entacapone and apocodeine

entacapone has been researched along with apocodeine* in 1 studies

Other Studies

1 other study(ies) available for entacapone and apocodeine

Article	Year
Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine. Journal of mass spectrometry : JMS, 2005, Volume: 40, Issue:12 A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human plasma and urine with N-propylnorapomorphine as internal standard using gas chromatography/mass spectrometry (GC/MS) and single-ion monitoring after a single liquid-liquid extraction and silylation of compounds. The quantification limits were 1 ng/ml for apomorphine and apocodeine and 25 ng/ml for norapomorphine. Calibration curves were linear, within the range 1-100 ng/ml. Variation in intraday and interday precision was below 10%. This method was applied to study apomorphine bioavailability in nine patients with Parkinson's disease before and after coadministration of a catechol-O-methyl transferase inhibitor. Topics: Apomorphine; Catechol O-Methyltransferase Inhibitors; Catechols; Gas Chromatography-Mass Spectrometry; Humans; Nitriles; Parkinson Disease; Reproducibility of Results	2005

Article

Year

Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine.

Journal of mass spectrometry : JMS, 2005, Volume: 40, Issue:12

A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human plasma and urine with N-propylnorapomorphine as internal standard using gas chromatography/mass spectrometry (GC/MS) and single-ion monitoring after a single liquid-liquid extraction and silylation of compounds. The quantification limits were 1 ng/ml for apomorphine and apocodeine and 25 ng/ml for norapomorphine. Calibration curves were linear, within the range 1-100 ng/ml. Variation in intraday and interday precision was below 10%. This method was applied to study apomorphine bioavailability in nine patients with Parkinson's disease before and after coadministration of a catechol-O-methyl transferase inhibitor.

Topics: Apomorphine; Catechol O-Methyltransferase Inhibitors; Catechols; Gas Chromatography-Mass Spectrometry; Humans; Nitriles; Parkinson Disease; Reproducibility of Results

2005