Page last updated: 2024-09-03

enkephalin-leu, arg(6)- and enkephalin, leucine

enkephalin-leu, arg(6)- has been researched along with enkephalin, leucine in 23 studies

Compound Research Comparison

Studies
(enkephalin-leu, arg(6)-)
Trials
(enkephalin-leu, arg(6)-)
Recent Studies (post-2010)
(enkephalin-leu, arg(6)-)
Studies
(enkephalin, leucine)
Trials
(enkephalin, leucine)
Recent Studies (post-2010) (enkephalin, leucine)
231111,52480754

Protein Interaction Comparison

ProteinTaxonomyenkephalin-leu, arg(6)- (IC50)enkephalin, leucine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.0142
Kappa-type opioid receptorMus musculus (house mouse)0.0417
Mu-type opioid receptorHomo sapiens (human)9.5
Mu-type opioid receptorMus musculus (house mouse)0.0308
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.246

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199010 (43.48)18.7374
1990's11 (47.83)18.2507
2000's1 (4.35)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cassel, JA; Chung, NN; Daubert, JD; DeHaven, RN; Goodman, M; Schiller, PW; Schlechtingen, G; Taulane, JP1
Butler, SH; Nyberg, F; Persson, S; Post, C; Weil-Fugazza, J1
Demuth, HU; Nyberg, F; Silberring, J1
Nyberg, F; Silberring, J2
Demuth, HU; Nyberg, F1
Lantz, I; Nyberg, F; Terenius, L1
Christensson-Nylander, I; Nyberg, F; Ragnarsson, U; Terenius, L1
Nordström, K; Nyberg, F; Terenius, L1
Lindberg, B; Lyrenäs, S; Nyberg, F; Terenius, L1
Lantz, I; Terenius, L1
Shishkina, IuA; Smirnova, AP; Zavalishina, NA; Zverev, MD1
Kimura, S; Lewis, RV; Rossier, J; Stein, S; Stern, AS; Udenfriend, S1
Tan, L; Yu, PH1
Danilova, EI; Grafova, VN; Kryzhanovskiĭ, GN1
Kangawa, K; Matsuo, H; Minamino, N; Mizuno, K1
Nylander, I; Terenius, L; Vlaskovska, M1
Nylander, I; Silberring, J; Tan-No, K; Winter, A1
Gintzler, AR; Gupta, D; Medina, VM1
Aĭzman, RI; Dushina, EN; Mikhaĭlova, NN; Slepushkin, VD1
Domschke, W; Konturek, JW; Konturek, SJ; Pawlik, T1
Kasakov, L; Nylander, I; Sandin, J; Silberring, J; Tan-No, K; Terenius, L; Winter, A1
Cadel, S; Darmon, C; Foulon, T; Hervé, G; Pernier, J1

Trials

1 trial(s) available for enkephalin-leu, arg(6)- and enkephalin, leucine

ArticleYear
Physiological role of nitric oxide in gallbladder emptying in men.
    Digestion, 1997, Volume: 58, Issue:4

    Topics: Adult; Analysis of Variance; Cholecystokinin; Eating; Enkephalin, Leucine; Gallbladder; Gallbladder Emptying; Hemodynamics; Humans; Infusions, Intravenous; Male; Nitric Oxide; omega-N-Methylarginine; Reference Values; Sincalide; Ultrasonography

1997

Other Studies

22 other study(ies) available for enkephalin-leu, arg(6)- and enkephalin, leucine

ArticleYear
Structure-activity relationships of dynorphin a analogues modified in the address sequence.
    Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11

    Topics: Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oligopeptides; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship

2003
Decreased cerebrospinal fluid neuropeptide-converting enzyme activity in monoarthritic rats.
    Neuroscience letters, 1992, Aug-31, Volume: 143, Issue:1-2

    Topics: Animals; Arthritis, Experimental; Cerebrospinal Fluid; Cysteine Endopeptidases; Enkephalin, Leucine; Male; Metalloendopeptidases; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Substance P

1992
Inhibition of proteases with enkephalin-analogue inhibitors.
    Journal of enzyme inhibition, 1991, Volume: 4, Issue:4

    Topics: Amino Acid Sequence; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalins; Hydroxylamines; Molecular Sequence Data; Papain; Protease Inhibitors; Serine Proteinase Inhibitors; Trypsin

1991
Isoforms of a dynorphin B converting enzyme isolated by column electrophoresis in agarose suspension.
    Biochemistry international, 1991, Volume: 23, Issue:1

    Topics: Animals; Cattle; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Dynorphins; Electrophoresis, Agar Gel; Endorphins; Enkephalin, Leucine; Hydroxymercuribenzoates; Isoelectric Point; Isoenzymes; Kinetics; Molecular Weight; Spinal Cord

1991
Studies of specificity and inhibition of human cerebrospinal fluid dynorphin converting enzyme.
    Journal of enzyme inhibition, 1991, Volume: 4, Issue:4

    Topics: Amino Acid Sequence; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Humans; Hydroxylamines; Molecular Sequence Data; Peptides; Protease Inhibitors; Substrate Specificity

1991
Molecular heterogeneity of angiotensin converting enzyme in human cerebrospinal fluid.
    Biochemistry international, 1991, Volume: 23, Issue:5

    Topics: Amino Acid Sequence; Angiotensin-Converting Enzyme Inhibitors; Captopril; Chlorides; Chromatography, High Pressure Liquid; Enalapril; Enkephalin, Leucine; Humans; Molecular Sequence Data; Molecular Weight; Neurokinin A; Peptidyl-Dipeptidase A; Radioimmunoassay; Substance P

1991
A novel bovine spinal cord endoprotease with high specificity for dynorphin B.
    The Journal of biological chemistry, 1989, Jul-05, Volume: 264, Issue:19

    Topics: Amino Acid Sequence; Animals; Cations, Divalent; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Dynorphins; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Endorphins; Enkephalin, Leucine; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; Protease Inhibitors; Spinal Cord; Substrate Specificity; Sulfhydryl Reagents

1989
A general procedure for analysis of proenkephalin B derived opioid peptides.
    Regulatory peptides, 1985, Volume: 11, Issue:1

    Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Humans; Hypothalamus; Molecular Weight; Pituitary Gland; Protein Precursors

1985
Endopeptidase in human cerebrospinal fluid which cleaves proenkephalin B opioid peptides at consecutive basic amino acids.
    Biochemical and biophysical research communications, 1985, Sep-30, Volume: 131, Issue:3

    Topics: Amino Acids; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Humans; Hydrolysis; Protein Precursors; Radioimmunoassay; Serine Endopeptidases; Serine Proteinase Inhibitors

1985
Cerebrospinal fluid activity of dynorphin-converting enzyme at term pregnancy.
    Obstetrics and gynecology, 1988, Volume: 72, Issue:1

    Topics: Cesarean Section; Chromatography, High Pressure Liquid; Dynorphins; Enkephalin, Leucine; Enkephalins; Female; Humans; Luteal Phase; Pregnancy; Protein Precursors; Radioimmunoassay; Serine Endopeptidases

1988
High enkephalyl peptide degradation, due to angiotensin-converting enzyme-like activity in human CSF.
    FEBS letters, 1985, Nov-25, Volume: 193, Issue:1

    Topics: Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalins; Humans; Peptidyl-Dipeptidase A

1985
[Effect of enkephalins on the motor function of smooth-muscle cells of the stomach and mesenteric lymphatic vessels].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1985, Volume: 71, Issue:2

    Topics: Animals; Cattle; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Methionine; Gastrointestinal Motility; In Vitro Techniques; Lymphatic System; Male; Mesentery; Muscle Contraction; Muscle, Smooth; Peristalsis; Rats; Stomach

1985
Opioid hexapeptides and heptapeptides in adrenal medulla and brain possible implications on the biosynthesis of enkephalins.
    Archives of biochemistry and biophysics, 1980, Volume: 205, Issue:2

    Topics: Adrenal Medulla; Amino Acids; Animals; Brain Chemistry; Cattle; Cell Line; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Neuroblastoma; Receptors, Opioid

1980
De novo biosynthesis of enkephalins and their homologues in the human placenta.
    Biochemical and biophysical research communications, 1981, Feb-12, Volume: 98, Issue:3

    Topics: Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; In Vitro Techniques; Peptide Fragments; Placenta; Pregnancy; Radioimmunoassay; Tyrosine

1981
[Demonstration of latent postural asymmetry by means of a synthetic hexapeptide].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:7

    Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalins; Muscle Rigidity; Muscles; Posture; Rats; Spinal Cord Diseases; Tetanus Toxin

1981
Radioimmunoassay for detecting Pro-Leu-enkephalins in tissue extracts: purification and identification of [Arg6]-Leu-enkephalin in porcine pituitary.
    Biochemical and biophysical research communications, 1980, Aug-29, Volume: 95, Issue:4

    Topics: Amino Acid Sequence; Amino Acids; Animals; Endorphins; Enkephalin, Leucine; Enkephalins; Pituitary Gland; Protein Precursors; Radioimmunoassay; Swine; Tissue Extracts

1980
The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats.
    Psychopharmacology, 1995, Volume: 118, Issue:4

    Topics: Analysis of Variance; Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Male; Morphine; Naloxone; Peptides; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

1995
Processing of prodynorphin-derived peptides in striatal extracts. Identification by electrospray ionization mass spectrometry linked to size-exclusion chromatography.
    Life sciences, 1995, Volume: 57, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Chromatography, Gel; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Male; Mass Spectrometry; Peptide Hydrolases; Peptides; Protein Precursors; Rats; Sensitivity and Specificity; Tissue Extracts

1995
Spinal cord dynorphin precursor intermediates decline during late gestation.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Analgesia; Animals; Dynorphins; Enkephalin, Leucine; Female; Molecular Weight; Pregnancy; Pregnancy, Animal; Protein Precursors; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Trypsin

1995
[The effects of enkephalins on the water-salt metabolism of rats in ontogeny].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:8

    Topics: Aging; Animals; Diuresis; Enkephalin, Leucine; Natriuresis; Potassium; Rats; Rats, Wistar; Sodium; Time Factors; Water-Electrolyte Balance

1993
Differential metabolism of dynorphins in substantia nigra, striatum, and hippocampus.
    Peptides, 1997, Volume: 18, Issue:7

    Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dynorphins; Endorphins; Enkephalin, Leucine; Hippocampus; Male; Mass Spectrometry; Protein Precursors; Rats; Substantia Nigra; Tissue Distribution

1997
The M1 family of vertebrate aminopeptidases: role of evolutionarily conserved tyrosines in the enzymatic mechanism of aminopeptidase B.
    Biochimie, 2015, Volume: 109

    Topics: Amino Acid Sequence; Aminopeptidases; Animals; Biocatalysis; Blotting, Western; Conserved Sequence; Enkephalin, Leucine; Evolution, Molecular; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine; Vertebrates

2015