enprostil and acetylsalicylic-acid-lysinate

Prostaglandins protect the gastric mucosa in animals, but the evidence of an effect independent of pH changes in man is not overwhelming. Gastrointestinal bleeding because of non-steroidal anti-inflammatory drugs is a major clinical problem, which we have investigated in a model system measuring bleeding rates caused by short-term administration of aspirin. Of the various strategies tested, only those that elevated intra-gastric pH reduced aspirin-induced bleeding.

Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cattle; Enprostil; Fatty Acids, Essential; Fatty Acids, Unsaturated; Female; gamma-Linolenic Acid; Gastrointestinal Hemorrhage; Humans; Linoleic Acid; Linoleic Acids; Lysine; Male; Milk; Oenothera biennis; Plant Oils; Prostaglandins E, Synthetic; Ranitidine