enng and nitrosobis(2-oxopropyl)amine

It may be useful to study the incipient phase and growth behavior of pancreatic cancer if experimental pancreatic carcinoma can be produced in dogs. Twelve mongrel dogs were used. Pancreatography was done every month. N-nitrosobis (2-oxopropyl) amine (BOP) was administered through the drainage tube inserted into the dorsal pancreatic duct in 4 dogs. Macroscopically, atrophy of the pancreas was recognized, but microscopically, no tumors were observed. BOP was injected intraperitoneally in 2 dogs. No tumors were found, and the hepatic necrosis was detected in one dog. N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered into the dorsal pancreatic duct in 2 dogs. Macroscopically, atrophy of the pancreas was recognized, but microscopically, no tumors were observed. ENNG was administered through the drainage tube inserted into the tail portion in 4 dogs. In one dog received a total dose of 595mg of ENNG, duct obstruction was detected by pancreatography and duct adenocarcinoma microscopically was found. Papillary hyperplasia of the epithelium of pancreatic duct was observed in all others. Pancreatic duct adenocarcinoma and papillary hyperplasia were successfully produced in dogs by intraductal administration of ENNG through the pancreatic tail portion. This method seems to be useful for producing experimental pancreatic cancer.

Topics: Adenocarcinoma; Animals; Disease Models, Animal; Dogs; Female; Male; Methylnitronitrosoguanidine; Nitrosamines; Pancreatic Ducts; Pancreatic Neoplasms