enkephalin, ser(2), leu(5), thr(6)- and enkephalin, d-penicillamine (2,5)-

enkephalin, ser(2), leu(5), thr(6)- has been researched along with enkephalin, d-penicillamine (2,5)- in 53 studies

Compound Research Comparison

Studies (enkephalin, ser(2), leu(5), thr(6)-)	Trials (enkephalin, ser(2), leu(5), thr(6)-)	Recent Studies (post-2010) (enkephalin, ser(2), leu(5), thr(6)-)	Studies (enkephalin, d-penicillamine (2,5)-)	Trials (enkephalin, d-penicillamine (2,5)-)	Recent Studies (post-2010) (enkephalin, d-penicillamine (2,5)-)
224	0	5	1,314	0	73

Protein Interaction Comparison

Protein	Taxonomy	enkephalin, ser(2), leu(5), thr(6)- (IC50)	enkephalin, d-penicillamine (2,5)- (IC50)
Mu-type opioid receptor	Homo sapiens (human)		0.0016
Delta-type opioid receptor	Homo sapiens (human)		0.0011

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (24.53)	18.7374
1990's	35 (66.04)	18.2507
2000's	5 (9.43)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L	1
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Grossman, A; Hucks, D; Joel, SP; McLoughlin, L; Patel, N; Rees, LH; Slevin, ML; Thompson, PI	1
Borsodi, A; Búzás, B; Cavagnero, S; Hruby, VJ; Tóth, G	1
Olianas, MC; Onali, P	1
Fan, LQ; Hiller, JM; Ofri, D; Simon, EJ	1
Portoghese, PS; Sofuoglu, M; Takemori, AE	1
Crook, TJ; Hill, RG; Kitchen, I	1
Bowen, WD; Jiang, Q; Mosberg, HI; Porreca, F; Portoghese, PS; Sultana, M; Takemori, AE	1
Bhargava, HN; Gulati, A; Rahmani, NH	1
Henderson, G; Rogers, H	1
Fan, LQ; Hiller, JM; Simon, EJ	2
Clark, MJ; Medzihradsky, F; Nordby, GL	1
Bidlack, JM; Selley, DE	1
Bodnar, RJ; Gistrak, MA; Pasternak, GW; Paul, D	1
de Castiglione, R; Guglietta, A; Lazarus, LH; Wilson, WE	1
Smith, CB	1
Bodnar, RJ; Lee, SJ; Pasternak, GW; Williams, CL	1
Ho, BY; Naeseth, JS; Portoghese, PS; Takemori, AE	1
Chavkin, C; Mailheau, S; Neumaier, JF	1
Clark, JA; Houghten, R; Pasternak, GW	1
Clark, JA; Hruby, VJ; Itzhak, Y; Pasternak, GW; Yamamura, HI	1
Akil, H; Khachaturian, H; Lewis, ME; Mansour, A; Watson, SJ	1
Heyman, JS; Mosberg, HI; Omnaas, JR; Porreca, F; Vaught, JL	1
Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI	1
Chiappinelli, VA; Feng, C; McMahon, LL; Wolf, KM; Yum, L	1
Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H	1
Búzás, B; Cox, BM; Izenwasser, S	1
Davis, T; Shah, S; Yoburn, BC	1
Erikson, LJ; Evans, C; Law, PY; Loh, HH; McGinn, TM; Wick, MJ	1
Fukushima, N; Misu, Y; Miyamae, T; Ueda, H	1
Breivogel, CS; Childers, SR; Selley, DE	1
Chang, KJ; Comer, SD; De Costa, BR; Hoenicke, EM; McNutt, RW; Mosberg, HI; Sable, AI; Woods, JH	1
Chakrabarti, S; Portoghese, PS; Sultana, M; Takemori, AE	1
Búzás, B; Cox, BM; Izenwasser, S; Portoghese, PS	1
Lanthorn, TH; Watson, GB	1
Hruby, VJ; Kovelowski, CJ; Nichols, ML; Ossipov, MH; Porreca, F	1
Endoh, T; Suzuki, T	1
Christensen, CB; Christrup, LL; Kristensen, K; Nielsen, LC	1
Fujimoto, J; Ho, BY; Holmes, BB; Zhao, J	1
Cheng, Z; Pei, G; Wang, C; Wu, Y; Zhou, D; Zhu, X	1
Blake, AD; Bot, G; Li, S; Reisine, T	1
Lishmanov, IuB; Maslov, LN; Ugdyzhekova, DS	1
Clark, MJ; Liu, XY; Medzihradsky, F; Remmers, AE	1
Chen, J; Chi, ZQ; Li, GE; Pei, G; Wang, CH; Zhou, DH	1
Fujimoto, JM; Holmes, BB; Rady, JJ	1
Gafni, M; Keren, O; Sarne, Y	1
Campbell, WB; Fujimoto, JM; Rady, JJ	1
Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB	1
Gross, GJ; Krylatov, AV; Lasukova, TV; Lishmanov, YB; Maslov, LN; Stefano, GB	1
Gross, GJ; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stefano, GB; Tam, SW	1
Cools, AR; Hirose, N; Koshikawa, N; Murakawa, K; Nagase, H; Oi, Y; Suzuki, T; Takada, K	1

Other Studies

53 other study(ies) available for enkephalin, ser(2), leu(5), thr(6)- and enkephalin, d-penicillamine (2,5)-

Article	Year
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Molecular pharmacology, 1994, Volume: 45, Issue:2 Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software	1994
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide. British journal of cancer, 1992, Volume: 65, Issue:1 Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Morphine; Morphine Derivatives; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Subcellular Fractions	1992
Synthesis and binding characteristics of the highly delta-specific new tritiated opioid peptide, [3H]deltorphin II. Life sciences, 1992, Volume: 50, Issue:14 Topics: Analgesics; Animals; Benzeneacetamides; Brain; Cell Membrane; Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indicators and Reagents; Isotope Labeling; Kinetics; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	1992
Characterization of opioid receptors mediating stimulation of adenylate cyclase activity in rat olfactory bulb. Molecular pharmacology, 1992, Volume: 42, Issue:1 Topics: Adenylyl Cyclases; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Enzyme Activation; Male; Narcotic Antagonists; Olfactory Bulb; Oligopeptides; Opioid Peptides; Rats; Rats, Inbred Strains; Receptors, Opioid	1992
Lesioning of the nucleus basalis of Meynert has differential effects on mu, delta and kappa opioid receptor binding in rat brain: a quantitative autoradiographic study. Brain research, 1992, May-29, Volume: 581, Issue:2 Topics: Animals; Autoradiography; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kinetics; Male; Organ Specificity; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values; Substantia Innominata; Tritium	1992
delta-Opioid receptor binding in mouse brain: evidence for heterogeneous binding sites. European journal of pharmacology, 1992, Jun-05, Volume: 216, Issue:2 Topics: Animals; Binding, Competitive; Brain Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Membranes; Mice; Naltrexone; Narcotic Antagonists; Receptors, Opioid, delta	1992
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats. British journal of pharmacology, 1992, Volume: 107, Issue:2 Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta	1992
Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:3 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Injections, Intraventricular; Isothiocyanates; Male; Mice; Mice, Inbred ICR; Morphinans; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Thiocyanates	1991
Differences in the binding of [3H][D-Ser2,Thr6]leucine-enkephalin and [3H][D-Pen2,D-Pen5]enkephalin to brain membranes of morphine tolerant-dependent rats. European journal of pharmacology, 1991, Sep-24, Volume: 202, Issue:3 Topics: Analgesics; Animals; Brain; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Ligands; Male; Morphine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Substance-Related Disorders	1991
Activation of mu- and delta-opioid receptors present on the same nerve terminals depresses transmitter release in the mouse hypogastric ganglion. British journal of pharmacology, 1990, Volume: 101, Issue:3 Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Ganglia; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Nerve Endings; Neurotransmitter Agents; Oligopeptides; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1990
Differential effects of cyanogen bromide on ligand binding by mu, delta and kappa opioid receptors. Life sciences, 1990, Volume: 47, Issue:24 Topics: Animals; Brain; Cell Membrane; Cyanogen Bromide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ligands; Male; Methionine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Relationship between opioid-receptor occupancy and stimulation of low-Km GTPase in brain membranes. Journal of neurochemistry, 1989, Volume: 52, Issue:4 Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; Guanosine Triphosphate; Magnesium; Membranes; Naltrexone; Oligopeptides; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium	1989
Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements. Brain research, 1989, Jul-24, Volume: 493, Issue:1 Topics: beta-Endorphin; Cations; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Hybrid Cells; Neuroblastoma; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride; Tumor Cells, Cultured	1989
Different mu receptor subtypes mediate spinal and supraspinal analgesia in mice. European journal of pharmacology, 1989, Sep-22, Volume: 168, Issue:3 Topics: Analgesia; Anesthesia, Spinal; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1989
Dermorphin gene sequence peptide with high affinity and selectivity for delta-opioid receptors. The Journal of biological chemistry, 1989, Feb-25, Volume: 264, Issue:6 Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Oligopeptides; Opioid Peptides; Protein Conformation; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Synaptosomes	1989
New approaches to the evaluation of opioid agonists and antagonists upon the isolated, electrically stimulated mouse vas deferens preparation. NIDA research monograph, 1987, Volume: 76 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Receptors, Opioid; Vas Deferens	1987
Role of mu 1-opiate receptors in supraspinal opiate analgesia: a microinjection study. Brain research, 1988, Apr-26, Volume: 447, Issue:1 Topics: Analgesia; Animals; Brain; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Male; Microinjections; Morphine; Oligopeptides; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord	1988
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Male; Mice; Morphine; Naltrexone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa	1988
Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GABA Antagonists; Hippocampus; Interneurons; Naloxone; Oligopeptides; Rats; Receptors, Opioid	1988
Opiate binding in calf thalamic membranes: a selective mu 1 binding assay. Molecular pharmacology, 1988, Volume: 34, Issue:3 Topics: Animals; Cattle; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hydrogen-Ion Concentration; In Vitro Techniques; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus	1988
[D-Pen2,D-Pen5]enkephalin (DPDPE): a delta-selective enkephalin with low affinity for mu 1 opiate binding sites. European journal of pharmacology, 1986, Sep-09, Volume: 128, Issue:3 Topics: Animals; Brain Chemistry; Cattle; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1986
Pharmacological and anatomical evidence of selective mu, delta, and kappa opioid receptor binding in rat brain. Brain research, 1986, Dec-03, Volume: 399, Issue:1 Topics: Animals; Autoradiography; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1986
Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: Analgesia; Anesthesia, Spinal; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1987
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:19 Topics: Animals; Binding, Competitive; Biological Assay; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isomerism; Kinetics; Muscle Contraction; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship	1983
Different responses to opioids measured in terminals and somas of Edinger-Westphal neurons. Neuroscience, 1993, Volume: 57, Issue:2 Topics: Amino Acid Sequence; Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; GTP-Binding Proteins; In Vitro Techniques; Molecular Sequence Data; Naloxone; Nerve Endings; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Reticular Formation; Substance P	1993
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes. Neuroscience letters, 1994, Jul-18, Volume: 176, Issue:1 Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity	1994
Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1 Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Benzeneacetamides; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Molecular Sequence Data; Naloxone; Naltrexone; Nucleus Accumbens; Oligopeptides; Putamen; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Somatostatin	1993
The effect of naltrindole on spinal and supraspinal delta opioid receptors and analgesia. Life sciences, 1994, Volume: 55, Issue:19 Topics: Analgesia; Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Injections, Spinal; Kinetics; Male; Mice; Naltrexone; Pain Measurement; Receptors, Opioid, delta; Spinal Cord	1994
Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density? The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3 Topics: Adenylyl Cyclase Inhibitors; Animals; Base Sequence; CHO Cells; Cricetinae; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Molecular Sequence Data; Receptors, Opioid, delta; RNA, Messenger; Transfection	1994
Delta opioid receptor mediates phospholipase C activation via Gi in Xenopus oocytes. FEBS letters, 1993, Nov-01, Volume: 333, Issue:3 Topics: Analgesics; Animals; Benzeneacetamides; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Female; Gene Expression; GTP-Binding Proteins; Membrane Potentials; Mice; Naltrexone; Narcotic Antagonists; Oocytes; Pyrrolidines; Receptors, Opioid, delta; Type C Phospholipases; Xenopus laevis	1993
Modification of G protein-coupled functions by low-pH pretreatment of membranes from NG108-15 cells: increase in opioid agonist efficacy by decreased inactivation of G proteins. Molecular pharmacology, 1993, Volume: 44, Issue:4 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guanosine Triphosphate; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mice; Rats; Receptors, Opioid; Sodium; Tritium; Tumor Cells, Cultured	1993
Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2 Topics: Amino Acid Sequence; Animals; Anticonvulsants; Benzamides; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Midazolam; Molecular Sequence Data; Naltrexone; Pentylenetetrazole; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, mu; Seizures	1993
Differential antagonism by naltrindole-5'-isothiocyanate on [3H]DSLET and [3H]DPDPE binding to striatal slices of mice. Life sciences, 1993, Volume: 53, Issue:23 Topics: Analgesics; Animals; Corpus Striatum; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Isothiocyanates; Kinetics; Male; Mice; Naltrexone; Radioligand Assay; Receptors, Opioid, delta; Tritium	1993
Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain. Life sciences, 1994, Volume: 54, Issue:7 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Benzylidene Compounds; Caudate Nucleus; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta	1994
Electrophysiological actions of delta opioids in CA1 of the rat hippocampal slice are mediated by one delta receptor subtype. Brain research, 1993, Jan-22, Volume: 601, Issue:1-2 Topics: Analgesics; Animals; Electric Stimulation; Electrophysiology; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Indoles; Ligands; Male; Morphinans; Morphine; Naltrexone; Narcotic Antagonists; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	1993
Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain, 1995, Volume: 62, Issue:3 Topics: Animals; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Medulla Oblongata; Morphine; Nociceptors; Oligopeptides; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reticular Formation	1995
The effects of delta-opioid receptor agonists on synaptic transmission in hamster submandibular ganglion. The Bulletin of Tokyo Dental College, 1995, Volume: 36, Issue:2 Topics: Animals; Autonomic Fibers, Preganglionic; Cricetinae; Dimethylphenylpiperazinium Iodide; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Ganglia, Parasympathetic; Ganglionic Stimulants; Naloxone; Narcotic Antagonists; Presynaptic Terminals; Receptors, Opioid, delta; Submandibular Gland; Synaptic Transmission	1995
Autoradiographic comparison of [3H]DPDPE and [3H]DSLET binding: evidence for distinct delta 1 and delta 2 opioid receptor populations in rat brain. Brain research, 1996, May-06, Volume: 719, Issue:1-2 Topics: Animals; Autoradiography; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta	1996
The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene. Pharmacology & toxicology, 1996, Volume: 79, Issue:2 Topics: Allylamine; Analgesics, Opioid; Animals; Binding, Competitive; Cattle; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Isonipecotic Acids; Meperidine; Parasympatholytics; Phenols; Receptors, Opioid, delta; Receptors, Opioid, mu	1996
Determination of delta-opioid in NG108-15 cells. European journal of pharmacology, 1997, Jan-14, Volume: 319, Issue:1 Topics: Animals; Benzylidene Compounds; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured	1997
The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activation. Biochemical and biophysical research communications, 1997, Mar-17, Volume: 232, Issue:2 Topics: Amino Acid Sequence; Animals; Biological Transport; Cell Line; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Humans; Kidney; Mice; Receptors, Opioid, delta; Signal Transduction; Transfection	1997
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells. Molecular pharmacology, 1997, Volume: 52, Issue:2 Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship	1997
[The use of central administration of the delta1- and delta2-opiate receptor agonists for prevention of the experimental adrenal arrhythmias]. Biulleten' eksperimental'noi biologii i meditsiny, 1997, Volume: 124, Issue:9 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Epinephrine; Injections, Intraventricular; Male; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Vagus Nerve	1997
Delta opioid receptor down-regulation is independent of functional G protein yet is dependent on agonist efficacy. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2 Topics: Adenylyl Cyclase Inhibitors; Animals; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Rats; Receptors, Opioid; Tumor Cells, Cultured	1998
Binding properties of C-truncated delta opioid receptors. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:4 Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Peptide Fragments; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu	1997
Antianalgesic action of dynorphin A mediated by spinal cholecystokinin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 220, Issue:3 Topics: Analgesia; Analgesics; Animals; Antibodies; Cholecystokinin; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Injections, Spinal; Male; Meglumine; Mice; Morphine; Proglumide; Receptors, Cholecystokinin; Receptors, Opioid, delta; Spinal Cord	1999
Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels. Brain research, 1999, Oct-02, Volume: 843, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Calcium Channel Blockers; Calcium Channels, N-Type; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Humans; Neuroblastoma; omega-Conotoxins; Pertussis Toxin; Potassium Cyanide; Receptors, Opioid, kappa; Tumor Cells, Cultured; Virulence Factors, Bordetella	1999
Antianalgesic action of nociceptin originating in the brain is mediated by spinal prostaglandin E(2) in mice. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:1 Topics: Analgesics, Opioid; Animals; Brain; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Indomethacin; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptin; Opioid Peptides; Pain Measurement; Receptors, Prostaglandin; Spinal Cord; Substance P	2001
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2001, Volume: 87, Issue:12 Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan	2001
Effect of in vivo and in vitro stimulation of delta1-opioid receptors on myocardial resistance to arrhythmogenic action of ischemia and reperfusion. Bulletin of experimental biology and medicine, 2002, Volume: 134, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta	2002
Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels. Life sciences, 2003, Jul-04, Volume: 73, Issue:7 Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Decanoic Acids; Disease Models, Animal; Drug Antagonism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Hydroxy Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Naloxone; Potassium Channels; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Opioid, delta; Sclerosis; Ventricular Fibrillation	2003
Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens. Neuroscience, 2005, Volume: 135, Issue:1 Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Benzylidene Compounds; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Male; Microdialysis; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Tetrodotoxin	2005