epibatidine and nicotine

epibatidine has been researched along with nicotine in 257 studies

Research

Studies (257)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's47 (18.29)18.2507
2000's155 (60.31)29.6817
2010's53 (20.62)24.3611
2020's2 (0.78)2.80

Authors

AuthorsStudies
Adams, P; Anderson, DJ; Bannon, AW; Brioni, JD; Buckley, MJ; Decker, MW; Donnelly-Roberts, D; Kang, CH; Piattoni-Kaplan, M; Sullivan, JP1
Biftu, T; Eckman, J; Ip, S; Li, T; Libertine-Garahan, L; Qian, C; Shen, TY1
Damaj, MI; Martin, BR1
Nordberg, A; Warpman, U1
Khan, IM; Marsala, M; Printz, MP; Taylor, P; Yaksh, TL1
Changeux, JP; Léna, C2
Baranyi, M; Lajtha, A; Lendvai, B; Santha, E; Sershen, H; Vizi, ES1
Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS1
Flores, CM; Hargreaves, KM; Ulrich, YM1
Dávila-García, MI; Flores, CM; Kellar, KJ; Ulrich, YM1
Bickler, PE; Eilers, H; Forsayeth, JR; Schaeffer, E1
Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M1
Gallardo, KA; Leslie, FM1
Bishop, K; Gong, ZH; Liu, C; Miao, H; Nordberg, A; Zhang, X1
Gorbounova, O; Hellström-Lindahl, E; Jönsson, P; Miao, H; Mousavi, M; Nordberg, A; Svensson, AL1
Bencherif, M; Bhatti, BS; Caldwell, WS; Crooks, P; Fowler, K; Lippiello, PM; Lovette, ME; Reeves, L; Schmitt, JD1
Baylis, HA; Buckingham, SD; Freeman, JC; Matsuda, K; Sattelle, DB; Squire, MD1
Friberg, L; Gillespie, A; Hellström-Lindahl, E; Nordberg, A; Warpman, U; Zhang, X1
Arneric, SP; Delbono, O; Gopalakrishnan, M; Messi, ML; Molinari, EJ; Renganathan, M; Sullivan, JP1
Gurley, DA; Lanthorn, TH1
Mellerup, E; Plenge, P1
Gillberg, PG; Nordberg, A; Sihver, W1
Kellar, KJ; Meyer, EL; Surin, A; Thompson, JM; Wroblewski, J; Xiao, Y1
Gorbounova, O; Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Seiger, A1
Dannals, RF; Finley, P; Mochizuki, T; Musachio, JL; Scheffel, U; Villemagne, VL; Wagner, HN; Zhan, Y1
Bogdanovic, N; Marutle, A; Nordberg, A; Warpman, U1
Albuquerque, EX; Conti-Fine, BM; Cortes, WS; Horton, RM; Karachunski, PI; Macklin, K; Maus, AD; Navaneetham, D; Pereira, EF1
Beck, A; Luetje, CW; Parker, MJ1
Gong, ZH; Liu, C; Miao, H; Nordberg, A; Zhang, X1
Buerkle, H; Khan, IM; Taylor, P; Yaksh, TL1
Bayer, BM; Mellon, RD1
Bogdanovic, N; Lannfelt, L; Marutle, A; Nordberg, A; Warpman, U1
Bottlaender, M; Coulon, C; Crouzel, C; Dollé, F; Fuseau, C; Guenther, I; Hinnen, F; Ottaviani, M; Valette, H1
Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Ravid, R; Zhang, X1
Kellar, KJ; Wainer, IW; Xiao, Y; Zhang, Y1
Changeux, JP; Cordero-Erausquin, M; Damaj, MI; de Kerchove d'Exaerde, A; del Mar Arroyo-Jimenez, M; Huchet, M; Le Novère, N; Léna, C; Marubio, LM1
Lembeck, F1
Cohen, BN; Crooks, PA; Dwoskin, LP; Figl, A; Forsayeth, JR; Houng, M; Sandhu, S; Shafaee, N; Truong, A; Viseshakul, N1
Gillberg, PG; Nordberg, A; Sihver, W; Svensson, AL1
Nordberg, A; Svensson, AL1
Bertrand, D; Blanchet, C; Raggenbass, M; Tribollet, E; Zaninetti, M1
Collins, AC; Gallagher, T; Kaiser, S; Marks, MJ; Sharples, CG; Soliakov, L; Spencer, JA; Washburn, M; Whiteaker, P; Wonnacott, S; Wright, E1
Boye, S; Clarke, PB; Reuben, M1
Anderson, DJ; Dart, MJ; Decker, MW; Kim, KH; Meyer, MD; Rueter, LE; Sullivan, JP; Williams, M1
Fujii, S; Jia, Y; Sumikawa, K; Yang, A1
Clementi, F; Di Angelantonio, S; Gotti, C; Moretti, M; Nistri, A1
Boyce, S; Hill, RG; Rupniak, NMJ; Russell, MGN; Shepheard, SL; Webb, JK1
Davis, CB; Lee, J; Reitz, AB; Rivero, RA; Shank, RP1
Booth, S; Breese, CR; Caggiula, AR; Donny, EC; Lee, MJ; Leonard, S; McCallum, SE; Sved, AF1
Berkovic, SF; Clifford, JJ; Drago, J; Horne, MK; Kinsella, A; Kola, I; Massalas, JS; Ross, SA; Scheffer, IE; Waddington, JL; Wong, JY1
Adams, CE; Breese, CR; Collins, AC; Gillen, KM; Lee, MJ; Leonard, S; Logel, J; Marks, MJ; Sullivan, B1
Collins, AC; Jimenez, M; Marks, MJ; McIntosh, JM; Whiteaker, P1
Bertrand, D; Buisson, B; Green, WN; Vallejo, YF1
Faltynek, CR; Jacobs, I; Puttfarcken, PS1
Ahtee, L; Seppä, T1
Perry, DC; Tizabi, Y1
Hauser, KF; Opanashuk, LA; Pauly, JR1
Breese, CR; Lee, MJ; Leonard, S; Strook, ML1
Morgan, D; Parsons, ME; Whelan, CJ1
Gaynor, CM; Handley, SL1
Cormier, A; Lagrue, G; Morin, C; Tillement, JP; Zini, R1
Tuominen, RK; Vainio, PJ1
Ridley, DL; Rogers, A; Wonnacott, S1
Kellar, KJ; Meyer, EL; Xiao, Y1
Hellström-Lindahl, E; Kjaeldgaard, A; Nordberg, A1
Gündisch, D; Harms, K; Schwarz, S; Seitz, G; Stubbs, MT; Wegge, T1
Genzen, JR; McGehee, DS; Van Cleve, W1
Casida, JE; Cowan, A; Tomizawa, M1
Bassetto, L; Broide, R; De Biasi, M; Franceschini, D; Gotti, C; Paylor, R; Salas, R1
Bessis, A; Champtiaux, N; Changeux, JP; Han, ZY; Marubio, L; McIntosh, JM; Rossi, FM; Zoli, M1
Changeux, JP; Grutter, T; Le Novère, N1
Gong, ZH; Meyerson, B; Nordberg, A; Svensson, AL; Tian, JY; Zhang, X1
Bottlaender, M; Coulon, C; Dannals, RF; Dolle, F; Kassiou, M; Loc'h, C; Maziere, B; Musachio, JL; Ottaviani, M1
Anderson, DJ; Jacobs, I; Puttfarcken, PS; Surowy, CS1
Rashid, MH; Ueda, H1
Gálvez, E; Iriepa, I; Maseras, F; Morreale, A1
Harkness, PC; Millar, NS1
Gentry, CL; Lukas, RJ; Wilkins, LH1
Margiotta, JF; McIntosh, JM; Nai, Q1
Lee, DH; Wang, HY1
Markus, RP; Reno, LA; Santos, JM; Zago, W1
Pauly, JR; Scheff, SW; Verbois, SL1
Kiss, JP; Mandl, P; Vizi, ES1
Guan, ZZ; Nordberg, A; Yu, WF1
Arroyo-Jimenez, MM; Champtiaux, N; Changeux, JP; David, D; Durier, S; Gardier, AM; Klink, R; Marubio, LM; McIntosh, JM; Rossi, F; Zoli, M1
Bourgeois, JP; Cardona, A; Changeux, JP; Han, ZY; Le Novère, N; Zoli, M1
Dávila-García, MI; Kellar, KJ; Musachio, JL1
Dukat, M; Glennon, RA1
Hopkins, DM; Pauly, JR; Scheff, SW; Verbois, SL1
Akamatsu, M; Komai, K; Kuwamura, M; Matsuda, K; Miyagawa, H; Nakagawa, Y; Nishiwaki, H; Sato, K1
Bräuner-Osborne, H; Falch, E; Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Mikkelsen, I1
Ascarrunz, VS; Avila, AM; Dávila-García, MI; Kellar, KJ; Xiao, Y1
Nguyen, HN; Perry, DC; Rasmussen, BA2
Adams, P; Correa, LD; Rao, TS; Sacaan, AI; Santori, EM1
Matsumoto, A; Matsuyama, S1
Dussor, GO; Flores, CM; Gracia, NB; Hargreaves, KM; Kilo, S; Leong, AS; Price, TJ1
Fernández, R; Larraín, C; Reyes, EP; Zapata, P1
Court, JA; Davis, KL; Haroutunian, VH; Long, P; Martin-Ruiz, CM; Perry, EK; Young, AH1
Fu, Y; Lindstrom, JM; Luo, J; McAllen, K; McIntosh, JM; Parker, SL; Sharp, BM1
Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Ravid, R1
Kellar, KJ; Xiao, Y1
Kellar, KJ; Kozikowski, AP; Wei, ZL; Xiao, Y1
Cao, JZ; Collins, AC; Grady, SR; Marks, MJ; McCallum, SE; Rowell, PP1
Ahtee, L; Janhunen, S1
Bednar, I; Friberg, L; Nordberg, A1
Bordia, T; Clementi, F; Fan, H; Gotti, C; Kulak, JM; McIntosh, JM; Quik, M; Vailati, S1
Collins, AC; Deshpande, P; Labarca, C; Lester, HA; Marks, MJ; McKinney, SL; Nashmi, R; Schwarz, J; Tapper, AR; Whiteaker, P1
De Biasi, M; Pieri, F; Salas, R1
Frenz, CM; Gueorguiev, VD; Ronald, KM; Sabban, EL1
Fryer, JD; George, AA; Groppi, VE; Hurst, RS; Leonard, SS; Lukas, RJ; Morrissy, S; Peng, JH; Schroeder, KM1
Chaijale, N; Commons, KG; Cucchiaro, G1
Ingram, N; Loiacono, R; Martin, S; van den Buuse, M; van der Laan, S; Wang, JH1
Cashin, AL; Dougherty, DA; Lester, HA; Petersson, EJ1
Genzen, JR; McGehee, DS1
Jozwiak, K; Moaddel, R; Wainer, IW; Whittington, K1
Casida, JE; Durkin, KA; Kanne, DB; Tomizawa, M1
Edwards, B; Richmond, JE; Sattelle, DB; Towers, PR1
Ahtee, L; Janhunen, S; Piepponen, TP; Tuominen, RK1
Collins, AC; Grady, SR; Marks, MJ; McIntosh, JM; Salminen, O; Whiteaker, P1
Eaton, JB; Kuo, YP; Lukas, RJ; Wu, J; Xu, L; Zhao, L1
Ahtee, L; Nuutinen, S; Tuominen, RK1
Ahtee, L; Janhunen, S; Tuominen, RK1
Grilli, M; Marchi, M; Parodi, M; Raiteri, M1
Changeux, JP; Corringer, PJ; Devillers-Thiery, A; Pons, S; Prado de Carvalho, L; Sallette, J; Soudant, M1
Jones, IW; Pullar, IA; Rousseau, SJ; Wonnacott, S1
Collins, AC; Marks, MJ; McCallum, SE; Paylor, R1
Chen, H; Matta, SG; Parker, SL; Sharp, BM1
Gao, J; Hui, X; Ogiku, T; Suto, N; Wang, MW; Xie, X1
Bills, KL; Botting, SK; Lindstrom, J; Liu, H; Person, AM; Wells, GB1
Guan, ZZ; Mousavi, M; Nordberg, A; Nordman, T; Olsson, JM; Shan, KR; Xiu, J; Yu, WF1
Canu-Boido, C; Clementi, F; Di Angelantonio, S; Gaimarri, A; Gotti, C; Matteoni, C; Nistri, A; Riganti, L; Sparatore, F1
Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA1
Garzotti, M; Heidbreder, CA; Mugnaini, M; Pilla, M; Repeto, P; Sartori, I; Tessari, M1
Badyuk, M; Daly, JW; Kellar, KJ; Ohtani, M; Oka, T; Xiao, Y1
Abin-Carriquiry, JA; Bermúdez, I; Cassels, BK; Dajas, F; Wonnacott, S1
Ahtee, L; Janhunen, S; Linnervuo, A; Svensk, M1
Grilli, M; Marchi, M; Parodi, M; Patti, L; Raiteri, L; Raiteri, M1
Hu, J; Kuo, YP; Liu, Q; Lukas, RJ; Segerberg, M; St John, PA; Wu, J; Yu, K1
Bordia, T; Fan, H; Langston, JW; McIntosh, JM; Parameswaran, N; Quik, M1
Akamatsu, M; Ihara, M; Matsuda, K; Sattelle, DB; Shimomura, M; Yokota, M1
Casares, FM; Kream, RM; Mantione, KJ; Sheehan, MH; Stefano, GB; Zhu, W1
Huang, LZ; Winzer-Serhan, UH1
Abraham, P; Damaj, MI; Ivy Carroll, F; Ma, W; Martin, BR; Navarro, HA; Wolckenhauer, SA1
Di Monte, DA; Khwaja, M; McCormack, A; McIntosh, JM; Quik, M1
Collins, AC; Damaj, MI; Deshpande, P; Fonck, C; Labarca, C; Lester, HA; Marks, MJ; Martin, BR1
Abbott, LC; Huang, LZ; Winzer-Serhan, UH1
Drisdel, RC; Green, WN; Hales, TG; Henderson, T; Sharp, D1
Boyd, RT; Dávila-García, MI; Langley, R; Mishra, NC; Nandi, JS; Pena-Philippides, JC; Razani-Boroujerdi, S; Singh, SP; Sopori, ML1
Kellar, KJ; Mao, D; Perry, DC; Wolfe, BB; Yasuda, RP1
Gahring, LC; Osborne-Hereford, AV; Rogers, SW; Vasquez-Opazo, GA1
Bernier, M; Hyppolite, P; Juhaszova, M; Kellar, KJ; Kimura, T; Moaddel, R; Oliveira, RV; Wainer, IW; Xiao, Y1
Kaniaková, M; Krůsek, J; Lindovský, J; Svobodová, L; Vyskocil, F1
Gross, D; James, JR; Pehrson, AL; Philibin, SD; Robinson, SE; Rosecrans, JA; Vann, RE1
Besanger, TR; Brennan, JD; Sharma, J1
Huang, LZ; Quik, M; Riveles, K1
Kuryatov, A; Lindstrom, J; Onksen, J1
Casida, JE; Harel, M; Hibbs, RE; Radic, Z; Talley, TT; Taylor, P; Tomizawa, M1
De Biasi, M; Salas, R1
Parker, R; Vincler, M; Wittenauer, S; Young, T1
Benowitz, NL1
Ben-Ari, S; De Biasi, M; Gangitano, DA; Main, A; Salas, R; Soreq, H; Zimmerman, G1
Gandía, L; García, AG; García-Eguiagaray, J; Tapia, L1
Bernal, JA; Castillo, M; Criado, M; Mulet, J; Sala, F; Sala, S1
Bertrand, D; D'hoedt, D1
Chen, Y; Cui, Y; Lin, JW; Liu, WF; Wang, TH; Xiang, QL1
Andreasen, JT; Nielsen, EO; Redrobe, JP1
Arnaud-Neu, F; Bibal, B; Buffeteau, T; Givelet, C; Hubscher-Bruder, V1
Crouch, EL; Hesterberg, KG; Homanics, GE; Stitzel, JA; Wilking, JA1
Bordia, T; Campos, C; McIntosh, JM; Quik, M1
Belozertseva, I; Chistyakov, V; Galankin, T; Patkina, N; Salminen, O; Talka, R; Tammimäki, A; Tuominen, R; Zvartau, E1
Blum, AP; Dougherty, DA; Lester, HA1
Dederer, H; Ilg, T; Werr, M1
Cook, D; Gardner, DR; Green, BT; Welch, KD1
Antolin-Fontes, B; Auer, S; Ferrarese, L; Filkin, S; Fontaine, JF; Frahm, S; Ibañez-Tallon, I; Maskos, U; Pons, S; Santos-Torres, J; Slimak, MA; Tsetlin, V1
Arias, HR; Feuerbach, D; Jozwiak, K; Targowska-Duda, KM1
Grady, SR; Huang, LZ; Quik, M1
Brooks, EA; Jutkiewicz, EM; Kynaston, AD; Rice, KC; Woods, JH1
Booker, TK; Grady, SR; Heinemann, SF; McGranahan, TM; Patzlaff, NE1
De Esch, IJ; de Kloe, G; Edink, E; Heus, F; Irth, H; Kool, J; Leurs, R; Lingeman, H; Niessen, WM; Smit, AB1
Hussmann, GP; Kellar, KJ; Lomazzo, E; Perry, DC; Wolfe, BB; Yasuda, RP1
Alvehus, M; Andersson, T; Jacobsson, SO; Rodriguez-Gaztelumendi, A1
Costello, MR; Jiang, F; Khroyan, TV; Leslie, FM; Polgar, WE; Stauber, GB; Toll, L; Xie, XS; Zaveri, NT; Zhou, W1
Sieber, M1
Collins, AC; Grady, SR; Marks, MJ; Salamander, RM; Zambrano, CA1
Crouch, EL; Horton, WJ; Maier, SI; Marsolek, M; Mexal, S; Stitzel, JA; Wilkinson, AL1
Blendy, JA; Gould, TJ; Turner, JR; Wilkinson, DS1
He, YX; Qi, JS; Wu, MN; Zhang, H1
Camarasa, J; Escubedo, E; Garcia-Ratés, S; Pubill, D1
Lukas, RJ; Salminen, O; Talka, R; Tuominen, RK; Whiteaker, P1
Blum, AP; Dougherty, DA; German, LA; Lester, HA; Van Arnam, EB1
Al-Hasani, R; Bailey, A; Berwick, A; Farshim, P; Hourani, S; Kitchen, I; Ledent, C; Metaxas, A; Tubby, K1
Carroll, FI; Coaker, H1
Feng, CS; Liu, Y; Piao, MH; Qiu, JP; Wang, YS1
Grady, SR; Marks, MJ; Wageman, CR1
Ahring, PK; Dyhring, T; Grunnet, M; Jensen, ML; Peters, D; Rasmussen, AH; Strøbæk, D; Timmermann, DB1
Gelernter, J; Levy, AD; Lindstrom, J; McClure-Begley, TD; Papke, RL; Picciotto, MR; Stokes, C; Stone, KL; Xie, P1
Grady, SR; Marks, MJ; McIntosh, JM; Paley, MA; Salminen, O; Wageman, CR; Whiteaker, P1
Carroll, FI; Cunningham, CS; McMahon, LR; Moura, FB; Ondachi, P; Rodriguez, JS1
Loetz, EC; Marks, MJ; Meyers, EE1
Ahring, PK; Balle, T; Chebib, M; Gajhede, M; Indurthi, DC; Kastrup, JS; Nielsen, EØ; Olsen, JA; Pedersen, MH; Peters, D; Rohde, LA; Shahsavar, A1
Aguilar, BL; Ahern, GP; Kellar, KJ; Olson, TT; Smart, AE; Ton, HT1
Hoegberg, BG; Lee, NH; Lomazzo, E; Perry, DC1
Ellis, JD; Fleckenstein, AE; Hanson, GR; McFadden, LM; McIntosh, JM; Nielsen, SM; Stout, KA; Vieira-Brock, PL; Walters, ET; Wilkins, DG1
Brown, LL; Dávila-García, MI; Fortunak, JM; Ogunjirin, AE; Xiao, Y1
Daugherty, SL; de Groat, WC; Yu, Y1
Cook, D; Green, BT; Kem, WR; Lee, ST; Welch, KD1
Carroll, FI; Cunningham, CS; Javors, MA; McMahon, LR; Moerke, MJ1
de Moura, FB; McMahon, LR2
Bredt, DS; Davini, WB; Gu, S; Harrington, AW; Lord, B; Matta, JA; Siuda, ER1
Al-Muhtasib, N; Fitch, RW; Foxman, BM; Olson, TT; Pandya, AA; Panter, KE; Snider, BB; Welch, KD; Xiao, Y; Yakel, JL; Zhou, Q1
Jin, X; Markou, A; Marks, MJ; McClure-Begley, TD; Semenova, S; Tadman, MP1
Bollinger, I; Escobar, D; Ramos-Santiago, T; Stitzel, J; Zambrano, CA1
Abreo, MA; Anderson, DJ; Arneric, SP; Donnelly-roberts, DL; Garvey, DS; Gunn, DE; Hettinger, AM; Holladay, MW; Lin, NH; Martin, YC; Pavlik, PA; Sullivan, JP; Wasicak, JT; Williams, M1
Abraham, P; Carroll, FI; Ding, YS; Fowler, J; Kotian, P; Kuhar, MJ; Liang, F; Navarro, HA; Volkow, N1
Dart, MJ; Holladay, MW; Lynch, JK1
Bottlaender, M; Coulon, C; Crouzel, C; Dolci, L; Doll, F; Fuseau, C; Guenther, I; Hinnen, F; Valette, H; Vaufrey, F1
Caldwell, WS; Schmitt, JD; Sharples, CG1
Begtrup, M; Christensen, B; Ehrbar, U; Hansen, JB; Olesen, PH; Pettersson, I; Rimvall, K; Tønder, JE1
Casida, JE; Lee, DL; Tomizawa, M1
Abraham, P; Brieaddy, LE; Carroll, FI; Damaj, MI; Lee, JR; Martin, BR; Navarro, HA1
Gohlke, H; Gündisch, D; Schwarz, S; Seitz, G; Tilotta, MC; Wegge, T1
Casida, JE; Tomizawa, M; Zhang, N1
Chen, S; Cheng, J; Izenwasser, S; Paul, D; Stevens, ED; Trudell, ML; Wade, D; Zhang, C1
George, C; Kellar, KJ; Kozikowski, AP; Petukhov, PA; Tückmantel, W; Wei, ZL; Xiao, Y1
Damaj, MI; Dukat, M; Ferretti, G; Giannella, M; Glennon, RA; Martin, BR; Piergentili, A; Pigini, M; Quaglia, W1
Bremner, JB; Godfrey, CA; Jensen, AA; Smith, RJ1
Baydyuk, M; Davis, HE; Kellar, KJ; Wang, HP; Xiao, Y1
Carroll, FI1
Basak, S; Chen, HT; Jozwiak, K; Lin, CC; Moaddel, R; Sarkar, TK; Wainer, I; Yamaguchi, R1
Brieaddy, LE; Carroll, FI; Damaj, MI; Lee, JR; Ma, W; Martin, BR; Navarro, HA; Yokota, Y1
Baydyuk, M; Kellar, KJ; Kozikowski, AP; Musachio, JL; Petukhov, PA; Wei, ZL; Xiao, Y; Yuan, H1
Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T1
Huang, Y; Laruelle, M; Xiao, Y; Zhu, Z1
Chellappan, SK; Kellar, KJ; Kozikowski, AP; Tueckmantel, W; Xiao, Y1
Burlingame, AL; Casida, JE; Durkin, KA; Maltby, D; Medzihradszky, KF; Talley, TT; Taylor, P; Tomizawa, M1
Anderson, DJ; Barlocco, D; Buckley, M; Bunnelle, WH; Cao, YJ; Curzon, P; Daanen, JF; Dart, MJ; Frost, JM; Gelain, A; Ji, J; Meyer, MD; Putman, CB; Puttfarcken, P; Ryther, KB; Schrimpf, MR; Searle, X; Surowy, C; Toma, L1
Ahring, PK; Anderson, DJ; Bunnelle, WH; Dyhring, T; Faltynek, C; Ji, J; Li, T; Meyer, MD; Schrimpf, MR; Sippy, KB; Surowy, CS1
Brieaddy, LE; Burgess, JP; Damaj, MI; Ivy Carroll, F; Lee, JR; Ma, W; Martin, BR; Navarro, HA; Yokota, Y1
Anderson, DJ; Bunnelle, WH; Hutchins, CW; Schrimpf, MR; Sippy, KB1
Alexander, M; Dannals, RF; Endres, CJ; Gao, Y; Hilton, J; Holt, DP; Horti, AG; Kumar, A; Kuwabara, H; Ravert, HT; Wong, DF; Xiao, Y1
Anderson, DJ; Bunnelle, WH; Dyhring, T; Frost, JM; Grønlien, JH; Ji, J; Li, T; Meyer, MD; Peters, D; Scanio, MJ; Shi, L; Thorin-Hagene, K; Tietje, KR; Ween, H1
Jiang, F; Olsen, C; Polgar, W; Toll, L; Zaveri, N1
Casida, JE; Tomizawa, M1
Bertrand, D; Bertrand, S; Bréthous, L; Garcia-Delgado, N; Reymond, JL; Schwartz, J1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Bartkowiak, JM; Carroll, FI; Castro, AH; Damaj, MI; Luetje, CW; Mascarella, SW; Navarro, HA; Ondachi, PW1
Asproni, B; Deligia, F; Fasoli, F; Fucile, S; Gotti, C; Loriga, G; Murineddu, G; Pinna, GA; Plutino, S; Ragusa, G; Sciaccaluga, M1
Curtis, MA; Lin, SX; Sperry, J1
Abraham, P; Brieaddy, LE; Carroll, FI; Damaj, MI; Liang, F; Martin, BR; Navarro, HA1
Kagabu, S; Kiriyama, K; Kumamoto, Y; Nishimura, K; Nishiwaki, H; Tada, T1
Brieaddy, LE; Carroll, FI; Damaj, MI; Martin, BR; Navarro, HA; Ware, R1
Abdrakhmanova, GR; Carroll, FI; Damaj, MI; Deschamps, J; Hu, X; Martin, BR; Navarro, HA1
Danielson, UH; de Esch, IJ; de Kloe, GE; Geitmann, M; Homan, E; Retra, K; Smit, AB1
de la Fuente Revenga, M; Estrada-Valencia, M; Herrera-Arozamena, C; Martí-Marí, O; Pérez, C; Rodríguez-Franco, MI; Villalba-Galea, CA1

Reviews

7 review(s) available for epibatidine and nicotine

ArticleYear
Epibatidine: impact on nicotinic receptor research.
    Cellular and molecular neurobiology, 2003, Volume: 23, Issue:3

    Topics: Acetylcholine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System; Humans; Models, Molecular; Molecular Structure; Neurons; Nicotine; Pyridines; Receptors, Nicotinic

2003
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research.
    Drug discovery today, 2005, Volume: 10, Issue:23-24

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Drug Design; Humans; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship

2005
Nicotinic acetylcholine receptors: an overview on drug discovery.
    Expert opinion on therapeutic targets, 2009, Volume: 13, Issue:4

    Topics: Allosteric Regulation; Analgesics; Bridged Bicyclo Compounds, Heterocyclic; Cardiovascular Diseases; Drug Discovery; Hearing; Humans; Myasthenia Gravis; Neurodegenerative Diseases; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Protein Subunits; Psoriasis; Pyridines; Receptors, Nicotinic; Schizophrenia; Smoking; Smoking Cessation; Tobacco Use Disorder

2009
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship

1997
Epibatidine structure-activity relationships.
    Bioorganic & medicinal chemistry letters, 2004, Apr-19, Volume: 14, Issue:8

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Molecular Structure; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2004
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
    Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15

    Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic

2005
Pyridine alkaloids with activity in the central nervous system.
    Bioorganic & medicinal chemistry, 2020, 12-15, Volume: 28, Issue:24

    Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic

2020

Other Studies

250 other study(ies) available for epibatidine and nicotine

ArticleYear
(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Alkaloids; Analgesics; Animals; Azocines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Motor Activity; Nicotine; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes

1994
Epibatidine is a nicotinic analgesic.
    European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3

    Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Mecamylamine; Mice; Nicotine; Pyridines; Quinolizines; Rats; Receptors, Nicotinic

1993
Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice.
    European journal of pharmacology, 1996, Apr-04, Volume: 300, Issue:1-2

    Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Stereoisomerism

1996
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.
    Neuroreport, 1995, Nov-27, Volume: 6, Issue:17

    Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection

1995
Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:1

    Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Excitatory Amino Acids; Injections, Spinal; Male; Microdialysis; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord

1996
Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jan-15, Volume: 17, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Alkaloids; Animals; Arousal; Atropine; Azocines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cations, Divalent; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; GABA Antagonists; gamma-Aminobutyric Acid; Ion Transport; Lobeline; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium; Pyridazines; Pyridines; Quinolizines; Receptors, GABA-A; Receptors, Nicotinic; Tetrodotoxin; Thalamic Nuclei

1997
Differential mechanisms involved in the effect of nicotinic agonists DMPP and lobeline to release [3H]5-HT from rat hippocampal slices.
    Neuropharmacology, 1996, Volume: 35, Issue:12

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tritium; Tubocurarine

1996
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission

1997
A comparison of multiple injections versus continuous infusion of nicotine for producing up-regulation of neuronal [3H]-epibatidine binding sites.
    Neuropharmacology, 1997, Volume: 36, Issue:8

    Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Infusions, Intravenous; Injections, Subcutaneous; Male; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Trigeminal Ganglion; Up-Regulation

1997
Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration.
    Journal of neurochemistry, 1997, Volume: 69, Issue:5

    Topics: Adrenal Glands; Alkaloids; Animals; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Male; Multivariate Analysis; Neurons; Nicotine; Nicotinic Agonists; Organ Specificity; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Thalamus; Up-Regulation

1997
Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism.
    Molecular pharmacology, 1997, Volume: 52, Issue:6

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Enzyme Inhibitors; Humans; Kinetics; Neurons; Nicotine; Nicotinic Agonists; Phosphoric Monoester Hydrolases; Protein Conformation; Protein Kinase C; Pyridines; Receptors, Nicotinic; Sensitivity and Specificity; Transfection; Up-Regulation

1997
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
    Science (New York, N.Y.), 1998, Jan-02, Volume: 279, Issue:5347

    Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Dose-Response Relationship, Drug; In Vitro Techniques; Ligands; Mecamylamine; Morphine; Nerve Fibers; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Receptors, Nicotinic; Spinal Cord; Substance Withdrawal Syndrome; Synaptic Transmission

1998
Nicotine-stimulated release of [3H]norepinephrine from fetal rat locus coeruleus cells in culture.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Dimethylphenylpiperazinium Iodide; Fetus; Locus Coeruleus; N-Methylaspartate; Neurons; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Rhombencephalon; Structure-Activity Relationship; Tetrodotoxin; Tritium

1998
Nicotine exposure during a critical period of development leads to persistent changes in nicotinic acetylcholine receptors of adult rat brain.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Mice; Nicotine; Nicotinic Agonists; Organ Specificity; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus

1998
Chronic ethanol treatment decreases [3H]epibatidine and [3H]nicotine binding and differentially regulates mRNA levels of nicotinic acetylcholine receptor subunits expressed in M10 and SH-SY5Y neuroblastoma cells.
    Journal of neurochemistry, 1998, Volume: 70, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System Depressants; Culture Media; Ethanol; Gene Expression Regulation; Humans; Mice; Neuroblastoma; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; RNA, Messenger; Tritium; Tumor Cells, Cultured

1998
The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cholinergic Agents; Female; Guinea Pigs; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Nicotine; Pyridines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship

1998
Effects of the alpha subunit on imidacloprid sensitivity of recombinant nicotinic acetylcholine receptors.
    British journal of pharmacology, 1998, Volume: 123, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drosophila; Evoked Potentials; Female; Imidazoles; Insecticides; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pyridines; Receptors, Nicotinic; Recombinant Proteins; Xenopus laevis

1998
Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells.
    Journal of neurochemistry, 1998, Volume: 70, Issue:5

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Chickens; Humans; Mice; Neuroblastoma; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Cholinergic; Receptors, Nicotinic; RNA, Messenger; Time Factors; Tumor Cells, Cultured

1998
Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands.
    European journal of pharmacology, 1998, Apr-17, Volume: 347, Issue:1

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Benzylidene Compounds; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dimethylphenylpiperazinium Iodide; Humans; Insecticides; Iodine Radioisotopes; Kidney; Kinetics; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Transfection; Up-Regulation

1998
Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes.
    Neuroscience letters, 1998, May-15, Volume: 247, Issue:2-3

    Topics: Acetylcholine; Animals; Bacterial Toxins; Benzylidene Compounds; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Choline; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; DNA, Complementary; Female; Marine Toxins; Mice; Microcystins; Multigene Family; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin Antagonists; Structure-Activity Relationship; Xenopus laevis

1998
Non-acetylcholine displaceable 3[H]epibatidine binding in the rat brain.
    Neuroscience letters, 1998, May-22, Volume: 248, Issue:1

    Topics: Acetylcholine; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Tritium

1998
Laminar distribution of nicotinic receptor subtypes in human cerebral cortex as determined by [3H](-)nicotine, [3H]cytisine and [3H]epibatidine in vitro autoradiography.
    Neuroscience, 1998, Volume: 85, Issue:4

    Topics: Aged; Aged, 80 and over; Alkaloids; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Humans; In Vitro Techniques; Kinetics; Male; Microtomy; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic

1998
Rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function.
    Molecular pharmacology, 1998, Volume: 54, Issue:2

    Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Dose-Response Relationship, Drug; Humans; Ligands; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Rubidium; Sodium; Transfection

1998
Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord.
    Brain research. Developmental brain research, 1998, Jun-15, Volume: 108, Issue:1-2

    Topics: Aged; Aged, 80 and over; Alkaloids; Azocines; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; DNA Probes; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Medulla Oblongata; Mesencephalon; Middle Aged; Nicotine; Nicotinic Agonists; Peptidylprolyl Isomerase; Polymerase Chain Reaction; Pons; Pregnancy; Pregnancy Trimester, First; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA-Directed DNA Polymerase; RNA, Messenger; Spinal Cord; Tritium

1998
Nicotine induced up-regulation of nicotinic receptors in CD-1 mice demonstrated with an in vivo radiotracer: gender differences.
    Synapse (New York, N.Y.), 1998, Volume: 30, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Female; Iodine Radioisotopes; Male; Mice; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Sex Characteristics; Up-Regulation

1998
Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (+/-)-[3H]epibatidine.
    Brain research, 1998, Aug-10, Volume: 801, Issue:1-2

    Topics: Aged; Aged, 80 and over; Aging; Binding Sites; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Female; Humans; Isomerism; Male; Middle Aged; Nicotine; Protein Binding; Pyridines; Receptors, Nicotinic; Tritium

1998
Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors.
    Molecular pharmacology, 1998, Volume: 54, Issue:5

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Cell Adhesion; Cell Size; Cells, Cultured; Cholinergic Antagonists; Epithelial Cells; Fluorescent Antibody Technique; Humans; In Situ Hybridization; Membrane Potentials; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rabbits; Rats; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Species Specificity; Trachea; Tritium

1998
Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity.
    Molecular pharmacology, 1998, Volume: 54, Issue:6

    Topics: Acetylcholine; Alkaloids; Anabasine; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Dimethylphenylpiperazinium Iodide; Lobeline; Nicotine; Nicotinic Agonists; Oocytes; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Xenopus laevis

1998
Postnatal changes of nicotinic acetylcholine receptor alpha 2, alpha 3, alpha 4, alpha 7 and beta 2 subunits genes expression in rat brain.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1998, Volume: 16, Issue:6

    Topics: Animals; Brain; Brain Chemistry; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cerebellum; Cerebral Cortex; Corpus Striatum; DNA Primers; Female; Gene Expression Regulation, Developmental; Hippocampus; Nicotine; Nicotinic Agonists; Pregnancy; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Thalamus; Tritium

1998
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
    Neuropharmacology, 1998, Volume: 37, Issue:12

    Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal

1998
The effects of morphine, nicotine and epibatidine on lymphocyte activity and hypothalamic-pituitary-adrenal axis responses.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Adjuvants, Immunologic; Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chlorisondamine; Dose-Response Relationship, Drug; Drug Interactions; Hypothalamo-Hypophyseal System; Lymphocyte Activation; Male; Morphine; Naltrexone; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pituitary-Adrenal System; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid; T-Lymphocytes

1999
Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor protein 670/671 mutation.
    Journal of neurochemistry, 1999, Volume: 72, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Apolipoproteins E; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Humans; Kinetics; Male; Middle Aged; Mutation; Neurofibrillary Tangles; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Sweden

1999
Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo.
    Life sciences, 1999, Volume: 64, Issue:5

    Topics: Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Fluorine Radioisotopes; Frontal Lobe; Kinetics; Ligands; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus; Tissue Distribution

1999
Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain.
    Brain research. Molecular brain research, 1999, Mar-20, Volume: 66, Issue:1-2

    Topics: Aged; Aged, 80 and over; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cerebellum; Female; Hippocampus; Humans; Iodine Radioisotopes; Male; Middle Aged; Nicotine; Nicotinic Agonists; Peptidylprolyl Isomerase; Pyridines; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Temporal Lobe; Tritium

1999
Liquid chromatographic studies with immobilized neuronal nicotinic acetylcholine receptor stationary phases: effects of receptor subtypes, pH and ionic strength on drug-receptor interactions.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Mar-05, Volume: 724, Issue:1

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Ion Exchange; Hydrogen-Ion Concentration; Neurons; Nicotine; Osmolar Concentration; Prosencephalon; Pyridines; Rats; Receptors, Nicotinic; Recombinant Proteins

1999
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits.
    Nature, 1999, Apr-29, Volume: 398, Issue:6730

    Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Raphe Nuclei; Receptors, Nicotinic; Spinal Cord; Thalamus

1999
The role of beta 2-subunit-containing nicotinic acetylcholine receptors in the brain explored with a mutant mouse.
    Annals of the New York Academy of Sciences, 1999, Apr-30, Volume: 868

    Topics: Alkaloids; Animals; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Dopamine Agonists; Mice; Mice, Knockout; Nicotine; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic

1999
Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:5

    Topics: Animals; Auditory Pathways; Brain; Bridged Bicyclo Compounds, Heterocyclic; Decerebrate State; Female; Ganglia, Sympathetic; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Nicotine; Nicotinic Agonists; Oculomotor Muscles; Pain Threshold; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Succinylcholine; Sympathetic Fibers, Postganglionic

1999
Pharmacological similarities between native brain and heterologously expressed alpha4beta2 nicotinic receptors.
    British journal of pharmacology, 1999, Volume: 128, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Dihydro-beta-Erythroidine; Female; Gene Expression; Humans; Kinetics; Nicotine; Oocytes; Precipitin Tests; Pyridines; Rats; Receptors, Nicotinic; Recombinant Fusion Proteins; Tritium; Xenopus

1999
Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease.
    Neuroscience, 1999, Volume: 94, Issue:3

    Topics: Acetylcholine; Age Factors; Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Female; Humans; Male; Membrane Transport Proteins; Middle Aged; Nicotine; Piperidines; Pyridines; Quinolizines; Reference Values; Temporal Lobe; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins

1999
Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors.
    Neuroreport, 1999, Nov-26, Volume: 10, Issue:17

    Topics: Aconitine; Amyloid beta-Peptides; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cell Survival; Cholinesterase Inhibitors; Estradiol; Formazans; Humans; Mecamylamine; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Tetrazolium Salts; Tumor Cells, Cultured

1999
Magnocellular neurons of the rat supraoptic nucleus are endowed with functional nicotinic acetylcholine receptors.
    Neuroscience, 2000, Volume: 95, Issue:2

    Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Iodine Radioisotopes; Male; Membrane Potentials; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Supraoptic Nucleus; Tritium; Vasodilator Agents

2000
UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Apr-15, Volume: 20, Issue:8

    Topics: Animals; Bacterial Toxins; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cells, Cultured; Conotoxins; Corpus Striatum; Cyanobacteria Toxins; Dopamine; Humans; Marine Toxins; Microcystins; Neurotoxins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic; Synaptosomes; Tropanes; Xenopus

2000
Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically.
    European journal of pharmacology, 2000, Mar-30, Volume: 393, Issue:1-3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Hippocampus; Male; Mecamylamine; Motor Activity; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recombinant Proteins; Synaptosomes; Tetrodotoxin; Tritium

2000
The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain.
    European journal of pharmacology, 2000, Mar-30, Volume: 393, Issue:1-3

    Topics: Analgesics; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Humans; Models, Molecular; Neurons; Nicotine; Nicotinic Agonists; Pain; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2000
Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region.
    Brain research, 2000, Apr-28, Volume: 863, Issue:1-2

    Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Insecticides; Interneurons; Long-Term Potentiation; Muscimol; Neural Pathways; Nicotine; Nicotinic Agonists; Pyramidal Cells; Pyridines; Rats; Receptors, GABA-A; Receptors, Nicotinic

2000
Antagonism of nicotinic receptors of rat chromaffin cells by N,N, N-trimethyl-1-(4-trans-stilbenoxy)-2-propylammonium iodide: a patch clamp and ligand binding study.
    British journal of pharmacology, 2000, Volume: 129, Issue:8

    Topics: Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Chickens; Chromaffin Cells; Drug Interactions; Electrophysiology; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Species Specificity; Stereoisomerism; Stilbenes

2000
Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats.
    Pain, 2000, Volume: 85, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Hot Temperature; Hypertension; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Postural Balance; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Substance-Related Disorders

2000
Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.
    Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Esters; Inhibitory Concentration 50; Ligands; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Receptors, Nicotinic; Structure-Activity Relationship

2000
Mecamylamine prevents tolerance but enhances whole brain [3H]epibatidine binding in response to repeated nicotine administration in rats.
    Psychopharmacology, 2000, Volume: 150, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Tolerance; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2000
Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Sep-01, Volume: 20, Issue:17

    Topics: Aggression; Alkaloids; Animals; Autoradiography; Azocines; Base Sequence; Body Constitution; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Exploratory Behavior; Female; Fertility; Habituation, Psychophysiologic; Homozygote; Male; Mice; Mice, Knockout; Molecular Sequence Data; Motor Activity; Neurons; Nicotine; Oligonucleotide Probes; Phenotype; Pyridines; Quinolizines; Receptors, Nicotinic; Restriction Mapping; Social Behavior; Tritium

2000
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:4

    Topics: Aconitine; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Bridged Bicyclo Compounds, Heterocyclic; Child; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Regression Analysis; Schizophrenia; Smoking

2000
Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine.
    British journal of pharmacology, 2000, Volume: 131, Issue:4

    Topics: Alkaloids; Animals; Autoradiography; Azetidines; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Iodine Radioisotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic

2000
The unusual nature of epibatidine responses at the alpha4beta2 nicotinic acetylcholine receptor.
    Neuropharmacology, 2000, Volume: 39, Issue:13

    Topics: Algorithms; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; DNA; Ion Channel Gating; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Up-Regulation

2000
Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum.
    Neuropharmacology, 2000, Volume: 39, Issue:13

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Dopamine; Exocytosis; Male; Neostriatum; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Temperature

2000
Comparison of the effects of epibatidine and nicotine on the output of dopamine in the dorsal and ventral striatum of freely-moving rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:4-5

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Male; Microdialysis; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic

2000
Prenatal nicotine exposure is associated with an increase in [125I]epibatidine binding in discrete cortical regions in rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Female; Iodine Radioisotopes; Male; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Sprague-Dawley

2000
Effect of nicotine on cerebellar granule neuron development.
    The European journal of neuroscience, 2001, Volume: 13, Issue:1

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cells, Cultured; Cellular Senescence; Cerebellum; DNA; Mice; Mice, Inbred ICR; Neurons; Nicotine; Nicotinic Agonists; Protein Isoforms; Pyridines; Quinolizines; Receptors, Cholinergic; Stem Cells

2001
The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain.
    Brain research. Molecular brain research, 2001, Jan-31, Volume: 86, Issue:1-2

    Topics: Aconitine; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Antagonists; Haloperidol; Insecticides; Male; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Nicotinic; Schizophrenia; Smoking; Spiperone; Tritium

2001
Investigation of nicotine binding to THP-1 cells: evidence for a non-cholinergic binding site.
    Biochemical pharmacology, 2001, Mar-15, Volume: 61, Issue:6

    Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Humans; Monocytes; Nicotine; Nicotinic Agonists; Pyridines; Tritium; Tumor Cells, Cultured

2001
Effects of nicotine on head-shakes and tryptophan metabolites.
    Psychopharmacology, 2001, Volume: 153, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Head Movements; Hydroxyindoleacetic Acid; Indophenol; Kynurenine; Male; Mice; Nicotine; Nicotinic Agonists; Pyridines; Serotonin; Serotonin Receptor Agonists; Tics; Tryptophan

2001
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.
    Brain research, 2001, May-04, Volume: 900, Issue:1

    Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anthraquinones; Antimycin A; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cotinine; Electron Transport Complex I; Electron Transport Complex II; Hexamethonium; Male; Membrane Proteins; Mitochondria; Mitochondrial Proton-Translocating ATPases; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Neuroprotective Agents; Nicotine; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Prosencephalon; Pyridines; Quinolizines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic; Rotenone; Succinate Dehydrogenase; Superoxides; Synaptosomes

2001
Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2001, Volume: 3, Issue:2

    Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Membrane; Chromaffin Cells; Cotinine; Frontal Lobe; Hippocampus; Male; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic

2001
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.
    British journal of pharmacology, 2001, Volume: 133, Issue:8

    Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bacterial Toxins; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cells, Cultured; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; Hippocampus; Humans; Inhibitory Concentration 50; Marine Toxins; Microcystins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Tubocurarine; Tumor Cells, Cultured; Up-Regulation; Verapamil

2001
Agonist regulation of rat alpha 3 beta 4 nicotinic acetylcholine receptors stably expressed in human embryonic kidney 293 cells.
    Molecular pharmacology, 2001, Volume: 60, Issue:3

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Humans; Kidney; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Time Factors; Transfection; Tritium

2001
Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain.
    Neuroscience, 2001, Volume: 105, Issue:3

    Topics: Alkaloids; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA, Messenger; Smoking; Tritium; Up-Regulation

2001
Synthesis and evaluation of diazine containing bioisosteres of (-)-ferruginine as ligands for nicotinic acetylcholine receptors.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:10

    Topics: Animals; Bacterial Toxins; Brain; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Chromatography, Thin Layer; Crystallography, X-Ray; Cyanobacteria Toxins; Ligands; Marine Toxins; Mesylates; Microcystins; Molecular Conformation; Molecular Structure; Nicotine; Organotin Compounds; Palladium; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Tropanes; Vinyl Compounds

2001
Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes.
    Journal of neurophysiology, 2001, Volume: 86, Issue:4

    Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Size; Cells, Cultured; DNA Primers; Electrophysiology; Ganglia, Spinal; Gene Expression; Insecticides; Neurons, Afferent; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Vasodilator Agents

2001
Analgesic and toxic effects of neonicotinoid insecticides in mice.
    Toxicology and applied pharmacology, 2001, Nov-15, Volume: 177, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Fibroblasts; Imidazoles; Insecticides; Mecamylamine; Mice; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Pain; Pain Measurement; Pyridines; Receptors, Nicotinic; Thiazines; Time Factors

2001
Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures.
    Brain research. Molecular brain research, 2002, Jan-31, Volume: 98, Issue:1-2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dose-Response Relationship, Drug; Female; Hippocampus; Injections, Intraperitoneal; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Protein Subunits; Pyridines; Receptors, Nicotinic; RNA, Messenger; Seizures

2002
Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Feb-15, Volume: 22, Issue:4

    Topics: Alkaloids; Animals; Autoradiography; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Dopamine; Homozygote; Mice; Mice, Knockout; Mice, Mutant Strains; Nicotine; Nicotinic Antagonists; Organ Specificity; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Retinal Ganglion Cells; Tobacco Use Disorder; Visual Pathways

2002
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Mar-05, Volume: 99, Issue:5

    Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Carrier Proteins; Chickens; Cholinergic Agonists; Models, Molecular; Molecular Sequence Data; Nicotine; Protein Structure, Tertiary; Pyridines; Rats; Receptors, Nicotinic; Sequence Homology, Amino Acid; Torpedo

2002
Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.
    Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:3

    Topics: Aging; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Male; Nicotine; Nicotinic Agonists; Parasympathomimetics; Pirenzepine; Pyridines; Radioligand Assay; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Tacrine; Tritium

2002
Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors.
    Synapse (New York, N.Y.), 2002, Volume: 45, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Animals; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Agents; Ellipticines; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors; Tomography, Emission-Computed

2002
Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration.
    Neuropharmacology, 2002, Volume: 43, Issue:5

    Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dopamine; Hippocampus; Male; Membranes; Neostriatum; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2002
Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism.
    Brain research, 2002, Oct-25, Volume: 953, Issue:1-2

    Topics: Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Spinal; Mice; Nicotine; Nicotinic Agonists; Pyridines; Sciatic Nerve; Sciatica; Spinal Cord

2002
Ligand-receptor interaction at the neural nicotinic acetylcholine binding site: a theoretical model.
    Journal of molecular graphics & modelling, 2002, Volume: 21, Issue:2

    Topics: Acetylcholine; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Computer Simulation; Ligands; Models, Molecular; Molecular Structure; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic

2002
Changes in conformation and subcellular distribution of alpha4beta2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Dec-01, Volume: 22, Issue:23

    Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Humans; Immunoblotting; Kidney; Ligands; Mice; Nicotine; Protein Conformation; Protein Folding; Protein Subunits; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Recombinant Fusion Proteins; Time; Up-Regulation

2002
Effects of prolonged nicotinic ligand exposure on function of heterologously expressed, human alpha4beta2- and alpha4beta4-nicotinic acetylcholine receptors.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1

    Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Cholinergic Agents; Humans; In Situ Hybridization; Ligands; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Rubidium Radioisotopes

2003
Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function.
    Molecular pharmacology, 2003, Volume: 63, Issue:2

    Topics: Animals; Benzylidene Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Chick Embryo; Cholinergic Antagonists; Conotoxins; Kinetics; Neurons; Nicotine; Nicotinic Agonists; Protein Subunits; Pyridines; Receptors, Nicotinic

2003
Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.
    Journal of neurobiology, 2003, Volume: 55, Issue:1

    Topics: Acetylcholine; Alkaloids; Amyloid beta-Peptides; Animals; Atropine; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Conotoxins; Dose-Response Relationship, Drug; Frontal Lobe; In Vitro Techniques; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Potassium; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Subcellular Fractions; Synaptosomes

2003
Melatonin nocturnal surge modulates nicotinic receptors and nicotine-induced [3H]glutamate release in rat cerebellum slices.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2

    Topics: Adrenergic beta-Antagonists; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Choline; Circadian Rhythm; Darkness; Glutamic Acid; In Vitro Techniques; Light; Male; Melatonin; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Propranolol; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic

2003
Chronic nicotine treatment attenuates alpha 7 nicotinic receptor deficits following traumatic brain injury.
    Neuropharmacology, 2003, Volume: 44, Issue:2

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Calcium Channels, L-Type; Disease Models, Animal; Dose-Response Relationship, Drug; Isradipine; Male; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Protein Isoforms; Pyridines; Quinuclidinyl Benzilate; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Tritium

2003
Functional neurochemical evidence for the presence of presynaptic nicotinic acetylcholine receptors at the terminal region of myenteric motoneurons: a study with epibatidine.
    Neurochemical research, 2003, Volume: 28, Issue:3-4

    Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Motor Neurons; Muscle, Skeletal; Myenteric Plexus; Nicotine; Nicotinic Agonists; Osmolar Concentration; Presynaptic Terminals; Pyridines; Receptors, Nicotinic

2003
Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells.
    Neurochemistry international, 2003, Volume: 43, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Lipid Peroxidation; Neuroprotective Agents; Nicotine; Oxidative Stress; PC12 Cells; Pyridines; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Tritium

2003
Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors.
    The European journal of neuroscience, 2003, Volume: 17, Issue:7

    Topics: Animals; Autoradiography; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; In Vitro Techniques; Iodine Isotopes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Mutagenesis; Neural Networks, Computer; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Substantia Nigra; Time Factors; Ventral Tegmental Area

2003
Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta.
    The Journal of comparative neurology, 2003, Jun-16, Volume: 461, Issue:1

    Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Azocines; Binding Sites; Brain; Brain Mapping; Bridged Bicyclo Compounds, Heterocyclic; Diencephalon; Macaca mulatta; Male; Mesencephalon; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Telencephalon; Tissue Distribution

2003
Chronic nicotine administration does not increase nicotinic receptors labeled by [125I]epibatidine in adrenal gland, superior cervical ganglia, pineal or retina.
    Journal of neurochemistry, 2003, Volume: 85, Issue:5

    Topics: Adrenal Glands; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Infusion Pumps, Implantable; Iodine Radioisotopes; Ligands; Male; Nicotine; Nicotinic Agonists; Pineal Gland; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Retina; Superior Cervical Ganglion; Time

2003
Chronic intermittent nicotine administration attenuates traumatic brain injury-induced cognitive dysfunction.
    Neuroscience, 2003, Volume: 119, Issue:4

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cognition Disorders; Drug Administration Schedule; Male; Maze Learning; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Up-Regulation

2003
Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities.
    Pest management science, 2003, Volume: 59, Issue:9

    Topics: Algorithms; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Drosophila; Electrophysiology; Imidazoles; Insecticides; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Oocytes; Pyridines; Receptors, Nicotinic; Tritium; Xenopus laevis

2003
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.
    Molecular pharmacology, 2003, Volume: 64, Issue:4

    Topics: Aconitine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cells, Cultured; Humans; N-Methylscopolamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympatholytics; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Tritium

2003
Differential regulation of nicotinic acetylcholine receptors in PC12 cells by nicotine and nerve growth factor.
    Molecular pharmacology, 2003, Volume: 64, Issue:4

    Topics: Animals; Azetidines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Differentiation; Iodine Radioisotopes; Nerve Growth Factor; Nicotine; Nicotinic Agonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Rubidium Radioisotopes; Tritium

2003
Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:3

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Drug Tolerance; Male; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tobacco Use Disorder; Up-Regulation

2003
Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists.
    Brain research, 2003, Nov-14, Volume: 990, Issue:1-2

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Prefrontal Cortex; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tetrodotoxin

2003
Epibatidine induces long-term potentiation (LTP) via activation of alpha4beta2 nicotinic acetylcholine receptors (nAChRs) in vivo in the intact mouse dentate gyrus: both alpha7 and alpha4beta2 nAChRs essential to nicotinic LTP.
    Journal of pharmacological sciences, 2003, Volume: 93, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Choline; Dentate Gyrus; Drug Synergism; In Vitro Techniques; Long-Term Potentiation; Mecamylamine; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic

2003
Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine.
    The European journal of neuroscience, 2003, Volume: 18, Issue:9

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; In Situ Hybridization; Male; Mecamylamine; Mouth Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Nicotinic; Trigeminal Ganglion

2003
Cholinergic actions on carotid chemosensory system.
    Advances in experimental medicine and biology, 2003, Volume: 536

    Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carotid Body; Cats; Chemoreceptor Cells; Cholinergic Agents; Electrophysiology; In Vitro Techniques; Nicotine; Nicotinic Agonists; Pyridines; Tidal Volume

2003
Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia.
    Biological psychiatry, 2003, Dec-01, Volume: 54, Issue:11

    Topics: Aged; Aged, 80 and over; Bridged Bicyclo Compounds, Heterocyclic; Case-Control Studies; Cotinine; Dementia; Female; Humans; Male; Middle Aged; Nicotine; Prefrontal Cortex; Psychiatric Status Rating Scales; Pyridines; Radioligand Assay; Receptors, Nicotinic; RNA, Messenger; Schizophrenia; Severity of Illness Index; Smoking

2003
Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the alpha6 subunit.
    Molecular pharmacology, 2004, Volume: 65, Issue:3

    Topics: Animals; Antibodies; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Immunosorbent Techniques; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Prosencephalon; Protein Subunits; Pyridines; Rats; Rats, Inbred Lew; Receptors, Nicotinic; Self Administration; Sodium Chloride; Time; Up-Regulation

2004
Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients.
    Neurobiology of disease, 2004, Volume: 15, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cystine; Down-Regulation; Humans; Iodine Radioisotopes; Middle Aged; Nicotine; Nicotinic Agonists; Peptide Fragments; Pyridines; Radioligand Assay; Receptors, Nicotinic; Smoking; Tritium

2004
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:1

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Cholinergic Agonists; Gene Expression; Humans; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Transfection; Tritium; Up-Regulation

2004
Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors.
    Bioorganic & medicinal chemistry letters, 2004, Apr-19, Volume: 14, Issue:8

    Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Ligands; Molecular Structure; Neurons; Nicotine; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2004
Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment.
    Neuropharmacology, 2004, Volume: 46, Issue:8

    Topics: Acetylcholine; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Iodine Radioisotopes; Mice; Mice, Inbred C57BL; Nicotine; Pyridines; Receptors, Cholinergic; Rubidium Radioisotopes

2004
Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment.
    Journal of neurochemistry, 2004, Volume: 90, Issue:1

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cotinine; Dose-Response Relationship, Drug; Infusion Pumps, Implantable; Ligands; Male; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes; Time Factors; Up-Regulation

2004
Comparison of the effects of nicotine and epibatidine on the striatal extracellular dopamine.
    European journal of pharmacology, 2004, Jun-28, Volume: 494, Issue:2-3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Caudate Nucleus; Dopamine; Extracellular Space; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Microdialysis; Neostriatum; Nicotine; Nicotinic Agonists; Putamen; Pyridines; Rats; Rats, Wistar

2004
Modulation of dopamine release by the nicotinic agonist epibatidine in the frontal cortex and the nucleus accumbens of naive and chronic nicotine treated rats.
    Neurochemistry international, 2004, Volume: 45, Issue:7

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Frontal Lobe; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Pyridines; Rats; Rats, Sprague-Dawley

2004
Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA.
    Molecular pharmacology, 2005, Volume: 67, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Amino Acid Sequence; Animals; Antibodies; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Humans; Iodine Radioisotopes; Levodopa; Molecular Sequence Data; Nicotine; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Saimiri

2005
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization.
    Science (New York, N.Y.), 2004, Nov-05, Volume: 306, Issue:5698

    Topics: Alkaloids; Animals; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Drug Tolerance; Leucine; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Nicotine; Point Mutation; Pyridines; Quinolizines; Receptors, Nicotinic; Reward; Serine; Tobacco Use Disorder; Up-Regulation

2004
Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Nov-10, Volume: 24, Issue:45

    Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Grooming; Hyperalgesia; Infusion Pumps, Implantable; Male; Mastication; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nicotine; Pyridines; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tremor

2004
Nicotine and epibatidine triggered prolonged rise in calcium and TH gene transcription in PC12 cells.
    European journal of pharmacology, 2004, Dec-03, Volume: 506, Issue:1

    Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Dideoxyadenosine; Dose-Response Relationship, Drug; Egtazic Acid; Luciferases; Nicotine; PC12 Cells; Promoter Regions, Genetic; Pyridines; Rats; Recombinant Fusion Proteins; Time Factors; Transcription, Genetic; Tyrosine 3-Monooxygenase

2004
High-affinity epibatidine binding of functional, human alpha7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Autoradiography; Blotting, Northern; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line; Cell Line, Tumor; DNA, Complementary; Epithelial Cells; Humans; Immunohistochemistry; Immunoprecipitation; Membrane Potentials; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Plasmids; Pyridines; Receptors, Nicotinic; RNA; Transfection

2005
The dorsal raphe nucleus as a site of action of the antinociceptive and behavioral effects of the alpha4 nicotinic receptor agonist epibatidine.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Formaldehyde; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2005
Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice.
    Neuropharmacology, 2005, Volume: 48, Issue:1

    Topics: Adrenalectomy; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Body Weight; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Conditioning, Classical; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Organ Size; Pyridines; Reflex, Startle; Spleen; Time Factors

2005
Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor.
    Journal of the American Chemical Society, 2005, Jan-12, Volume: 127, Issue:1

    Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chemical Phenomena; Chemistry, Physical; Cholinergic Agonists; Crystallography, X-Ray; Hydrogen Bonding; Kinetics; Models, Molecular; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Static Electricity; Surface Properties; Threonine; Tryptophan; Xenopus laevis

2005
Nicotinic modulation of GABAergic synaptic transmission in the spinal cord dorsal horn.
    Brain research, 2005, Jan-21, Volume: 1031, Issue:2

    Topics: Analgesics; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Long-Term Synaptic Depression; Lumbar Vertebrae; Neural Inhibition; Nicotine; Nicotinic Agonists; Organ Culture Techniques; Patch-Clamp Techniques; Posterior Horn Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glycine; Receptors, Nicotinic; Spinal Cord; Synaptic Transmission

2005
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.
    Analytical chemistry, 2005, Feb-01, Volume: 77, Issue:3

    Topics: Alkaloids; Azocines; Binding, Competitive; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Dextromethorphan; Mecamylamine; Membranes, Artificial; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic

2005
6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.
    Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Humans; Models, Molecular; Molecular Conformation; Nicotine; Protein Binding; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Tropanes

2005
The Caenorhabditis elegans lev-8 gene encodes a novel type of nicotinic acetylcholine receptor alpha subunit.
    Journal of neurochemistry, 2005, Volume: 93, Issue:1

    Topics: Action Potentials; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antinematodal Agents; Behavior, Animal; Blotting, Northern; Body Size; Bridged Bicyclo Compounds, Heterocyclic; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cloning, Molecular; Electrophysiology; Epithelial Cells; Feeding Behavior; Gene Expression; Genomics; Green Fluorescent Proteins; Levamisole; Movement; Muscles; Mutation; Neuromuscular Junction; Neurons; Nicotine; Nicotinic Agonists; Pharynx; Phenotype; Pyridines; Receptors, Nicotinic; Reproduction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transgenes

2005
Nicotine and epibatidine alter differently nomifensine-elevated dopamine output in the rat dorsal and ventral striatum.
    European journal of pharmacology, 2005, Mar-28, Volume: 511, Issue:2-3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Caudate Nucleus; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Extracellular Space; Homovanillic Acid; Male; Microdialysis; Nicotine; Nicotinic Agonists; Nomifensine; Nucleus Accumbens; Putamen; Pyridines; Rats; Rats, Wistar

2005
The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Acetylcholine; Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Conotoxins; Dose-Response Relationship, Drug; Drug Interactions; Hydrogen-Ion Concentration; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Protein Subunits; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Time Factors

2005
Roles for nicotinic acetylcholine receptor subunit large cytoplasmic loop sequences in receptor expression and function.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Amino Acid Sequence; Animals; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cloning, Molecular; Cytoplasm; DNA, Complementary; Humans; Immunoprecipitation; Mice; Molecular Sequence Data; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Rubidium Radioisotopes; Transfection

2005
Time and brain region specific up-regulation of low affinity neuronal nicotinic receptors during chronic nicotine administration in mice.
    European journal of pharmacology, 2005, May-16, Volume: 515, Issue:1-3

    Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Mesencephalon; Mice; Mice, Inbred Strains; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Time Factors; Tritium; Up-Regulation

2005
Comparison of the effects of nicotine and epibatidine given in combination with nomifensine on rotational behaviour in rats.
    Neuroscience letters, 2005, Jun-24, Volume: 381, Issue:3

    Topics: Adrenergic Agents; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nomifensine; Oxidopamine; Parkinsonian Disorders; Pyridines; Rats; Rats, Wistar

2005
Chronic nicotine differentially affects the function of nicotinic receptor subtypes regulating neurotransmitter release.
    Journal of neurochemistry, 2005, Volume: 93, Issue:5

    Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; D-Aspartic Acid; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; Male; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium; Protein Isoforms; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptosomes

2005
Nicotine upregulates its own receptors through enhanced intracellular maturation.
    Neuron, 2005, May-19, Volume: 46, Issue:4

    Topics: Antibodies; Autoradiography; Binding, Competitive; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cell Line; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; Glycosylation; Humans; Immunoprecipitation; Intracellular Space; Membrane Potentials; Models, Biological; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Binding; Protein Subunits; Pyridines; Receptors, Nicotinic; Time Factors; Transfection; Tritium; Up-Regulation

2005
Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro.
    Neuropharmacology, 2005, Volume: 49, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Aspartic Acid; Azetidines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Choline; Cyanobacteria Toxins; Dicarboxylic Acids; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Frontal Lobe; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Mecamylamine; Microcystins; Microscopy, Confocal; Neurotransmitter Uptake Inhibitors; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphopyruvate Hydratase; Potassium Chloride; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium; Tropanes

2005
Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation.
    Psychopharmacology, 2006, Volume: 184, Issue:3-4

    Topics: Animals; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chromosome Deletion; Genotype; Heterozygote; Infusions, Intravenous; Injections, Intravenous; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Mutation; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Tobacco Use Disorder; Up-Regulation

2006
Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats.
    The European journal of neuroscience, 2005, Volume: 22, Issue:2

    Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Dopamine; Female; Gene Expression Regulation, Developmental; Male; Microscopy, Confocal; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Protein Binding; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Factors

2005
A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor.
    Acta pharmacologica Sinica, 2005, Volume: 26, Issue:10

    Topics: Alkaloids; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Drug Evaluation, Preclinical; Embryo, Mammalian; Humans; Kidney; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Scintillation Counting

2005
Extracellular domain nicotinic acetylcholine receptors formed by alpha4 and beta2 subunits.
    The Journal of biological chemistry, 2005, Dec-02, Volume: 280, Issue:48

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cross-Linking Reagents; Crystallography, X-Ray; Detergents; Dimerization; DNA; Dose-Response Relationship, Drug; Epitopes; Glycosylation; Humans; Immunoblotting; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Nicotine; Oocytes; Plasmids; Protein Binding; Protein Structure, Tertiary; Pyridines; Receptors, Nicotinic; Time Factors; Xenopus laevis

2005
Lovastatin stimulates up-regulation of alpha7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the alpha-form of secreted amyloid precursor protein.
    Journal of neuroscience research, 2005, Nov-15, Volume: 82, Issue:4

    Topics: Amyloid beta-Protein Precursor; Animals; Blotting, Northern; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line, Tumor; Cholesterol; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isotopes; Lovastatin; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; PC12 Cells; Protein Binding; Pyridines; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ubiquinone; Up-Regulation

2005
Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells.
    British journal of pharmacology, 2005, Volume: 146, Issue:8

    Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Membrane Potentials; Nerve Tissue Proteins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Structure, Quaternary; Protein Transport; Pyridines; Quinolizines; Receptors, Nicotinic; Subcellular Fractions; Time Factors; Up-Regulation

2005
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
    Journal of medicinal chemistry, 2005, Nov-17, Volume: 48, Issue:23

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Ligands; Male; Mice; Motor Activity; Nicotine; Nicotinic Agonists; Norbornanes; Pain; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism

2005
Selective down-regulation of [(125)I]Y0-alpha-conotoxin MII binding in rat mesostriatal dopamine pathway following continuous infusion of nicotine.
    Neuroscience, 2006, Volume: 137, Issue:2

    Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Iodine Radioisotopes; Male; Mesencephalon; Neural Pathways; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Substance Withdrawal Syndrome; Substantia Nigra; Tobacco Use Disorder; Ventral Tegmental Area

2006
Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release.
    Molecular pharmacology, 2006, Volume: 69, Issue:3

    Topics: Alkaloids; Animals; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Signaling; Cell Membrane; Dimethylphenylpiperazinium Iodide; Insulin; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Mice; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic; Tumor Cells, Cultured

2006
Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:4

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Psychological; Male; Motor Activity; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar

2005
P2X(7) receptors exert a permissive role on the activation of release-enhancing presynaptic alpha7 nicotinic receptors co-existing on rat neocortex glutamatergic terminals.
    Neuropharmacology, 2006, Volume: 50, Issue:6

    Topics: Adenosine Triphosphate; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Choline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Enzyme Activation; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Neocortex; Nicotine; Nicotinic Agonists; Presynaptic Terminals; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Time Factors; Tritium

2006
Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors.
    The Journal of physiology, 2006, Oct-01, Volume: 576, Issue:Pt 1

    Topics: Acetylcholine; Alkaloids; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Electrophysiology; Epithelial Cells; Hexamethonium; Humans; Lobeline; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Quinolizines; Receptors, Nicotinic; Transfection

2006
Partial recovery of striatal nicotinic receptors in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with chronic oral nicotine.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:1

    Topics: Animals; Azetidines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Female; MPTP Poisoning; Nicotine; Parkinson Disease; Pyridines; Receptors, Nicotinic; Saimiri

2006
Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site.
    Molecular pharmacology, 2006, Volume: 70, Issue:4

    Topics: Acetylcholine; Anabasine; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Imidazoles; Insecticides; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Oocytes; Patch-Clamp Techniques; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus laevis

2006
Cholinergic regulation of endogenous morphine release from lobster nerve cord.
    Medical science monitor : international medical journal of experimental and clinical research, 2006, Volume: 12, Issue:9

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Ethanol; Ganglia, Invertebrate; Hexamethonium; In Vitro Techniques; Morphine; Nephropidae; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic

2006
Chronic neonatal nicotine upregulates heteromeric nicotinic acetylcholine receptor binding without change in subunit mRNA expression.
    Brain research, 2006, Oct-03, Volume: 1113, Issue:1

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Female; Gene Expression Regulation, Developmental; In Situ Hybridization; Iodine Isotopes; Male; Nicotine; Nicotinic Agonists; Pregnancy; Protein Binding; Protein Subunits; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger

2006
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs.
    Bioorganic & medicinal chemistry, 2007, Jan-15, Volume: 15, Issue:2

    Topics: Aconitine; Analgesics; Animals; Anticonvulsants; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Data Interpretation, Statistical; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain Measurement; Pyridines; Rats; Reaction Time; Receptors, Nicotinic; Seizures

2007
Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRs.
    Journal of neurochemistry, 2007, Volume: 100, Issue:1

    Topics: Analysis of Variance; Animals; Autoradiography; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Conotoxins; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Paraquat; Protein Binding; Pyridines; Receptors, Nicotinic; Substantia Nigra

2007
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord

2007
Effects of chronic neonatal nicotine exposure on nicotinic acetylcholine receptor binding, cell death and morphology in hippocampus and cerebellum.
    Neuroscience, 2007, Jun-08, Volume: 146, Issue:4

    Topics: Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Count; Cell Death; Cerebellum; Female; Gene Expression Regulation, Developmental; Hippocampus; In Situ Hybridization; In Situ Nick-End Labeling; Nicotine; Nicotinic Agonists; Pregnancy; Protein Binding; Protein Subunits; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2007
High affinity binding of epibatidine to serotonin type 3 receptors.
    The Journal of biological chemistry, 2008, Apr-11, Volume: 283, Issue:15

    Topics: Animals; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Humans; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists

2008
T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Sep-01, Volume: 179, Issue:5

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; CD3 Complex; Cell Membrane; Humans; Immunoprecipitation; Jurkat Cells; Leukocytes; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Neurons; Nicotine; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fyn; Pyridines; Rats; Receptors, Antigen, T-Cell; Receptors, Nicotinic; RNA, Small Interfering; T-Lymphocytes

2007
The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo.
    Journal of neurochemistry, 2008, Volume: 104, Issue:2

    Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Immunoprecipitation; Nicotine; Nicotinic Agonists; Protein Subunits; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Up-Regulation

2008
Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway.
    The Journal of biological chemistry, 2008, Jan-11, Volume: 283, Issue:2

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Humans; Kidney; Nicotine; Nicotinic Agonists; p38 Mitogen-Activated Protein Kinases; Pyridines; Radioligand Assay; Receptors, Nicotinic; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation

2008
Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type.
    Analytical chemistry, 2008, Jan-01, Volume: 80, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line; Cell Membrane; Cells, Immobilized; Chromatography, Affinity; Fluorescein-5-isothiocyanate; Humans; Kinetics; Microscopy, Confocal; Nicotine; Organ Specificity; Pyridines; Receptors, Nicotinic

2008
Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors.
    Biochimica et biophysica acta, 2008, Volume: 1778, Issue:4

    Topics: Amino Acid Sequence; Amino Acids; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chlorocebus aethiops; COS Cells; Kinetics; Molecular Sequence Data; Mutation; Neurons; Nicotine; Nicotinic Agonists; Protein Structure, Secondary; Protein Subunits; Pyridines; Rats; Receptors, Nicotinic; Sequence Alignment; Structure-Activity Relationship; Tubocurarine

2008
The effects of acute and repeated nicotine doses on spontaneous activity in male and female Sprague Dawley rats: analysis of brain area epibatidine binding and cotinine levels.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:3

    Topics: Animals; Behavior, Animal; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cotinine; Female; Male; Motor Activity; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Sex Characteristics

2008
Assaying small-molecule-receptor interactions by continuous flow competitive displacement chromatography/mass spectrometry.
    Analytical chemistry, 2008, May-01, Volume: 80, Issue:9

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, Affinity; Fluorescein; Kinetics; Nanotechnology; Nicotine; Pyridines; Receptors, Nicotinic; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Torpedo

2008
Cigarette smoke, nicotine and cotinine protect against 6-hydroxydopamine-induced toxicity in SH-SY5Y cells.
    Neurotoxicology, 2008, Volume: 29, Issue:3

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Catecholamines; Cell Count; Cell Differentiation; Cell Line; Cell Survival; Cotinine; Humans; Immunohistochemistry; Neuroprotective Agents; Nicotiana; Nicotine; Nicotinic Agonists; Oxidopamine; Phenotype; Pyridines; Receptors, Nicotinic; Smoke; Smoking; Tyrosine 3-Monooxygenase

2008
Roles of accessory subunits in alpha4beta2(*) nicotinic receptors.
    Molecular pharmacology, 2008, Volume: 74, Issue:1

    Topics: Acetylcholine; Allosteric Regulation; Antibodies, Monoclonal; Binding Sites; Biotinylation; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Galantamine; Humans; Inhibitory Concentration 50; Kidney; Mecamylamine; Mutation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioimmunoassay; Receptors, Nicotinic; Transfection; Up-Regulation

2008
Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, May-27, Volume: 105, Issue:21

    Topics: Animals; Aplysia; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Imidazoles; Imidazolines; Kinetics; Ligands; Neonicotinoids; Nicotine; Nicotinic Agonists; Nitro Compounds; Protein Conformation; Pyridines; Receptors, Nicotinic; Thiazines

2008
Opposing actions of chronic stress and chronic nicotine on striatal function in mice.
    Neuroscience letters, 2008, Jul-25, Volume: 440, Issue:1

    Topics: Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Female; In Vitro Techniques; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Stress, Physiological

2008
Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Male; Nicotine; Pain; Peripheral Nervous System Diseases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Spinal Nerves

2008
Nicotine and postoperative management of pain.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:3

    Topics: Administration, Cutaneous; Analgesics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Humans; Mice; Nicotine; Pain; Postoperative Period; Pyridines; Receptors, Cholinergic; Receptors, Nicotinic; Smoking; Spinal Cord

2008
Nicotine relieves anxiogenic-like behavior in mice that overexpress the read-through variant of acetylcholinesterase but not in wild-type mice.
    Molecular pharmacology, 2008, Volume: 74, Issue:6

    Topics: Acetylcholinesterase; Animals; Anxiety; Behavior, Animal; Brain; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Isoenzymes; Maze Learning; Mice; Mice, Transgenic; Motor Activity; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Pyridines; Radioligand Assay; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Up-Regulation

2008
Preconditioning stimuli that augment chromaffin cell secretion.
    American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:4

    Topics: Acetylcholine; Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Catecholamines; Cattle; Cells, Cultured; Choline; Chromaffin Cells; Dose-Response Relationship, Drug; Mecamylamine; Methacholine Chloride; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Potassium; Pyridines; Receptors, Muscarinic; Receptors, Nicotinic; Sympathetic Nervous System; Time Factors

2009
Single-channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor.
    FEBS letters, 2009, Mar-18, Volume: 583, Issue:6

    Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cattle; Cholinergic Agonists; Ion Channel Gating; Models, Biological; Nicotine; Patch-Clamp Techniques; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin 5-HT3 Receptor Agonists; Xenopus

2009
Modulatory role of estradiol in nicotinic antinociception in adult female rats.
    Life sciences, 2009, Jul-03, Volume: 85, Issue:1-2

    Topics: Analgesics; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Estradiol; Female; Immunohistochemistry; Injections, Spinal; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Ovariectomy; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic; Spinal Cord

2009
Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test.
    Psychopharmacology, 2009, Volume: 205, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nicotinic Agonists; Norepinephrine; Pyridines; Radioligand Assay; Receptors, Nicotinic; Serotonin; Stress, Psychological

2009
A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine.
    The Journal of organic chemistry, 2009, Jul-17, Volume: 74, Issue:14

    Topics: Acetylcholine; Ammonia; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Magnetic Resonance Spectroscopy; Molecular Structure; Nicotine; Pyridines; Solubility; Thermodynamics; Water

2009
Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity.
    Pharmacogenetics and genomics, 2010, Volume: 20, Issue:2

    Topics: Acetylcholine; Administration, Oral; Animals; Bridged Bicyclo Compounds, Heterocyclic; Gene Knock-In Techniques; Mice; Mutation; Nicotine; Organ Specificity; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Reproducibility of Results

2010
Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:3

    Topics: Amphetamine; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Central Nervous System Stimulants; Cocaine; Conotoxins; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Male; Mecamylamine; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereotyped Behavior

2010
Nicotine exposure throughout early development promotes nicotine self-administration in adolescent mice and induces long-lasting behavioural changes.
    European journal of pharmacology, 2010, Aug-25, Volume: 640, Issue:1-3

    Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cotinine; Female; Fetal Development; Lactation; Maternal Exposure; Mice; Motor Activity; Nicotine; Pregnancy; Pyridines; Self Administration; Smoking; Swimming; Time Factors

2010
Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jul-27, Volume: 107, Issue:30

    Topics: Acetylcholine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Carbon; Female; Hydrogen Bonding; Membrane Potentials; Microinjections; Models, Molecular; Molecular Structure; Mutation; Nicotine; Nicotinic Agonists; Oocytes; Protein Structure, Tertiary; Pyridines; Rats; Receptors, Nicotinic; RNA, Messenger; Xenopus laevis

2010
Differential sensitivity of Ctenocephalides felis and Drosophila melanogaster nicotinic acetylcholine receptor α1 and α2 subunits in recombinant hybrid receptors to nicotinoids and neonicotinoid insecticides.
    Insect biochemistry and molecular biology, 2011, Volume: 41, Issue:1

    Topics: Acetylcholine; Amino Acid Sequence; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cats; Chickens; Cloning, Molecular; Ctenocephalides; Dose-Response Relationship, Drug; Drosophila melanogaster; Imidazoles; Insecticides; Kinetics; Molecular Sequence Data; Neonicotinoids; Nicotine; Nitro Compounds; Oocytes; Phylogeny; Protein Subunits; Pyridines; Receptors, Nicotinic; Recombinant Proteins; Xenopus laevis

2011
Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors.
    European journal of pharmacology, 2011, Jul-15, Volume: 662, Issue:1-3

    Topics: Acetylcholine; Aconitine; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cholinesterase Inhibitors; Diterpenes; Drug Synergism; Fetus; Humans; Ligands; Membrane Potentials; Muscles; Neostigmine; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship

2011
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.
    Neuron, 2011, May-12, Volume: 70, Issue:3

    Topics: Administration, Oral; Analysis of Variance; Animals; Animals, Newborn; Asparagine; Aspartic Acid; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Conditioning, Operant; Electric Stimulation; Green Fluorescent Proteins; Habenula; Humans; In Vitro Techniques; Iodine Isotopes; Mice; Mice, Transgenic; Models, Molecular; Mutation; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Stereotaxic Techniques; Xenopus

2011
Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states.
    The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:9

    Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cell Line; Computer Simulation; Electric Organ; Humans; Ibogaine; Linear Models; Models, Molecular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo

2011
Nicotine reduces L-DOPA-induced dyskinesias by acting at beta2* nicotinic receptors.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3

    Topics: Animals; Antiparkinson Agents; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Cotinine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Oxidopamine; Pyridines; Receptors, Nicotinic; Substantia Nigra; Sympatholytics

2011
Patterns of nicotinic receptor antagonism: nicotine discrimination studies.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:1

    Topics: Animals; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Data Interpretation, Statistical; Dihydro-beta-Erythroidine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Varenicline

2011
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jul-27, Volume: 31, Issue:30

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Receptors, Nicotinic; Reward; Synaptosomes; Tritium

2011
High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology.
    Journal of biomolecular screening, 2011, Volume: 16, Issue:8

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Chemical Fractionation; Chromatography, Affinity; Chromatography, High Pressure Liquid; Complex Mixtures; Flow Injection Analysis; High-Throughput Screening Assays; Ligands; Mass Spectrometry; Nanotechnology; Nicotine; Nicotinic Agonists; Protein Binding; Pyridines; Radioligand Assay; Recombinant Proteins; Reproducibility of Results

2011
Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons.
    Journal of neurochemistry, 2011, Volume: 119, Issue:1

    Topics: Animals; Biotinylation; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Cycloheximide; Female; Hippocampus; Immunoprecipitation; Methionine; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Protein Synthesis Inhibitors; Pyridines; Rats; Receptors, Nicotinic; Up-Regulation

2011
Comparison of the effects of nicotine upon the transcellular electrical resistance and sucrose permeability of human ECV304/rat C6 co-cultures and human CaCo₂ cells.
    Toxicology letters, 2011, Nov-10, Volume: 207, Issue:1

    Topics: Animals; Blood-Brain Barrier; Bridged Bicyclo Compounds, Heterocyclic; Caco-2 Cells; Cell Membrane Permeability; Coculture Techniques; Electric Impedance; Endothelial Cells; Humans; Immunohistochemistry; Membrane Proteins; Nicotine; Nicotinic Agonists; Occludin; Phosphoproteins; Pyridines; Rats; Receptors, Nicotinic; Sucrose; Zonula Occludens-1 Protein

2011
AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:6

    Topics: Analysis of Variance; Animals; Biophysics; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line, Transformed; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Food; Humans; Male; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Oligopeptides; Patch-Clamp Techniques; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Self Administration; Transfection; Tritium

2012
Neuroprotective properties of nicotine.
    Current medicinal chemistry, 2012, Volume: 19, Issue:2

    Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Chickens; Cortical Spreading Depression; In Vitro Techniques; N-Methylaspartate; Neuroprotective Agents; Nicotine; Pyridines; Receptors, N-Methyl-D-Aspartate; Retina; Video Recording

2012
Regulation of the distribution and function of [(125)I]epibatidine binding sites by chronic nicotine in mouse embryonic neuronal cultures.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:2

    Topics: Alkylation; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane; Cells, Cultured; Diencephalon; Hippocampus; Iodine Radioisotopes; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Pyridines; Receptors, Nicotinic; Up-Regulation

2012
Diurnal variation in nicotine sensitivity in mice: role of genetic background and melatonin.
    Neuropharmacology, 2012, Volume: 63, Issue:6

    Topics: Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Male; Maze Learning; Melatonin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Motor Activity; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Sex Characteristics; Signal Transduction; Species Specificity

2012
Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus.
    Psychopharmacology, 2013, Volume: 225, Issue:1

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Psychological; Fear; Hippocampus; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Species Specificity; Substance Withdrawal Syndrome; Tobacco Use Disorder; Up-Regulation

2013
Amyloid β-protein suppressed nicotinic acetylcholine receptor-mediated currents in acutely isolated rat hippocampal CA1 pyramidal neurons.
    Synapse (New York, N.Y.), 2013, Volume: 67, Issue:1

    Topics: Amyloid beta-Peptides; Animals; Bridged Bicyclo Compounds, Heterocyclic; CA1 Region, Hippocampal; Choline; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic

2013
3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors.
    Neurotoxicology, 2013, Volume: 35

    Topics: Aconitine; Animals; Blotting, Western; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Drug Synergism; Immunoprecipitation; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Nicotinic Agonists; Paroxetine; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin Plasma Membrane Transport Proteins; Time Factors; Up-Regulation

2013
Nicotine-morphine interactions at α4β2, α7 and α3(⁎) nicotinic acetylcholine receptors.
    European journal of pharmacology, 2013, Feb-15, Volume: 701, Issue:1-3

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line, Tumor; Drug Interactions; Humans; Morphine; Nicotine; Pyridines; Receptors, Nicotinic; Rubidium Radioisotopes

2013
Binding interactions with the complementary subunit of nicotinic receptors.
    The Journal of biological chemistry, 2013, Mar-08, Volume: 288, Issue:10

    Topics: Acetylcholine; Amino Acid Sequence; Animals; Asparagine; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Female; Humans; Hydrogen Bonding; Leucine; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Nicotine; Oocytes; Patch-Clamp Techniques; Protein Binding; Pyridines; Receptors, Nicotinic; Sequence Homology, Amino Acid; Xenopus laevis

2013
Genetic deletion of the adenosine A(2A) receptor prevents nicotine-induced upregulation of α7, but not α4β2* nicotinic acetylcholine receptor binding in the brain.
    Neuropharmacology, 2013, Volume: 71

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cotinine; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Protein Subunits; Pyridines; Receptor, Adenosine A2A; Receptors, Nicotinic; Tobacco Use Disorder; Up-Regulation

2013
Interview with Frank Ivy Carroll.
    Future medicinal chemistry, 2013, Volume: 5, Issue:10

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dopamine Uptake Inhibitors; Humans; Nicotine; Protein Binding; Pyridines; Receptor, Adenosine A2B; Receptors, Nicotinic; Research; Substance-Related Disorders; Tropanes

2013
Volatile anesthetic isoflurane inhibits LTP induction of hippocampal CA1 neurons through α4β2 nAChR subtype-mediated mechanisms.
    Annales francaises d'anesthesie et de reanimation, 2013, Volume: 32, Issue:10

    Topics: Anesthetics, Inhalation; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; CA1 Region, Hippocampal; Dihydro-beta-Erythroidine; Drug Interactions; Electric Stimulation; In Vitro Techniques; Isoflurane; Long-Term Potentiation; Mecamylamine; Muscarinic Agonists; Neural Pathways; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2013
Effectiveness of nicotinic agonists as desensitizers at presynaptic α4β2- and α4α5β2-nicotinic acetylcholine receptors.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014, Volume: 16, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Mice; Mice, Mutant Strains; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Smoking Cessation

2014
Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells.
    Brain research, 2014, Jan-13, Volume: 1542

    Topics: Acetylcholine; Biophysical Phenomena; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Cholinergic Agents; Conotoxins; Dose-Response Relationship, Drug; Green Fluorescent Proteins; HEK293 Cells; Humans; Membrane Potentials; Mutation; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Plant Lectins; Protein Subunits; Pyridines; Receptors, Nicotinic; Transfection

2014
Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 348, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Female; HEK293 Cells; Humans; Nicotine; Nicotinic Agonists; Oocytes; Phosphorylation; Polymorphism, Genetic; Protein Subunits; Pyridines; Receptors, Nicotinic; Up-Regulation; Xenopus laevis

2014
α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration.
    Journal of neurochemistry, 2014, Volume: 130, Issue:2

    Topics: Alkaloids; Animals; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; In Vitro Techniques; Mice; Mice, Knockout; Neostriatum; Nicotine; Nicotinic Agonists; Olfactory Bulb; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Synaptosomes

2014
Discriminative stimulus and hypothermic effects of some derivatives of the nAChR agonist epibatidine in mice.
    Psychopharmacology, 2014, Volume: 231, Issue:23

    Topics: Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Dihydro-beta-Erythroidine; Discrimination Learning; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic

2014
Differential expression of the beta4 neuronal nicotinic receptor subunit affects tolerance development and nicotinic binding sites following chronic nicotine treatment.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 130

    Topics: Alkaloids; Animals; Azocines; Binding Sites; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Iodine Radioisotopes; Maze Learning; Mice; Mutation; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic

2015
Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface.
    Neuropharmacology, 2015, Volume: 92

    Topics: Acetylcholine; Animals; Azepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Electric Stimulation; HEK293 Cells; Humans; Membrane Potentials; Models, Molecular; Nicotine; Nicotinic Agonists; Oocytes; Protein Binding; Protein Subunits; Pyridines; Receptors, Nicotinic; Transfection; Tritium; Xenopus laevis

2015
Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors.
    Molecular pharmacology, 2015, Volume: 88, Issue:2

    Topics: Acetylcholine; Allosteric Regulation; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cholinergic Agonists; HEK293 Cells; Humans; Ion Channels; Menthol; Mice; Mice, Inbred C57BL; Nicotine; Nodose Ganglion; Pyridines; Receptors, Nicotinic; Sensory Receptor Cells; Signal Transduction

2015
Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine.
    Neuropharmacology, 2015, Volume: 99

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Female; Immunoprecipitation; Male; Nicotine; Nicotinic Agonists; Pyridines; Rats, Sprague-Dawley; Receptors, Nicotinic; Sex Characteristics; Tritium; Up-Regulation

2015
Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits.
    The Journal of pharmacology and experimental therapeutics, 2015, Volume: 355, Issue:3

    Topics: Age of Onset; Aging; Animals; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Male; Methamphetamine; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic

2015
Competition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen.
    Neurochemical research, 2015, Volume: 40, Issue:10

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Humans; Neurons; Nicotine; Nitrogen; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2015
Effects of nicotinic receptor agonists on bladder afferent nerve activity in an in vitro bladder-pelvic nerve preparation.
    Brain research, 2016, Apr-15, Volume: 1637

    Topics: Action Potentials; Administration, Intravesical; Animals; Bridged Bicyclo Compounds, Heterocyclic; Male; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peripheral Nervous System; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Urinary Bladder

2016
Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids.
    Toxins, 2016, 07-04, Volume: 8, Issue:7

    Topics: Anabasine; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Membrane Potentials; Muscle Cells; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Risk Assessment; Teratogens; Time Factors

2016
Attenuated nicotine-like effects of varenicline but not other nicotinic ACh receptor agonists in monkeys receiving nicotine daily.
    British journal of pharmacology, 2016, Volume: 173, Issue:24

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Varenicline

2016
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice.
    Psychopharmacology, 2017, Volume: 234, Issue:5

    Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline

2017
NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain.
    Cell reports, 2017, 04-25, Volume: 19, Issue:4

    Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line; Cognitive Dysfunction; Conotoxins; Humans; Iodine Radioisotopes; Membrane Proteins; Mice; Mice, Knockout; Molecular Chaperones; Neurons; Nicotine; Protein Binding; Protein Subunits; Pyridines; Radiopharmaceuticals; Receptors, Nicotinic

2017
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.
    Journal of natural products, 2018, 04-27, Volume: 81, Issue:4

    Topics: Alkaloids; Amphibian Venoms; Animals; Anura; Bridged Bicyclo Compounds, Heterocyclic; Heterocyclic Compounds, Bridged-Ring; Nicotine; Nicotinic Agonists; Poisons; Pyridines; Receptors, Nicotinic; Stereoisomerism

2018
Differential effects of withdrawal from intermittent and continuous nicotine exposure on reward deficit and somatic aspects of nicotine withdrawal and expression of α4β2* nAChRs in Wistar male rats.
    Pharmacology, biochemistry, and behavior, 2018, Volume: 171

    Topics: Animals; Autoantigens; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Infusion Pumps, Implantable; Iodine Radioisotopes; Limbic Lobe; Male; Nicotine; Nucleus Accumbens; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Substance Withdrawal Syndrome; Up-Regulation; Ventral Tegmental Area

2018
Differential cross-tolerance to the effects of nicotinic acetylcholine receptor drugs in C57BL/6J mice following chronic varenicline.
    Behavioural pharmacology, 2019, Volume: 30, Issue:5

    Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Conditioning, Operant; Drug Tolerance; Female; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Reinforcement, Psychology; Smoking Cessation; Varenicline

2019
Serine residues in the α4 nicotinic acetylcholine receptor subunit regulate surface α4β2
    Biochemical pharmacology, 2019, Volume: 159

    Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis, Site-Directed; Mutation; Neurons; Nicotine; Pyridines; Receptors, Nicotinic; Serine; Up-Regulation

2019
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.
    Journal of medicinal chemistry, 1996, Feb-16, Volume: 39, Issue:4

    Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Cell Line; Cell Membrane; Ethers; Ganglia; Humans; Molecular Structure; Neurons; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Tritium

1996
Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.
    Journal of medicinal chemistry, 1997, Jul-18, Volume: 40, Issue:15

    Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Mice; Nicotinic Antagonists; Papio; Pyridines; Radioligand Assay; Receptors, Nicotinic; Tomography, Emission-Computed

1997
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.
    Journal of medicinal chemistry, 1999, Jun-17, Volume: 42, Issue:12

    Topics: Animals; Azetidines; Brain; Fluorine Radioisotopes; Humans; Ligands; Male; Papio; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tissue Distribution; Tomography, Emission-Computed

1999
Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Amino Acids; Ligands; Models, Molecular; Molecular Conformation; Quantum Theory; Receptors, Nicotinic; Structure-Activity Relationship

1999
Improving the nicotinic pharmacophore with a series of (Isoxazole)methylene-1-azacyclic compounds: synthesis, structure-activity relationship, and molecular modeling.
    Journal of medicinal chemistry, 1999, Dec-02, Volume: 42, Issue:24

    Topics: Animals; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Hydrogen Bonding; Isoxazoles; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Nicotine; Nitrogen; Quinuclidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Static Electricity; Structure-Activity Relationship; Thermodynamics

1999
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
    Journal of agricultural and food chemistry, 2000, Volume: 48, Issue:12

    Topics: Animals; Chromatography, High Pressure Liquid; Insecta; Insecticides; Magnetic Resonance Spectroscopy; Mammals; Molecular Structure; Nicotine

2000
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted-3'-phenyl-5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel nicotinic antagonist.
    Journal of medicinal chemistry, 2001, Nov-22, Volume: 44, Issue:24

    Topics: Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Male; Mice; Nicotinic Antagonists; Protein Subunits; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2001
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
    Journal of medicinal chemistry, 2002, Feb-28, Volume: 45, Issue:5

    Topics: Adrenal Glands; Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; In Vitro Techniques; Ligands; Nicotinic Agonists; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Swine

2002
Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Animals; Azides; Binding Sites; Binding, Competitive; Cell Line; Drosophila; Imidazoles; Imines; Insecticides; Mice; Neonicotinoids; Nitro Compounds; Photoaffinity Labels; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship; Thiazoles

2002
Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes.
    Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14

    Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Dopamine; In Vitro Techniques; Injections, Spinal; Ligands; Mice; Nicotinic Agonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship

2002
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues.
    Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6

    Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Crystallography, X-Ray; Cyclization; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Protein Subunits; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2003
Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors.
    Bioorganic & medicinal chemistry letters, 2003, Feb-24, Volume: 13, Issue:4

    Topics: Humans; Molecular Mimicry; Neurons; Nicotine; Protein Binding; Receptors, Nicotinic; Structure-Activity Relationship

2003
Synthesis and nicotinic receptor activity of a hydroxylated tropane.
    Bioorganic & medicinal chemistry letters, 2004, Jan-05, Volume: 14, Issue:1

    Topics: Animals; Humans; Hydroxylation; Nicotinic Agonists; Protein Binding; Rats; Receptors, Nicotinic; Tropanes

2004
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.
    Bioorganic & medicinal chemistry letters, 2004, Apr-19, Volume: 14, Issue:8

    Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Gene Expression; Humans; Neurons; Nicotinic Agonists; Protein Subunits; Rats; Receptors, Nicotinic; Transfection

2004
Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine.
    Journal of medicinal chemistry, 2004, Dec-30, Volume: 47, Issue:27

    Topics: Anabasine; Crystallography, X-Ray; Molecular Conformation; Nicotine; Receptors, Nicotinic; Structure-Activity Relationship

2004
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.
    Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4

    Topics: Analgesics; Animals; Binding, Competitive; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Male; Mice; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2005
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.
    Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Ligands; Models, Molecular; Neurons; Protein Subunits; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic

2005
Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors.
    Bioorganic & medicinal chemistry letters, 2005, Oct-01, Volume: 15, Issue:19

    Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Ligands; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship; Transfection

2005
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.
    Journal of medicinal chemistry, 2006, May-04, Volume: 49, Issue:9

    Topics: Alkaloids; Azocines; Cholinergic Agonists; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Structure; Nicotine; Quinolizines; Receptors, Cholinergic

2006
Mapping the elusive neonicotinoid binding site.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, May-22, Volume: 104, Issue:21

    Topics: Animals; Aplysia; Binding Sites; Carrier Proteins; Cell Line; Humans; Mass Spectrometry; Models, Molecular; Molecular Structure; Nicotine; Photoaffinity Labels

2007
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: Analgesics; Animals; Binding, Competitive; Brain; Cell Line; Diamines; Dopamine; Heterocyclic Compounds, Bridged-Ring; In Vitro Techniques; Ligands; Models, Molecular; Nicotinic Agonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyridines; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2007
Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.
    Journal of medicinal chemistry, 2007, Nov-01, Volume: 50, Issue:22

    Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Heptanes; Humans; In Vitro Techniques; Ligands; Nicotinic Agonists; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2007
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs.
    Bioorganic & medicinal chemistry, 2008, Jan-15, Volume: 16, Issue:2

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Molecular Structure; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship

2008
Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.
    Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6

    Topics: Animals; Azetidines; Chemistry, Pharmaceutical; Diamines; Drug Design; Humans; Kinetics; Ligands; Models, Chemical; Molecular Conformation; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2009
Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.
    Bioorganic & medicinal chemistry, 2009, Jul-01, Volume: 17, Issue:13

    Topics: Animals; Brain Chemistry; Carbon Radioisotopes; Humans; Lipids; Male; Mice; Papio; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Nicotinic; Structure-Activity Relationship

2009
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
    Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Cell Line; Diamines; Humans; Ligands; Nicotinic Agonists; Pyrroles; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Substrate Specificity

2009
Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.
    Journal of medicinal chemistry, 2010, Nov-25, Volume: 53, Issue:22

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Indoles; Ligands; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Transfection

2010
Unique neonicotinoid binding conformations conferring selective receptor interactions.
    Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7

    Topics: Anabasine; Animals; Aplysia; Binding Sites; Insecticides; Lymnaea; Models, Molecular; Molecular Conformation; Protein Conformation; Receptors, Nicotinic

2011
Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Allosteric Regulation; Animals; Benzamides; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Databases, Factual; Female; Humans; Models, Molecular; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Xenopus

2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.
    Journal of medicinal chemistry, 2014, Feb-13, Volume: 57, Issue:3

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Contraindications; Female; Male; Mice; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pain; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus

2014
Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α
    European journal of medicinal chemistry, 2018, May-25, Volume: 152

    Topics: Aniline Compounds; Animals; Bridged Bicyclo Compounds; Cell Line; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Structure; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2018
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues.
    Journal of medicinal chemistry, 2001, Jun-21, Volume: 44, Issue:13

    Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Pain Measurement; Pyridines; Radioligand Assay; Rats; Reaction Time; Receptors, Nicotinic; Structure-Activity Relationship

2001
Asymmetric chloronicotinyl insecticide, 1-[1-(6-chloro-3-pyridyl)ethyl]-2-nitroiminoimidazolidine: preparation, resolution and biological activities toward insects and their nerve preparations.
    Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:5

    Topics: Animals; Binding Sites; Cockroaches; Crystallography, X-Ray; Houseflies; Imidazoles; Imidazolidines; Indicators and Reagents; Insecticides; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neonicotinoids; Nervous System; Neurons; Nitro Compounds; Plants; Pyridines; Receptors, Cholinergic

2003
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist.
    Journal of medicinal chemistry, 2004, Aug-26, Volume: 47, Issue:18

    Topics: Analgesics; Animals; Body Temperature; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Mice; Nicotinic Antagonists; Pain; Protein Binding; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2004
Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes.
    Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11

    Topics: Analgesics; Animals; Cell Line; Cerebral Cortex; Crystallography, X-Ray; Discrimination Learning; Male; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Measurement; Patch-Clamp Techniques; Pyridines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Tropanes

2006
Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.
    Biochemistry, 2010, Sep-21, Volume: 49, Issue:37

    Topics: Acetylcholine; Animals; Biophysical Phenomena; Carrier Proteins; Ligands; Lymnaea; Nicotine; Proteins; Synaptic Transmission

2010
Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups.
    European journal of medicinal chemistry, 2020, Aug-15, Volume: 200

    Topics: Animals; Azo Compounds; Humans; Isomerism; Ligands; Light; Neuromuscular Agents; Nicotinic Agonists; Oocytes; Quaternary Ammonium Compounds; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus laevis

2020