mutation; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Stereotaxic Techniques; Xenopus | 2011 |
Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cell Line; Computer Simulation; Electric Organ; Humans; Ibogaine; Linear Models; Models, Molecular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo | 2011 |
Nicotine reduces L-DOPA-induced dyskinesias by acting at beta2* nicotinic receptors.
Topics: Animals; Antiparkinson Agents; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Cotinine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Oxidopamine; Pyridines; Receptors, Nicotinic; Substantia Nigra; Sympatholytics | 2011 |
Patterns of nicotinic receptor antagonism: nicotine discrimination studies.
Topics: Animals; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Data Interpretation, Statistical; Dihydro-beta-Erythroidine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Varenicline | 2011 |
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Receptors, Nicotinic; Reward; Synaptosomes; Tritium | 2011 |
High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Chemical Fractionation; Chromatography, Affinity; Chromatography, High Pressure Liquid; Complex Mixtures; Flow Injection Analysis; High-Throughput Screening Assays; Ligands; Mass Spectrometry; Nanotechnology; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Radioligand Assay; Recombinant Proteins; Reproducibility of Results | 2011 |
Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons.
Topics: Animals; Biotinylation; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Cycloheximide; Female; Hippocampus; Immunoprecipitation; Methionine; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Protein Synthesis Inhibitors; Pyridines; Rats; Receptors, Nicotinic; Up-Regulation | 2011 |
Comparison of the effects of nicotine upon the transcellular electrical resistance and sucrose permeability of human ECV304/rat C6 co-cultures and human CaCo₂ cells.
Topics: Animals; Blood-Brain Barrier; Bridged Bicyclo Compounds, Heterocyclic; Caco-2 Cells; Cell Membrane Permeability; Coculture Techniques; Electric Impedance; Endothelial Cells; Humans; Immunohistochemistry; Membrane Proteins; Nicotine; Nicotinic Agonists; Occludin; Phosphoproteins; Pyridines; Rats; Receptors, Nicotinic; Sucrose; Zonula Occludens-1 Protein | 2011 |
AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats.
Topics: Analysis of Variance; Animals; Biophysics; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line, Transformed; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Food; Humans; Male; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Oligopeptides; Patch-Clamp Techniques; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Self Administration; Transfection; Tritium | 2012 |
Neuroprotective properties of nicotine.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Chickens; Cortical Spreading Depression; In Vitro Techniques; N-Methylaspartate; Neuroprotective Agents; Nicotine; Pyridines; Receptors, N-Methyl-D-Aspartate; Retina; Video Recording | 2012 |
Regulation of the distribution and function of [(125)I]epibatidine binding sites by chronic nicotine in mouse embryonic neuronal cultures.
Topics: Alkylation; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane; Cells, Cultured; Diencephalon; Hippocampus; Iodine Radioisotopes; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Pyridines; Receptors, Nicotinic; Up-Regulation | 2012 |
Diurnal variation in nicotine sensitivity in mice: role of genetic background and melatonin.
Topics: Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Male; Maze Learning; Melatonin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Motor Activity; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Sex Characteristics; Signal Transduction; Species Specificity | 2012 |
Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Psychological; Fear; Hippocampus; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Species Specificity; Substance Withdrawal Syndrome; Tobacco Use Disorder; Up-Regulation | 2013 |
Amyloid β-protein suppressed nicotinic acetylcholine receptor-mediated currents in acutely isolated rat hippocampal CA1 pyramidal neurons.
Topics: Amyloid beta-Peptides; Animals; Bridged Bicyclo Compounds, Heterocyclic; CA1 Region, Hippocampal; Choline; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic | 2013 |
3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors.
Topics: Aconitine; Animals; Blotting, Western; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Drug Synergism; Immunoprecipitation; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Nicotinic Agonists; Paroxetine; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin Plasma Membrane Transport Proteins; Time Factors; Up-Regulation | 2013 |
Nicotine-morphine interactions at α4β2, α7 and α3(⁎) nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line, Tumor; Drug Interactions; Humans; Morphine; Nicotine; Pyridines; Receptors, Nicotinic; Rubidium Radioisotopes | 2013 |
Binding interactions with the complementary subunit of nicotinic receptors.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Asparagine; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Female; Humans; Hydrogen Bonding; Leucine; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Nicotine; Oocytes; Patch-Clamp Techniques; Protein Binding; Pyridines; Receptors, Nicotinic; Sequence Homology, Amino Acid; Xenopus laevis | 2013 |
Genetic deletion of the adenosine A(2A) receptor prevents nicotine-induced upregulation of α7, but not α4β2* nicotinic acetylcholine receptor binding in the brain.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cotinine; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Protein Subunits; Pyridines; Receptor, Adenosine A2A; Receptors, Nicotinic; Tobacco Use Disorder; Up-Regulation | 2013 |
Interview with Frank Ivy Carroll.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dopamine Uptake Inhibitors; Humans; Nicotine; Protein Binding; Pyridines; Receptor, Adenosine A2B; Receptors, Nicotinic; Research; Substance-Related Disorders; Tropanes | 2013 |
Volatile anesthetic isoflurane inhibits LTP induction of hippocampal CA1 neurons through α4β2 nAChR subtype-mediated mechanisms.
Topics: Anesthetics, Inhalation; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; CA1 Region, Hippocampal; Dihydro-beta-Erythroidine; Drug Interactions; Electric Stimulation; In Vitro Techniques; Isoflurane; Long-Term Potentiation; Mecamylamine; Muscarinic Agonists; Neural Pathways; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2013 |
Effectiveness of nicotinic agonists as desensitizers at presynaptic α4β2- and α4α5β2-nicotinic acetylcholine receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Mice; Mice, Mutant Strains; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Smoking Cessation | 2014 |
Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells.
Topics: Acetylcholine; Biophysical Phenomena; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Cholinergic Agents; Conotoxins; Dose-Response Relationship, Drug; Green Fluorescent Proteins; HEK293 Cells; Humans; Membrane Potentials; Mutation; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Plant Lectins; Protein Subunits; Pyridines; Receptors, Nicotinic; Transfection | 2014 |
Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Female; HEK293 Cells; Humans; Nicotine; Nicotinic Agonists; Oocytes; Phosphorylation; Polymorphism, Genetic; Protein Subunits; Pyridines; Receptors, Nicotinic; Up-Regulation; Xenopus laevis | 2014 |
α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration.
Topics: Alkaloids; Animals; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; In Vitro Techniques; Mice; Mice, Knockout; Neostriatum; Nicotine; Nicotinic Agonists; Olfactory Bulb; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Synaptosomes | 2014 |
Discriminative stimulus and hypothermic effects of some derivatives of the nAChR agonist epibatidine in mice.
Topics: Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Dihydro-beta-Erythroidine; Discrimination Learning; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic | 2014 |
Differential expression of the beta4 neuronal nicotinic receptor subunit affects tolerance development and nicotinic binding sites following chronic nicotine treatment.
Topics: Alkaloids; Animals; Azocines; Binding Sites; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Iodine Radioisotopes; Maze Learning; Mice; Mutation; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic | 2015 |
Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface.
Topics: Acetylcholine; Animals; Azepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Electric Stimulation; HEK293 Cells; Humans; Membrane Potentials; Models, Molecular; Nicotine; Nicotinic Agonists; Oocytes; Protein Binding; Protein Subunits; Pyridines; Receptors, Nicotinic; Transfection; Tritium; Xenopus laevis | 2015 |
Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors.
Topics: Acetylcholine; Allosteric Regulation; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cholinergic Agonists; HEK293 Cells; Humans; Ion Channels; Menthol; Mice; Mice, Inbred C57BL; Nicotine; Nodose Ganglion; Pyridines; Receptors, Nicotinic; Sensory Receptor Cells; Signal Transduction | 2015 |
Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Female; Immunoprecipitation; Male; Nicotine; Nicotinic Agonists; Pyridines; Rats, Sprague-Dawley; Receptors, Nicotinic; Sex Characteristics; Tritium; Up-Regulation | 2015 |
Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits.
Topics: Age of Onset; Aging; Animals; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Male; Methamphetamine; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2015 |
Competition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Humans; Neurons; Nicotine; Nitrogen; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2015 |
Effects of nicotinic receptor agonists on bladder afferent nerve activity in an in vitro bladder-pelvic nerve preparation.
Topics: Action Potentials; Administration, Intravesical; Animals; Bridged Bicyclo Compounds, Heterocyclic; Male; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peripheral Nervous System; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Urinary Bladder | 2016 |
Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids.
Topics: Anabasine; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Membrane Potentials; Muscle Cells; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Risk Assessment; Teratogens; Time Factors | 2016 |
Attenuated nicotine-like effects of varenicline but not other nicotinic ACh receptor agonists in monkeys receiving nicotine daily.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Varenicline | 2016 |
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline | 2017 |
NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line; Cognitive Dysfunction; Conotoxins; Humans; Iodine Radioisotopes; Membrane Proteins; Mice; Mice, Knockout; Molecular Chaperones; Neurons; Nicotine; Protein Binding; Protein Subunits; Pyridines; Radiopharmaceuticals; Receptors, Nicotinic | 2017 |
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.
Topics: Alkaloids; Amphibian Venoms; Animals; Anura; Bridged Bicyclo Compounds, Heterocyclic; Heterocyclic Compounds, Bridged-Ring; Nicotine; Nicotinic Agonists; Poisons; Pyridines; Receptors, Nicotinic; Stereoisomerism | 2018 |
Differential effects of withdrawal from intermittent and continuous nicotine exposure on reward deficit and somatic aspects of nicotine withdrawal and expression of α4β2* nAChRs in Wistar male rats.
Topics: Animals; Autoantigens; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Infusion Pumps, Implantable; Iodine Radioisotopes; Limbic Lobe; Male; Nicotine; Nucleus Accumbens; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome; Up-Regulation; Ventral Tegmental Area | 2018 |
Differential cross-tolerance to the effects of nicotinic acetylcholine receptor drugs in C57BL/6J mice following chronic varenicline.
Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Conditioning, Operant; Drug Tolerance; Female; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Reinforcement, Psychology; Smoking Cessation; Varenicline | 2019 |
Serine residues in the α4 nicotinic acetylcholine receptor subunit regulate surface α4β2
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis, Site-Directed; Mutation; Neurons; Nicotine; Pyridines; Receptors, Nicotinic; Serine; Up-Regulation | 2019 |
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Cell Line; Cell Membrane; Ethers; Ganglia; Humans; Molecular Structure; Neurons; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Tritium | 1996 |
Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Mice; Nicotinic Antagonists; Papio; Pyridines; Radioligand Assay; Receptors, Nicotinic; Tomography, Emission-Computed | 1997 |
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.
Topics: Animals; Azetidines; Brain; Fluorine Radioisotopes; Humans; Ligands; Male; Papio; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tissue Distribution; Tomography, Emission-Computed | 1999 |
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.
Topics: Amino Acids; Ligands; Models, Molecular; Molecular Conformation; Quantum Theory; Receptors, Nicotinic; Structure-Activity Relationship | 1999 |
Improving the nicotinic pharmacophore with a series of (Isoxazole)methylene-1-azacyclic compounds: synthesis, structure-activity relationship, and molecular modeling.
Topics: Animals; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Hydrogen Bonding; Isoxazoles; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Nicotine; Nitrogen; Quinuclidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Static Electricity; Structure-Activity Relationship; Thermodynamics | 1999 |
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
Topics: Animals; Chromatography, High Pressure Liquid; Insecta; Insecticides; Magnetic Resonance Spectroscopy; Mammals; Molecular Structure; Nicotine | 2000 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted-3'-phenyl-5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel nicotinic antagonist.
Topics: Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Male; Mice; Nicotinic Antagonists; Protein Subunits; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2001 |
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
Topics: Adrenal Glands; Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; In Vitro Techniques; Ligands; Nicotinic Agonists; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Swine | 2002 |
Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.
Topics: Animals; Azides; Binding Sites; Binding, Competitive; Cell Line; Drosophila; Imidazoles; Imines; Insecticides; Mice; Neonicotinoids; Nitro Compounds; Photoaffinity Labels; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship; Thiazoles | 2002 |
Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes.
Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Dopamine; In Vitro Techniques; Injections, Spinal; Ligands; Mice; Nicotinic Agonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship | 2002 |
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Crystallography, X-Ray; Cyclization; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Protein Subunits; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2003 |
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors.
Topics: Humans; Molecular Mimicry; Neurons; Nicotine; Protein Binding; Receptors, Nicotinic; Structure-Activity Relationship | 2003 |
Synthesis and nicotinic receptor activity of a hydroxylated tropane.
Topics: Animals; Humans; Hydroxylation; Nicotinic Agonists; Protein Binding; Rats; Receptors, Nicotinic; Tropanes | 2004 |
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Gene Expression; Humans; Neurons; Nicotinic Agonists; Protein Subunits; Rats; Receptors, Nicotinic; Transfection | 2004 |
Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine.
Topics: Anabasine; Crystallography, X-Ray; Molecular Conformation; Nicotine; Receptors, Nicotinic; Structure-Activity Relationship | 2004 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.
Topics: Analgesics; Animals; Binding, Competitive; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Male; Mice; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2005 |
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Ligands; Models, Molecular; Neurons; Protein Subunits; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic | 2005 |
Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Ligands; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship; Transfection | 2005 |
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.
Topics: Alkaloids; Azocines; Cholinergic Agonists; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Structure; Nicotine; Quinolizines; Receptors, Cholinergic | 2006 |
Mapping the elusive neonicotinoid binding site.
Topics: Animals; Aplysia; Binding Sites; Carrier Proteins; Cell Line; Humans; Mass Spectrometry; Models, Molecular; Molecular Structure; Nicotine; Photoaffinity Labels | 2007 |
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Cell Line; Diamines; Dopamine; Heterocyclic Compounds, Bridged-Ring; In Vitro Techniques; Ligands; Models, Molecular; Nicotinic Agonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyridines; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2007 |
Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Heptanes; Humans; In Vitro Techniques; Ligands; Nicotinic Agonists; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2007 |
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs.
Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Molecular Structure; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship | 2008 |
Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.
Topics: Animals; Azetidines; Chemistry, Pharmaceutical; Diamines; Drug Design; Humans; Kinetics; Ligands; Models, Chemical; Molecular Conformation; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2009 |
Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.
Topics: Animals; Brain Chemistry; Carbon Radioisotopes; Humans; Lipids; Male; Mice; Papio; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Nicotinic; Structure-Activity Relationship | 2009 |
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Cell Line; Diamines; Humans; Ligands; Nicotinic Agonists; Pyrroles; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Substrate Specificity | 2009 |
Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Indoles; Ligands; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Transfection | 2010 |
Unique neonicotinoid binding conformations conferring selective receptor interactions.
Topics: Anabasine; Animals; Aplysia; Binding Sites; Insecticides; Lymnaea; Models, Molecular; Molecular Conformation; Protein Conformation; Receptors, Nicotinic | 2011 |
Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).
Topics: Allosteric Regulation; Animals; Benzamides; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Databases, Factual; Female; Humans; Models, Molecular; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Xenopus | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.
Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Contraindications; Female; Male; Mice; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pain; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus | 2014 |
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α
Topics: Aniline Compounds; Animals; Bridged Bicyclo Compounds; Cell Line; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Structure; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2018 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues.
Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Pain Measurement; Pyridines; Radioligand Assay; Rats; Reaction Time; Receptors, Nicotinic; Structure-Activity Relationship | 2001 |
Asymmetric chloronicotinyl insecticide, 1-[1-(6-chloro-3-pyridyl)ethyl]-2-nitroiminoimidazolidine: preparation, resolution and biological activities toward insects and their nerve preparations.
Topics: Animals; Binding Sites; Cockroaches; Crystallography, X-Ray; Houseflies; Imidazoles; Imidazolidines; Indicators and Reagents; Insecticides; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neonicotinoids; Nervous System; Neurons; Nitro Compounds; Plants; Pyridines; Receptors, Cholinergic | 2003 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist.
Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Mice; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship | 2004 |
Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes.
Topics: Analgesics; Animals; Cell Line; Cerebral Cortex; Crystallography, X-Ray; Discrimination Learning; Male; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Tropanes | 2006 |
Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.
Topics: Acetylcholine; Animals; Biophysical Phenomena; Carrier Proteins; Ligands; Lymnaea; Nicotine; Proteins; Synaptic Transmission | 2010 |
Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups.
Topics: Animals; Azo Compounds; Humans; Isomerism; Ligands; Light; Neuromuscular Agents; Nicotinic Agonists; Oocytes; Quaternary Ammonium Compounds; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus laevis | 2020 |