Page last updated: 2024-09-05

enzastaurin and guanine

enzastaurin has been researched along with guanine in 11 studies

Compound Research Comparison

Studies
(enzastaurin)
Trials
(enzastaurin)
Recent Studies (post-2010)
(enzastaurin)
Studies
(guanine)
Trials
(guanine)
Recent Studies (post-2010) (guanine)
188529916,2788224,809

Protein Interaction Comparison

ProteinTaxonomyenzastaurin (IC50)guanine (IC50)
Purine nucleoside phosphorylaseHomo sapiens (human)5

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's6 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alice Miller, M; Pearce, HL1
Blatter, J; Eismann, U; Hanauske, AR; Lahn, MM; Ma, D; Oberschmidt, O; Schulz, L; Struck, S1
Boehm, A; Dietz, A; Giannis, A; Mozet, C; Wichmann, G1
Giovannetti, E; Graff, JR; Peters, GJ; Sigmond, J; Smid, K; Tekle, C1
Giaccone, G; Graefe, T; Hanauske, AR; Kuenen, B; Lahn, M; McNealy, P; Musib, LC; Thornton, D; Weigang-Köhler, K; Yilmaz, E1
Giaccone, G; Giovannetti, E; Hanauske, AR; Honeywell, R; Kuenen, B; Peters, GJ; Sigmond, J; Tekle, C1
Barata, F; Barlesi, F; Bearz, A; Bepler, G; Chiappori, A; Chouaki, N; Iscoe, N; Liepa, AM; Park, K; Reck, M; Scagliotti, G; Soria, JC; von Pawel, J; Wagle, A; Zhao, YD1
Baldwin, JR; Koshiji, M; Kunitoh, H; Murakami, H; Nakamura, Y; Nokihara, H; Ohe, Y; Shukuya, T; Takahashi, T; Tamura, T; Tanai, C; Yamamoto, N1
Bradford, D; Bufill, J; Casey, EM; Fisher, W; Hanna, N; Harb, W; Latz, JE; Li, X; Nattam, S; Patel, J; Wu, J1
Asmar, L; Barrera, D; Bromund, J; Choksi, JK; Couch, LS; Jotte, R; Kocs, DM; Obasaju, CK; Patt, DA; Peng, G; Periman, PO; Pritchard, S; Raju, RN; Rousey, SR; Schlossberg, HR; Socinski, MA; Stinchcombe, T; Treat, J; Wang, Y; Weissman, CH1
Chouaki, N; Eschbach, C; Kennedy, L; Ramlau, R; Reck, M; San Antonio, B; Szczesna, A; Vansteenkiste, J; Visseren-Grul, C; von Pawel, J1

Reviews

2 review(s) available for enzastaurin and guanine

ArticleYear
Current aspects of targeted therapy in head and neck tumors.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2008, Volume: 265 Suppl 1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cetuximab; ErbB Receptors; Folic Acid Antagonists; Glutamates; Guanine; Head and Neck Neoplasms; Humans; Indoles; Pemetrexed; Protein-Tyrosine Kinases

2008
Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).
    Current drug targets, 2010, Volume: 11, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Pemetrexed

2010

Trials

6 trial(s) available for enzastaurin and guanine

ArticleYear
Phase Ib safety and pharmacokinetic evaluation of daily and twice daily oral enzastaurin in combination with pemetrexed in advanced/metastatic cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:9

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Glutamates; Guanine; Humans; Indoles; Male; Middle Aged; Neoplasms; Pemetrexed

2009
Phase II, double-blinded, randomized study of enzastaurin plus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Double-Blind Method; Female; Folic Acid; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Pemetrexed; Prognosis; Salvage Therapy; Survival Rate; Vitamin B 12

2010
A phase I study of enzastaurin combined with pemetrexed in advanced non-small cell lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:7

    Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Female; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Neoplasms, Squamous Cell; Pemetrexed; Survival Rate; Tissue Distribution; Treatment Outcome

2010
Randomized, double-blinded, multicenter, phase II study of pemetrexed, carboplatin, and bevacizumab with enzastaurin or placebo in chemonaïve patients with stage IIIB/IV non-small cell lung cancer: Hoosier Oncology Group LUN06-116.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:11

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Carboplatin; Double-Blind Method; Female; Glutamates; Guanine; Humans; Indoles; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Placebos; Pleural Neoplasms; Survival Rate; Treatment Outcome

2010
Randomized, phase II trial of pemetrexed and carboplatin with or without enzastaurin versus docetaxel and carboplatin as first-line treatment of patients with stage IIIB/IV non-small cell lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Female; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Quality of Life

2010
A phase II randomized study of cisplatin-pemetrexed plus either enzastaurin or placebo in chemonaive patients with advanced non-small cell lung cancer.
    Oncology, 2012, Volume: 82, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Double-Blind Method; Female; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Male; Middle Aged; Pemetrexed; Placebos

2012

Other Studies

3 other study(ies) available for enzastaurin and guanine

ArticleYear
The evolution of cancer research and drug discovery at Lilly Research Laboratories.
    Advances in enzyme regulation, 2005, Volume: 45

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Deoxycytidine; Drug Industry; Gemcitabine; Glutamates; Guanine; History, 20th Century; Humans; Indoles; Neoplasms; Pemetrexed; United States

2005
Enzastaurin and pemetrexed exert synergistic antitumor activity in thyroid cancer cell lines in vitro.
    International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Pemetrexed; Protein Kinase C; Protein Kinase C beta; Thyroid Neoplasms

2005
Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.
    British journal of cancer, 2008, Sep-02, Volume: 99, Issue:5

    Topics: Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclooxygenase 2; Drug Synergism; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Lung Neoplasms; Pemetrexed; Phosphorylation; Polymerase Chain Reaction; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Vascular Endothelial Growth Factor A

2008