enng and epigallocatechin-gallate

enng has been researched along with epigallocatechin-gallate* in 2 studies

Other Studies

2 other study(ies) available for enng and epigallocatechin-gallate

Article	Year
Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis. Cancer, 1996, Apr-15, Volume: 77, Issue:8 Suppl Recently, and epidemiologic study showed a lower risk of gastrointestinal carcinogenesis in green tea drinkers. An experiment on two-stage skin carcinogenesis in mice showed that (-)-epigallocatechin gallate (EGCG), one of the main constituents of green tea, inhibited tumor formation.. The inhibitory effects of EGCG and green tea extract (GTE) on N-ethyl-N'-nitro-N-nitroguanidine (ENNG)-induced duodenal carcinogenesis in the mouse, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced carcinogenesis of the glandular stomach in the rat, and azoxymethane-induced colon carcinogenesis in the rat were examined. The toxicity of GTE was assessed experimentally and GTE was applied clinically in normal volunteers to determine the effective dose and to assess its harmful effects.. EGCG and GRE inhibited chemical carcinogenesis of the gastrointestinal tract in rodents. Judging from the epidemiologic and experimental findings, it was determined that 1 g per day of GTE might be an effective dose. GTE was not toxic and no harmful effect was found during its clinical use.. These findings suggest that EGCG and GTE are useful in preventing gastrointestinal carcinogenesis, and the clinical usefulness of GTE, which has no harmful effects and is inexpensive, should be studied further. Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Catechin; Gastrointestinal Neoplasms; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutagenicity Tests; Plant Extracts; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Tea	1996
Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum. Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:6 (-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically. Topics: Animals; Carcinogens; Catechin; Duodenal Neoplasms; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Molecular Structure	1989

Article

Year

Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis.

Cancer, 1996, Apr-15, Volume: 77, Issue:8 Suppl

Recently, and epidemiologic study showed a lower risk of gastrointestinal carcinogenesis in green tea drinkers. An experiment on two-stage skin carcinogenesis in mice showed that (-)-epigallocatechin gallate (EGCG), one of the main constituents of green tea, inhibited tumor formation.. The inhibitory effects of EGCG and green tea extract (GTE) on N-ethyl-N'-nitro-N-nitroguanidine (ENNG)-induced duodenal carcinogenesis in the mouse, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced carcinogenesis of the glandular stomach in the rat, and azoxymethane-induced colon carcinogenesis in the rat were examined. The toxicity of GTE was assessed experimentally and GTE was applied clinically in normal volunteers to determine the effective dose and to assess its harmful effects.. EGCG and GRE inhibited chemical carcinogenesis of the gastrointestinal tract in rodents. Judging from the epidemiologic and experimental findings, it was determined that 1 g per day of GTE might be an effective dose. GTE was not toxic and no harmful effect was found during its clinical use.. These findings suggest that EGCG and GTE are useful in preventing gastrointestinal carcinogenesis, and the clinical usefulness of GTE, which has no harmful effects and is inexpensive, should be studied further.

Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Catechin; Gastrointestinal Neoplasms; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutagenicity Tests; Plant Extracts; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Tea

1996

Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum.

Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:6

(-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.

Topics: Animals; Carcinogens; Catechin; Duodenal Neoplasms; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Molecular Structure

1989