epibatidine and cytisine

epibatidine has been researched along with cytisine in 76 studies

Research

Studies (76)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	21 (27.63)	18.2507
2000's	44 (57.89)	29.6817
2010's	10 (13.16)	24.3611
2020's	1 (1.32)	2.80

Authors

Authors	Studies
Adams, P; Anderson, DJ; Bannon, AW; Brioni, JD; Buckley, MJ; Decker, MW; Donnelly-Roberts, D; Kang, CH; Piattoni-Kaplan, M; Sullivan, JP	1
Biftu, T; Eckman, J; Ip, S; Li, T; Libertine-Garahan, L; Qian, C; Shen, TY	1
Nordberg, A; Warpman, U	1
Changeux, JP; Léna, C	2
Baranyi, M; Lajtha, A; Lendvai, B; Santha, E; Sershen, H; Vizi, ES	1
Boyd, RT; Bryant, DL; McKay, DB; Wenger, BW	1
Dávila-García, MI; Flores, CM; Kellar, KJ; Ulrich, YM	1
Gallardo, KA; Leslie, FM	1
Anderson, DJ; Arneric, SP; Briggs, CA; Campbell, JE; Donnelly-Roberts, DL; Holladay, MW; Kuntzweiler, TA; McKenna, DG; Piattoni-Kaplan, M; Puttfarcken, PS; Wasicak, JT; Williams, M	1
Gillberg, PG; Nordberg, A; Sihver, W	1
Gorbounova, O; Hellström-Lindahl, E; Mousavi, M; Nordberg, A; Seiger, A	1
Beck, A; Luetje, CW; Parker, MJ	1
Kruse, CG; Scheeren, HW; Seerden, JP; Tulp, MT	1
Buerkle, H; Khan, IM; Taylor, P; Yaksh, TL	1
Bottlaender, M; Coulon, C; Crouzel, C; Dollé, F; Fuseau, C; Guenther, I; Hinnen, F; Ottaviani, M; Valette, H	1
Dávila-García, MI; Kellar, KJ; Perry, DC; Stockmeier, CA	1
Gnädisch, D; Hill, GR; London, ED; Mukhin, AG; Terry, P	1
Gillberg, PG; Nordberg, A; Sihver, W; Svensson, AL	1
Berkovic, SF; Clifford, JJ; Drago, J; Horne, MK; Kinsella, A; Kola, I; Massalas, JS; Ross, SA; Scheffer, IE; Waddington, JL; Wong, JY	1
Collins, AC; Jimenez, M; Marks, MJ; McIntosh, JM; Whiteaker, P	1
Faltynek, CR; Jacobs, I; Puttfarcken, PS	1
Hauser, KF; Opanashuk, LA; Pauly, JR	1
Cormier, A; Lagrue, G; Morin, C; Tillement, JP; Zini, R	1
Gündisch, D; Imming, P; Klaperski, P; Seitz, G; Stubbs, MT	1
Ridley, DL; Rogers, A; Wonnacott, S	1
Hellström-Lindahl, E; Kjaeldgaard, A; Nordberg, A	1
Genzen, JR; McGehee, DS; Van Cleve, W	1
Bessis, A; Champtiaux, N; Changeux, JP; Han, ZY; Marubio, L; McIntosh, JM; Rossi, FM; Zoli, M	1
Collins, AC; Grady, SR; Marks, MJ; McIntosh, JM; Picciotto, MR; Whiteaker, P	1
Kulak, JM; McIntosh, JM; Polonskaya, Y; Quik, M	1
Bottlaender, M; Coulon, C; Dannals, RF; Dolle, F; Kassiou, M; Loc'h, C; Maziere, B; Musachio, JL; Ottaviani, M	1
Mellerup, ET; Plenge, P; Wörtwein, G	1
Dávila-García, MI; Kellar, KJ; Musachio, JL; Nguyen, HN; Perry, DC; Xiao, Y	1
Anderson, DJ; Jacobs, I; Puttfarcken, PS; Surowy, CS	1
Lee, DH; Wang, HY	1
Bourgeois, JP; Cardona, A; Changeux, JP; Han, ZY; Le Novère, N; Zoli, M	1
Gohlke, H; Gündisch, D; Schwarz, S; Seitz, G; Tilotta, MC; Weber, A; Wegge, T	1
Astles, PC; Baker, SR; Boot, JR; Broad, LM; Dell, CP; Keenan, M	1
Baldani-Guerra, B; Canu-Boido, C; Carbonnelle, E; Clementi, F; Gotti, C; Salvagno, C; Sparatore, F; Terstappen, G; Vijverberg, H; Zwart, R	1
Adams, P; Correa, LD; Rao, TS; Sacaan, AI; Santori, EM	1
Dussor, GO; Flores, CM; Gracia, NB; Hargreaves, KM; Kilo, S; Leong, AS; Price, TJ	1
Bordia, T; Clementi, F; Fan, H; Gotti, C; Kulak, JM; McIntosh, JM; Quik, M; Vailati, S	1
Collins, AC; Deshpande, P; Labarca, C; Lester, HA; Marks, MJ; McKinney, SL; Nashmi, R; Schwarz, J; Tapper, AR; Whiteaker, P	1
Jozwiak, K; Moaddel, R; Wainer, IW; Whittington, K	1
Collins, AC; Grady, SR; Marks, MJ; McIntosh, JM; Salminen, O; Whiteaker, P	1
Gao, J; Hui, X; Ogiku, T; Suto, N; Wang, MW; Xie, X	1
Canu-Boido, C; Clementi, F; Di Angelantonio, S; Gaimarri, A; Gotti, C; Matteoni, C; Nistri, A; Riganti, L; Sparatore, F	1
Badyuk, M; Daly, JW; Kellar, KJ; Ohtani, M; Oka, T; Xiao, Y	1
Abin-Carriquiry, JA; Bermúdez, I; Cassels, BK; Dajas, F; Wonnacott, S	1
Collins, AC; Marks, MJ; Whiteaker, P	1
Hu, J; Kuo, YP; Liu, Q; Lukas, RJ; Segerberg, M; St John, PA; Wu, J; Yu, K	1
Collins, AC; Damaj, MI; Deshpande, P; Fonck, C; Labarca, C; Lester, HA; Marks, MJ; Martin, BR	1
Guan, ZZ; Nordberg, A; Yu, WF	1
Collins, AC; Drago, J; Marks, MJ; Meinerz, NM	1
Deerinck, T; Khan, IM; Printz, MP; Singletary, EA; Stanislaus, S; Wart, CV; Yaksh, TL	1
Bernal, JA; Castillo, M; Criado, M; Mulet, J; Sala, F; Sala, S	1
Arias, HR; Feuerbach, D; Jozwiak, K; Targowska-Duda, KM	1
Arias, HR; Benson, LC; Fedorov, NB; Feuerbach, D; Gatto, GJ; Lippiello, PM; Ortells, MO	1
Grady, SR; Marks, MJ; McIntosh, JM; Paley, MA; Salminen, O; Wageman, CR; Whiteaker, P	1
Loetz, EC; Marks, MJ; Meyers, EE	1
de Moura, FB; McMahon, LR	2
Dart, MJ; Holladay, MW; Lynch, JK	1
Bottlaender, M; Coulon, C; Crouzel, C; Dolci, L; Doll, F; Fuseau, C; Guenther, I; Hinnen, F; Valette, H; Vaufrey, F	1
Chen, S; Cheng, J; Izenwasser, S; Paul, D; Stevens, ED; Trudell, ML; Wade, D; Zhang, C	1
Baydyuk, M; Davis, HE; Kellar, KJ; Wang, HP; Xiao, Y	1
Daly, JW; Fitch, RW; Gündisch, D; Kaneko, Y; Klaperski, P; Seitz, G	1
Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Liljefors, T	1
Chellappan, SK; Kellar, KJ; Kozikowski, AP; Tueckmantel, W; Xiao, Y	1
Broad, LM; Folly, L; Handa, S; Malpass, JR; Mogg, A; Richard Baker, S; White, R	1
Clementi, F; Dallanoce, C; De Amici, M; Frigerio, F; Gotti, C; Grazioso, G; Martelli, G; Matera, C; Pomè, DY; Pucci, L	1
Jiang, F; Olsen, C; Polgar, W; Toll, L; Zaveri, N	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Al-Muhtasib, N; Fitch, RW; Foxman, BM; Olson, TT; Pandya, AA; Panter, KE; Snider, BB; Welch, KD; Xiao, Y; Yakel, JL; Zhou, Q	1
Curtis, MA; Lin, SX; Sperry, J	1

Reviews

5 review(s) available for epibatidine and cytisine

Article	Year
Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands. Current drug targets. CNS and neurological disorders, 2002, Volume: 1, Issue:4 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Humans; Ligands; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic	2002
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research. Drug discovery today, 2005, Volume: 10, Issue:23-24 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Drug Design; Humans; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship	2005
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26 Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship	1997
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15 Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Humans; Ligands; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Protein Subunits; Receptors, Nicotinic	2005
Pyridine alkaloids with activity in the central nervous system. Bioorganic & medicinal chemistry, 2020, 12-15, Volume: 28, Issue:24 Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic	2020

Other Studies

71 other study(ies) available for epibatidine and cytisine

Article	Year
(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2 Topics: Alkaloids; Analgesics; Animals; Azocines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Motor Activity; Nicotine; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rubidium Radioisotopes	1994
Epibatidine is a nicotinic analgesic. European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3 Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Mecamylamine; Mice; Nicotine; Pyridines; Quinolizines; Rats; Receptors, Nicotinic	1993
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains. Neuroreport, 1995, Nov-27, Volume: 6, Issue:17 Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection	1995
Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jan-15, Volume: 17, Issue:2 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Alkaloids; Animals; Arousal; Atropine; Azocines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cations, Divalent; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; GABA Antagonists; gamma-Aminobutyric Acid; Ion Transport; Lobeline; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium; Pyridazines; Pyridines; Quinolizines; Receptors, GABA-A; Receptors, Nicotinic; Tetrodotoxin; Thalamic Nuclei	1997
Differential mechanisms involved in the effect of nicotinic agonists DMPP and lobeline to release [3H]5-HT from rat hippocampal slices. Neuropharmacology, 1996, Volume: 35, Issue:12 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Hippocampus; In Vitro Techniques; Kinetics; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tritium; Tubocurarine	1996
Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:2 Topics: Acetylcholine; Adrenal Glands; Alkaloids; Animals; Antibodies, Monoclonal; Azocines; Base Sequence; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cells, Cultured; Chromaffin Granules; DNA, Complementary; Down-Regulation; Molecular Sequence Data; Nicotinic Agonists; Polymerase Chain Reaction; Pyridines; Quinolizines; Receptors, Nicotinic; Sequence Homology, Nucleic Acid	1997
Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration. Journal of neurochemistry, 1997, Volume: 69, Issue:5 Topics: Adrenal Glands; Alkaloids; Animals; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Male; Multivariate Analysis; Neurons; Nicotine; Nicotinic Agonists; Organ Specificity; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Thalamus; Up-Regulation	1997
Nicotine-stimulated release of [3H]norepinephrine from fetal rat locus coeruleus cells in culture. Journal of neurochemistry, 1998, Volume: 70, Issue:2 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Dimethylphenylpiperazinium Iodide; Fetus; Locus Coeruleus; N-Methylaspartate; Neurons; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Rhombencephalon; Structure-Activity Relationship; Tetrodotoxin; Tritium	1998
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2 Topics: Administration, Oral; Alkaloids; Analgesics, Non-Narcotic; Animals; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcitonin Gene-Related Peptide; Calcium; Humans; Male; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Xenopus laevis	1998
Laminar distribution of nicotinic receptor subtypes in human cerebral cortex as determined by [3H](-)nicotine, [3H]cytisine and [3H]epibatidine in vitro autoradiography. Neuroscience, 1998, Volume: 85, Issue:4 Topics: Aged; Aged, 80 and over; Alkaloids; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Humans; In Vitro Techniques; Kinetics; Male; Microtomy; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic	1998
Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord. Brain research. Developmental brain research, 1998, Jun-15, Volume: 108, Issue:1-2 Topics: Aged; Aged, 80 and over; Alkaloids; Azocines; Brain; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; DNA Probes; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Medulla Oblongata; Mesencephalon; Middle Aged; Nicotine; Nicotinic Agonists; Peptidylprolyl Isomerase; Polymerase Chain Reaction; Pons; Pregnancy; Pregnancy Trimester, First; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA-Directed DNA Polymerase; RNA, Messenger; Spinal Cord; Tritium	1998
Neuronal nicotinic receptor beta2 and beta4 subunits confer large differences in agonist binding affinity. Molecular pharmacology, 1998, Volume: 54, Issue:6 Topics: Acetylcholine; Alkaloids; Anabasine; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Dimethylphenylpiperazinium Iodide; Lobeline; Nicotine; Nicotinic Agonists; Oocytes; Protein Binding; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Xenopus laevis	1998
Synthesis and structure-activity data of some new epibatidine analogues. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:11 Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Drug Design; Indicators and Reagents; Kinetics; Models, Molecular; Molecular Conformation; Molecular Structure; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Structure-Activity Relationship	1998
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology, 1998, Volume: 37, Issue:12 Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; Hindlimb; Hot Temperature; Injections, Spinal; Lobeline; Male; Mecamylamine; Microinjections; Nicotine; Nicotinic Agonists; Pain; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine; Vocalization, Animal	1998
Characterization of the nicotinic ligand 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine in vivo. Life sciences, 1999, Volume: 64, Issue:5 Topics: Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Fluorine Radioisotopes; Frontal Lobe; Kinetics; Ligands; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thalamus; Tissue Distribution	1999
Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3 Topics: Adult; Aged; Aging; Alkaloids; Autopsy; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Female; Hippocampus; Humans; Male; Middle Aged; Neurons; Nicotinic Agonists; Prefrontal Cortex; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Smoking; Temporal Lobe; Tritium	1999
The role of beta 2-subunit-containing nicotinic acetylcholine receptors in the brain explored with a mutant mouse. Annals of the New York Academy of Sciences, 1999, Apr-30, Volume: 868 Topics: Alkaloids; Animals; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Dopamine Agonists; Mice; Mice, Knockout; Nicotine; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic	1999
High affinity binding of [3H]epibatidine to rat brain membranes. Neuroreport, 1999, Jun-03, Volume: 10, Issue:8 Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Cholinergic; Temperature	1999
Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease. Neuroscience, 1999, Volume: 94, Issue:3 Topics: Acetylcholine; Age Factors; Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Female; Humans; Male; Membrane Transport Proteins; Middle Aged; Nicotine; Piperidines; Pyridines; Quinolizines; Reference Values; Temporal Lobe; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins	1999
Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Sep-01, Volume: 20, Issue:17 Topics: Aggression; Alkaloids; Animals; Autoradiography; Azocines; Base Sequence; Body Constitution; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Exploratory Behavior; Female; Fertility; Habituation, Psychophysiologic; Homozygote; Male; Mice; Mice, Knockout; Molecular Sequence Data; Motor Activity; Neurons; Nicotine; Oligonucleotide Probes; Phenotype; Pyridines; Quinolizines; Receptors, Nicotinic; Restriction Mapping; Social Behavior; Tritium	2000
Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine. British journal of pharmacology, 2000, Volume: 131, Issue:4 Topics: Alkaloids; Animals; Autoradiography; Azetidines; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Iodine Radioisotopes; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic	2000
Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum. Neuropharmacology, 2000, Volume: 39, Issue:13 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dimethylphenylpiperazinium Iodide; Dopamine; Exocytosis; Male; Neostriatum; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Temperature	2000
Effect of nicotine on cerebellar granule neuron development. The European journal of neuroscience, 2001, Volume: 13, Issue:1 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cells, Cultured; Cellular Senescence; Cerebellum; DNA; Mice; Mice, Inbred ICR; Neurons; Nicotine; Nicotinic Agonists; Protein Isoforms; Pyridines; Quinolizines; Receptors, Cholinergic; Stem Cells	2001
In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation. Brain research, 2001, May-04, Volume: 900, Issue:1 Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anthraquinones; Antimycin A; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cotinine; Electron Transport Complex I; Electron Transport Complex II; Hexamethonium; Male; Membrane Proteins; Mitochondria; Mitochondrial Proton-Translocating ATPases; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Neuroprotective Agents; Nicotine; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Prosencephalon; Pyridines; Quinolizines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic; Rotenone; Succinate Dehydrogenase; Superoxides; Synaptosomes	2001
Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands. European journal of medicinal chemistry, 2001, Volume: 36, Issue:4 Topics: Aconitine; Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Drug Evaluation, Preclinical; Halogens; Ligands; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship	2001
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells. British journal of pharmacology, 2001, Volume: 133, Issue:8 Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bacterial Toxins; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cells, Cultured; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; Hippocampus; Humans; Inhibitory Concentration 50; Marine Toxins; Microcystins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Tubocurarine; Tumor Cells, Cultured; Up-Regulation; Verapamil	2001
Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain. Neuroscience, 2001, Volume: 105, Issue:3 Topics: Alkaloids; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Female; Fetus; Gene Expression Regulation, Developmental; Humans; Neurons; Nicotine; Nicotinic Agonists; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; RNA, Messenger; Smoking; Tritium; Up-Regulation	2001
Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes. Journal of neurophysiology, 2001, Volume: 86, Issue:4 Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Size; Cells, Cultured; DNA Primers; Electrophysiology; Ganglia, Spinal; Gene Expression; Insecticides; Neurons, Afferent; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Vasodilator Agents	2001
Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Feb-15, Volume: 22, Issue:4 Topics: Alkaloids; Animals; Autoradiography; Azocines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Conotoxins; Corpus Striatum; Dopamine; Homozygote; Mice; Mice, Knockout; Mice, Mutant Strains; Nicotine; Nicotinic Antagonists; Organ Specificity; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Retinal Ganglion Cells; Tobacco Use Disorder; Visual Pathways	2002
Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice. Journal of neurochemistry, 2002, Volume: 81, Issue:5 Topics: Acetylcholine; Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Inferior Colliculi; Iodine Radioisotopes; Mesencephalon; Mice; Mice, Mutant Strains; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Rubidium Radioisotopes; Tritium	2002
Differential nicotinic receptor expression in monkey basal ganglia: effects of nigrostriatal damage. Neuroscience, 2002, Volume: 112, Issue:3 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Animals; Azocines; Basal Ganglia; Brain Diseases; Bridged Bicyclo Compounds, Heterocyclic; Caudate Nucleus; Conotoxins; Corpus Striatum; Dopamine Agents; Female; Male; Nicotinic Agonists; Nicotinic Antagonists; Putamen; Pyridines; Quinolizines; Receptors, Nicotinic; Reference Values; Saimiri; Substantia Nigra; Tissue Distribution	2002
Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors. Synapse (New York, N.Y.), 2002, Volume: 45, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Animals; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Agents; Ellipticines; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors; Tomography, Emission-Computed	2002
Characterization of epibatidine binding to medial habenula: potential role in analgesia. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2 Topics: Alkaloids; Analgesia; Analgesics, Non-Narcotic; Animals; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Habenula; Pyridines; Quinolizines; Rats; Tissue Distribution; Tritium	2002
Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography. Journal of neurochemistry, 2002, Volume: 82, Issue:3 Topics: Alkaloids; Animals; Autoradiography; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Iodine Radioisotopes; Kidney; Ligands; Male; Nicotinic Antagonists; Organ Specificity; Pineal Gland; Protein Subunits; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Superior Cervical Ganglion; Tissue Distribution	2002
Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration. Neuropharmacology, 2002, Volume: 43, Issue:5 Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dopamine; Hippocampus; Male; Membranes; Neostriatum; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium Chloride; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic	2002
Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42. Journal of neurobiology, 2003, Volume: 55, Issue:1 Topics: Acetylcholine; Alkaloids; Amyloid beta-Peptides; Animals; Atropine; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Conotoxins; Dose-Response Relationship, Drug; Frontal Lobe; In Vitro Techniques; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Potassium; Pyridines; Quinolizines; Rats; Receptors, Nicotinic; Subcellular Fractions; Synaptosomes	2003
Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta. The Journal of comparative neurology, 2003, Jun-16, Volume: 461, Issue:1 Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Azocines; Binding Sites; Brain; Brain Mapping; Bridged Bicyclo Compounds, Heterocyclic; Diencephalon; Macaca mulatta; Male; Mesencephalon; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Telencephalon; Tissue Distribution	2003
3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor. Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11 Topics: Alkaloids; Animals; Azocines; Bacterial Toxins; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cyanobacteria Toxins; Drug Design; In Vitro Techniques; Ligands; Marine Toxins; Microcystins; Models, Molecular; Prosencephalon; Protein Subunits; Pyridines; Quantitative Structure-Activity Relationship; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Tropanes	2003
Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes. European journal of pharmacology, 2003, Jun-20, Volume: 471, Issue:2 Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Cell Line; Female; Gene Expression; Iodine Radioisotopes; Molecular Structure; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Nitrogen; Oocytes; Pyridines; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Tritium; Xenopus laevis	2003
Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists. Brain research, 2003, Nov-14, Volume: 990, Issue:1-2 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Prefrontal Cortex; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin; Tetrodotoxin	2003
Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine. The European journal of neuroscience, 2003, Volume: 18, Issue:9 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Capsaicin; In Situ Hybridization; Male; Mecamylamine; Mouth Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Nicotinic; Trigeminal Ganglion	2003
Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA. Molecular pharmacology, 2005, Volume: 67, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alkaloids; Amino Acid Sequence; Animals; Antibodies; Autoradiography; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Humans; Iodine Radioisotopes; Levodopa; Molecular Sequence Data; Nicotine; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Saimiri	2005
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science (New York, N.Y.), 2004, Nov-05, Volume: 306, Issue:5698 Topics: Alkaloids; Animals; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Drug Tolerance; Leucine; Mice; Mice, Inbred C57BL; Motor Activity; Neurons; Nicotine; Point Mutation; Pyridines; Quinolizines; Receptors, Nicotinic; Reward; Serine; Tobacco Use Disorder; Up-Regulation	2004
Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors. Analytical chemistry, 2005, Feb-01, Volume: 77, Issue:3 Topics: Alkaloids; Azocines; Binding, Competitive; Biomarkers; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Dextromethorphan; Mecamylamine; Membranes, Artificial; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic	2005
The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay. Neuropharmacology, 2005, Volume: 48, Issue:5 Topics: Acetylcholine; Alkaloids; Animals; Azetidines; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Conotoxins; Dose-Response Relationship, Drug; Drug Interactions; Hydrogen-Ion Concentration; Iodine Isotopes; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Protein Subunits; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Time Factors	2005
A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor. Acta pharmacologica Sinica, 2005, Volume: 26, Issue:10 Topics: Alkaloids; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Drug Evaluation, Preclinical; Embryo, Mammalian; Humans; Kidney; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Scintillation Counting	2005
Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. British journal of pharmacology, 2005, Volume: 146, Issue:8 Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Membrane Potentials; Nerve Tissue Proteins; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Structure, Quaternary; Protein Transport; Pyridines; Quinolizines; Receptors, Nicotinic; Subcellular Fractions; Time Factors; Up-Regulation	2005
Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release. Molecular pharmacology, 2006, Volume: 69, Issue:3 Topics: Alkaloids; Animals; Azetidines; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Signaling; Cell Membrane; Dimethylphenylpiperazinium Iodide; Insulin; Insulin-Secreting Cells; Insulinoma; Membrane Potentials; Mice; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Receptors, Nicotinic; Tumor Cells, Cultured	2006
Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine. Molecular pharmacology, 2006, Volume: 70, Issue:3 Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Gene Deletion; Iodine Radioisotopes; Kinetics; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nicotinic Agonists; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic	2006
Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors. The Journal of physiology, 2006, Oct-01, Volume: 576, Issue:Pt 1 Topics: Acetylcholine; Alkaloids; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Electrophysiology; Epithelial Cells; Hexamethonium; Humans; Lobeline; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Quinolizines; Receptors, Nicotinic; Transfection	2006
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3 Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Membrane; Male; Mecamylamine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Mice, Knockout; Morphine; Nicotine; Nicotinic Antagonists; Pain; Pyridines; Quinolizines; Reaction Time; Receptors, Nicotinic; Spinal Cord	2007
Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice. Neuroscience, 2007, Jun-08, Volume: 146, Issue:4 Topics: Age Factors; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Azocines; Brain; Bridged Bicyclo Compounds, Heterocyclic; Gene Expression Regulation, Developmental; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation	2007
Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine. Neuropharmacology, 2007, Volume: 53, Issue:3 Topics: Acetylcholine; Alkaloids; Animals; Azocines; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cholinergic Agents; Dose-Response Relationship, Drug; Drug Interactions; Gene Targeting; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Subunits; Pyridines; Quinolizines; Receptors, Nicotinic; Rubidium; Rubidium Radioisotopes	2007
Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology, 2008, Volume: 54, Issue:2 Topics: Alkaloids; Animals; Azocines; Behavior, Animal; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Cell Death; Heart Rate; Immunohistochemistry; Ligands; Male; Neurons; Nicotinic Agonists; Nociceptors; Posterior Horn Cells; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P	2008
Single-channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor. FEBS letters, 2009, Mar-18, Volume: 583, Issue:6 Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cattle; Cholinergic Agonists; Ion Channel Gating; Models, Biological; Nicotine; Patch-Clamp Techniques; Protein Binding; Pyridines; Quinolizines; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin 5-HT3 Receptor Agonists; Xenopus	2009
Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states. The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:9 Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cell Line; Computer Simulation; Electric Organ; Humans; Ibogaine; Linear Models; Models, Molecular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Pyridines; Quinolizines; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo	2011
Functional and structural interaction of (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1 Topics: Adrenergic Uptake Inhibitors; Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Epithelial Cells; HEK293 Cells; Humans; Imipramine; Models, Molecular; Molecular Conformation; Morpholines; Nicotinic Agonists; Patch-Clamp Techniques; Pyridines; Quinolizines; Radioligand Assay; Reboxetine; Receptors, Nicotinic; Torpedo	2013
α6β2-subtype nicotinic acetylcholine receptors are more sensitive than α4β2-subtype receptors to regulation by chronic nicotine administration. Journal of neurochemistry, 2014, Volume: 130, Issue:2 Topics: Alkaloids; Animals; Autoradiography; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; In Vitro Techniques; Mice; Mice, Knockout; Neostriatum; Nicotine; Nicotinic Agonists; Olfactory Bulb; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic; Synaptosomes	2014
Differential expression of the beta4 neuronal nicotinic receptor subunit affects tolerance development and nicotinic binding sites following chronic nicotine treatment. Pharmacology, biochemistry, and behavior, 2015, Volume: 130 Topics: Alkaloids; Animals; Azocines; Binding Sites; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Tolerance; Iodine Radioisotopes; Maze Learning; Mice; Mutation; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Radioligand Assay; Receptors, Nicotinic	2015
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice. Psychopharmacology, 2017, Volume: 234, Issue:5 Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline	2017
Differential cross-tolerance to the effects of nicotinic acetylcholine receptor drugs in C57BL/6J mice following chronic varenicline. Behavioural pharmacology, 2019, Volume: 30, Issue:5 Topics: Alkaloids; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Conditioning, Operant; Drug Tolerance; Female; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Reinforcement, Psychology; Smoking Cessation; Varenicline	2019
Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors. Journal of medicinal chemistry, 1999, Jun-17, Volume: 42, Issue:12 Topics: Animals; Azetidines; Brain; Fluorine Radioisotopes; Humans; Ligands; Male; Papio; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tissue Distribution; Tomography, Emission-Computed	1999
Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes. Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14 Topics: Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Dopamine; In Vitro Techniques; Injections, Spinal; Ligands; Mice; Nicotinic Agonists; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship	2002
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorganic & medicinal chemistry letters, 2004, Apr-19, Volume: 14, Issue:8 Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Gene Expression; Humans; Neurons; Nicotinic Agonists; Protein Subunits; Rats; Receptors, Nicotinic; Transfection	2004
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4 Topics: Alkaloids; Animals; Azocines; Calcium Signaling; Cells, Cultured; Dose-Response Relationship, Drug; Halogens; Humans; Membrane Potentials; Nicotinic Agonists; Protein Binding; Quinolizines; Rats; Receptors, Nicotinic; Structure-Activity Relationship	2005
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. Journal of medicinal chemistry, 2006, May-04, Volume: 49, Issue:9 Topics: Alkaloids; Azocines; Cholinergic Agonists; Hydrophobic and Hydrophilic Interactions; Ligands; Molecular Structure; Nicotine; Quinolizines; Receptors, Cholinergic	2006
Epibatidine isomers and analogues: structure-activity relationships. Bioorganic & medicinal chemistry letters, 2006, Nov-01, Volume: 16, Issue:21 Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Isomerism; Nicotinic Agonists; Pyridines; Structure-Activity Relationship	2006
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes. Bioorganic & medicinal chemistry, 2010, Jun-15, Volume: 18, Issue:12 Topics: Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Heterocyclic Compounds, 3-Ring; Isoxazoles; Ligands; Models, Molecular; Neurons; Protein Binding; Quinolizines; Rats; Receptors, Nicotinic	2010
Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. Journal of medicinal chemistry, 2010, Nov-25, Volume: 53, Issue:22 Topics: alpha7 Nicotinic Acetylcholine Receptor; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Humans; Indoles; Ligands; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship; Transfection	2010
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine. Journal of natural products, 2018, 04-27, Volume: 81, Issue:4 Topics: Alkaloids; Amphibian Venoms; Animals; Anura; Bridged Bicyclo Compounds, Heterocyclic; Heterocyclic Compounds, Bridged-Ring; Nicotine; Nicotinic Agonists; Poisons; Pyridines; Receptors, Nicotinic; Stereoisomerism	2018