Page last updated: 2024-09-03

enkephalin-met, arg(6)-phe(7)- and naloxone

enkephalin-met, arg(6)-phe(7)- has been researched along with naloxone in 21 studies

Compound Research Comparison

Studies
(enkephalin-met, arg(6)-phe(7)-)
Trials
(enkephalin-met, arg(6)-phe(7)-)
Recent Studies (post-2010)
(enkephalin-met, arg(6)-phe(7)-)
Studies
(naloxone)
Trials
(naloxone)
Recent Studies (post-2010) (naloxone)
18911020,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomyenkephalin-met, arg(6)-phe(7)- (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199010 (47.62)18.7374
1990's5 (23.81)18.2507
2000's5 (23.81)29.6817
2010's1 (4.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Classen, M; Erberl, T; Madaus, S; Schusdziarra, V; Seufferlein, T1
Scharrer, B; Shipp, MA; Stefano, GB1
Rand, MJ; Wong-Dusting, H1
Greenberg, MJ; Tse, SY; Wong, TM1
Bitar, KN; Makhlouf, GM1
Hirst, M; Kavaliers, M; Teskey, GC1
Giles, TD; Sander, GE1
Audigier, Y; Cros, J; Mazarguil, H; Rossier, J1
Gayton, RJ1
Fei, H; Han, JS; Zhou, ZF1
Chapman, RW; Chipkin, RE1
Inturrisi, CE; Lewis, RV; Stein, S; Stern, AS; Udenfriend, S; Umans, JG; Wolff, D1
Benyhe, S; Farkas, J; Tóth, G; Wollemann, M1
Benyhe, S; Borsodi, A; Medzihradszky, K; Orosz, G; Rónai, AZ; Sartania, N; Szatmári, I1
Chien, GL; Takasaki, Y; van Winkle, DM; Wolff, RA1
Benyhe, S; Bozó, B; Farkas, J; Szucs, M; Tóth, G; Wollemann, M1
Cheong, YP; Cho, KP; Kim, CJ; Kim, JK; Kim, KW; Kwun, J; Woo, RS1
Koob, GF; Terenius, L; Walker, JR1
Bujdosó, E; Farkas, J; Jászberényi, M; Telegdy, G; Tóth, G; Wollemann, M1
Jin, XL; Kobayashi, H; Kosaka, K; Oka, T; Takahashi, S; Yoshikawa, M1
Bagosi, Z; Csabafi, K; Jászberényi, M; Telegdy, G; Tóth, G; Wollemann, M1

Other Studies

21 other study(ies) available for enkephalin-met, arg(6)-phe(7)- and naloxone

ArticleYear
Effect of met-enkephalin and met-enkephalin-Arg6-Phe7 on bombesin-like immunoreactivity (BLI), somatostatin and gastrin secretion from the perfused rat stomach.
    Hepato-gastroenterology, 1990, Volume: 37, Issue:2

    Topics: Animals; Bombesin; Enkephalin, Methionine; Gastric Mucosa; Gastrins; Naloxone; Rats; Somatostatin

1990
A possible immunoregulatory function for [Met]-enkephalin-Arg6-Phe7 involving human and invertebrate granulocytes.
    Journal of neuroimmunology, 1991, Volume: 31, Issue:2

    Topics: Animals; Bivalvia; Cell Movement; Enkephalin, Methionine; Granulocytes; Humans; Immune System; Naloxone; Oligopeptides

1991
Effects of the opioid peptides [Met5]enkephalin-Arg6-Phe7 and [Met5]enkephalin-Arg6-Gly7-Leu8 on cholinergic neurotransmission in the rabbit isolated atria.
    Clinical and experimental pharmacology & physiology, 1987, Volume: 14, Issue:9

    Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Female; Heart; Heart Rate; In Vitro Techniques; Male; Naloxone; Parasympathetic Nervous System; Propranolol; Rabbits; Synaptic Transmission

1987
Cardiovascular effects of intraventricular injection of FMRFamide, Met-enkephalin and their common analogues in the rat.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1985, Volume: 81, Issue:1

    Topics: Animals; Blood Pressure; Enkephalin, Methionine; FMRFamide; Injections, Intraventricular; Male; Naloxone; Oligopeptides; Rats; Structure-Activity Relationship

1985
Selective presence of opiate receptors on intestinal circular muscle cells.
    Life sciences, 1985, Oct-21, Volume: 37, Issue:16

    Topics: Acetylcholine; Animals; Atropine; Benzomorphans; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Humans; Jejunum; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Proglumide; Receptors, Opioid; Sincalide

1985
The effects of opioid and FMRF-amide peptides on thermal behavior in the snail.
    Neuropharmacology, 1985, Volume: 24, Issue:7

    Topics: Animals; beta-Endorphin; Body Temperature; Body Temperature Regulation; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Humans; Morphine; Naloxone; Snails; Stereotyped Behavior

1985
Cardiovascular activities of intravenous methionine-enkephalin-Arg6-Phe7 and methionine-enkephalin-Arg6-Gly7-Leu8 in the conscious dog.
    Life sciences, 1985, Jun-10, Volume: 36, Issue:23

    Topics: Animals; Blood Pressure; Cardiovascular System; Dogs; Endopeptidases; Enkephalin, Methionine; Heart Rate; Naloxone; Structure-Activity Relationship

1985
Met-enkephalin[Arg6,Phe7] interacts with the kappa-receptors on guinea-pig ileum.
    European journal of pharmacology, 1980, Nov-21, Volume: 68, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Naloxone; Receptors, Opioid

1980
Mammalian neuronal actions of FMRFamide and the structurally related opioid Met-enkephalin-Arg6-Phe7.
    Nature, 1982, Jul-15, Volume: 298, Issue:5871

    Topics: Action Potentials; Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; FMRFamide; Male; Medulla Oblongata; Naloxone; Neurons, Efferent; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid

1982
Met-enkephalin-Arg6-Phe7-like immunoreactive substances mediate electroacupuncture analgesia in the periaqueductal gray of the rabbit.
    Brain research, 1984, Nov-26, Volume: 322, Issue:2

    Topics: Acupuncture Therapy; Animals; Brain Mapping; Captopril; Combined Modality Therapy; Electric Stimulation Therapy; Enkephalin, Methionine; Male; Naloxone; Pain; Pain Management; Periaqueductal Gray; Rabbits

1984
Enkephalin heptapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Phe)-induced bronchospasm in guinea pigs: a non-naloxone reversible phenomenon.
    Life sciences, 1984, May-07, Volume: 34, Issue:19

    Topics: Animals; Bronchi; Chromones; Dose-Response Relationship, Drug; Enkephalin, Methionine; Guinea Pigs; Ibuprofen; Imidazoles; Male; Naloxone; Pressure; Trachea; Vagotomy

1984
Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:9

    Topics: Analgesics; Animals; Diarrhea; Diuresis; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Naloxone; Rats

1980
Characterization of [3H]Met-enkephalin-Arg6-Phe7 binding to multiple sites in rat and guinea pig cerebellum.
    Life sciences, 1999, Volume: 64, Issue:14

    Topics: Animals; Binding Sites; Binding, Competitive; Cerebellum; Enkephalin, Methionine; Guinea Pigs; Naloxone; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, sigma; Species Specificity

1999
Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative.
    European journal of pharmacology, 1999, Jun-04, Volume: 373, Issue:2-3

    Topics: Affinity Labels; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brain; Enkephalin, Methionine; Female; Guinea Pigs; Male; Melphalan; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Receptors, Opioid

1999
Met5-enkephalin protects isolated adult rabbit cardiomyocytes via delta-opioid receptors.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; beta-Endorphin; Cell Hypoxia; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Heart; Ischemic Preconditioning; Male; Models, Cardiovascular; Morphine; Myocardial Ischemia; Myocardium; Naloxone; Rabbits; Rats; Receptors, Opioid, delta

1999
Receptor binding and G-protein activation by new Met5-enkephalin-Arg6-Phe7 derived peptides.
    Life sciences, 2000, Feb-18, Volume: 66, Issue:13

    Topics: Animals; Brain; Enkephalin, Methionine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Naloxone; Radioligand Assay; Rana esculenta; Rats; Receptors, Opioid, kappa

2000
Receptor selectivity of Met-enkephalin-Arg6-Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat.
    Life sciences, 2000, May-26, Volume: 67, Issue:1

    Topics: Adult; Animals; Benzeneacetamides; Benzomorphans; Binding Sites; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Ethylketocyclazocine; Female; Humans; Male; Naloxone; Naltrexone; Norepinephrine; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin

2000
Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 27, Issue:2

    Topics: Animals; Behavior, Animal; Conditioning, Psychological; Cues; Down-Regulation; Dynorphins; Electric Stimulation; Enkephalin, Methionine; Male; Naloxone; Narcotic Antagonists; Nociceptin; Olfactory Pathways; Opioid Peptides; Opioid-Related Disorders; Prefrontal Cortex; Rats; Rats, Wistar; Reinforcement, Psychology; Stress, Physiological; Substance Withdrawal Syndrome

2002
Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF.
    Hormones and behavior, 2003, Volume: 43, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Corticotropin-Releasing Hormone; Dopamine; Enkephalin, Methionine; Exploratory Behavior; Haloperidol; Hormone Antagonists; Hypothalamo-Hypophyseal System; Male; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Neostriatum; Organ Culture Techniques; Peptide Fragments; Pituitary-Adrenal System

2003
The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:1

    Topics: Analgesics; Animals; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar

2007
The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
    Peptides, 2011, Volume: 32, Issue:8

    Topics: Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Naloxone; Naltrexone; Oligopeptides; Pituitary-Adrenal System

2011